diff --git a/spyder/plugins/layout/plugin.py b/spyder/plugins/layout/plugin.py
index 927c789e715..c5489b2fa45 100644
--- a/spyder/plugins/layout/plugin.py
+++ b/spyder/plugins/layout/plugin.py
@@ -668,7 +668,10 @@ def save_current_window_settings(self, prefix, section='main',
         )
         self.set_conf(
             prefix + 'position',
-            (pos.x(), pos.y()),
+            # We need to do these validations to avoid an error that breaks
+            # doing mouse clicks in WSL.
+            # Fixes spyder-ide/spyder#20851
+            (pos.x() if pos.x() > 0 else 0, pos.y() if pos.y() > 0 else 0),
             section=section,
         )