diff --git a/Cargo.lock b/Cargo.lock
index 2d5761bf..19852e94 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -31,7 +31,7 @@ dependencies = [
  "actix-utils",
  "ahash",
  "base64",
- "bitflags 2.3.3",
+ "bitflags 2.4.0",
  "brotli",
  "bytes",
  "bytestring",
@@ -60,12 +60,12 @@ dependencies = [
 
 [[package]]
 name = "actix-macros"
-version = "0.2.3"
+version = "0.2.4"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "465a6172cf69b960917811022d8f29bc0b7fa1398bc4f78b3c466673db1213b6"
+checksum = "e01ed3140b2f8d422c68afa1ed2e85d996ea619c988ac834d255db32138655cb"
 dependencies = [
  "quote",
- "syn 1.0.109",
+ "syn 2.0.37",
 ]
 
 [[package]]
@@ -83,9 +83,9 @@ dependencies = [
 
 [[package]]
 name = "actix-rt"
-version = "2.8.0"
+version = "2.9.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "15265b6b8e2347670eb363c47fc8c75208b4a4994b27192f345fcbe707804f3e"
+checksum = "28f32d40287d3f402ae0028a9d54bef51af15c8769492826a69d28f81893151d"
 dependencies = [
  "futures-core",
  "tokio",
@@ -93,9 +93,9 @@ dependencies = [
 
 [[package]]
 name = "actix-server"
-version = "2.2.0"
+version = "2.3.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "3e8613a75dd50cc45f473cee3c34d59ed677c0f7b44480ce3b8247d7dc519327"
+checksum = "3eb13e7eef0423ea6eab0e59f6c72e7cb46d33691ad56a726b3cd07ddec2c2d4"
 dependencies = [
  "actix-rt",
  "actix-service",
@@ -103,8 +103,7 @@ dependencies = [
  "futures-core",
  "futures-util",
  "mio",
- "num_cpus",
- "socket2 0.4.9",
+ "socket2",
  "tokio",
  "tracing",
 ]
@@ -165,28 +164,28 @@ dependencies = [
  "serde_json",
  "serde_urlencoded",
  "smallvec",
- "socket2 0.5.3",
+ "socket2",
  "time",
  "url",
 ]
 
 [[package]]
 name = "actix-web-codegen"
-version = "4.2.0"
+version = "4.2.2"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "2262160a7ae29e3415554a3f1fc04c764b1540c116aa524683208078b7a75bc9"
+checksum = "eb1f50ebbb30eca122b188319a4398b3f7bb4a8cdf50ecfb73bfc6a3c3ce54f5"
 dependencies = [
  "actix-router",
  "proc-macro2",
  "quote",
- "syn 1.0.109",
+ "syn 2.0.37",
 ]
 
 [[package]]
 name = "addr2line"
-version = "0.20.0"
+version = "0.21.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "f4fa78e18c64fce05e902adecd7a5eed15a5e0a3439f7b0e169f0252214865e3"
+checksum = "8a30b2e23b9e17a9f90641c7ab1549cd9b44f296d3ccbf309d2863cfe398a0cb"
 dependencies = [
  "gimli",
 ]
@@ -211,9 +210,9 @@ dependencies = [
 
 [[package]]
 name = "aho-corasick"
-version = "1.0.2"
+version = "1.0.5"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "43f6cb1bf222025340178f382c426f13757b2960e89779dfcb319c32542a5a41"
+checksum = "0c378d78423fdad8089616f827526ee33c19f2fddbd5de1629152c9593ba4783"
 dependencies = [
  "memchr",
 ]
@@ -235,9 +234,9 @@ dependencies = [
 
 [[package]]
 name = "allocator-api2"
-version = "0.2.15"
+version = "0.2.16"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "56fc6cf8dc8c4158eed8649f9b8b0ea1518eb62b544fe9490d66fa0b349eafe9"
+checksum = "0942ffc6dcaadf03badf6e6a2d0228460359d5e34b57ccdc720b7382dfbd5ec5"
 
 [[package]]
 name = "android-tzdata"
@@ -256,9 +255,9 @@ dependencies = [
 
 [[package]]
 name = "annonars"
-version = "0.14.1"
+version = "0.20.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "a535a1cd6a637e969e5871a6e94951d179a54121a34be9e65eea98a8b495720b"
+checksum = "856d2a30152c991d240d14a38c724f0f800e65d44a5b9ea34279cd67a9e6f912"
 dependencies = [
  "actix-web",
  "anyhow",
@@ -269,7 +268,7 @@ dependencies = [
  "clap",
  "clap-verbosity-flag",
  "csv",
- "enum-map 2.6.0",
+ "enum-map 2.6.3",
  "env_logger",
  "flate2",
  "hgvs",
@@ -282,8 +281,8 @@ dependencies = [
  "noodles-csi",
  "noodles-tabix",
  "noodles-vcf",
- "prost 0.11.9",
- "prost-build 0.11.9",
+ "prost",
+ "prost-build",
  "rayon",
  "rocksdb",
  "rocksdb-utils-lookup",
@@ -312,9 +311,9 @@ dependencies = [
 
 [[package]]
 name = "anstyle"
-version = "1.0.1"
+version = "1.0.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "3a30da5c5f2d5e72842e00bcb57657162cdabef0931f40e2deb9b4140440cecd"
+checksum = "b84bf0a05bbb2a83e5eb6fa36bb6e87baa08193c35ff52bbf6b38d8af2890e46"
 
 [[package]]
 name = "anstyle-parse"
@@ -361,13 +360,13 @@ dependencies = [
 
 [[package]]
 name = "async-trait"
-version = "0.1.69"
+version = "0.1.73"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "7b2d0f03b3640e3a630367e40c468cb7f309529c708ed1d88597047b0e7c6ef7"
+checksum = "bc00ceb34980c03614e35a3a4e218276a0a824e911d07651cd0d858a51e8c0f0"
 dependencies = [
  "proc-macro2",
  "quote",
- "syn 2.0.26",
+ "syn 2.0.37",
 ]
 
 [[package]]
@@ -378,9 +377,9 @@ checksum = "d468802bab17cbc0cc575e9b053f41e72aa36bfa6b7f55e3529ffa43161b97fa"
 
 [[package]]
 name = "backtrace"
-version = "0.3.68"
+version = "0.3.69"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "4319208da049c43661739c5fade2ba182f09d1dc2299b32298d3a31692b17e12"
+checksum = "2089b7e3f35b9dd2d0ed921ead4f6d318c27680d4a5bd167b3ee120edb105837"
 dependencies = [
  "addr2line",
  "cc",
@@ -399,9 +398,9 @@ checksum = "4c7f02d4ea65f2c1853089ffd8d2787bdbc63de2f0d29dedbcf8ccdfa0ccd4cf"
 
 [[package]]
 name = "base64"
-version = "0.21.2"
+version = "0.21.4"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "604178f6c5c21f02dc555784810edfb88d34ac2c73b2eae109655649ee73ce3d"
+checksum = "9ba43ea6f343b788c8764558649e08df62f86c6ef251fdaeb1ffd010a9ae50a2"
 
 [[package]]
 name = "bgzip"
@@ -427,20 +426,20 @@ dependencies = [
  "lazy_static",
  "lazycell",
  "peeking_take_while",
- "prettyplease 0.2.9",
+ "prettyplease",
  "proc-macro2",
  "quote",
  "regex",
  "rustc-hash",
  "shlex",
- "syn 2.0.26",
+ "syn 2.0.37",
 ]
 
 [[package]]
 name = "bio"
-version = "1.3.1"
+version = "1.4.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "549b4c9b9f56970dd6c169a59d04cf4b940aba860c4023cb8427ec4967b4d84e"
+checksum = "ea643e25059ce02b94e8f6eb4e902d160baa6d0beb91834ed971dd5a880c02ba"
 dependencies = [
  "anyhow",
  "approx",
@@ -454,7 +453,7 @@ dependencies = [
  "enum-map 1.1.1",
  "fxhash",
  "getset",
- "itertools 0.11.0",
+ "itertools",
  "itertools-num",
  "lazy_static",
  "multimap",
@@ -470,7 +469,7 @@ dependencies = [
  "serde_derive",
  "statrs",
  "strum",
- "strum_macros 0.25.1",
+ "strum_macros",
  "thiserror",
  "triple_accel",
  "vec_map",
@@ -478,14 +477,14 @@ dependencies = [
 
 [[package]]
 name = "bio-types"
-version = "1.0.0"
+version = "1.0.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "c915bf6c578d40e1e497f8c571a4514bc89c3195cec2abb8be6dd5500405c752"
+checksum = "9d45749b87f21808051025e9bf714d14ff4627f9d8ca967eade6946ea769aa4a"
 dependencies = [
  "derive-new",
  "lazy_static",
  "regex",
- "strum_macros 0.24.3",
+ "strum_macros",
  "thiserror",
 ]
 
@@ -512,9 +511,9 @@ checksum = "bef38d45163c2f1dde094a7dfd33ccf595c92905c8f8f4fdc18d06fb1037718a"
 
 [[package]]
 name = "bitflags"
-version = "2.3.3"
+version = "2.4.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "630be753d4e58660abd17930c71b647fe46c27ea6b63cc59e1e3851406972e42"
+checksum = "b4682ae6287fcf752ecaabbfcc7b6f9b72aa33933dc23a554d853aea8eea8635"
 
 [[package]]
 name = "block-buffer"
@@ -554,9 +553,9 @@ dependencies = [
 
 [[package]]
 name = "bumpalo"
-version = "3.13.0"
+version = "3.14.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "a3e2c3daef883ecc1b5d58c15adae93470a91d425f3532ba1695849656af3fc1"
+checksum = "7f30e7476521f6f8af1a1c4c0b8cc94f0bee37d91763d0ca2665f299b6cd8aec"
 
 [[package]]
 name = "bv"
@@ -586,9 +585,9 @@ checksum = "2c676a478f63e9fa2dd5368a42f28bba0d6c560b775f38583c8bbaa7fcd67c9c"
 
 [[package]]
 name = "bytemuck"
-version = "1.13.1"
+version = "1.14.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "17febce684fd15d89027105661fec94afb475cb995fbc59d2865198446ba2eea"
+checksum = "374d28ec25809ee0e23827c2ab573d729e293f281dfe393500e7ad618baa61c6"
 
 [[package]]
 name = "byteorder"
@@ -598,9 +597,9 @@ checksum = "14c189c53d098945499cdfa7ecc63567cf3886b3332b312a5b4585d8d3a6a610"
 
 [[package]]
 name = "bytes"
-version = "1.4.0"
+version = "1.5.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "89b2fd2a0dcf38d7971e2194b6b6eebab45ae01067456a7fd93d5547a61b70be"
+checksum = "a2bd12c1caf447e69cd4528f47f94d203fd2582878ecb9e9465484c4148a8223"
 
 [[package]]
 name = "bytestring"
@@ -624,11 +623,12 @@ dependencies = [
 
 [[package]]
 name = "cc"
-version = "1.0.79"
+version = "1.0.83"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "50d30906286121d95be3d479533b458f87493b30a4b5f79a607db8f5d11aa91f"
+checksum = "f1174fb0b6ec23863f8b971027804a42614e347eafb0a95bf0b12cdae21fc4d0"
 dependencies = [
  "jobserver",
+ "libc",
 ]
 
 [[package]]
@@ -648,9 +648,9 @@ checksum = "baf1de4339761588bc0619e3cbc0120ee582ebb74b53b4efbf79117bd2da40fd"
 
 [[package]]
 name = "chrono"
-version = "0.4.30"
+version = "0.4.31"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "defd4e7873dbddba6c7c91e199c7fcb946abc4a6a4ac3195400bcfb01b5de877"
+checksum = "7f2c685bad3eb3d45a01354cedb7d5faa66194d1d58ba6e267a8de788f79db38"
 dependencies = [
  "android-tzdata",
  "iana-time-zone",
@@ -658,7 +658,7 @@ dependencies = [
  "num-traits",
  "serde",
  "wasm-bindgen",
- "windows-targets 0.48.1",
+ "windows-targets 0.48.5",
 ]
 
 [[package]]
@@ -674,9 +674,9 @@ dependencies = [
 
 [[package]]
 name = "clap"
-version = "4.4.2"
+version = "4.4.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "6a13b88d2c62ff462f88e4a121f17a82c1af05693a2f192b5c38d14de73c19f6"
+checksum = "84ed82781cea27b43c9b106a979fe450a13a31aab0500595fb3fc06616de08e6"
 dependencies = [
  "clap_builder",
  "clap_derive",
@@ -713,14 +713,14 @@ dependencies = [
  "heck",
  "proc-macro2",
  "quote",
- "syn 2.0.26",
+ "syn 2.0.37",
 ]
 
 [[package]]
 name = "clap_lex"
-version = "0.5.0"
+version = "0.5.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "2da6da31387c7e4ef160ffab6d5e7f00c42626fe39aea70a7b0f1773f7dd6c1b"
+checksum = "cd7cc57abe963c6d3b9d8be5b06ba7c8957a930305ca90304f24ef040aa6f961"
 
 [[package]]
 name = "colorchoice"
@@ -766,9 +766,9 @@ checksum = "e496a50fda8aacccc86d7529e2c1e0892dbd0f898a6b5645b5561b89c3210efa"
 
 [[package]]
 name = "cpufeatures"
-version = "0.2.8"
+version = "0.2.9"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "03e69e28e9f7f77debdedbaafa2866e1de9ba56df55a8bd7cfc724c25a09987c"
+checksum = "a17b76ff3a4162b0b27f354a0c87015ddad39d35f9c0c36607a3bdd175dde1f1"
 dependencies = [
  "libc",
 ]
@@ -864,9 +864,9 @@ checksum = "ef8ae57c4978a2acd8b869ce6b9ca1dfe817bff704c220209fdef2c0b75a01b9"
 
 [[package]]
 name = "darling"
-version = "0.20.1"
+version = "0.20.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "0558d22a7b463ed0241e993f76f09f30b126687447751a8638587b864e4b3944"
+checksum = "0209d94da627ab5605dcccf08bb18afa5009cfbef48d8a8b7d7bdbc79be25c5e"
 dependencies = [
  "darling_core",
  "darling_macro",
@@ -874,27 +874,36 @@ dependencies = [
 
 [[package]]
 name = "darling_core"
-version = "0.20.1"
+version = "0.20.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "ab8bfa2e259f8ee1ce5e97824a3c55ec4404a0d772ca7fa96bf19f0752a046eb"
+checksum = "177e3443818124b357d8e76f53be906d60937f0d3a90773a664fa63fa253e621"
 dependencies = [
  "fnv",
  "ident_case",
  "proc-macro2",
  "quote",
  "strsim",
- "syn 2.0.26",
+ "syn 2.0.37",
 ]
 
 [[package]]
 name = "darling_macro"
-version = "0.20.1"
+version = "0.20.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "29a358ff9f12ec09c3e61fef9b5a9902623a695a46a917b07f269bff1445611a"
+checksum = "836a9bbc7ad63342d6d6e7b815ccab164bc77a2d95d84bc3117a8c0d5c98e2d5"
 dependencies = [
  "darling_core",
  "quote",
- "syn 2.0.26",
+ "syn 2.0.37",
+]
+
+[[package]]
+name = "deranged"
+version = "0.3.8"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "f2696e8a945f658fd14dc3b87242e6b80cd0f36ff04ea560fa39082368847946"
+dependencies = [
+ "serde",
 ]
 
 [[package]]
@@ -957,9 +966,9 @@ checksum = "3e02df23d5b1c6f9e69fa603b890378123b93073df998a21e6e33b9db0a32613"
 
 [[package]]
 name = "either"
-version = "1.8.1"
+version = "1.9.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "7fcaabb2fef8c910e7f4c7ce9f67a1283a1715879a7c230ca9d6d1ae31f16d91"
+checksum = "a26ae43d7bcc3b814de94796a5e736d4029efb0ee900c12e2d54c993ad1a1e07"
 
 [[package]]
 name = "encode_unicode"
@@ -969,9 +978,9 @@ checksum = "a357d28ed41a50f9c765dbfe56cbc04a64e53e5fc58ba79fbc34c10ef3df831f"
 
 [[package]]
 name = "encoding_rs"
-version = "0.8.32"
+version = "0.8.33"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "071a31f4ee85403370b58aca746f01041ede6f0da2730960ad001edc2b71b394"
+checksum = "7268b386296a025e474d5140678f75d6de9493ae55a5d709eeb9dd08149945e1"
 dependencies = [
  "cfg-if",
 ]
@@ -987,11 +996,11 @@ dependencies = [
 
 [[package]]
 name = "enum-map"
-version = "2.6.0"
+version = "2.6.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "017b207acb4cc917f4c31758ed95c0bc63ddb0f358b22eb38f80a2b2a43f6b1f"
+checksum = "c188012f8542dee7b3996e44dd89461d64aa471b0a7c71a1ae2f595d259e96e5"
 dependencies = [
- "enum-map-derive 0.12.0",
+ "enum-map-derive 0.14.0",
  "serde",
 ]
 
@@ -1008,13 +1017,13 @@ dependencies = [
 
 [[package]]
 name = "enum-map-derive"
-version = "0.12.0"
+version = "0.14.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "8560b409800a72d2d7860f8e5f4e0b0bd22bea6a352ea2a9ce30ccdef7f16d2f"
+checksum = "04d0b288e3bb1d861c4403c1774a6f7a798781dfc519b3647df2a3dd4ae95f25"
 dependencies = [
  "proc-macro2",
  "quote",
- "syn 2.0.26",
+ "syn 2.0.37",
 ]
 
 [[package]]
@@ -1032,15 +1041,15 @@ dependencies = [
 
 [[package]]
 name = "equivalent"
-version = "1.0.0"
+version = "1.0.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "88bffebc5d80432c9b140ee17875ff173a8ab62faad5b257da912bd2f6c1c0a1"
+checksum = "5443807d6dff69373d433ab9ef5378ad8df50ca6298caf15de6e52e24aaf54d5"
 
 [[package]]
 name = "errno"
-version = "0.3.1"
+version = "0.3.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "4bcfec3a70f97c962c307b2d2c56e358cf1d00b558d74262b5f929ee8cc7e73a"
+checksum = "136526188508e25c6fef639d7927dfb3e0e3084488bf202267829cf7fc23dbdd"
 dependencies = [
  "errno-dragonfly",
  "libc",
@@ -1071,12 +1080,9 @@ checksum = "7360491ce676a36bf9bb3c56c1aa791658183a54d2744120f27285738d90465a"
 
 [[package]]
 name = "fastrand"
-version = "1.9.0"
+version = "2.0.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "e51093e27b0797c359783294ca4f0a911c270184cb10f85783b118614a1501be"
-dependencies = [
- "instant",
-]
+checksum = "6999dc1837253364c2ebb0704ba97994bd874e8f195d665c50b7548f6ea92764"
 
 [[package]]
 name = "feature-probe"
@@ -1084,6 +1090,12 @@ version = "0.1.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "835a3dc7d1ec9e75e2b5fb4ba75396837112d2060b03f7d43bc1897c7f7211da"
 
+[[package]]
+name = "finl_unicode"
+version = "1.2.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "8fcfdc7a0362c9f4444381a9e697c79d435fe65b52a37466fc2c1184cee9edc6"
+
 [[package]]
 name = "fixedbitset"
 version = "0.4.2"
@@ -1177,7 +1189,7 @@ checksum = "89ca545a94061b6365f2c7355b4b32bd20df3ff95f02da9329b34ccc3bd6ee72"
 dependencies = [
  "proc-macro2",
  "quote",
- "syn 2.0.26",
+ "syn 2.0.37",
 ]
 
 [[package]]
@@ -1260,9 +1272,9 @@ dependencies = [
 
 [[package]]
 name = "gimli"
-version = "0.27.3"
+version = "0.28.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "b6c80984affa11d98d1b88b66ac8853f143217b399d3c74116778ff8fdb4ed2e"
+checksum = "6fb8d784f27acf97159b40fc4db5ecd8aa23b9ad5ef69cdd136d3bc80665f0c0"
 
 [[package]]
 name = "glob"
@@ -1272,9 +1284,9 @@ checksum = "d2fabcfbdc87f4758337ca535fb41a6d701b65693ce38287d856d1674551ec9b"
 
 [[package]]
 name = "h2"
-version = "0.3.20"
+version = "0.3.21"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "97ec8491ebaf99c8eaa73058b045fe58073cd6be7f596ac993ced0b0a0c01049"
+checksum = "91fc23aa11be92976ef4729127f1a74adf36d8436f7816b185d18df956790833"
 dependencies = [
  "bytes",
  "fnv",
@@ -1295,12 +1307,6 @@ version = "0.12.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "8a9ee70c43aaf417c914396645a0fa852624801b24ebb7ae78fe8272889ac888"
 
-[[package]]
-name = "hashbrown"
-version = "0.13.2"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "43a3c133739dddd0d2990f9a4bdf8eb4b21ef50e4851ca85ab661199821d510e"
-
 [[package]]
 name = "hashbrown"
 version = "0.14.0"
@@ -1313,9 +1319,9 @@ dependencies = [
 
 [[package]]
 name = "hashlink"
-version = "0.8.3"
+version = "0.8.4"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "312f66718a2d7789ffef4f4b7b213138ed9f1eb3aa1d0d82fc99f88fb3ffd26f"
+checksum = "e8094feaf31ff591f651a2664fb9cfd92bba7a60ce3197265e9482ebe753c8f7"
 dependencies = [
  "hashbrown 0.14.0",
 ]
@@ -1340,14 +1346,14 @@ checksum = "7f24254aa9a54b5c858eaee2f5bccdb46aaf0e486a595ed5fd8f86ba55232a70"
 
 [[package]]
 name = "hgvs"
-version = "0.10.1"
+version = "0.11.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "5dd5d595b05540a8288c2b44fba457fa0a408fb0dc4f856b55b2f720d74c95a9"
+checksum = "d2c8237412c585364c6d56a985ea67f550a2e8fd55c6b8f949e732a89d2274a7"
 dependencies = [
  "base16ct",
  "bio",
  "chrono",
- "enum-map 2.6.0",
+ "enum-map 2.6.3",
  "flate2",
  "indexmap 2.0.0",
  "lazy_static",
@@ -1358,7 +1364,7 @@ dependencies = [
  "quick_cache",
  "regex",
  "rustc-hash",
- "seqrepo 0.6.1",
+ "seqrepo",
  "serde",
  "serde_json",
  "thiserror",
@@ -1373,6 +1379,15 @@ dependencies = [
  "digest",
 ]
 
+[[package]]
+name = "home"
+version = "0.5.5"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "5444c27eef6923071f7ebcc33e3444508466a76f7a2b93da00ed6e19f30c1ddb"
+dependencies = [
+ "windows-sys 0.48.0",
+]
+
 [[package]]
 name = "http"
 version = "0.2.9"
@@ -1392,9 +1407,9 @@ checksum = "d897f394bad6a705d5f4104762e116a75639e470d80901eed05a860a95cb1904"
 
 [[package]]
 name = "httpdate"
-version = "1.0.2"
+version = "1.0.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "c4a1e36c821dbe04574f602848a19f742f4fb3c98d40449f11bcad18d6b17421"
+checksum = "df3b46402a9d5adb4c86a0cf463f42e19994e3ee891101b1841f30a545cb49a9"
 
 [[package]]
 name = "humantime"
@@ -1513,24 +1528,15 @@ dependencies = [
 
 [[package]]
 name = "is-terminal"
-version = "0.4.8"
+version = "0.4.9"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "24fddda5af7e54bf7da53067d6e802dbcc381d0a8eef629df528e3ebf68755cb"
+checksum = "cb0889898416213fab133e1d33a0e5858a48177452750691bde3666d0fdbaf8b"
 dependencies = [
  "hermit-abi",
- "rustix 0.38.2",
+ "rustix 0.38.13",
  "windows-sys 0.48.0",
 ]
 
-[[package]]
-name = "itertools"
-version = "0.10.5"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "b0fd2260e829bddf4cb6ea802289de2f86d6a7a690192fbe91b3f46e0f2c8473"
-dependencies = [
- "either",
-]
-
 [[package]]
 name = "itertools"
 version = "0.11.0"
@@ -1551,9 +1557,9 @@ dependencies = [
 
 [[package]]
 name = "itoa"
-version = "1.0.8"
+version = "1.0.9"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "62b02a5381cc465bd3041d84623d0fa3b66738b52b8e2fc3bab8ad63ab032f4a"
+checksum = "af150ab688ff2122fcef229be89cb50dd66af9e01a4ff320cc137eecc9bacc38"
 
 [[package]]
 name = "jobserver"
@@ -1604,9 +1610,9 @@ checksum = "830d08ce1d1d941e6b30645f1a0eb5643013d835ce3779a5fc208261dbe10f55"
 
 [[package]]
 name = "libc"
-version = "0.2.147"
+version = "0.2.148"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "b4668fb0ea861c1df094127ac5f1da3409a82116a4ba74fca2e58ef927159bb3"
+checksum = "9cdc71e17332e86d2e1d38c1f99edcb6288ee11b815fb1a4b049eaa2114d369b"
 
 [[package]]
 name = "libloading"
@@ -1652,9 +1658,9 @@ dependencies = [
 
 [[package]]
 name = "libz-sys"
-version = "1.1.9"
+version = "1.1.12"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "56ee889ecc9568871456d42f603d6a0ce59ff328d291063a45cbdf0036baf6db"
+checksum = "d97137b25e321a73eef1418d1d5d2eda4d77e12813f8e6dead84bc52c5870a7b"
 dependencies = [
  "cc",
  "pkg-config",
@@ -1675,25 +1681,18 @@ checksum = "f051f77a7c8e6957c0696eac88f26b0117e54f52d3fc682ab19397a8812846a4"
 
 [[package]]
 name = "linux-raw-sys"
-version = "0.3.8"
+version = "0.4.7"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "ef53942eb7bf7ff43a617b3e2c1c4a5ecf5944a7c1bc12d7ee39bbb15e5c1519"
-
-[[package]]
-name = "linux-raw-sys"
-version = "0.4.3"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "09fc20d2ca12cb9f044c93e3bd6d32d523e6e2ec3db4f7b2939cd99026ecd3f0"
+checksum = "1a9bad9f94746442c783ca431b22403b519cd7fbeed0533fdd6328b2f2212128"
 
 [[package]]
 name = "local-channel"
-version = "0.1.3"
+version = "0.1.4"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "7f303ec0e94c6c54447f84f3b0ef7af769858a9c4ef56ef2a986d3dcd4c3fc9c"
+checksum = "e0a493488de5f18c8ffcba89eebb8532ffc562dc400490eb65b84893fae0b178"
 dependencies = [
  "futures-core",
  "futures-sink",
- "futures-util",
  "local-waker",
 ]
 
@@ -1777,21 +1776,21 @@ dependencies = [
  "noodles-bgzf",
  "noodles-core",
  "noodles-csi",
- "noodles-fasta 0.27.0",
+ "noodles-fasta",
  "noodles-tabix",
  "noodles-vcf",
  "parse-display",
  "pretty_assertions",
  "procfs",
- "prost 0.11.9",
- "prost-build 0.12.0",
+ "prost",
+ "prost-build",
  "quick_cache",
  "rand 0.8.5",
  "rand_core 0.6.4",
  "rocksdb",
  "rstest",
  "rustc-hash",
- "seqrepo 0.7.0",
+ "seqrepo",
  "serde",
  "serde_json",
  "serde_with",
@@ -1807,9 +1806,9 @@ dependencies = [
 
 [[package]]
 name = "memchr"
-version = "2.5.0"
+version = "2.6.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "2dffe52ecf27772e601905b7522cb4ef790d2cc203488bbd0e2fe85fcb74566d"
+checksum = "8f232d6ef707e1956a43342693d2a31e72989554d58299d7a88738cc95b0d35c"
 
 [[package]]
 name = "memoffset"
@@ -1934,9 +1933,9 @@ dependencies = [
 
 [[package]]
 name = "noodles-bgzf"
-version = "0.22.0"
+version = "0.24.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "2985a96e0306878a47e223f1bc8b5c988de6ef1516797796e05349dac0a727b2"
+checksum = "8f4c43ff0879c542c1d8fd570c03e368f629587721d10267f2619e36afc9c9b0"
 dependencies = [
  "byteorder",
  "bytes",
@@ -1952,9 +1951,9 @@ checksum = "94fbe3192fe33acacabaedd387657f39b0fc606f1996d546db0dfe14703b843a"
 
 [[package]]
 name = "noodles-csi"
-version = "0.22.0"
+version = "0.24.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "55329e145d9b5ba58299e3f9e36512d143e19379f13c3480db7346bcfaadc679"
+checksum = "1b2bb780250c88bc9ea69b56c1aa9df75decc6b79035f3f5ab10c0cd84d24fc6"
 dependencies = [
  "bit-vec",
  "byteorder",
@@ -1965,21 +1964,9 @@ dependencies = [
 
 [[package]]
 name = "noodles-fasta"
-version = "0.25.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "e096096e1c04ab76fe034ea499c692d8a4401a321155b542cd8ea3b1f7d08d12"
-dependencies = [
- "bytes",
- "memchr",
- "noodles-bgzf",
- "noodles-core",
-]
-
-[[package]]
-name = "noodles-fasta"
-version = "0.27.0"
+version = "0.29.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "a8af3e2fd41a831ab9fbbbd33ce00ab2c1299d6548c13ffc30152ede4d10f6ea"
+checksum = "1012431f881aad1912f9650a8d33e7f7493c6202bc2e889949ec1bc26a55f26d"
 dependencies = [
  "bytes",
  "memchr",
@@ -1989,9 +1976,9 @@ dependencies = [
 
 [[package]]
 name = "noodles-tabix"
-version = "0.25.0"
+version = "0.29.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "9056c1880629bbd50c7737c4d2cffcfb3610045a024776dad5cd606dd88feefc"
+checksum = "056e394ddb4c64bcc9806551a69833294062159600aa8ecf7167a922512bda4f"
 dependencies = [
  "bit-vec",
  "byteorder",
@@ -2002,13 +1989,12 @@ dependencies = [
 
 [[package]]
 name = "noodles-vcf"
-version = "0.34.0"
+version = "0.39.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "90ef8021080bdca5eb1328716ed418b0813deb950a244d2faf15e977a565048f"
+checksum = "1a056c06c7b33d5ba10bb59c09cca9500b02c3e0ead964dd4cf8f0068159783a"
 dependencies = [
  "indexmap 2.0.0",
  "memchr",
- "nom",
  "noodles-bgzf",
  "noodles-core",
  "noodles-csi",
@@ -2028,9 +2014,9 @@ dependencies = [
 
 [[package]]
 name = "num-complex"
-version = "0.4.3"
+version = "0.4.4"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "02e0d21255c828d6f128a1e41534206671e8c3ea0c62f32291e808dc82cff17d"
+checksum = "1ba157ca0885411de85d6ca030ba7e2a83a28636056c7c699b07c8b6f7383214"
 dependencies = [
  "num-traits",
 ]
@@ -2058,9 +2044,9 @@ dependencies = [
 
 [[package]]
 name = "num-traits"
-version = "0.2.15"
+version = "0.2.16"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "578ede34cf02f8924ab9447f50c28075b4d3e5b269972345e7e0372b38c6cdcd"
+checksum = "f30b0abd723be7e2ffca1272140fac1a2f084c77ec3e123c192b66af1ee9e6c2"
 dependencies = [
  "autocfg",
  "libm",
@@ -2084,9 +2070,9 @@ checksum = "830b246a0e5f20af87141b25c173cd1b609bd7779a4617d6ec582abaf90870f3"
 
 [[package]]
 name = "object"
-version = "0.31.1"
+version = "0.32.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "8bda667d9f2b5051b8833f59f3bf748b28ef54f850f4fcb389a252aa383866d1"
+checksum = "9cf5f9dd3933bd50a9e1f149ec995f39ae2c496d31fd772c1fd45ebc27e902b0"
 dependencies = [
  "memchr",
 ]
@@ -2099,9 +2085,9 @@ checksum = "dd8b5dd2ae5ed71462c540258bedcb51965123ad7e7ccf4b9a8cafaa4a63576d"
 
 [[package]]
 name = "ordered-float"
-version = "3.7.0"
+version = "3.9.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "2fc2dbde8f8a79f2102cc474ceb0ad68e3b80b85289ea62389b60e66777e4213"
+checksum = "2a54938017eacd63036332b4ae5c8a49fc8c0c1d6d629893057e4f13609edd06"
 dependencies = [
  "num-traits",
 ]
@@ -2132,7 +2118,7 @@ dependencies = [
  "libc",
  "redox_syscall",
  "smallvec",
- "windows-targets 0.48.1",
+ "windows-targets 0.48.5",
 ]
 
 [[package]]
@@ -2158,14 +2144,14 @@ dependencies = [
  "regex",
  "regex-syntax",
  "structmeta",
- "syn 2.0.26",
+ "syn 2.0.37",
 ]
 
 [[package]]
 name = "paste"
-version = "1.0.13"
+version = "1.0.14"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "b4b27ab7be369122c218afc2079489cdcb4b517c0a3fc386ff11e1fedfcc2b35"
+checksum = "de3145af08024dea9fa9914f381a17b8fc6034dfb00f3a84013f7ff43f29ed4c"
 
 [[package]]
 name = "peeking_take_while"
@@ -2181,12 +2167,12 @@ checksum = "9b2a4787296e9989611394c33f193f676704af1686e70b8f8033ab5ba9a35a94"
 
 [[package]]
 name = "petgraph"
-version = "0.6.3"
+version = "0.6.4"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "4dd7d28ee937e54fe3080c91faa1c3a46c06de6252988a7f4592ba2310ef22a4"
+checksum = "e1d3afd2628e69da2be385eb6f2fd57c8ac7977ceeff6dc166ff1657b0e386a9"
 dependencies = [
  "fixedbitset",
- "indexmap 1.9.3",
+ "indexmap 2.0.0",
 ]
 
 [[package]]
@@ -2209,9 +2195,9 @@ dependencies = [
 
 [[package]]
 name = "pin-project-lite"
-version = "0.2.10"
+version = "0.2.13"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "4c40d25201921e5ff0c862a505c6557ea88568a4e3ace775ab55e93f2f4f9d57"
+checksum = "8afb450f006bf6385ca15ef45d71d2288452bc3683ce2e2cacc0d18e4be60b58"
 
 [[package]]
 name = "pin-utils"
@@ -2227,15 +2213,15 @@ checksum = "26072860ba924cbfa98ea39c8c19b4dd6a4a25423dbdf219c1eca91aa0cf6964"
 
 [[package]]
 name = "portable-atomic"
-version = "1.3.3"
+version = "1.4.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "767eb9f07d4a5ebcb39bbf2d452058a93c011373abf6832e24194a1c3f004794"
+checksum = "31114a898e107c51bb1609ffaf55a0e011cf6a4d7f1170d0015a165082c0338b"
 
 [[package]]
 name = "postgres"
-version = "0.19.5"
+version = "0.19.7"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "0bed5017bc2ff49649c0075d0d7a9d676933c1292480c1d137776fb205b5cd18"
+checksum = "7915b33ed60abc46040cbcaa25ffa1c7ec240668e0477c4f3070786f5916d451"
 dependencies = [
  "bytes",
  "fallible-iterator",
@@ -2247,9 +2233,9 @@ dependencies = [
 
 [[package]]
 name = "postgres-protocol"
-version = "0.6.5"
+version = "0.6.6"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "78b7fa9f396f51dffd61546fd8573ee20592287996568e6175ceb0f8699ad75d"
+checksum = "49b6c5ef183cd3ab4ba005f1ca64c21e8bd97ce4699cfea9e8d9a2c4958ca520"
 dependencies = [
  "base64",
  "byteorder",
@@ -2265,9 +2251,9 @@ dependencies = [
 
 [[package]]
 name = "postgres-types"
-version = "0.2.5"
+version = "0.2.6"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "f028f05971fe20f512bcc679e2c10227e57809a3af86a7606304435bc8896cd6"
+checksum = "8d2234cdee9408b523530a9b6d2d6b373d1db34f6a8e51dc03ded1828d7fb67c"
 dependencies = [
  "bytes",
  "chrono",
@@ -2293,22 +2279,12 @@ dependencies = [
 
 [[package]]
 name = "prettyplease"
-version = "0.1.25"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "6c8646e95016a7a6c4adea95bafa8a16baab64b583356217f2c85db4a39d9a86"
-dependencies = [
- "proc-macro2",
- "syn 1.0.109",
-]
-
-[[package]]
-name = "prettyplease"
-version = "0.2.9"
+version = "0.2.15"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "9825a04601d60621feed79c4e6b56d65db77cdca55cef43b46b0de1096d1c282"
+checksum = "ae005bd773ab59b4725093fd7df83fd7892f7d8eafb48dbd7de6e024e4215f9d"
 dependencies = [
  "proc-macro2",
- "syn 2.0.26",
+ "syn 2.0.37",
 ]
 
 [[package]]
@@ -2337,9 +2313,9 @@ dependencies = [
 
 [[package]]
 name = "proc-macro2"
-version = "1.0.66"
+version = "1.0.67"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "18fb31db3f9bddb2ea821cde30a9f70117e3f119938b5ee630b7403aa6e2ead9"
+checksum = "3d433d9f1a3e8c1263d9456598b16fec66f4acc9a74dacffd35c7bb09b3a1328"
 dependencies = [
  "unicode-ident",
 ]
@@ -2356,133 +2332,80 @@ dependencies = [
  "flate2",
  "hex",
  "lazy_static",
- "rustix 0.36.14",
-]
-
-[[package]]
-name = "prost"
-version = "0.11.9"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "0b82eaa1d779e9a4bc1c3217db8ffbeabaae1dca241bf70183242128d48681cd"
-dependencies = [
- "bytes",
- "prost-derive 0.11.9",
+ "rustix 0.36.15",
 ]
 
 [[package]]
 name = "prost"
-version = "0.12.0"
+version = "0.12.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "aa8473a65b88506c106c28ae905ca4a2b83a2993640467a41bb3080627ddfd2c"
+checksum = "f4fdd22f3b9c31b53c060df4a0613a1c7f062d4115a2b984dd15b1858f7e340d"
 dependencies = [
  "bytes",
- "prost-derive 0.12.0",
+ "prost-derive",
 ]
 
 [[package]]
 name = "prost-build"
-version = "0.11.9"
-source = "registry+https://github.com/rust-lang/crates.io-index"
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-dependencies = [
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- "heck",
- "itertools 0.10.5",
- "lazy_static",
- "log",
- "multimap",
- "petgraph",
- "prettyplease 0.1.25",
- "prost 0.11.9",
- "prost-types 0.11.9",
- "regex",
- "syn 1.0.109",
- "tempfile",
- "which",
-]
-
-[[package]]
-name = "prost-build"
-version = "0.12.0"
+version = "0.12.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "30d3e647e9eb04ddfef78dfee2d5b3fefdf94821c84b710a3d8ebc89ede8b164"
+checksum = "8bdf592881d821b83d471f8af290226c8d51402259e9bb5be7f9f8bdebbb11ac"
 dependencies = [
  "bytes",
  "heck",
- "itertools 0.11.0",
+ "itertools",
  "log",
  "multimap",
  "once_cell",
  "petgraph",
- "prettyplease 0.2.9",
- "prost 0.12.0",
- "prost-types 0.12.0",
+ "prettyplease",
+ "prost",
+ "prost-types",
  "regex",
- "syn 2.0.26",
+ "syn 2.0.37",
  "tempfile",
  "which",
 ]
 
 [[package]]
 name = "prost-derive"
-version = "0.11.9"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "e5d2d8d10f3c6ded6da8b05b5fb3b8a5082514344d56c9f871412d29b4e075b4"
-dependencies = [
- "anyhow",
- "itertools 0.10.5",
- "proc-macro2",
- "quote",
- "syn 1.0.109",
-]
-
-[[package]]
-name = "prost-derive"
-version = "0.12.0"
+version = "0.12.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "56075c27b20ae524d00f247b8a4dc333e5784f889fe63099f8e626bc8d73486c"
+checksum = "265baba7fabd416cf5078179f7d2cbeca4ce7a9041111900675ea7c4cb8a4c32"
 dependencies = [
  "anyhow",
- "itertools 0.11.0",
+ "itertools",
  "proc-macro2",
  "quote",
- "syn 2.0.26",
-]
-
-[[package]]
-name = "prost-types"
-version = "0.11.9"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "213622a1460818959ac1181aaeb2dc9c7f63df720db7d788b3e24eacd1983e13"
-dependencies = [
- "prost 0.11.9",
+ "syn 2.0.37",
 ]
 
 [[package]]
 name = "prost-types"
-version = "0.12.0"
+version = "0.12.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "cebe0a918c97f86c217b0f76fd754e966f8b9f41595095cf7d74cb4e59d730f6"
+checksum = "e081b29f63d83a4bc75cfc9f3fe424f9156cf92d8a4f0c9407cce9a1b67327cf"
 dependencies = [
- "prost 0.12.0",
+ "prost",
 ]
 
 [[package]]
 name = "quick_cache"
-version = "0.3.0"
+version = "0.4.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "5253a3a0d56548d5b0be25414171dc780cc6870727746d05bd2bde352eee96c5"
+checksum = "f69f8d22fa3f34f3083d9a4375c038732c7a7e964de1beb81c544da92dfc40b8"
 dependencies = [
  "ahash",
- "hashbrown 0.13.2",
+ "equivalent",
+ "hashbrown 0.14.0",
  "parking_lot",
 ]
 
 [[package]]
 name = "quote"
-version = "1.0.29"
+version = "1.0.33"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "573015e8ab27661678357f27dc26460738fd2b6c86e46f386fde94cb5d913105"
+checksum = "5267fca4496028628a95160fc423a33e8b2e6af8a5302579e322e4b520293cae"
 dependencies = [
  "proc-macro2",
 ]
@@ -2603,9 +2526,9 @@ dependencies = [
 
 [[package]]
 name = "regex"
-version = "1.9.1"
+version = "1.9.5"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "b2eae68fc220f7cf2532e4494aded17545fce192d59cd996e0fe7887f4ceb575"
+checksum = "697061221ea1b4a94a624f67d0ae2bfe4e22b8a17b6a192afb11046542cc8c47"
 dependencies = [
  "aho-corasick",
  "memchr",
@@ -2615,9 +2538,9 @@ dependencies = [
 
 [[package]]
 name = "regex-automata"
-version = "0.3.3"
+version = "0.3.8"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "39354c10dd07468c2e73926b23bb9c2caca74c5501e38a35da70406f1d923310"
+checksum = "c2f401f4955220693b56f8ec66ee9c78abffd8d1c4f23dc41a23839eb88f0795"
 dependencies = [
  "aho-corasick",
  "memchr",
@@ -2626,15 +2549,15 @@ dependencies = [
 
 [[package]]
 name = "regex-syntax"
-version = "0.7.4"
+version = "0.7.5"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "e5ea92a5b6195c6ef2a0295ea818b312502c6fc94dde986c5553242e18fd4ce2"
+checksum = "dbb5fb1acd8a1a18b3dd5be62d25485eb770e05afb408a9627d14d451bae12da"
 
 [[package]]
 name = "relative-path"
-version = "1.8.0"
+version = "1.9.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "4bf2521270932c3c7bed1a59151222bd7643c79310f2916f01925e1e16255698"
+checksum = "c707298afce11da2efef2f600116fa93ffa7a032b5d7b628aa17711ec81383ca"
 
 [[package]]
 name = "remove_dir_all"
@@ -2657,9 +2580,9 @@ dependencies = [
 
 [[package]]
 name = "rocksdb-utils-lookup"
-version = "0.2.0"
+version = "0.3.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "d2689a1a506aeb888b493f7e2d8259dd659f7c3589d1694e0c8d328541c722ff"
+checksum = "b83002edb508bf7fc5b234bde1489ccaea5bffbaeaf0aae00270257c858b5f9f"
 dependencies = [
  "rocksdb",
  "thiserror",
@@ -2691,7 +2614,7 @@ dependencies = [
  "regex",
  "relative-path",
  "rustc_version 0.4.0",
- "syn 2.0.26",
+ "syn 2.0.37",
  "unicode-ident",
 ]
 
@@ -2701,7 +2624,7 @@ version = "0.29.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "549b9d036d571d42e6e85d1c1425e2ac83491075078ca9a15be021c56b1641f2"
 dependencies = [
- "bitflags 2.3.3",
+ "bitflags 2.4.0",
  "fallible-iterator",
  "fallible-streaming-iterator",
  "hashlink",
@@ -2736,14 +2659,14 @@ version = "0.4.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "bfa0f585226d2e68097d4f95d113b15b83a82e819ab25717ec0590d9584ef366"
 dependencies = [
- "semver 1.0.17",
+ "semver 1.0.18",
 ]
 
 [[package]]
 name = "rustix"
-version = "0.36.14"
+version = "0.36.15"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "14e4d67015953998ad0eb82887a0eb0129e18a7e2f3b7b0f6c422fddcd503d62"
+checksum = "c37f1bd5ef1b5422177b7646cba67430579cfe2ace80f284fee876bca52ad941"
 dependencies = [
  "bitflags 1.3.2",
  "errno",
@@ -2755,57 +2678,43 @@ dependencies = [
 
 [[package]]
 name = "rustix"
-version = "0.37.22"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "8818fa822adcc98b18fedbb3632a6a33213c070556b5aa7c4c8cc21cff565c4c"
-dependencies = [
- "bitflags 1.3.2",
- "errno",
- "io-lifetimes",
- "libc",
- "linux-raw-sys 0.3.8",
- "windows-sys 0.48.0",
-]
-
-[[package]]
-name = "rustix"
-version = "0.38.2"
+version = "0.38.13"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "aabcb0461ebd01d6b79945797c27f8529082226cb630a9865a71870ff63532a4"
+checksum = "d7db8590df6dfcd144d22afd1b83b36c21a18d7cbc1dc4bb5295a8712e9eb662"
 dependencies = [
- "bitflags 2.3.3",
+ "bitflags 2.4.0",
  "errno",
  "libc",
- "linux-raw-sys 0.4.3",
+ "linux-raw-sys 0.4.7",
  "windows-sys 0.48.0",
 ]
 
 [[package]]
 name = "rustversion"
-version = "1.0.13"
+version = "1.0.14"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "dc31bd9b61a32c31f9650d18add92aa83a49ba979c143eefd27fe7177b05bd5f"
+checksum = "7ffc183a10b4478d04cbbbfc96d0873219d962dd5accaff2ffbd4ceb7df837f4"
 
 [[package]]
 name = "ryu"
-version = "1.0.14"
+version = "1.0.15"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "fe232bdf6be8c8de797b22184ee71118d63780ea42ac85b61d1baa6d3b782ae9"
+checksum = "1ad4cc8da4ef723ed60bced201181d83791ad433213d8c24efffda1eec85d741"
 
 [[package]]
 name = "safe_arch"
-version = "0.7.0"
+version = "0.7.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "62a7484307bd40f8f7ccbacccac730108f2cae119a3b11c74485b48aa9ea650f"
+checksum = "f398075ce1e6a179b46f51bd88d0598b92b00d3551f1a2d4ac49e771b56ac354"
 dependencies = [
  "bytemuck",
 ]
 
 [[package]]
 name = "scopeguard"
-version = "1.1.0"
+version = "1.2.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "d29ab0c6d3fc0ee92fe66e2d99f700eab17a8d57d1c1d3b748380fb20baa78cd"
+checksum = "94143f37725109f92c262ed2cf5e59bce7498c01bcc1502d7b9afe439a4e9f49"
 
 [[package]]
 name = "semver"
@@ -2815,35 +2724,20 @@ checksum = "d4f410fedcf71af0345d7607d246e7ad15faaadd49d240ee3b24e5dc21a820ac"
 
 [[package]]
 name = "semver"
-version = "1.0.17"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "bebd363326d05ec3e2f532ab7660680f3b02130d780c299bca73469d521bc0ed"
-
-[[package]]
-name = "seqrepo"
-version = "0.6.1"
+version = "1.0.18"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "bcda5a65689d34400b5002c579fb2371908a2f712f4d70ea5a2b354540f719ca"
-dependencies = [
- "chrono",
- "noodles-bgzf",
- "noodles-core",
- "noodles-fasta 0.25.0",
- "rusqlite",
- "thiserror",
- "tracing",
-]
+checksum = "b0293b4b29daaf487284529cc2f5675b8e57c61f70167ba415a463651fd6a918"
 
 [[package]]
 name = "seqrepo"
-version = "0.7.0"
+version = "0.8.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "6eaad4e5d741cc89ab31eb3c1de020427331b2a58ff7d587befb18055a7484c9"
+checksum = "94b3579efbd2915e936798fb9f52629feec3cbeef1ef23eb556d49d89ff31455"
 dependencies = [
  "chrono",
  "noodles-bgzf",
  "noodles-core",
- "noodles-fasta 0.25.0",
+ "noodles-fasta",
  "rusqlite",
  "thiserror",
  "tracing",
@@ -2851,29 +2745,29 @@ dependencies = [
 
 [[package]]
 name = "serde"
-version = "1.0.179"
+version = "1.0.188"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "0a5bf42b8d227d4abf38a1ddb08602e229108a517cd4e5bb28f9c7eaafdce5c0"
+checksum = "cf9e0fcba69a370eed61bcf2b728575f726b50b55cba78064753d708ddc7549e"
 dependencies = [
  "serde_derive",
 ]
 
 [[package]]
 name = "serde_derive"
-version = "1.0.179"
+version = "1.0.188"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "741e124f5485c7e60c03b043f79f320bff3527f4bbf12cf3831750dc46a0ec2c"
+checksum = "4eca7ac642d82aa35b60049a6eccb4be6be75e599bd2e9adb5f875a737654af2"
 dependencies = [
  "proc-macro2",
  "quote",
- "syn 2.0.26",
+ "syn 2.0.37",
 ]
 
 [[package]]
 name = "serde_json"
-version = "1.0.106"
+version = "1.0.107"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "2cc66a619ed80bf7a0f6b17dd063a84b88f6dea1813737cf469aef1d081142c2"
+checksum = "6b420ce6e3d8bd882e9b243c6eed35dbc9a6110c9769e74b584e0d68d1f20c65"
 dependencies = [
  "indexmap 2.0.0",
  "itoa",
@@ -2919,7 +2813,7 @@ dependencies = [
  "darling",
  "proc-macro2",
  "quote",
- "syn 2.0.26",
+ "syn 2.0.37",
 ]
 
 [[package]]
@@ -2955,9 +2849,9 @@ dependencies = [
 
 [[package]]
 name = "shlex"
-version = "1.1.0"
+version = "1.2.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "43b2853a4d09f215c24cc5489c992ce46052d359b5109343cbafbf26bc62f8a3"
+checksum = "a7cee0529a6d40f580e7a5e6c495c8fbfe21b7b52795ed4bb5e62cdf92bc6380"
 
 [[package]]
 name = "signal-hook-registry"
@@ -2989,40 +2883,30 @@ checksum = "420acb44afdae038210c99e69aae24109f32f15500aa708e81d46c9f29d55fcf"
 
 [[package]]
 name = "siphasher"
-version = "0.3.10"
+version = "0.3.11"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "7bd3e3206899af3f8b12af284fafc038cc1dc2b41d1b89dd17297221c5d225de"
+checksum = "38b58827f4464d87d377d175e90bf58eb00fd8716ff0a62f80356b5e61555d0d"
 
 [[package]]
 name = "slab"
-version = "0.4.8"
+version = "0.4.9"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "6528351c9bc8ab22353f9d776db39a20288e8d6c37ef8cfe3317cf875eecfc2d"
+checksum = "8f92a496fb766b417c996b9c5e57daf2f7ad3b0bebe1ccfca4856390e3d3bb67"
 dependencies = [
  "autocfg",
 ]
 
 [[package]]
 name = "smallvec"
-version = "1.10.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "a507befe795404456341dfab10cef66ead4c041f62b8b11bbb92bffe5d0953e0"
-
-[[package]]
-name = "socket2"
-version = "0.4.9"
+version = "1.11.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "64a4a911eed85daf18834cfaa86a79b7d266ff93ff5ba14005426219480ed662"
-dependencies = [
- "libc",
- "winapi",
-]
+checksum = "62bb4feee49fdd9f707ef802e22365a35de4b7b299de4763d44bfea899442ff9"
 
 [[package]]
 name = "socket2"
-version = "0.5.3"
+version = "0.5.4"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "2538b18701741680e0322a2302176d3253a35388e2e62f172f64f4f16605f877"
+checksum = "4031e820eb552adee9295814c0ced9e5cf38ddf1e8b7d566d6de8e2538ea989e"
 dependencies = [
  "libc",
  "windows-sys 0.48.0",
@@ -3043,10 +2927,11 @@ dependencies = [
 
 [[package]]
 name = "stringprep"
-version = "0.1.2"
+version = "0.1.4"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "8ee348cb74b87454fff4b551cbf727025810a004f88aeacae7f85b87f4e9a1c1"
+checksum = "bb41d74e231a107a1b4ee36bd1214b11285b77768d2e3824aedafa988fd36ee6"
 dependencies = [
+ "finl_unicode",
  "unicode-bidi",
  "unicode-normalization",
 ]
@@ -3066,7 +2951,7 @@ dependencies = [
  "proc-macro2",
  "quote",
  "structmeta-derive",
- "syn 2.0.26",
+ "syn 2.0.37",
 ]
 
 [[package]]
@@ -3077,7 +2962,7 @@ checksum = "a60bcaff7397072dca0017d1db428e30d5002e00b6847703e2e42005c95fbe00"
 dependencies = [
  "proc-macro2",
  "quote",
- "syn 2.0.26",
+ "syn 2.0.37",
 ]
 
 [[package]]
@@ -3086,33 +2971,20 @@ version = "0.25.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "290d54ea6f91c969195bdbcd7442c8c2a2ba87da8bf60a7ee86a235d4bc1e125"
 dependencies = [
- "strum_macros 0.25.1",
-]
-
-[[package]]
-name = "strum_macros"
-version = "0.24.3"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "1e385be0d24f186b4ce2f9982191e7101bb737312ad61c1f2f984f34bcf85d59"
-dependencies = [
- "heck",
- "proc-macro2",
- "quote",
- "rustversion",
- "syn 1.0.109",
+ "strum_macros",
 ]
 
 [[package]]
 name = "strum_macros"
-version = "0.25.1"
+version = "0.25.2"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "6069ca09d878a33f883cc06aaa9718ede171841d3832450354410b718b097232"
+checksum = "ad8d03b598d3d0fff69bf533ee3ef19b8eeb342729596df84bcc7e1f96ec4059"
 dependencies = [
  "heck",
  "proc-macro2",
  "quote",
  "rustversion",
- "syn 2.0.26",
+ "syn 2.0.37",
 ]
 
 [[package]]
@@ -3134,9 +3006,9 @@ dependencies = [
 
 [[package]]
 name = "syn"
-version = "2.0.26"
+version = "2.0.37"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "45c3457aacde3c65315de5031ec191ce46604304d2446e803d71ade03308d970"
+checksum = "7303ef2c05cd654186cb250d29049a24840ca25d2747c25c0381c8d9e2f582e8"
 dependencies = [
  "proc-macro2",
  "quote",
@@ -3161,15 +3033,14 @@ dependencies = [
 
 [[package]]
 name = "tempfile"
-version = "3.6.0"
+version = "3.8.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "31c0432476357e58790aaa47a8efb0c5138f137343f3b5f23bd36a27e3b0a6d6"
+checksum = "cb94d2f3cc536af71caac6b6fcebf65860b347e7ce0cc9ebe8f70d3e521054ef"
 dependencies = [
- "autocfg",
  "cfg-if",
  "fastrand",
  "redox_syscall",
- "rustix 0.37.22",
+ "rustix 0.38.13",
  "windows-sys 0.48.0",
 ]
 
@@ -3184,22 +3055,22 @@ dependencies = [
 
 [[package]]
 name = "thiserror"
-version = "1.0.40"
+version = "1.0.48"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "978c9a314bd8dc99be594bc3c175faaa9794be04a5a5e153caba6915336cebac"
+checksum = "9d6d7a740b8a666a7e828dd00da9c0dc290dff53154ea77ac109281de90589b7"
 dependencies = [
  "thiserror-impl",
 ]
 
 [[package]]
 name = "thiserror-impl"
-version = "1.0.40"
+version = "1.0.48"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "f9456a42c5b0d803c8cd86e73dd7cc9edd429499f37a3550d286d5e86720569f"
+checksum = "49922ecae66cc8a249b77e68d1d0623c1b2c514f0060c27cdc68bd62a1219d35"
 dependencies = [
  "proc-macro2",
  "quote",
- "syn 2.0.26",
+ "syn 2.0.37",
 ]
 
 [[package]]
@@ -3220,10 +3091,11 @@ dependencies = [
 
 [[package]]
 name = "time"
-version = "0.3.22"
+version = "0.3.28"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "ea9e1b3cf1243ae005d9e74085d4d542f3125458f3a81af210d901dcd7411efd"
+checksum = "17f6bb557fd245c28e6411aa56b6403c689ad95061f50e4be16c274e70a17e48"
 dependencies = [
+ "deranged",
  "itoa",
  "serde",
  "time-core",
@@ -3238,9 +3110,9 @@ checksum = "7300fbefb4dadc1af235a9cef3737cea692a9d97e1b9cbcd4ebdae6f8868e6fb"
 
 [[package]]
 name = "time-macros"
-version = "0.2.9"
+version = "0.2.14"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "372950940a5f07bf38dbe211d7283c9e6d7327df53794992d293e534c733d09b"
+checksum = "1a942f44339478ef67935ab2bbaec2fb0322496cf3cbe84b261e06ac3814c572"
 dependencies = [
  "time-core",
 ]
@@ -3262,11 +3134,10 @@ checksum = "1f3ccbac311fea05f86f61904b462b55fb3df8837a366dfc601a0161d0532f20"
 
 [[package]]
 name = "tokio"
-version = "1.29.1"
+version = "1.32.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "532826ff75199d5833b9d2c5fe410f29235e25704ee5f0ef599fb51c21f4a4da"
+checksum = "17ed6077ed6cd6c74735e21f37eb16dc3935f96878b1fe961074089cc80893f9"
 dependencies = [
- "autocfg",
  "backtrace",
  "bytes",
  "libc",
@@ -3274,15 +3145,15 @@ dependencies = [
  "parking_lot",
  "pin-project-lite",
  "signal-hook-registry",
- "socket2 0.4.9",
+ "socket2",
  "windows-sys 0.48.0",
 ]
 
 [[package]]
 name = "tokio-postgres"
-version = "0.7.8"
+version = "0.7.10"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "6e89f6234aa8fd43779746012fcf53603cdb91fdd8399aa0de868c2d56b6dde1"
+checksum = "d340244b32d920260ae7448cb72b6e238bddc3d4f7603394e7dd46ed8e48f5b8"
 dependencies = [
  "async-trait",
  "byteorder",
@@ -3297,9 +3168,11 @@ dependencies = [
  "pin-project-lite",
  "postgres-protocol",
  "postgres-types",
- "socket2 0.5.3",
+ "rand 0.8.5",
+ "socket2",
  "tokio",
  "tokio-util",
+ "whoami",
 ]
 
 [[package]]
@@ -3337,7 +3210,7 @@ checksum = "5f4f31f56159e98206da9efd823404b79b6ef3143b4a7ab76e67b1751b25a4ab"
 dependencies = [
  "proc-macro2",
  "quote",
- "syn 2.0.26",
+ "syn 2.0.37",
 ]
 
 [[package]]
@@ -3383,9 +3256,9 @@ checksum = "22048bc95dfb2ffd05b1ff9a756290a009224b60b2f0e7525faeee7603851e63"
 
 [[package]]
 name = "typenum"
-version = "1.16.0"
+version = "1.17.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "497961ef93d974e23eb6f433eb5fe1b7930b659f06d12dec6fc44a8f554c0bba"
+checksum = "42ff0bf0c66b8238c6f3b578df37d0b7848e55df8577b3f74f92a69acceeb825"
 
 [[package]]
 name = "unicode-bidi"
@@ -3395,9 +3268,9 @@ checksum = "92888ba5573ff080736b3648696b70cafad7d250551175acbaa4e0385b3e1460"
 
 [[package]]
 name = "unicode-ident"
-version = "1.0.10"
+version = "1.0.12"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "22049a19f4a68748a168c0fc439f9516686aa045927ff767eca0a85101fb6e73"
+checksum = "3354b9ac3fae1ff6755cb6db53683adb661634f67557942dea4facebec0fee4b"
 
 [[package]]
 name = "unicode-normalization"
@@ -3416,9 +3289,9 @@ checksum = "c0edd1e5b14653f783770bce4a4dabb4a5108a5370a5f5d8cfe8710c361f6c8b"
 
 [[package]]
 name = "url"
-version = "2.4.0"
+version = "2.4.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "50bff7831e19200a85b17131d085c25d7811bc4e186efdaf54bbd132994a88cb"
+checksum = "143b538f18257fac9cad154828a57c6bf5157e1aa604d4816b5995bf6de87ae5"
 dependencies = [
  "form_urlencoded",
  "idna",
@@ -3502,7 +3375,7 @@ dependencies = [
  "once_cell",
  "proc-macro2",
  "quote",
- "syn 2.0.26",
+ "syn 2.0.37",
  "wasm-bindgen-shared",
 ]
 
@@ -3524,7 +3397,7 @@ checksum = "54681b18a46765f095758388f2d0cf16eb8d4169b639ab575a8f5693af210c7b"
 dependencies = [
  "proc-macro2",
  "quote",
- "syn 2.0.26",
+ "syn 2.0.37",
  "wasm-bindgen-backend",
  "wasm-bindgen-shared",
 ]
@@ -3535,22 +3408,43 @@ version = "0.2.87"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "ca6ad05a4870b2bf5fe995117d3728437bd27d7cd5f06f13c17443ef369775a1"
 
+[[package]]
+name = "web-sys"
+version = "0.3.64"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "9b85cbef8c220a6abc02aefd892dfc0fc23afb1c6a426316ec33253a3877249b"
+dependencies = [
+ "js-sys",
+ "wasm-bindgen",
+]
+
 [[package]]
 name = "which"
-version = "4.4.0"
+version = "4.4.2"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "2441c784c52b289a054b7201fc93253e288f094e2f4be9058343127c4226a269"
+checksum = "87ba24419a2078cd2b0f2ede2691b6c66d8e47836da3b6db8265ebad47afbfc7"
 dependencies = [
  "either",
- "libc",
+ "home",
  "once_cell",
+ "rustix 0.38.13",
+]
+
+[[package]]
+name = "whoami"
+version = "1.4.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "22fc3756b8a9133049b26c7f61ab35416c130e8c09b660f5b3958b446f52cc50"
+dependencies = [
+ "wasm-bindgen",
+ "web-sys",
 ]
 
 [[package]]
 name = "wide"
-version = "0.7.10"
+version = "0.7.11"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "40018623e2dba2602a9790faba8d33f2ebdebf4b86561b83928db735f8784728"
+checksum = "aa469ffa65ef7e0ba0f164183697b89b854253fd31aeb92358b7b6155177d62f"
 dependencies = [
  "bytemuck",
  "safe_arch",
@@ -3593,7 +3487,7 @@ version = "0.48.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "e686886bc078bc1b0b600cac0147aadb815089b6e4da64016cbd754b6342700f"
 dependencies = [
- "windows-targets 0.48.1",
+ "windows-targets 0.48.5",
 ]
 
 [[package]]
@@ -3611,7 +3505,7 @@ version = "0.48.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "677d2418bec65e3338edb076e806bc1ec15693c5d0104683f2efe857f61056a9"
 dependencies = [
- "windows-targets 0.48.1",
+ "windows-targets 0.48.5",
 ]
 
 [[package]]
@@ -3631,17 +3525,17 @@ dependencies = [
 
 [[package]]
 name = "windows-targets"
-version = "0.48.1"
+version = "0.48.5"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "05d4b17490f70499f20b9e791dcf6a299785ce8af4d709018206dc5b4953e95f"
+checksum = "9a2fa6e2155d7247be68c096456083145c183cbbbc2764150dda45a87197940c"
 dependencies = [
- "windows_aarch64_gnullvm 0.48.0",
- "windows_aarch64_msvc 0.48.0",
- "windows_i686_gnu 0.48.0",
- "windows_i686_msvc 0.48.0",
- "windows_x86_64_gnu 0.48.0",
- "windows_x86_64_gnullvm 0.48.0",
- "windows_x86_64_msvc 0.48.0",
+ "windows_aarch64_gnullvm 0.48.5",
+ "windows_aarch64_msvc 0.48.5",
+ "windows_i686_gnu 0.48.5",
+ "windows_i686_msvc 0.48.5",
+ "windows_x86_64_gnu 0.48.5",
+ "windows_x86_64_gnullvm 0.48.5",
+ "windows_x86_64_msvc 0.48.5",
 ]
 
 [[package]]
@@ -3652,9 +3546,9 @@ checksum = "597a5118570b68bc08d8d59125332c54f1ba9d9adeedeef5b99b02ba2b0698f8"
 
 [[package]]
 name = "windows_aarch64_gnullvm"
-version = "0.48.0"
+version = "0.48.5"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "91ae572e1b79dba883e0d315474df7305d12f569b400fcf90581b06062f7e1bc"
+checksum = "2b38e32f0abccf9987a4e3079dfb67dcd799fb61361e53e2882c3cbaf0d905d8"
 
 [[package]]
 name = "windows_aarch64_msvc"
@@ -3664,9 +3558,9 @@ checksum = "e08e8864a60f06ef0d0ff4ba04124db8b0fb3be5776a5cd47641e942e58c4d43"
 
 [[package]]
 name = "windows_aarch64_msvc"
-version = "0.48.0"
+version = "0.48.5"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "b2ef27e0d7bdfcfc7b868b317c1d32c641a6fe4629c171b8928c7b08d98d7cf3"
+checksum = "dc35310971f3b2dbbf3f0690a219f40e2d9afcf64f9ab7cc1be722937c26b4bc"
 
 [[package]]
 name = "windows_i686_gnu"
@@ -3676,9 +3570,9 @@ checksum = "c61d927d8da41da96a81f029489353e68739737d3beca43145c8afec9a31a84f"
 
 [[package]]
 name = "windows_i686_gnu"
-version = "0.48.0"
+version = "0.48.5"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "622a1962a7db830d6fd0a69683c80a18fda201879f0f447f065a3b7467daa241"
+checksum = "a75915e7def60c94dcef72200b9a8e58e5091744960da64ec734a6c6e9b3743e"
 
 [[package]]
 name = "windows_i686_msvc"
@@ -3688,9 +3582,9 @@ checksum = "44d840b6ec649f480a41c8d80f9c65108b92d89345dd94027bfe06ac444d1060"
 
 [[package]]
 name = "windows_i686_msvc"
-version = "0.48.0"
+version = "0.48.5"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "4542c6e364ce21bf45d69fdd2a8e455fa38d316158cfd43b3ac1c5b1b19f8e00"
+checksum = "8f55c233f70c4b27f66c523580f78f1004e8b5a8b659e05a4eb49d4166cca406"
 
 [[package]]
 name = "windows_x86_64_gnu"
@@ -3700,9 +3594,9 @@ checksum = "8de912b8b8feb55c064867cf047dda097f92d51efad5b491dfb98f6bbb70cb36"
 
 [[package]]
 name = "windows_x86_64_gnu"
-version = "0.48.0"
+version = "0.48.5"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "ca2b8a661f7628cbd23440e50b05d705db3686f894fc9580820623656af974b1"
+checksum = "53d40abd2583d23e4718fddf1ebec84dbff8381c07cae67ff7768bbf19c6718e"
 
 [[package]]
 name = "windows_x86_64_gnullvm"
@@ -3712,9 +3606,9 @@ checksum = "26d41b46a36d453748aedef1486d5c7a85db22e56aff34643984ea85514e94a3"
 
 [[package]]
 name = "windows_x86_64_gnullvm"
-version = "0.48.0"
+version = "0.48.5"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "7896dbc1f41e08872e9d5e8f8baa8fdd2677f29468c4e156210174edc7f7b953"
+checksum = "0b7b52767868a23d5bab768e390dc5f5c55825b6d30b86c844ff2dc7414044cc"
 
 [[package]]
 name = "windows_x86_64_msvc"
@@ -3724,9 +3618,9 @@ checksum = "9aec5da331524158c6d1a4ac0ab1541149c0b9505fde06423b02f5ef0106b9f0"
 
 [[package]]
 name = "windows_x86_64_msvc"
-version = "0.48.0"
+version = "0.48.5"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "1a515f5799fe4961cb532f983ce2b23082366b898e52ffbce459c86f67c8378a"
+checksum = "ed94fce61571a4006852b7389a063ab983c02eb1bb37b47f8272ce92d06d9538"
 
 [[package]]
 name = "yaml-rust"
@@ -3754,9 +3648,9 @@ dependencies = [
 
 [[package]]
 name = "zstd-safe"
-version = "6.0.5+zstd.1.5.4"
+version = "6.0.6"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "d56d9e60b4b1758206c238a10165fbcae3ca37b01744e394c463463f6529d23b"
+checksum = "ee98ffd0b48ee95e6c5168188e44a54550b1564d9d530ee21d5f0eaed1069581"
 dependencies = [
  "libc",
  "zstd-sys",
diff --git a/Cargo.toml b/Cargo.toml
index f249c2df..a0628ae5 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -27,7 +27,7 @@ path = "src/main.rs"
 
 [dependencies]
 actix-web = "4.4"
-annonars = "0.14"
+annonars = "0.20"
 anyhow = "1.0"
 bgzip = "0.3"
 bio = "1.3"
@@ -40,28 +40,28 @@ csv = "1.2"
 derivative = "2.2"
 env_logger = "0.10"
 flate2 = "1.0"
-hgvs = "0.10"
+hgvs = "0.11"
 indexmap = "2.0"
 indicatif = "0.17"
 jsonl = "4.0"
 lazy_static = "1.4"
 log = "0.4"
 nom = "7.1"
-noodles-bgzf = "0.22"
+noodles-bgzf = "0.24"
 noodles-core = "0.12"
-noodles-csi = "0.22"
-noodles-fasta = "0.27"
-noodles-tabix = "0.25"
-noodles-vcf = "0.34"
+noodles-csi = "0.24"
+noodles-fasta = "0.29"
+noodles-tabix = "0.29"
+noodles-vcf = "0.39"
 parse-display = "0.8"
 procfs = "0.15"
-prost = "0.11"
-quick_cache = "0.3"
+prost = "0.12"
+quick_cache = "0.4"
 rand = "0.8"
 rand_core = "0.6"
 rocksdb = { version = "0.21", features = ["multi-threaded-cf"] }
 rustc-hash = "1.1"
-seqrepo = "0.7"
+seqrepo = "0.8"
 serde = { version = "1.0", features = ["derive"] }
 serde_json = "1.0"
 serde_with = "3.3"
diff --git a/src/annotate/seqvars/csq.rs b/src/annotate/seqvars/csq.rs
index 6964da60..7b2f7282 100644
--- a/src/annotate/seqvars/csq.rs
+++ b/src/annotate/seqvars/csq.rs
@@ -144,7 +144,7 @@ impl ConsequencePredictor {
 
         // Skip transcripts that are protein coding but do not have a CDS.
         // TODO: do not include such transcripts when building the database.
-        if TranscriptBiotype::from_i32(tx.biotype).expect("invalid tx biotype")
+        if TranscriptBiotype::try_from(tx.biotype).expect("invalid tx biotype")
             == TranscriptBiotype::Coding
             && tx.start_codon.is_none()
         {
@@ -222,11 +222,11 @@ impl ConsequencePredictor {
             if var_start <= exon_start && var_end >= exon_end {
                 consequences.push(Consequence::ExonLossVariant);
                 if var_start < exon_start {
-                    if Strand::from_i32(alignment.strand).expect("invalid strand") == Strand::Plus
+                    if Strand::try_from(alignment.strand).expect("invalid strand") == Strand::Plus
                         && rank.ord != 1
                     {
                         consequences.push(Consequence::SpliceAcceptorVariant);
-                    } else if Strand::from_i32(alignment.strand).expect("invalid strand")
+                    } else if Strand::try_from(alignment.strand).expect("invalid strand")
                         == Strand::Minus
                         && rank.ord != rank.total
                     {
@@ -234,11 +234,11 @@ impl ConsequencePredictor {
                     }
                 }
                 if var_end > exon_end {
-                    if Strand::from_i32(alignment.strand).expect("invalid strand") == Strand::Plus
+                    if Strand::try_from(alignment.strand).expect("invalid strand") == Strand::Plus
                         && rank.ord != rank.total
                     {
                         consequences.push(Consequence::SpliceDonorVariant);
-                    } else if Strand::from_i32(alignment.strand).expect("invalid strand")
+                    } else if Strand::try_from(alignment.strand).expect("invalid strand")
                         == Strand::Minus
                         && rank.ord != rank.total
                     {
@@ -255,7 +255,7 @@ impl ConsequencePredictor {
                 // Check the cases where the variant overlaps with the splice acceptor/donor site.
                 if var_start < intron_start + 2 && var_end > intron_start - ins_shift {
                     // Left side, is acceptor/donor depending on transcript's strand.
-                    match Strand::from_i32(alignment.strand).expect("invalid strand") {
+                    match Strand::try_from(alignment.strand).expect("invalid strand") {
                         Strand::Plus => consequences.push(Consequence::SpliceDonorVariant),
                         Strand::Minus => consequences.push(Consequence::SpliceAcceptorVariant),
                     }
@@ -263,7 +263,7 @@ impl ConsequencePredictor {
                 // Check the case where the variant overlaps with the splice donor site.
                 if var_start < intron_end + ins_shift && var_end > intron_end - 2 {
                     // Left side, is acceptor/donor depending on transcript's strand.
-                    match Strand::from_i32(alignment.strand).expect("invalid strand") {
+                    match Strand::try_from(alignment.strand).expect("invalid strand") {
                         Strand::Plus => consequences.push(Consequence::SpliceAcceptorVariant),
                         Strand::Minus => consequences.push(Consequence::SpliceDonorVariant),
                     }
@@ -279,7 +279,7 @@ impl ConsequencePredictor {
                     consequences.push(Consequence::SpliceRegionVariant);
                 }
                 if var_start < exon_end && var_end > exon_end - 3 {
-                    if Strand::from_i32(alignment.strand).expect("invalid strand") == Strand::Plus {
+                    if Strand::try_from(alignment.strand).expect("invalid strand") == Strand::Plus {
                         if rank.ord != rank.total {
                             consequences.push(Consequence::SpliceRegionVariant);
                         }
@@ -291,7 +291,7 @@ impl ConsequencePredictor {
                     }
                 }
                 if var_start < exon_start + 3 && var_end > exon_start {
-                    if Strand::from_i32(alignment.strand).expect("invalid strand") == Strand::Plus {
+                    if Strand::try_from(alignment.strand).expect("invalid strand") == Strand::Plus {
                         if rank.ord != 1 {
                             consequences.push(Consequence::SpliceRegionVariant);
                         }
@@ -314,7 +314,7 @@ impl ConsequencePredictor {
         let max_end = max_end.expect("must have seen exon");
 
         let feature_biotype =
-            match TranscriptBiotype::from_i32(tx.biotype).expect("invalid transcript biotype") {
+            match TranscriptBiotype::try_from(tx.biotype).expect("invalid transcript biotype") {
                 TranscriptBiotype::Coding => FeatureBiotype::Coding,
                 TranscriptBiotype::NonCoding => FeatureBiotype::Noncoding,
             };
@@ -334,7 +334,7 @@ impl ConsequencePredictor {
         } else if is_upstream {
             let val = -(min_start - var_end);
             if val.abs() <= 5_000 {
-                match Strand::from_i32(alignment.strand).expect("invalid strand") {
+                match Strand::try_from(alignment.strand).expect("invalid strand") {
                     Strand::Plus => consequences.push(Consequence::UpstreamGeneVariant),
                     Strand::Minus => consequences.push(Consequence::DownstreamGeneVariant),
                 }
@@ -343,7 +343,7 @@ impl ConsequencePredictor {
         } else if is_downstream {
             let val = var_start - max_end;
             if val.abs() <= 5_000 {
-                match Strand::from_i32(alignment.strand).expect("invalid strand") {
+                match Strand::try_from(alignment.strand).expect("invalid strand") {
                     Strand::Plus => consequences.push(Consequence::DownstreamGeneVariant),
                     Strand::Minus => consequences.push(Consequence::UpstreamGeneVariant),
                 }
diff --git a/src/annotate/seqvars/mod.rs b/src/annotate/seqvars/mod.rs
index 40a38e0a..92e75c45 100644
--- a/src/annotate/seqvars/mod.rs
+++ b/src/annotate/seqvars/mod.rs
@@ -212,12 +212,16 @@ fn build_header(header_in: &VcfHeader) -> VcfHeader {
     );
 
     header_out.infos_mut().insert(
-        field::Key::from_str("clinvar_patho").unwrap(),
-        Map::<Info>::new(Number::Count(1), Type::String, "ClinVar pathogenicity"),
+        field::Key::from_str("clinvar_clinsig").unwrap(),
+        Map::<Info>::new(
+            Number::Count(1),
+            Type::String,
+            "ClinVar clinical significance",
+        ),
     );
     header_out.infos_mut().insert(
-        field::Key::from_str("clinvar_vcv").unwrap(),
-        Map::<Info>::new(Number::Count(1), Type::String, "ClinVar VCV accession"),
+        field::Key::from_str("clinvar_rcv").unwrap(),
+        Map::<Info>::new(Number::Count(1), Type::String, "ClinVar RCV accession"),
     );
 
     header_out
@@ -392,24 +396,20 @@ where
             clinvar_minimal::pbs::Record::decode(&mut std::io::Cursor::new(&raw_value))?;
 
         let clinvar_minimal::pbs::Record {
-            summary_clinvar_pathogenicity,
-            vcv,
+            clinical_significance,
+            rcv,
             ..
         } = clinvar_record;
-        let summary_clinvar_pathogenicity: Vec<_> = summary_clinvar_pathogenicity
-            .into_iter()
-            .map(|i: i32| -> clinvar_minimal::cli::reading::Pathogenicity { i.into() })
-            .collect();
+        let clinical_significance: clinvar_minimal::cli::reading::ClinicalSignificance =
+            clinical_significance.into();
 
         vcf_record.info_mut().insert(
-            field::Key::from_str("clinvar_patho").unwrap(),
-            Some(field::Value::String(
-                summary_clinvar_pathogenicity.first().unwrap().to_string(),
-            )),
+            field::Key::from_str("clinvar_clinsig").unwrap(),
+            Some(field::Value::String(clinical_significance.to_string())),
         );
         vcf_record.info_mut().insert(
-            field::Key::from_str("clinvar_vcv").unwrap(),
-            Some(field::Value::String(vcv)),
+            field::Key::from_str("clinvar_rcv").unwrap(),
+            Some(field::Value::String(rcv)),
         );
     }
 
@@ -1078,15 +1078,15 @@ impl VarFishSeqvarTsvWriter {
     ) -> Result<(), anyhow::Error> {
         tsv_record.in_clinvar = record
             .info()
-            .get(&field::Key::from_str("clinvar_patho").unwrap())
+            .get(&field::Key::from_str("clinvar_clinsig").unwrap())
             .unwrap_or_default()
             .map(|v| match v {
                 field::Value::String(value) => {
-                    clinvar_minimal::cli::reading::Pathogenicity::from_str(value).unwrap_or(
-                        clinvar_minimal::cli::reading::Pathogenicity::UncertainSignificance,
-                    ) >= clinvar_minimal::cli::reading::Pathogenicity::LikelyPathogenic
+                    clinvar_minimal::cli::reading::ClinicalSignificance::from_str(value).unwrap_or(
+                        clinvar_minimal::cli::reading::ClinicalSignificance::UncertainSignificance,
+                    ) >= clinvar_minimal::cli::reading::ClinicalSignificance::LikelyPathogenic
                 }
-                _ => panic!("Unexpected value type for INFO/clinvar_patho"),
+                _ => panic!("Unexpected value type for INFO/clinvar_clinsig"),
             })
             .unwrap_or_default();
 
@@ -1368,7 +1368,7 @@ impl AnnotatedVcfWriter for VarFishSeqvarTsvWriter {
 /// Run the annotation with the given `Write` within the `VcfWriter`.
 fn run_with_writer(writer: &mut dyn AnnotatedVcfWriter, args: &Args) -> Result<(), anyhow::Error> {
     tracing::info!("Open VCF and read header");
-    let mut reader = VariantReaderBuilder::default().build_from_path(&args.path_input_vcf)?;
+    let mut reader = VariantReaderBuilder.build_from_path(&args.path_input_vcf)?;
     let header_in = reader.read_header()?;
     let header_out = build_header(&header_in);
 
diff --git a/src/annotate/seqvars/provider.rs b/src/annotate/seqvars/provider.rs
index 704f52f8..7ecd991f 100644
--- a/src/annotate/seqvars/provider.rs
+++ b/src/annotate/seqvars/provider.rs
@@ -257,7 +257,7 @@ impl ProviderInterface for MehariProvider {
                         tx_ac: tx_ac.to_string(),
                         alt_ac: alt_ac.to_string(),
                         alt_aln_method: ALT_ALN_METHOD.to_string(),
-                        alt_strand: match Strand::from_i32(genome_alignment.strand)
+                        alt_strand: match Strand::try_from(genome_alignment.strand)
                             .expect("invalid strand")
                         {
                             Strand::Plus => 1,
@@ -324,7 +324,7 @@ impl ProviderInterface for MehariProvider {
                 TxForRegionRecord {
                     tx_ac: tx.id.clone(),
                     alt_ac: alt_ac.to_string(),
-                    alt_strand: match Strand::from_i32(alt_strand).expect("invalid strand") {
+                    alt_strand: match Strand::try_from(alt_strand).expect("invalid strand") {
                         Strand::Plus => 1,
                         Strand::Minus => -1,
                     },
diff --git a/src/annotate/strucvars/mod.rs b/src/annotate/strucvars/mod.rs
index f49566fc..cadd37ba 100644
--- a/src/annotate/strucvars/mod.rs
+++ b/src/annotate/strucvars/mod.rs
@@ -112,7 +112,7 @@ pub mod vcf_header {
 
     use annonars::common::cli::is_canonical;
     use hgvs::static_data::{Assembly, ASSEMBLY_INFOS};
-    use noodles_vcf::header::record::value::map::{Contig, Filter, Format, Info, Meta, Other};
+    use noodles_vcf::header::record::value::map::{Contig, Filter, Format, Info, Other};
     use noodles_vcf::header::record::value::Map;
     use noodles_vcf::header::{self, Number};
     use noodles_vcf::record::genotypes::keys::key::{
@@ -187,14 +187,11 @@ pub mod vcf_header {
 
         for sequence in &assembly_info.sequences {
             if is_canonical(sequence.name.as_ref()) {
-                let mut contig = Map::<Contig>::try_from(vec![
-                    (String::from("length"), format!("{}", sequence.length)),
-                    (String::from("assembly"), assembly_name.clone()),
-                    (String::from("accession"), sequence.refseq_ac.clone()),
-                ])?;
-
-                Map::<Contig>::new();
-                *contig.length_mut() = Some(sequence.length);
+                let contig = Map::<Contig>::builder()
+                    .insert("assembly".parse()?, assembly_name.clone())
+                    .insert("accession".parse()?, sequence.refseq_ac.clone())
+                    .set_length(sequence.length)
+                    .build()?;
                 builder = builder.add_contig(sequence.name.parse()?, contig);
             }
         }
@@ -417,7 +414,7 @@ pub mod vcf_header {
         pedigree: &PedigreeByName,
         header: &Header,
     ) -> Result<Builder, anyhow::Error> {
-        let mut builder = add_meta_fields(builder);
+        let mut builder = add_meta_fields(builder)?;
 
         // Wait for https://github.com/zaeleus/noodles/issues/162#issuecomment-1514444101
         // let mut b: record::value::map::Builder<record::value::map::Other> = Map::<noodles_vcf::header::record::value::map::Other>::builder();
@@ -457,46 +454,44 @@ pub mod vcf_header {
     }
 
     // Define fields for the gonosomal karyotype, (sex for canonical), affected status
-    fn add_meta_fields(builder: Builder) -> Builder {
-        builder
-            .add_meta(
-                "Sex",
-                Map::<Meta>::new(vec![
-                    String::from("Male"),
-                    String::from("Female"),
-                    String::from("Other"),
-                    String::from("Unknown"),
-                ]),
-            )
-            .add_meta(
-                "GonosomalKaryotype",
-                Map::<Meta>::new(vec![
-                    // "canonical" female
-                    String::from("XX"),
-                    // "canonical" male
-                    String::from("XY"),
-                    // Turner syndrome
-                    String::from("XO"),
-                    // Klinefelter syndrome
-                    String::from("XXY"),
-                    // Triple X syndrome
-                    String::from("XXX"),
-                    // Jacobs syndrome
-                    String::from("XYY"),
-                    // Other
-                    String::from("Other"),
-                    // Unknown
-                    String::from("Unknown"),
-                ]),
-            )
-            .add_meta(
-                "Affected",
-                Map::<Meta>::new(vec![
-                    String::from("Yes"),
-                    String::from("No"),
-                    String::from("Unknown"),
-                ]),
-            )
+    fn add_meta_fields(builder: Builder) -> Result<Builder, anyhow::Error> {
+        Ok(builder
+            .insert(
+                "META".parse()?,
+                noodles_vcf::header::record::Value::Map(
+                    String::from("Sex"),
+                    Map::<Other>::builder()
+                        .insert("Type".parse()?, "String")
+                        .insert("Number".parse()?, ".")
+                        .insert("Values".parse()?, "[Male, Female, Other, Unknown]")
+                        .build()?,
+                ),
+            )?
+            .insert(
+                "META".parse()?,
+                noodles_vcf::header::record::Value::Map(
+                    String::from("GonosomalKaryotype"),
+                    Map::<Other>::builder()
+                        .insert("Type".parse()?, "String")
+                        .insert("Number".parse()?, ".")
+                        .insert(
+                            "Values".parse()?,
+                            "[XX, XY, XO, XXY, XXX, XYY, Other, Unknown]",
+                        )
+                        .build()?,
+                ),
+            )?
+            .insert(
+                "META".parse()?,
+                noodles_vcf::header::record::Value::Map(
+                    String::from("Affected"),
+                    Map::<Other>::builder()
+                        .insert("Type".parse()?, "String")
+                        .insert("Number".parse()?, ".")
+                        .insert("Values".parse()?, "[Yes, No, Unknown]")
+                        .build()?,
+                ),
+            )?)
     }
 }
 
@@ -840,7 +835,7 @@ impl AnnotatedVcfWriter for VarFishStrucvarTsvWriter {
                 ..Default::default()
             });
 
-            let mut entry = tsv_record.genotype.entries.last_mut().expect("just pushed");
+            let entry = tsv_record.genotype.entries.last_mut().expect("just pushed");
             let sample = gt_it.next().expect("genotype iterator exhausted");
 
             for (key, value) in sample.keys().iter().zip(sample.values().iter()) {
@@ -1282,7 +1277,7 @@ impl VarFishStrucvarTsvRecord {
         }
 
         for i in 0..self.genotype.entries.len() {
-            let mut lhs = self
+            let lhs = self
                 .genotype
                 .entries
                 .get_mut(i)
@@ -1607,7 +1602,7 @@ pub fn guess_sv_caller<P>(p: P) -> Result<SvCaller, anyhow::Error>
 where
     P: AsRef<Path>,
 {
-    let mut reader = noodles_vcf::reader::Builder::default().build_from_path(p)?;
+    let mut reader = noodles_vcf::reader::Builder.build_from_path(p)?;
     let header = reader.read_header()?;
     let mut records = reader.records(&header);
     let record = records
@@ -2560,7 +2555,7 @@ fn run_vcf_to_jsonl(
     let sv_caller = guess_sv_caller(path_input)?;
     tracing::debug!("guessed caller/version to be {:?}", &sv_caller);
 
-    let mut reader = noodles_vcf::reader::Builder::default().build_from_path(path_input)?;
+    let mut reader = noodles_vcf::reader::Builder.build_from_path(path_input)?;
     let header: VcfHeader = reader.read_header()?;
 
     let samples = header
@@ -2825,7 +2820,7 @@ pub fn run(_common: &crate::common::Args, args: &Args) -> Result<(), anyhow::Err
         GenomeRelease::Grch38 => Assembly::Grch38,
     });
     let (header, assembly) = {
-        let mut reader = VariantReaderBuilder::default().build_from_path(
+        let mut reader = VariantReaderBuilder.build_from_path(
             args.path_input_vcf
                 .first()
                 .expect("must have at least input VCF"),
@@ -3060,7 +3055,7 @@ mod test {
         let temp = TempDir::default();
         let out_jsonl = File::create(temp.join(out_file_name))?;
 
-        let mut reader = noodles_vcf::reader::Builder::default().build_from_path(path_input_vcf)?;
+        let mut reader = noodles_vcf::reader::Builder.build_from_path(path_input_vcf)?;
         let header_in = reader.read_header()?;
 
         // Setup deterministic bytes for UUID generation.
@@ -3095,7 +3090,7 @@ mod test {
 
     /// Helper that returns sample names from VCF.
     fn vcf_samples(path: &str) -> Result<Vec<String>, anyhow::Error> {
-        let mut reader = noodles_vcf::reader::Builder::default().build_from_path(path)?;
+        let mut reader = noodles_vcf::reader::Builder.build_from_path(path)?;
         let header: VcfHeader = reader.read_header()?;
         Ok(header
             .sample_names()
@@ -3363,44 +3358,41 @@ mod test {
 
     /// Generate example trio data.
     fn example_trio() -> PedigreeByName {
-        let individuals = indexmap::IndexMap::from_iter(
-            vec![
-                (
-                    String::from("index"),
-                    Individual {
-                        family: String::from("FAM"),
-                        name: String::from("index"),
-                        father: Some(String::from("father")),
-                        mother: Some(String::from("mother")),
-                        sex: Sex::Female,
-                        disease: Disease::Affected,
-                    },
-                ),
-                (
-                    String::from("father"),
-                    Individual {
-                        family: String::from("FAM"),
-                        name: String::from("father"),
-                        father: None,
-                        mother: None,
-                        sex: Sex::Male,
-                        disease: Disease::Unaffected,
-                    },
-                ),
-                (
-                    String::from("mother"),
-                    Individual {
-                        family: String::from("FAM"),
-                        name: String::from("mother"),
-                        father: None,
-                        mother: None,
-                        sex: Sex::Female,
-                        disease: Disease::Unaffected,
-                    },
-                ),
-            ]
-            .into_iter(),
-        );
+        let individuals = indexmap::IndexMap::from_iter(vec![
+            (
+                String::from("index"),
+                Individual {
+                    family: String::from("FAM"),
+                    name: String::from("index"),
+                    father: Some(String::from("father")),
+                    mother: Some(String::from("mother")),
+                    sex: Sex::Female,
+                    disease: Disease::Affected,
+                },
+            ),
+            (
+                String::from("father"),
+                Individual {
+                    family: String::from("FAM"),
+                    name: String::from("father"),
+                    father: None,
+                    mother: None,
+                    sex: Sex::Male,
+                    disease: Disease::Unaffected,
+                },
+            ),
+            (
+                String::from("mother"),
+                Individual {
+                    family: String::from("FAM"),
+                    name: String::from("mother"),
+                    father: None,
+                    mother: None,
+                    sex: Sex::Female,
+                    disease: Disease::Unaffected,
+                },
+            ),
+        ]);
         PedigreeByName { individuals }
     }
 
diff --git a/tests/data/annotate/strucvars/example-grch38.vcf b/tests/data/annotate/strucvars/example-grch38.vcf
index 4fdc9632..db9e7e71 100644
--- a/tests/data/annotate/strucvars/example-grch38.vcf
+++ b/tests/data/annotate/strucvars/example-grch38.vcf
@@ -1,3 +1,3 @@
 version https://git-lfs.github.com/spec/v1
-oid sha256:ec640b42e426e46a0508346baaba4aef8200999218732eb3ea2bce520fe66075
-size 5648
+oid sha256:269cd65dac9d34cfd0469e6bae1fbc3c56ce716e6ec2be767bb87620ea98034e
+size 5666
diff --git a/tests/data/annotate/strucvars/header-grch37-noped.vcf b/tests/data/annotate/strucvars/header-grch37-noped.vcf
index 10d08ba4..713d30a5 100644
--- a/tests/data/annotate/strucvars/header-grch37-noped.vcf
+++ b/tests/data/annotate/strucvars/header-grch37-noped.vcf
@@ -1,3 +1,3 @@
 version https://git-lfs.github.com/spec/v1
-oid sha256:20e29f4d58ff6a06cf91f47f975c7bbb319aab34ac865b361a1fc7ff512e1ca4
-size 4651
+oid sha256:ef422278360dfa7af198eff4be07764b6a3a1453d33e473c5464cc24ff1cf948
+size 4669
diff --git a/tests/data/annotate/strucvars/header-grch37-trio.vcf b/tests/data/annotate/strucvars/header-grch37-trio.vcf
index b6ea766b..8746c3ed 100644
--- a/tests/data/annotate/strucvars/header-grch37-trio.vcf
+++ b/tests/data/annotate/strucvars/header-grch37-trio.vcf
@@ -1,3 +1,3 @@
 version https://git-lfs.github.com/spec/v1
-oid sha256:051a1e125152c5c02ab56990644ca7d1c1e9258236e4898efdad99aafce8ee28
-size 4938
+oid sha256:19f9f4da757a7083532a8149668eb0c17a30d12cb19cc029ea88b25a43fbf706
+size 4956
diff --git a/tests/data/annotate/strucvars/header-grch38-noped.vcf b/tests/data/annotate/strucvars/header-grch38-noped.vcf
index 3e9cdd12..5b5556e1 100644
--- a/tests/data/annotate/strucvars/header-grch38-noped.vcf
+++ b/tests/data/annotate/strucvars/header-grch38-noped.vcf
@@ -1,3 +1,3 @@
 version https://git-lfs.github.com/spec/v1
-oid sha256:23bed5e1e6c06b7935428a4a418686ce47ccc8472f3a2bb8db08bb514f2ecd5c
-size 4658
+oid sha256:cf938ad4052b0bb0b59adc6fa03f5c8431608f01e20a2bdccefbb3ec1693b7cf
+size 4676
diff --git a/tests/data/annotate/strucvars/maelstrom/delly2-min-with-maelstrom.vcf b/tests/data/annotate/strucvars/maelstrom/delly2-min-with-maelstrom.vcf
index 9717c385..f09577f4 100644
--- a/tests/data/annotate/strucvars/maelstrom/delly2-min-with-maelstrom.vcf
+++ b/tests/data/annotate/strucvars/maelstrom/delly2-min-with-maelstrom.vcf
@@ -1,3 +1,3 @@
 version https://git-lfs.github.com/spec/v1
-oid sha256:dd43ff683144475414fcab8fee214cd7d5c843bf56f85f745fd8c512811bcc69
-size 5011
+oid sha256:33ccbbb691f8201b90584b0ea9dee52858ba8062276fbb08a8668680194efaaa
+size 5029
diff --git a/tests/data/db/create/seqvar_freqs/db-rs1263393206/output.vcf b/tests/data/db/create/seqvar_freqs/db-rs1263393206/output.vcf
index 98e9f866..0c120810 100644
--- a/tests/data/db/create/seqvar_freqs/db-rs1263393206/output.vcf
+++ b/tests/data/db/create/seqvar_freqs/db-rs1263393206/output.vcf
@@ -1,3 +1,3 @@
 version https://git-lfs.github.com/spec/v1
-oid sha256:af35d25008b9ffc3c84cfb4ef7df60ba3176cb0b74664270cd02cde8b3d1f82f
-size 17891
+oid sha256:75d6ddb0066c7962b23562c01c5c1e31cd9c0884076082d3da858b9c87672bbb
+size 17901