diff --git a/Cargo.lock b/Cargo.lock
index e9bf565e..b80939ba 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -277,9 +277,9 @@ checksum = "4b46cbb362ab8752921c97e041f5e366ee6297bd428a31275b9fcf1e380f7299"
 
 [[package]]
 name = "annonars"
-version = "0.41.3"
+version = "0.42.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "00b75fa31308f0d683d6f24bbfde06c76e2679661dc3ad5a6ca0347256b980ee"
+checksum = "86428b1ff21f6e8f5fc574928a3dc643300f4ddd4915eaed3f2c8cd47d0d5f79"
 dependencies = [
  "actix-web",
  "anyhow",
@@ -315,11 +315,11 @@ dependencies = [
  "serde_with",
  "serde_yaml",
  "strum",
- "thiserror",
+ "thiserror 2.0.3",
  "tracing",
  "tracing-subscriber",
- "utoipa 4.2.3",
- "utoipa-swagger-ui",
+ "utoipa 5.2.0",
+ "utoipa-swagger-ui 8.0.3",
 ]
 
 [[package]]
@@ -603,7 +603,7 @@ dependencies = [
  "flate2",
  "log",
  "rayon",
- "thiserror",
+ "thiserror 1.0.69",
 ]
 
 [[package]]
@@ -660,7 +660,7 @@ dependencies = [
  "statrs",
  "strum",
  "strum_macros",
- "thiserror",
+ "thiserror 1.0.69",
  "triple_accel",
  "vec_map",
 ]
@@ -675,7 +675,7 @@ dependencies = [
  "lazy_static",
  "regex",
  "strum_macros",
- "thiserror",
+ "thiserror 1.0.69",
 ]
 
 [[package]]
@@ -945,7 +945,7 @@ dependencies = [
  "cached_proc_macro_types",
  "hashbrown 0.14.5",
  "once_cell",
- "thiserror",
+ "thiserror 1.0.69",
  "web-time",
 ]
 
@@ -2030,7 +2030,7 @@ dependencies = [
  "seqrepo",
  "serde",
  "serde_json",
- "thiserror",
+ "thiserror 1.0.69",
 ]
 
 [[package]]
@@ -2488,7 +2488,7 @@ checksum = "1abae98f45234fc1980c198798166a80ad6b35eb5b7db4caa7bc72ff919e6b80"
 dependencies = [
  "serde",
  "serde_json",
- "thiserror",
+ "thiserror 1.0.69",
 ]
 
 [[package]]
@@ -2720,6 +2720,12 @@ dependencies = [
  "scopeguard",
 ]
 
+[[package]]
+name = "lockfree-object-pool"
+version = "0.1.6"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "9374ef4228402d4b7e403e5838cb880d9ee663314b0a900d5a6aabf0c213552e"
+
 [[package]]
 name = "log"
 version = "0.4.22"
@@ -2852,7 +2858,7 @@ dependencies = [
  "tracing-test",
  "utoipa 4.2.3",
  "utoipa-actix-web",
- "utoipa-swagger-ui",
+ "utoipa-swagger-ui 7.1.0",
  "uuid",
  "zstd",
 ]
@@ -3696,7 +3702,7 @@ dependencies = [
  "smallvec",
  "symbolic-demangle",
  "tempfile",
- "thiserror",
+ "thiserror 1.0.69",
 ]
 
 [[package]]
@@ -3902,7 +3908,7 @@ dependencies = [
  "rustc-hash 2.0.0",
  "rustls",
  "socket2",
- "thiserror",
+ "thiserror 1.0.69",
  "tokio",
  "tracing",
 ]
@@ -3919,7 +3925,7 @@ dependencies = [
  "rustc-hash 2.0.0",
  "rustls",
  "slab",
- "thiserror",
+ "thiserror 1.0.69",
  "tinyvec",
  "tracing",
 ]
@@ -4206,7 +4212,7 @@ source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "cfdff1c5ed63d35ce75ffc688318b3b9791c5e16a0c4b1ed8d8400149384f7bf"
 dependencies = [
  "rocksdb",
- "thiserror",
+ "thiserror 1.0.69",
  "tracing",
 ]
 
@@ -4459,7 +4465,7 @@ dependencies = [
  "chrono",
  "noodles 0.76.0",
  "rusqlite",
- "thiserror",
+ "thiserror 1.0.69",
  "tracing",
 ]
 
@@ -4618,6 +4624,12 @@ dependencies = [
  "wide",
 ]
 
+[[package]]
+name = "simd-adler32"
+version = "0.3.7"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "d66dc143e6b11c1eddc06d5c423cfc97062865baf299914ab64caa38182078fe"
+
 [[package]]
 name = "simdutf8"
 version = "0.1.5"
@@ -4861,7 +4873,16 @@ version = "1.0.69"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "b6aaf5339b578ea85b50e080feb250a3e8ae8cfcdff9a461c9ec2904bc923f52"
 dependencies = [
- "thiserror-impl",
+ "thiserror-impl 1.0.69",
+]
+
+[[package]]
+name = "thiserror"
+version = "2.0.3"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "c006c85c7651b3cf2ada4584faa36773bd07bac24acfb39f3c431b36d7e667aa"
+dependencies = [
+ "thiserror-impl 2.0.3",
 ]
 
 [[package]]
@@ -4875,6 +4896,17 @@ dependencies = [
  "syn 2.0.87",
 ]
 
+[[package]]
+name = "thiserror-impl"
+version = "2.0.3"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "f077553d607adc1caf65430528a576c757a71ed73944b66ebb58ef2bbd243568"
+dependencies = [
+ "proc-macro2",
+ "quote",
+ "syn 2.0.87",
+]
+
 [[package]]
 name = "thousands"
 version = "0.2.0"
@@ -5309,6 +5341,7 @@ dependencies = [
  "indexmap",
  "serde",
  "serde_json",
+ "serde_yaml",
  "utoipa-gen 5.2.0",
 ]
 
@@ -5344,6 +5377,7 @@ checksum = "5629efe65599d0ccd5d493688cbf6e03aa7c1da07fe59ff97cf5977ed0637f66"
 dependencies = [
  "proc-macro2",
  "quote",
+ "regex",
  "syn 2.0.87",
 ]
 
@@ -5362,7 +5396,24 @@ dependencies = [
  "serde_json",
  "url",
  "utoipa 4.2.3",
- "zip",
+ "zip 1.1.4",
+]
+
+[[package]]
+name = "utoipa-swagger-ui"
+version = "8.0.3"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "a5c80b4dd79ea382e8374d67dcce22b5c6663fa13a82ad3886441d1bbede5e35"
+dependencies = [
+ "actix-web",
+ "mime_guess",
+ "regex",
+ "rust-embed",
+ "serde",
+ "serde_json",
+ "url",
+ "utoipa 5.2.0",
+ "zip 2.2.1",
 ]
 
 [[package]]
@@ -5861,7 +5912,38 @@ dependencies = [
  "flate2",
  "indexmap",
  "num_enum",
- "thiserror",
+ "thiserror 1.0.69",
+]
+
+[[package]]
+name = "zip"
+version = "2.2.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "99d52293fc86ea7cf13971b3bb81eb21683636e7ae24c729cdaf1b7c4157a352"
+dependencies = [
+ "arbitrary",
+ "crc32fast",
+ "crossbeam-utils",
+ "displaydoc",
+ "flate2",
+ "indexmap",
+ "memchr",
+ "thiserror 2.0.3",
+ "zopfli",
+]
+
+[[package]]
+name = "zopfli"
+version = "0.8.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "e5019f391bac5cf252e93bbcc53d039ffd62c7bfb7c150414d61369afe57e946"
+dependencies = [
+ "bumpalo",
+ "crc32fast",
+ "lockfree-object-pool",
+ "log",
+ "once_cell",
+ "simd-adler32",
 ]
 
 [[package]]
diff --git a/Cargo.toml b/Cargo.toml
index 2d855c0a..aa00df5a 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -27,7 +27,7 @@ path = "src/main.rs"
 
 [dependencies]
 actix-web = "4.9"
-annonars = "0.41.3"
+annonars = "0.42.3"
 anyhow = "1.0"
 async-compression = { version = "0.4", features = ["tokio", "gzip"] }
 bgzip = "0.3"