diff --git a/acl_loader/main.py b/acl_loader/main.py
index 0d8386f5c7..e0df7eec8b 100644
--- a/acl_loader/main.py
+++ b/acl_loader/main.py
@@ -9,7 +9,7 @@
 import tabulate
 import pyangbind.lib.pybindJSON as pybindJSON
 from natsort import natsorted
-from sonic_py_common import device_info
+from sonic_py_common import device_info, multi_asic
 from swsscommon.swsscommon import SonicV2Connector, ConfigDBConnector, SonicDBConfig
 
 
@@ -114,8 +114,13 @@ def __init__(self):
         self.tables_db_info = {}
         self.rules_db_info = {}
         self.rules_info = {}
-        # Load global db config. This call is no-op in single npu platforms
-        SonicDBConfig.load_sonic_global_db_config()
+
+        if multi_asic.is_multi_asic():
+            # Load global db config
+            SonicDBConfig.load_sonic_global_db_config()
+        else:
+            SonicDBConfig.initialize()
+
         self.sessions_db_info = {}
         self.configdb = ConfigDBConnector()
         self.configdb.connect()
diff --git a/crm/main.py b/crm/main.py
index caf0108b12..fdde198b1a 100644
--- a/crm/main.py
+++ b/crm/main.py
@@ -211,15 +211,20 @@ def cli(ctx):
     # Use the db object if given as input.
     db = None if ctx.obj is None else ctx.obj.cfgdb
 
+    # Note: SonicDBConfig may be already initialized in unit test, then skip
+    if not SonicDBConfig.isInit():
+        if multi_asic.is_multi_asic():
+            # Load the global config file database_global.json once.
+            SonicDBConfig.load_sonic_global_db_config()
+        else:
+            SonicDBConfig.initialize()
+
     context = {
         "crm": Crm(db)
     }
 
     ctx.obj = context
 
-    # Load the global config file database_global.json once.
-    SonicDBConfig.load_sonic_global_db_config()
-
 @cli.group()
 @click.pass_context
 def config(ctx):
diff --git a/scripts/db_migrator.py b/scripts/db_migrator.py
index c5d8232e4a..6e18ca4034 100755
--- a/scripts/db_migrator.py
+++ b/scripts/db_migrator.py
@@ -555,6 +555,8 @@ def main():
 
         if args.namespace is not None:
             SonicDBConfig.load_sonic_global_db_config(namespace=args.namespace)
+        else:
+            SonicDBConfig.initialize()
 
         if socket_path:
             dbmgtr = DBMigrator(namespace, socket=socket_path)
diff --git a/scripts/lldpshow b/scripts/lldpshow
index b6682b8df1..c41e78db00 100755
--- a/scripts/lldpshow
+++ b/scripts/lldpshow
@@ -25,7 +25,7 @@ import subprocess
 import sys
 import xml.etree.ElementTree as ET
 
-from sonic_py_common import device_info
+from sonic_py_common import device_info, multi_asic
 from swsscommon.swsscommon import ConfigDBConnector, SonicDBConfig
 from tabulate import tabulate
 
@@ -47,7 +47,11 @@ class Lldpshow(object):
         # So far only find Router and Bridge two capabilities in lldpctl, so any other capacility types will be read as Other
         # if further capability type is supported like WLAN, can just add the tag definition here
         self.ctags = {'Router': 'R', 'Bridge': 'B'}
-        SonicDBConfig.load_sonic_global_db_config()
+
+        if multi_asic.is_multi_asic():
+            SonicDBConfig.load_sonic_global_db_config()
+        else:
+            SonicDBConfig.initialize()
 
         # For multi-asic platforms we will get only front-panel interface to display
         namespaces = device_info.get_all_namespaces()
diff --git a/scripts/portconfig b/scripts/portconfig
index 9a7cc545a3..b22e547101 100755
--- a/scripts/portconfig
+++ b/scripts/portconfig
@@ -82,6 +82,8 @@ def main():
 
     if args.namespace is not None:
         SonicDBConfig.load_sonic_global_db_config(namespace=args.namespace)
+    else:
+        SonicDBConfig.initialize()
 
     try:
         port = portconfig(args.verbose, args.port, args.namespace)