diff --git a/Lib/test/test_sqlite3/test_dbapi.py b/Lib/test/test_sqlite3/test_dbapi.py
index 825f335caef3f9..2aea1105a25101 100644
--- a/Lib/test/test_sqlite3/test_dbapi.py
+++ b/Lib/test/test_sqlite3/test_dbapi.py
@@ -29,7 +29,10 @@
 import unittest
 import urllib.parse
 
-from test.support import SHORT_TIMEOUT, bigmemtest, check_disallow_instantiation
+from test.support import (
+    SHORT_TIMEOUT, bigmemtest, check_disallow_instantiation, requires_subprocess,
+    is_emscripten, is_wasi
+)
 from test.support import threading_helper
 from _testcapi import INT_MAX, ULLONG_MAX
 from os import SEEK_SET, SEEK_CUR, SEEK_END
@@ -658,6 +661,7 @@ def test_open_with_path_like_object(self):
 
     @unittest.skipIf(sys.platform == "win32", "skipped on Windows")
     @unittest.skipIf(sys.platform == "darwin", "skipped on macOS")
+    @unittest.skipIf(is_emscripten or is_wasi, "not supported on Emscripten/WASI")
     @unittest.skipUnless(TESTFN_UNDECODABLE, "only works if there are undecodable paths")
     def test_open_with_undecodable_path(self):
         path = TESTFN_UNDECODABLE
@@ -703,6 +707,7 @@ def test_open_uri_readonly(self):
 
     @unittest.skipIf(sys.platform == "win32", "skipped on Windows")
     @unittest.skipIf(sys.platform == "darwin", "skipped on macOS")
+    @unittest.skipIf(is_emscripten or is_wasi, "not supported on Emscripten/WASI")
     @unittest.skipUnless(TESTFN_UNDECODABLE, "only works if there are undecodable paths")
     def test_open_undecodable_uri(self):
         path = TESTFN_UNDECODABLE
@@ -1458,6 +1463,7 @@ def test_blob_closed_db_read(self):
                                    blob.read)
 
 
+@threading_helper.requires_working_threading()
 class ThreadTests(unittest.TestCase):
     def setUp(self):
         self.con = sqlite.connect(":memory:")
@@ -1822,6 +1828,7 @@ def test_on_conflict_replace(self):
         self.assertEqual(self.cu.fetchall(), [('Very different data!', 'foo')])
 
 
+@requires_subprocess()
 class MultiprocessTests(unittest.TestCase):
     CONNECTION_TIMEOUT = SHORT_TIMEOUT / 1000.  # Defaults to 30 ms