diff --git a/java-life-sciences/CHANGELOG.md b/java-life-sciences/CHANGELOG.md
index f94bfea50633..8600e93e4b16 100644
--- a/java-life-sciences/CHANGELOG.md
+++ b/java-life-sciences/CHANGELOG.md
@@ -1,5 +1,17 @@
 # Changelog
 
+## [0.5.0](https://github.com/googleapis/java-life-sciences/compare/v0.4.1...v0.5.0) (2022-07-01)
+
+
+### Features
+
+* Enable REST transport for most of Java and Go clients ([#196](https://github.com/googleapis/java-life-sciences/issues/196)) ([ede5b3b](https://github.com/googleapis/java-life-sciences/commit/ede5b3b856dff94aa8ea48687531367f1086ec63))
+
+
+### Bug Fixes
+
+* update gapic-generator-java with mock service generation fixes ([#202](https://github.com/googleapis/java-life-sciences/issues/202)) ([96e93cb](https://github.com/googleapis/java-life-sciences/commit/96e93cb98baa006b435f0ae057cd59cfc824f056))
+
 ## [0.4.1](https://github.com/googleapis/java-life-sciences/compare/v0.4.0...v0.4.1) (2022-06-23)
 
 
diff --git a/java-life-sciences/google-cloud-life-sciences-bom/pom.xml b/java-life-sciences/google-cloud-life-sciences-bom/pom.xml
index a6dc21cd5018..660f89d2e9b6 100644
--- a/java-life-sciences/google-cloud-life-sciences-bom/pom.xml
+++ b/java-life-sciences/google-cloud-life-sciences-bom/pom.xml
@@ -3,7 +3,7 @@
   <modelVersion>4.0.0</modelVersion>
   <groupId>com.google.cloud</groupId>
   <artifactId>google-cloud-life-sciences-bom</artifactId>
-  <version>0.4.2-SNAPSHOT</version><!-- {x-version-update:google-cloud-life-sciences:current} -->
+  <version>0.5.0</version><!-- {x-version-update:google-cloud-life-sciences:current} -->
   <packaging>pom</packaging>
   <parent>
     <groupId>com.google.cloud</groupId>
@@ -56,17 +56,17 @@
       <dependency>
         <groupId>com.google.cloud</groupId>
         <artifactId>google-cloud-life-sciences</artifactId>
-        <version>0.4.2-SNAPSHOT</version><!-- {x-version-update:google-cloud-life-sciences:current} -->
+        <version>0.5.0</version><!-- {x-version-update:google-cloud-life-sciences:current} -->
       </dependency>
       <dependency>
         <groupId>com.google.api.grpc</groupId>
         <artifactId>grpc-google-cloud-life-sciences-v2beta</artifactId>
-        <version>0.4.2-SNAPSHOT</version><!-- {x-version-update:grpc-google-cloud-life-sciences-v2beta:current} -->
+        <version>0.5.0</version><!-- {x-version-update:grpc-google-cloud-life-sciences-v2beta:current} -->
       </dependency>
       <dependency>
         <groupId>com.google.api.grpc</groupId>
         <artifactId>proto-google-cloud-life-sciences-v2beta</artifactId>
-        <version>0.4.2-SNAPSHOT</version><!-- {x-version-update:proto-google-cloud-life-sciences-v2beta:current} -->
+        <version>0.5.0</version><!-- {x-version-update:proto-google-cloud-life-sciences-v2beta:current} -->
       </dependency>
     </dependencies>
   </dependencyManagement>
diff --git a/java-life-sciences/google-cloud-life-sciences/pom.xml b/java-life-sciences/google-cloud-life-sciences/pom.xml
index 4d101037a0c4..97ac69087f0e 100644
--- a/java-life-sciences/google-cloud-life-sciences/pom.xml
+++ b/java-life-sciences/google-cloud-life-sciences/pom.xml
@@ -3,7 +3,7 @@
   <modelVersion>4.0.0</modelVersion>
   <groupId>com.google.cloud</groupId>
   <artifactId>google-cloud-life-sciences</artifactId>
-  <version>0.4.2-SNAPSHOT</version><!-- {x-version-update:google-cloud-life-sciences:current} -->
+  <version>0.5.0</version><!-- {x-version-update:google-cloud-life-sciences:current} -->
   <packaging>jar</packaging>
   <name>Google Cloud Life Sciences</name>
   <url>https://github.com/googleapis/java-life-sciences</url>
@@ -11,7 +11,7 @@
   <parent>
     <groupId>com.google.cloud</groupId>
     <artifactId>google-cloud-life-sciences-parent</artifactId>
-    <version>0.4.2-SNAPSHOT</version><!-- {x-version-update:google-cloud-life-sciences:current} -->
+    <version>0.5.0</version><!-- {x-version-update:google-cloud-life-sciences:current} -->
   </parent>
   <properties>
     <site.installationModule>google-cloud-life-sciences</site.installationModule>
diff --git a/java-life-sciences/grpc-google-cloud-life-sciences-v2beta/pom.xml b/java-life-sciences/grpc-google-cloud-life-sciences-v2beta/pom.xml
index 3d46495cb50f..383a917d8823 100644
--- a/java-life-sciences/grpc-google-cloud-life-sciences-v2beta/pom.xml
+++ b/java-life-sciences/grpc-google-cloud-life-sciences-v2beta/pom.xml
@@ -4,13 +4,13 @@
   <modelVersion>4.0.0</modelVersion>
   <groupId>com.google.api.grpc</groupId>
   <artifactId>grpc-google-cloud-life-sciences-v2beta</artifactId>
-  <version>0.4.2-SNAPSHOT</version><!-- {x-version-update:grpc-google-cloud-life-sciences-v2beta:current} -->
+  <version>0.5.0</version><!-- {x-version-update:grpc-google-cloud-life-sciences-v2beta:current} -->
   <name>grpc-google-cloud-life-sciences-v2beta</name>
   <description>GRPC library for google-cloud-life-sciences</description>
   <parent>
     <groupId>com.google.cloud</groupId>
     <artifactId>google-cloud-life-sciences-parent</artifactId>
-    <version>0.4.2-SNAPSHOT</version><!-- {x-version-update:google-cloud-life-sciences:current} -->
+    <version>0.5.0</version><!-- {x-version-update:google-cloud-life-sciences:current} -->
   </parent>
   <dependencies>
     <dependency>
diff --git a/java-life-sciences/pom.xml b/java-life-sciences/pom.xml
index 31deee5b1bfe..dc8370e3e159 100644
--- a/java-life-sciences/pom.xml
+++ b/java-life-sciences/pom.xml
@@ -4,7 +4,7 @@
   <groupId>com.google.cloud</groupId>
   <artifactId>google-cloud-life-sciences-parent</artifactId>
   <packaging>pom</packaging>
-  <version>0.4.2-SNAPSHOT</version><!-- {x-version-update:google-cloud-life-sciences:current} -->
+  <version>0.5.0</version><!-- {x-version-update:google-cloud-life-sciences:current} -->
   <name>Google Cloud Life Sciences Parent</name>
   <url>https://github.com/googleapis/java-life-sciences</url>
   <description>
@@ -60,17 +60,17 @@
       <dependency>
         <groupId>com.google.cloud</groupId>
         <artifactId>google-cloud-life-sciences</artifactId>
-        <version>0.4.2-SNAPSHOT</version><!-- {x-version-update:google-cloud-life-sciences:current} -->
+        <version>0.5.0</version><!-- {x-version-update:google-cloud-life-sciences:current} -->
       </dependency>
       <dependency>
         <groupId>com.google.api.grpc</groupId>
         <artifactId>grpc-google-cloud-life-sciences-v2beta</artifactId>
-        <version>0.4.2-SNAPSHOT</version><!-- {x-version-update:grpc-google-cloud-life-sciences-v2beta:current} -->
+        <version>0.5.0</version><!-- {x-version-update:grpc-google-cloud-life-sciences-v2beta:current} -->
       </dependency>
       <dependency>
         <groupId>com.google.api.grpc</groupId>
         <artifactId>proto-google-cloud-life-sciences-v2beta</artifactId>
-        <version>0.4.2-SNAPSHOT</version><!-- {x-version-update:proto-google-cloud-life-sciences-v2beta:current} -->
+        <version>0.5.0</version><!-- {x-version-update:proto-google-cloud-life-sciences-v2beta:current} -->
       </dependency>
 
       <dependency>
diff --git a/java-life-sciences/proto-google-cloud-life-sciences-v2beta/pom.xml b/java-life-sciences/proto-google-cloud-life-sciences-v2beta/pom.xml
index ee603f43842a..1a2dfc937f85 100644
--- a/java-life-sciences/proto-google-cloud-life-sciences-v2beta/pom.xml
+++ b/java-life-sciences/proto-google-cloud-life-sciences-v2beta/pom.xml
@@ -4,13 +4,13 @@
   <modelVersion>4.0.0</modelVersion>
   <groupId>com.google.api.grpc</groupId>
   <artifactId>proto-google-cloud-life-sciences-v2beta</artifactId>
-  <version>0.4.2-SNAPSHOT</version><!-- {x-version-update:proto-google-cloud-life-sciences-v2beta:current} -->
+  <version>0.5.0</version><!-- {x-version-update:proto-google-cloud-life-sciences-v2beta:current} -->
   <name>proto-google-cloud-life-sciences-v2beta</name>
   <description>Proto library for google-cloud-life-sciences</description>
   <parent>
     <groupId>com.google.cloud</groupId>
     <artifactId>google-cloud-life-sciences-parent</artifactId>
-    <version>0.4.2-SNAPSHOT</version><!-- {x-version-update:google-cloud-life-sciences:current} -->
+    <version>0.5.0</version><!-- {x-version-update:google-cloud-life-sciences:current} -->
   </parent>
   <dependencies>
     <dependency>
diff --git a/java-life-sciences/versions.txt b/java-life-sciences/versions.txt
index 3455465ce31d..c7cb9a7f7896 100644
--- a/java-life-sciences/versions.txt
+++ b/java-life-sciences/versions.txt
@@ -1,6 +1,6 @@
 # Format:
 # module:released-version:current-version
 
-google-cloud-life-sciences:0.4.1:0.4.2-SNAPSHOT
-grpc-google-cloud-life-sciences-v2beta:0.4.1:0.4.2-SNAPSHOT
-proto-google-cloud-life-sciences-v2beta:0.4.1:0.4.2-SNAPSHOT
+google-cloud-life-sciences:0.5.0:0.5.0
+grpc-google-cloud-life-sciences-v2beta:0.5.0:0.5.0
+proto-google-cloud-life-sciences-v2beta:0.5.0:0.5.0