diff --git a/Wrapping/Generators/Python/itk/support/lazy.py b/Wrapping/Generators/Python/itk/support/lazy.py
index fa3cd703d33..d1d520717bc 100644
--- a/Wrapping/Generators/Python/itk/support/lazy.py
+++ b/Wrapping/Generators/Python/itk/support/lazy.py
@@ -23,18 +23,6 @@
 # use of the builtin set
 from builtins import set as _builtin_set
 
-# Need to use a recursive lock for thread ownership
-# within the given thread you can acquire a RLock as often as you like.
-# Other threads need to wait until this thread releases the resource again.
-from multiprocessing import RLock as _mp_RLock
-
-# A single lock is needed for all lazy loading.  This lock blocks
-# across all threads until this thread has completed all its imports
-# and dependancies.  The complex inter-relationship, and the recursive
-# nature of imports, makes a more fine-grained locking very difficult
-# to implement robustly.
-_gbl_lazy_load_lock: _mp_RLock = _mp_RLock()
-
 not_loaded: str = "not loaded"
 
 
@@ -45,6 +33,62 @@ def _lazy_itk_module_reconstructor(module_name, state):
 
     return lazy_module
 
+def _ThreadingRLock(*args, **kwargs):
+    """threading RLock"""
+    try:
+        from threading import RLock
+        return RLock(*args, **kwargs)
+    except (ImportError, OSError):
+        pass
+
+class ITKLazyLoadLock(object):
+    """Need to use a recursive lock for thread ownership
+    within the given thread you can acquire a RLock as often as you like.
+    Other threads need to wait until this thread releases the resource again.
+
+    A single lock is needed for all lazy loading.  This lock blocks
+    across all threads until this thread has completed all its imports
+    and dependancies.  The complex inter-relationship, and the recursive
+    nature of imports, makes a more fine-grained locking very difficult
+    to implement robustly."""
+
+    # global thread lock so no setup required for multithreading.
+    # NB: Do not create multiprocessing lock as it sets the multiprocessing
+    # context, disallowing `spawn()`/`forkserver()`
+    th_lock = _ThreadingRLock()
+
+    def __init__(self):
+        cls = type(self)
+        root_lock = cls.th_lock
+        if root_lock is not None:
+            root_lock.acquire()
+        cls.create_mp_lock()
+        self.locks = [lk for lk in [cls.mp_lock, cls.th_lock] if lk is not None]
+        if root_lock is not None:
+            root_lock.release()
+
+    def acquire(self, *a, **k):
+        for lock in self.locks:
+            lock.acquire(*a, **k)
+
+    def release(self):
+        for lock in self.locks[::-1]:  # Release in inverse order of acquisition
+            lock.release()
+
+    def __enter__(self):
+        self.acquire()
+
+    def __exit__(self, *exc):
+        self.release()
+
+    @classmethod
+    def create_mp_lock(cls):
+        if not hasattr(cls, 'mp_lock'):
+            try:
+                from multiprocessing import RLock
+                cls.mp_lock = RLock()
+            except (ImportError, OSError):
+                cls.mp_lock = None
 
 class LazyITKModule(types.ModuleType):
 
@@ -65,10 +109,22 @@ def __init__(self, name, lazy_attributes):
         setattr(self, "itk_base_global_lazy_attributes", lazy_attributes)
         setattr(self, "loaded_lazy_modules", _builtin_set())
 
+    @classmethod
+    def set_lock(cls, lock):
+        """Set the global lock."""
+        cls._lock = lock
+
+    @classmethod
+    def get_lock(cls):
+        """Get the global lock. Construct it if it does not exist."""
+        if not hasattr(cls, '_lock'):
+            cls._lock = ITKLazyLoadLock()
+        return cls._lock
+
     def __getattribute__(self, attr):
         value = types.ModuleType.__getattribute__(self, attr)
         if value is not_loaded:
-            with _gbl_lazy_load_lock:  # All but one thread will block here.
+            with type(self).get_lock():  # All but one thread will block here.
                 if value is not_loaded:
                     # Only the first thread needs to run this code, all other blocked threads skip
                     module = self.__belong_lazy_attributes[attr]