diff --git a/apis/python/setup.py b/apis/python/setup.py
index 515d8bc413..829bd464f4 100644
--- a/apis/python/setup.py
+++ b/apis/python/setup.py
@@ -269,9 +269,8 @@ def run(self):
     install_requires=[
         # Needed for Python 3.7 which anndata 0.9 doesn't support but we do
         "anndata < 0.9; python_version<'3.8'",
-        # Temporary until we align with a compatibility issue in AnnData 0.10.0.
-        # This is tracked in https://github.com/single-cell-data/TileDB-SOMA/issues/1765.
-        "anndata < 0.10.0; python_version>='3.8'",
+        # Tracked in https://github.com/single-cell-data/TileDB-SOMA/issues/1785
+        "anndata != 0.10.0; python_version>='3.8'",
         "attrs>=22.2",
         # Pinning numba & its particular numpy constraints:
         # The old pip solver (<=2020) doesn't deal with the transitive