diff --git a/poetry.lock b/poetry.lock
index e276af87..8b5f07bf 100644
--- a/poetry.lock
+++ b/poetry.lock
@@ -183,6 +183,38 @@ dev = ["black (>=20.8b1)", "docutils", "setuptools_scm"]
 doc = ["IPython", "awkward (>=2.0.7)", "myst_parser", "nbsphinx", "scanpydoc (>=0.7.7)", "sphinx (>=4.4)", "sphinx-autodoc-typehints (>=1.11.0)", "sphinx-rtd-theme (>=1.1.1)", "sphinx_issues", "sphinxext.opengraph", "zarr"]
 test = ["awkward (>=2.0.6)", "boltons", "dask[array]", "joblib", "loompy (>=3.0.5)", "matplotlib", "openpyxl", "pytest (>=6.0)", "pytest-cov (>=2.10)", "pytest_memray", "scanpy", "scikit-learn", "zarr"]
 
+[[package]]
+name = "ansicon"
+version = "1.89.0"
+description = "Python wrapper for loading Jason Hood's ANSICON"
+optional = false
+python-versions = "*"
+files = [
+    {file = "ansicon-1.89.0-py2.py3-none-any.whl", hash = "sha256:f1def52d17f65c2c9682cf8370c03f541f410c1752d6a14029f97318e4b9dfec"},
+    {file = "ansicon-1.89.0.tar.gz", hash = "sha256:e4d039def5768a47e4afec8e89e83ec3ae5a26bf00ad851f914d1240b444d2b1"},
+]
+
+[[package]]
+name = "anyio"
+version = "3.7.0"
+description = "High level compatibility layer for multiple asynchronous event loop implementations"
+optional = false
+python-versions = ">=3.7"
+files = [
+    {file = "anyio-3.7.0-py3-none-any.whl", hash = "sha256:eddca883c4175f14df8aedce21054bfca3adb70ffe76a9f607aef9d7fa2ea7f0"},
+    {file = "anyio-3.7.0.tar.gz", hash = "sha256:275d9973793619a5374e1c89a4f4ad3f4b0a5510a2b5b939444bee8f4c4d37ce"},
+]
+
+[package.dependencies]
+exceptiongroup = {version = "*", markers = "python_version < \"3.11\""}
+idna = ">=2.8"
+sniffio = ">=1.1"
+
+[package.extras]
+doc = ["Sphinx (>=6.1.0)", "packaging", "sphinx-autodoc-typehints (>=1.2.0)", "sphinx-rtd-theme", "sphinxcontrib-jquery"]
+test = ["anyio[trio]", "coverage[toml] (>=4.5)", "hypothesis (>=4.0)", "mock (>=4)", "psutil (>=5.9)", "pytest (>=7.0)", "pytest-mock (>=3.6.1)", "trustme", "uvloop (>=0.17)"]
+trio = ["trio (<0.22)"]
+
 [[package]]
 name = "appnope"
 version = "0.1.3"
@@ -396,6 +428,22 @@ webencodings = "*"
 [package.extras]
 css = ["tinycss2 (>=1.1.0,<1.2)"]
 
+[[package]]
+name = "blessed"
+version = "1.20.0"
+description = "Easy, practical library for making terminal apps, by providing an elegant, well-documented interface to Colors, Keyboard input, and screen Positioning capabilities."
+optional = false
+python-versions = ">=2.7"
+files = [
+    {file = "blessed-1.20.0-py2.py3-none-any.whl", hash = "sha256:0c542922586a265e699188e52d5f5ac5ec0dd517e5a1041d90d2bbf23f906058"},
+    {file = "blessed-1.20.0.tar.gz", hash = "sha256:2cdd67f8746e048f00df47a2880f4d6acbcdb399031b604e34ba8f71d5787680"},
+]
+
+[package.dependencies]
+jinxed = {version = ">=1.1.0", markers = "platform_system == \"Windows\""}
+six = ">=1.9.0"
+wcwidth = ">=0.1.4"
+
 [[package]]
 name = "cached-property"
 version = "1.5.2"
@@ -797,6 +845,20 @@ tomli = {version = "*", optional = true, markers = "python_full_version <= \"3.1
 [package.extras]
 toml = ["tomli"]
 
+[[package]]
+name = "croniter"
+version = "1.3.15"
+description = "croniter provides iteration for datetime object with cron like format"
+optional = false
+python-versions = ">=2.6, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*"
+files = [
+    {file = "croniter-1.3.15-py2.py3-none-any.whl", hash = "sha256:f17f877be1d93b9e3191151584a19d8b367b017ab0febc8c5472b9300da61c4c"},
+    {file = "croniter-1.3.15.tar.gz", hash = "sha256:924a38fda88f675ec6835667e1d32ac37ff0d65509c2152729d16ff205e32a65"},
+]
+
+[package.dependencies]
+python-dateutil = "*"
+
 [[package]]
 name = "custom-inherit"
 version = "2.4.1"
@@ -819,6 +881,21 @@ files = [
     {file = "cycler-0.11.0.tar.gz", hash = "sha256:9c87405839a19696e837b3b818fed3f5f69f16f1eec1a1ad77e043dcea9c772f"},
 ]
 
+[[package]]
+name = "dateutils"
+version = "0.6.12"
+description = "Various utilities for working with date and datetime objects"
+optional = false
+python-versions = "*"
+files = [
+    {file = "dateutils-0.6.12-py2.py3-none-any.whl", hash = "sha256:f33b6ab430fa4166e7e9cb8b21ee9f6c9843c48df1a964466f52c79b2a8d53b3"},
+    {file = "dateutils-0.6.12.tar.gz", hash = "sha256:03dd90bcb21541bd4eb4b013637e4f1b5f944881c46cc6e4b67a6059e370e3f1"},
+]
+
+[package.dependencies]
+python-dateutil = "*"
+pytz = "*"
+
 [[package]]
 name = "debugpy"
 version = "1.6.7"
@@ -874,6 +951,24 @@ numba = "*"
 tqdm = "*"
 typing-extensions = "*"
 
+[[package]]
+name = "deepdiff"
+version = "6.3.0"
+description = "Deep Difference and Search of any Python object/data. Recreate objects by adding adding deltas to each other."
+optional = false
+python-versions = ">=3.7"
+files = [
+    {file = "deepdiff-6.3.0-py3-none-any.whl", hash = "sha256:15838bd1cbd046ce15ed0c41e837cd04aff6b3e169c5e06fca69d7aa11615ceb"},
+    {file = "deepdiff-6.3.0.tar.gz", hash = "sha256:6a3bf1e7228ac5c71ca2ec43505ca0a743ff54ec77aa08d7db22de6bc7b2b644"},
+]
+
+[package.dependencies]
+ordered-set = ">=4.0.2,<4.2.0"
+
+[package.extras]
+cli = ["click (==8.1.3)", "pyyaml (==6.0)"]
+optimize = ["orjson"]
+
 [[package]]
 name = "defusedxml"
 version = "0.7.1"
@@ -968,17 +1063,6 @@ files = [
     {file = "docutils-0.19.tar.gz", hash = "sha256:33995a6753c30b7f577febfc2c50411fec6aac7f7ffeb7c4cfe5991072dcf9e6"},
 ]
 
-[[package]]
-name = "et-xmlfile"
-version = "1.1.0"
-description = "An implementation of lxml.xmlfile for the standard library"
-optional = false
-python-versions = ">=3.6"
-files = [
-    {file = "et_xmlfile-1.1.0-py3-none-any.whl", hash = "sha256:a2ba85d1d6a74ef63837eed693bcb89c3f752169b0e3e7ae5b16ca5e1b3deada"},
-    {file = "et_xmlfile-1.1.0.tar.gz", hash = "sha256:8eb9e2bc2f8c97e37a2dc85a09ecdcdec9d8a396530a6d5a33b30b9a92da0c5c"},
-]
-
 [[package]]
 name = "ete3"
 version = "3.1.3"
@@ -1045,6 +1129,27 @@ files = [
 [package.extras]
 tests = ["asttokens", "littleutils", "pytest", "rich"]
 
+[[package]]
+name = "fastapi"
+version = "0.88.0"
+description = "FastAPI framework, high performance, easy to learn, fast to code, ready for production"
+optional = false
+python-versions = ">=3.7"
+files = [
+    {file = "fastapi-0.88.0-py3-none-any.whl", hash = "sha256:263b718bb384422fe3d042ffc9a0c8dece5e034ab6586ff034f6b4b1667c3eee"},
+    {file = "fastapi-0.88.0.tar.gz", hash = "sha256:915bf304180a0e7c5605ec81097b7d4cd8826ff87a02bb198e336fb9f3b5ff02"},
+]
+
+[package.dependencies]
+pydantic = ">=1.6.2,<1.7 || >1.7,<1.7.1 || >1.7.1,<1.7.2 || >1.7.2,<1.7.3 || >1.7.3,<1.8 || >1.8,<1.8.1 || >1.8.1,<2.0.0"
+starlette = "0.22.0"
+
+[package.extras]
+all = ["email-validator (>=1.1.1)", "httpx (>=0.23.0)", "itsdangerous (>=1.1.0)", "jinja2 (>=2.11.2)", "orjson (>=3.2.1)", "python-multipart (>=0.0.5)", "pyyaml (>=5.3.1)", "ujson (>=4.0.1,!=4.0.2,!=4.1.0,!=4.2.0,!=4.3.0,!=5.0.0,!=5.1.0)", "uvicorn[standard] (>=0.12.0)"]
+dev = ["pre-commit (>=2.17.0,<3.0.0)", "ruff (==0.0.138)", "uvicorn[standard] (>=0.12.0,<0.19.0)"]
+doc = ["mdx-include (>=1.4.1,<2.0.0)", "mkdocs (>=1.1.2,<2.0.0)", "mkdocs-markdownextradata-plugin (>=0.1.7,<0.3.0)", "mkdocs-material (>=8.1.4,<9.0.0)", "pyyaml (>=5.3.1,<7.0.0)", "typer[all] (>=0.6.1,<0.7.0)"]
+test = ["anyio[trio] (>=3.2.1,<4.0.0)", "black (==22.10.0)", "coverage[toml] (>=6.5.0,<7.0)", "databases[sqlite] (>=0.3.2,<0.7.0)", "email-validator (>=1.1.1,<2.0.0)", "flask (>=1.1.2,<3.0.0)", "httpx (>=0.23.0,<0.24.0)", "isort (>=5.0.6,<6.0.0)", "mypy (==0.982)", "orjson (>=3.2.1,<4.0.0)", "passlib[bcrypt] (>=1.7.2,<2.0.0)", "peewee (>=3.13.3,<4.0.0)", "pytest (>=7.1.3,<8.0.0)", "python-jose[cryptography] (>=3.3.0,<4.0.0)", "python-multipart (>=0.0.5,<0.0.6)", "pyyaml (>=5.3.1,<7.0.0)", "ruff (==0.0.138)", "sqlalchemy (>=1.3.18,<=1.4.41)", "types-orjson (==3.6.2)", "types-ujson (==5.5.0)", "ujson (>=4.0.1,!=4.0.2,!=4.1.0,!=4.2.0,!=4.3.0,!=5.0.0,!=5.1.0,<6.0.0)"]
+
 [[package]]
 name = "fastjsonschema"
 version = "2.17.1"
@@ -1417,6 +1522,17 @@ files = [
 [package.dependencies]
 gitdb = ">=4.0.1,<5"
 
+[[package]]
+name = "h11"
+version = "0.14.0"
+description = "A pure-Python, bring-your-own-I/O implementation of HTTP/1.1"
+optional = false
+python-versions = ">=3.7"
+files = [
+    {file = "h11-0.14.0-py3-none-any.whl", hash = "sha256:e3fe4ac4b851c468cc8363d500db52c2ead036020723024a109d37346efaa761"},
+    {file = "h11-0.14.0.tar.gz", hash = "sha256:8f19fbbe99e72420ff35c00b27a34cb9937e902a8b810e2c88300c6f0a3b699d"},
+]
+
 [[package]]
 name = "h5netcdf"
 version = "1.2.0"
@@ -1622,6 +1738,22 @@ files = [
     {file = "iniconfig-2.0.0.tar.gz", hash = "sha256:2d91e135bf72d31a410b17c16da610a82cb55f6b0477d1a902134b24a455b8b3"},
 ]
 
+[[package]]
+name = "inquirer"
+version = "3.1.3"
+description = "Collection of common interactive command line user interfaces, based on Inquirer.js"
+optional = false
+python-versions = ">=3.8"
+files = [
+    {file = "inquirer-3.1.3-py3-none-any.whl", hash = "sha256:a7441fd74d06fcac4385218a1f5e8703f7a113f7944e01af47b8c58e84f95ce5"},
+    {file = "inquirer-3.1.3.tar.gz", hash = "sha256:aac309406f5b49d4b8ab7c6872117f43bf082a552dc256aa16bc95e16bb58bec"},
+]
+
+[package.dependencies]
+blessed = ">=1.19.0"
+python-editor = ">=1.0.4"
+readchar = ">=3.0.6"
+
 [[package]]
 name = "ipykernel"
 version = "6.23.2"
@@ -1715,6 +1847,17 @@ widgetsnbextension = ">=4.0.7,<4.1.0"
 [package.extras]
 test = ["ipykernel", "jsonschema", "pytest (>=3.6.0)", "pytest-cov", "pytz"]
 
+[[package]]
+name = "itsdangerous"
+version = "2.1.2"
+description = "Safely pass data to untrusted environments and back."
+optional = false
+python-versions = ">=3.7"
+files = [
+    {file = "itsdangerous-2.1.2-py3-none-any.whl", hash = "sha256:2c2349112351b88699d8d4b6b075022c0808887cb7ad10069318a8b0bc88db44"},
+    {file = "itsdangerous-2.1.2.tar.gz", hash = "sha256:5dbbc68b317e5e42f327f9021763545dc3fc3bfe22e6deb96aaf1fc38874156a"},
+]
+
 [[package]]
 name = "jax"
 version = "0.4.12"
@@ -1829,6 +1972,20 @@ MarkupSafe = ">=2.0"
 [package.extras]
 i18n = ["Babel (>=2.7)"]
 
+[[package]]
+name = "jinxed"
+version = "1.2.0"
+description = "Jinxed Terminal Library"
+optional = false
+python-versions = "*"
+files = [
+    {file = "jinxed-1.2.0-py2.py3-none-any.whl", hash = "sha256:cfc2b2e4e3b4326954d546ba6d6b9a7a796ddcb0aef8d03161d005177eb0d48b"},
+    {file = "jinxed-1.2.0.tar.gz", hash = "sha256:032acda92d5c57cd216033cbbd53de731e6ed50deb63eb4781336ca55f72cda5"},
+]
+
+[package.dependencies]
+ansicon = {version = "*", markers = "platform_system == \"Windows\""}
+
 [[package]]
 name = "joblib"
 version = "1.2.0"
@@ -2079,6 +2236,106 @@ files = [
 [package.dependencies]
 igraph = ">=0.10.0,<0.11"
 
+[[package]]
+name = "lightning"
+version = "2.0.3"
+description = "Use Lightning Apps to build everything from production-ready, multi-cloud ML systems to simple research demos."
+optional = false
+python-versions = ">=3.8"
+files = [
+    {file = "lightning-2.0.3-py3-none-any.whl", hash = "sha256:8ca7566a5db58e3fca6b120244850a107f00047803119f722fc491a49c5ffa78"},
+    {file = "lightning-2.0.3.tar.gz", hash = "sha256:5a70f05e40f1d7882f81eace0d4a86fe2604b423f8df42beaabd187bfdb420cf"},
+]
+
+[package.dependencies]
+arrow = ">=1.2.0,<3.0"
+beautifulsoup4 = ">=4.8.0,<6.0"
+click = "<10.0"
+croniter = ">=1.3.0,<1.4.0"
+dateutils = "<2.0"
+deepdiff = ">=5.7.0,<8.0"
+fastapi = ">=0.69.0,<0.89.0"
+fsspec = [
+    {version = ">=2022.5.0,<2024.0"},
+    {version = ">2021.06.0,<2025.0", extras = ["http"]},
+]
+inquirer = ">=2.10.0,<5.0"
+Jinja2 = "<5.0"
+lightning-cloud = ">=0.5.34"
+lightning-utilities = ">=0.7.0,<2.0"
+numpy = ">=1.17.2,<3.0"
+packaging = ">=17.1,<25.0"
+psutil = "<7.0"
+pydantic = ">=1.7.4,<4.0"
+python-multipart = ">=0.0.5,<2.0"
+pytorch-lightning = "*"
+PyYAML = ">=5.4,<8.0"
+requests = "<4.0"
+rich = ">=12.3.0,<15.0"
+starlette = "*"
+starsessions = ">=1.2.1,<2.0"
+torch = ">=1.11.0,<4.0"
+torchmetrics = ">=0.7.0,<2.0"
+tqdm = ">=4.57.0,<6.0"
+traitlets = ">=5.3.0,<7.0"
+typing-extensions = ">=4.0.0,<6.0"
+urllib3 = "<3.0"
+uvicorn = "<2.0"
+websocket-client = "<3.0"
+websockets = "<12.0"
+
+[package.extras]
+all = ["aiohttp (>=3.8.0,<4.0)", "deepspeed (>=0.8.2,<1.0)", "docker (>=5.0.0,<7.0)", "gym[classic-control] (>=0.17.0,<1.0)", "hydra-core (>=1.0.5,<2.0)", "ipython[all] (<9.0)", "jsonargparse[signatures] (>=4.18.0,<5.0)", "lightning-api-access (>=0.0.3)", "lightning-fabric (>=1.9.0)", "lightning-utilities (>=0.7.0,<1.0)", "lightning-utilities (>=0.8.0,<1.0)", "matplotlib (>3.1,<4.0)", "omegaconf (>=2.0.5,<3.0)", "panel (>=0.12.7,<1.0)", "pytorch-lightning (>=1.9.0)", "redis (>=4.0.1,<5.0)", "rich (>=12.3.0,<14.0)", "s3fs (>=2022.5.0,<2023.0)", "streamlit (>=1.13.0,<2.0)", "tensorboardX (>=2.2,<3.0)", "torchmetrics (>=0.10.0,<1.0)", "torchvision (>=0.12.0,<1.0)"]
+app-all = ["aiohttp (>=3.8.0,<4.0)", "docker (>=5.0.0,<7.0)", "lightning-api-access (>=0.0.3)", "lightning-fabric (>=1.9.0)", "panel (>=0.12.7,<1.0)", "pytorch-lightning (>=1.9.0)", "redis (>=4.0.1,<5.0)", "s3fs (>=2022.5.0,<2023.0)", "streamlit (>=1.13.0,<2.0)"]
+app-cloud = ["docker (>=5.0.0,<7.0)", "redis (>=4.0.1,<5.0)", "s3fs (>=2022.5.0,<2023.0)"]
+app-components = ["aiohttp (>=3.8.0,<4.0)", "lightning-api-access (>=0.0.3)", "lightning-fabric (>=1.9.0)", "pytorch-lightning (>=1.9.0)"]
+app-dev = ["aiohttp (>=3.8.0,<4.0)", "coverage (==7.2.5)", "docker (>=5.0.0,<7.0)", "httpx", "lightning-api-access (>=0.0.3)", "lightning-fabric (>=1.9.0)", "panel (>=0.12.7,<1.0)", "playwright (==1.32.1)", "psutil", "pympler", "pytest (==7.3.1)", "pytest-asyncio (==0.20.3)", "pytest-cov (==4.0.0)", "pytest-doctestplus (>=0.9.0)", "pytest-rerunfailures (<12.0)", "pytest-timeout (==2.1.0)", "pytorch-lightning (>=1.9.0)", "redis (>=4.0.1,<5.0)", "requests-mock", "s3fs (>=2022.5.0,<2023.0)", "setuptools (<68.0)", "streamlit (>=1.13.0,<2.0)", "trio (<0.22.0)"]
+app-extra = ["aiohttp (>=3.8.0,<4.0)", "docker (>=5.0.0,<7.0)", "lightning-api-access (>=0.0.3)", "lightning-fabric (>=1.9.0)", "panel (>=0.12.7,<1.0)", "pytorch-lightning (>=1.9.0)", "redis (>=4.0.1,<5.0)", "s3fs (>=2022.5.0,<2023.0)", "streamlit (>=1.13.0,<2.0)"]
+app-test = ["coverage (==7.2.5)", "httpx", "playwright (==1.32.1)", "psutil", "pympler", "pytest (==7.3.1)", "pytest-asyncio (==0.20.3)", "pytest-cov (==4.0.0)", "pytest-doctestplus (>=0.9.0)", "pytest-rerunfailures (<12.0)", "pytest-timeout (==2.1.0)", "requests-mock", "setuptools (<68.0)", "trio (<0.22.0)"]
+app-ui = ["panel (>=0.12.7,<1.0)", "streamlit (>=1.13.0,<2.0)"]
+cloud = ["docker (>=5.0.0,<7.0)", "redis (>=4.0.1,<5.0)", "s3fs (>=2022.5.0,<2023.0)"]
+components = ["aiohttp (>=3.8.0,<4.0)", "lightning-api-access (>=0.0.3)", "lightning-fabric (>=1.9.0)", "pytorch-lightning (>=1.9.0)"]
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+ui = ["panel (>=0.12.7,<1.0)", "streamlit (>=1.13.0,<2.0)"]
+
+[[package]]
+name = "lightning-cloud"
+version = "0.5.36"
+description = "Lightning Cloud"
+optional = false
+python-versions = ">=3.7.0"
+files = [
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+[package.dependencies]
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+fastapi = "*"
+pyjwt = "*"
+python-multipart = "*"
+requests = "*"
+rich = "*"
+six = "*"
+urllib3 = "*"
+uvicorn = "*"
+websocket-client = "*"
+
 [[package]]
 name = "lightning-utilities"
 version = "0.8.0"
@@ -3031,20 +3288,6 @@ examples = ["arviz", "jupyter", "matplotlib", "pandas", "scikit-learn", "seaborn
 test = ["black[jupyter] (>=21.8b0)", "flake8", "importlib-metadata (<5.0)", "isort (>=5.0)", "pyro-api (>=0.1.1)", "pytest (>=4.1)", "scipy (>=1.9)"]
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-[[package]]
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-version = "3.1.2"
-description = "A Python library to read/write Excel 2010 xlsx/xlsm files"
-optional = false
-python-versions = ">=3.6"
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-]
-
-[package.dependencies]
-et-xmlfile = "*"
-
 [[package]]
 name = "opt-einsum"
 version = "3.3.0"
@@ -3109,6 +3352,20 @@ typing_extensions = "*"
 [package.extras]
 dev = ["flax", "pytest", "pytest-xdist"]
 
+[[package]]
+name = "ordered-set"
+version = "4.1.0"
+description = "An OrderedSet is a custom MutableSet that remembers its order, so that every"
+optional = false
+python-versions = ">=3.7"
+files = [
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+]
+
+[package.extras]
+dev = ["black", "mypy", "pytest"]
+
 [[package]]
 name = "ott-jax"
 version = "0.4.0"
@@ -3644,6 +3901,58 @@ files = [
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 ]
 
+[[package]]
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+optional = false
+python-versions = ">=3.7"
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+
+[package.extras]
+dotenv = ["python-dotenv (>=0.10.4)"]
+email = ["email-validator (>=1.0.3)"]
+
 [[package]]
 name = "pydocstyle"
 version = "6.3.0"
@@ -3699,6 +4008,23 @@ files = [
 [package.extras]
 plugins = ["importlib-metadata"]
 
+[[package]]
+name = "pyjwt"
+version = "2.7.0"
+description = "JSON Web Token implementation in Python"
+optional = false
+python-versions = ">=3.7"
+files = [
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+    {file = "PyJWT-2.7.0.tar.gz", hash = "sha256:bd6ca4a3c4285c1a2d4349e5a035fdf8fb94e04ccd0fcbe6ba289dae9cc3e074"},
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+[package.extras]
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+docs = ["sphinx (>=4.5.0,<5.0.0)", "sphinx-rtd-theme", "zope.interface"]
+tests = ["coverage[toml] (==5.0.4)", "pytest (>=6.0.0,<7.0.0)"]
+
 [[package]]
 name = "pynndescent"
 version = "0.5.10"
@@ -3949,6 +4275,18 @@ files = [
 [package.dependencies]
 six = ">=1.5"
 
+[[package]]
+name = "python-editor"
+version = "1.0.4"
+description = "Programmatically open an editor, capture the result."
+optional = false
+python-versions = "*"
+files = [
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+    {file = "python_editor-1.0.4-py2-none-any.whl", hash = "sha256:5f98b069316ea1c2ed3f67e7f5df6c0d8f10b689964a4a811ff64f0106819ec8"},
+    {file = "python_editor-1.0.4-py3-none-any.whl", hash = "sha256:1bf6e860a8ad52a14c3ee1252d5dc25b2030618ed80c022598f00176adc8367d"},
+]
+
 [[package]]
 name = "python-igraph"
 version = "0.10.4"
@@ -3968,6 +4306,20 @@ matplotlib = ["matplotlib (>=3.3.0)"]
 plotly = ["plotly (>=5.3.0)"]
 plotting = ["cairocffi (>=1.2.0)"]
 
+[[package]]
+name = "python-multipart"
+version = "0.0.6"
+description = "A streaming multipart parser for Python"
+optional = false
+python-versions = ">=3.7"
+files = [
+    {file = "python_multipart-0.0.6-py3-none-any.whl", hash = "sha256:ee698bab5ef148b0a760751c261902cd096e57e10558e11aca17646b74ee1c18"},
+    {file = "python_multipart-0.0.6.tar.gz", hash = "sha256:e9925a80bb668529f1b67c7fdb0a5dacdd7cbfc6fb0bff3ea443fe22bdd62132"},
+]
+
+[package.extras]
+dev = ["atomicwrites (==1.2.1)", "attrs (==19.2.0)", "coverage (==6.5.0)", "hatch", "invoke (==1.7.3)", "more-itertools (==4.3.0)", "pbr (==4.3.0)", "pluggy (==1.0.0)", "py (==1.11.0)", "pytest (==7.2.0)", "pytest-cov (==4.0.0)", "pytest-timeout (==2.1.0)", "pyyaml (==5.1)"]
+
 [[package]]
 name = "pytorch-lightning"
 version = "1.9.5"
@@ -4189,6 +4541,20 @@ files = [
 [package.dependencies]
 cffi = {version = "*", markers = "implementation_name == \"pypy\""}
 
+[[package]]
+name = "readchar"
+version = "4.0.5"
+description = "Library to easily read single chars and key strokes"
+optional = false
+python-versions = ">=3.7"
+files = [
+    {file = "readchar-4.0.5-py3-none-any.whl", hash = "sha256:76ec784a5dd2afac3b7da8003329834cdd9824294c260027f8c8d2e4d0a78f43"},
+    {file = "readchar-4.0.5.tar.gz", hash = "sha256:08a456c2d7c1888cde3f4688b542621b676eb38cd6cfed7eb6cb2e2905ddc826"},
+]
+
+[package.dependencies]
+setuptools = ">=41.0"
+
 [[package]]
 name = "reportlab"
 version = "4.0.4"
@@ -4490,13 +4856,13 @@ test = ["asv", "gmpy2", "mpmath", "pooch", "pytest", "pytest-cov", "pytest-timeo
 
 [[package]]
 name = "scvi-tools"
-version = "0.20.3"
+version = "1.0.0"
 description = "Deep probabilistic analysis of single-cell omics data."
 optional = false
-python-versions = ">=3.8"
+python-versions = ">=3.9"
 files = [
-    {file = "scvi_tools-0.20.3-py3-none-any.whl", hash = "sha256:9e02c1d7770a56300569def2c48b4d99cb92f9ca5dcce9d2cb19d463d2aafed5"},
-    {file = "scvi_tools-0.20.3.tar.gz", hash = "sha256:db0088290d04485486890ae9112a0ea8977d8503ea4cd6a4b5badb7928c4e1c1"},
+    {file = "scvi_tools-1.0.0-py3-none-any.whl", hash = "sha256:08151167a303b360f036553f6c625ad6493a33b7fc5731ff97a2312375fbc12b"},
+    {file = "scvi_tools-1.0.0.tar.gz", hash = "sha256:e4b61ac7cc679fc48f487e8ade030ccd9c7a0fa4f603d5f3ca8327d57d3a764c"},
 ]
 
 [package.dependencies]
@@ -4507,28 +4873,31 @@ flax = "*"
 h5py = ">=2.9.0"
 jax = ">=0.4.4"
 jaxlib = ">=0.4.3"
+lightning = ">=2.0,<2.1"
 ml-collections = ">=0.1.1"
 mudata = ">=0.1.2"
 numpy = ">=1.17.0"
-numpyro = "*"
-openpyxl = ">=3.0"
+numpyro = ">=0.12.1"
 optax = "*"
 pandas = ">=1.0"
 pyro-ppl = ">=1.6.0"
-pytorch-lightning = ">=1.9.0,<1.10.0"
 rich = ">=12.0.0"
 scikit-learn = ">=0.21.2"
 scipy = "*"
+sparse = ">=0.14.0"
 torch = ">=1.8.0"
 torchmetrics = ">=0.11.0"
 tqdm = ">=4.56.0"
+xarray = ">=2023.2.0"
 
 [package.extras]
-autotune = ["hyperopt (>=0.2)", "ipython", "ray[tune] (>=2.2.0)", "scib-metrics (>=0.1.1)"]
-dev = ["black", "codecov", "flake8", "genomepy", "isort", "jupyter", "loompy (>=3.0.6)", "nbconvert", "nbformat", "pre-commit", "pymde", "pytest", "pytest-cov", "scanpy (>=1.6)"]
-docs = ["furo", "ipython", "myst-parser", "nbsphinx", "sphinx (>=4.1)", "sphinx-copybutton", "sphinx-design", "sphinx-hoverxref", "sphinxcontrib-bibtex (>=1.0.0)", "sphinxext-opengraph"]
+autotune = ["hyperopt (>=0.2)", "ipython", "ray[tune] (>=2.2.0)", "scib-metrics (>=0.3)"]
+census = ["cellxgene-census"]
+dev = ["black", "cellxgene-census", "flake8", "genomepy", "jupyter", "loompy (>=3.0.6)", "nbconvert", "nbformat", "pre-commit", "pymde", "pytest", "pytest-cov", "ruff", "scanpy (>=1.6)"]
+docs = ["ipython", "myst-nb", "myst-parser", "sphinx (>=4.1)", "sphinx-autodoc-typehints", "sphinx-book-theme (>=1.0.1)", "sphinx-copybutton", "sphinx-design", "sphinx-hoverxref", "sphinxcontrib-bibtex (>=1.0.0)", "sphinxext-opengraph"]
 hub = ["huggingface-hub"]
 pymde = ["pymde"]
+regseq = ["biopython (>=1.81)", "genomepy"]
 tutorials = ["genomepy", "huggingface-hub", "leidenalg", "loompy", "pymde", "pynndescent", "python-igraph", "scanpy", "scikit-misc"]
 
 [[package]]
@@ -4599,6 +4968,17 @@ files = [
     {file = "smmap-5.0.0.tar.gz", hash = "sha256:c840e62059cd3be204b0c9c9f74be2c09d5648eddd4580d9314c3ecde0b30936"},
 ]
 
+[[package]]
+name = "sniffio"
+version = "1.3.0"
+description = "Sniff out which async library your code is running under"
+optional = false
+python-versions = ">=3.7"
+files = [
+    {file = "sniffio-1.3.0-py3-none-any.whl", hash = "sha256:eecefdce1e5bbfb7ad2eeaabf7c1eeb404d7757c379bd1f7e5cce9d8bf425384"},
+    {file = "sniffio-1.3.0.tar.gz", hash = "sha256:e60305c5e5d314f5389259b7f22aaa33d8f7dee49763119234af3755c55b9101"},
+]
+
 [[package]]
 name = "snowballstemmer"
 version = "2.2.0"
@@ -4621,6 +5001,28 @@ files = [
     {file = "soupsieve-2.4.1.tar.gz", hash = "sha256:89d12b2d5dfcd2c9e8c22326da9d9aa9cb3dfab0a83a024f05704076ee8d35ea"},
 ]
 
+[[package]]
+name = "sparse"
+version = "0.14.0"
+description = "Sparse n-dimensional arrays"
+optional = false
+python-versions = ">=3.8, <4"
+files = [
+    {file = "sparse-0.14.0-py2.py3-none-any.whl", hash = "sha256:77e3c32ace6184de29074db94901c63e113c7729b28c8b3f1885aaf5e1934323"},
+    {file = "sparse-0.14.0.tar.gz", hash = "sha256:5f5827a37f6cd6f6730a541f994c95c60a3ae2329e01f4ba21ced5339aea0098"},
+]
+
+[package.dependencies]
+numba = ">=0.49"
+numpy = ">=1.17"
+scipy = ">=0.19"
+
+[package.extras]
+all = ["dask[array]", "pytest (>=3.5)", "pytest-black", "pytest-cov", "sphinx", "sphinx-rtd-theme", "tox"]
+docs = ["sphinx", "sphinx-rtd-theme"]
+tests = ["dask[array]", "pytest (>=3.5)", "pytest-black", "pytest-cov"]
+tox = ["dask[array]", "pytest (>=3.5)", "pytest-black", "pytest-cov", "tox"]
+
 [[package]]
 name = "sparsecca"
 version = "0.3.0"
@@ -4979,6 +5381,42 @@ pure-eval = "*"
 [package.extras]
 tests = ["cython", "littleutils", "pygments", "pytest", "typeguard"]
 
+[[package]]
+name = "starlette"
+version = "0.22.0"
+description = "The little ASGI library that shines."
+optional = false
+python-versions = ">=3.7"
+files = [
+    {file = "starlette-0.22.0-py3-none-any.whl", hash = "sha256:b5eda991ad5f0ee5d8ce4c4540202a573bb6691ecd0c712262d0bc85cf8f2c50"},
+    {file = "starlette-0.22.0.tar.gz", hash = "sha256:b092cbc365bea34dd6840b42861bdabb2f507f8671e642e8272d2442e08ea4ff"},
+]
+
+[package.dependencies]
+anyio = ">=3.4.0,<5"
+typing-extensions = {version = ">=3.10.0", markers = "python_version < \"3.10\""}
+
+[package.extras]
+full = ["httpx (>=0.22.0)", "itsdangerous", "jinja2", "python-multipart", "pyyaml"]
+
+[[package]]
+name = "starsessions"
+version = "1.3.0"
+description = "Pluggable session support for Starlette."
+optional = false
+python-versions = ">=3.6.2,<4.0.0"
+files = [
+    {file = "starsessions-1.3.0-py3-none-any.whl", hash = "sha256:c0758f2a1a2438ec7ba88b232e82008f2261a75584f01179c787b3636fae6040"},
+    {file = "starsessions-1.3.0.tar.gz", hash = "sha256:8d3b509d4e6d235655f7dd495fcf0afc1bd86da84de3a8d434e6f82137ebcde8"},
+]
+
+[package.dependencies]
+itsdangerous = ">=2.0.1,<3.0.0"
+starlette = ">=0,<1"
+
+[package.extras]
+redis = ["aioredis (>=2.0.0,<3.0.0)"]
+
 [[package]]
 name = "statannotations"
 version = "0.5.0"
@@ -5458,6 +5896,24 @@ secure = ["certifi", "cryptography (>=1.9)", "idna (>=2.0.0)", "pyopenssl (>=17.
 socks = ["pysocks (>=1.5.6,!=1.5.7,<2.0)"]
 zstd = ["zstandard (>=0.18.0)"]
 
+[[package]]
+name = "uvicorn"
+version = "0.22.0"
+description = "The lightning-fast ASGI server."
+optional = false
+python-versions = ">=3.7"
+files = [
+    {file = "uvicorn-0.22.0-py3-none-any.whl", hash = "sha256:e9434d3bbf05f310e762147f769c9f21235ee118ba2d2bf1155a7196448bd996"},
+    {file = "uvicorn-0.22.0.tar.gz", hash = "sha256:79277ae03db57ce7d9aa0567830bbb51d7a612f54d6e1e3e92da3ef24c2c8ed8"},
+]
+
+[package.dependencies]
+click = ">=7.0"
+h11 = ">=0.8"
+
+[package.extras]
+standard = ["colorama (>=0.4)", "httptools (>=0.5.0)", "python-dotenv (>=0.13)", "pyyaml (>=5.1)", "uvloop (>=0.14.0,!=0.15.0,!=0.15.1)", "watchfiles (>=0.13)", "websockets (>=10.4)"]
+
 [[package]]
 name = "virtualenv"
 version = "20.23.0"
@@ -5500,6 +5956,101 @@ files = [
     {file = "webencodings-0.5.1.tar.gz", hash = "sha256:b36a1c245f2d304965eb4e0a82848379241dc04b865afcc4aab16748587e1923"},
 ]
 
+[[package]]
+name = "websocket-client"
+version = "1.6.0"
+description = "WebSocket client for Python with low level API options"
+optional = false
+python-versions = ">=3.7"
+files = [
+    {file = "websocket-client-1.6.0.tar.gz", hash = "sha256:e84c7eafc66aade6d1967a51dfd219aabdf81d15b9705196e11fd81f48666b78"},
+    {file = "websocket_client-1.6.0-py3-none-any.whl", hash = "sha256:72d7802608745b0a212f79b478642473bd825777d8637b6c8c421bf167790d4f"},
+]
+
+[package.extras]
+docs = ["Sphinx (>=3.4)", "sphinx-rtd-theme (>=0.5)"]
+optional = ["python-socks", "wsaccel"]
+test = ["websockets"]
+
+[[package]]
+name = "websockets"
+version = "11.0.3"
+description = "An implementation of the WebSocket Protocol (RFC 6455 & 7692)"
+optional = false
+python-versions = ">=3.7"
+files = [
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+
 [[package]]
 name = "widgetsnbextension"
 version = "4.0.7"
@@ -5665,4 +6216,4 @@ ete3 = ["ete3"]
 [metadata]
 lock-version = "2.0"
 python-versions = ">=3.9.0,<3.11"
-content-hash = "03bd251630dd22f76177f1d9bc4a5b4018128543445359f4e9c45b83d14bd2f7"
+content-hash = "39fd5892a378c897456de4319987860a82967e3bdf2eace3eca232263bff5e3e"
diff --git a/pyproject.toml b/pyproject.toml
index 9e35fb3b..2b1965f5 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -29,7 +29,7 @@ switchlang = ">=0.1.0"
 scikit-misc = ">=0.1.4"
 plotnine = ">=0.10.1"
 scipy = ">=1.9.3"
-scvi-tools = "^0.20.3"
+scvi-tools = ">=0.20.3,<1.1.0"
 adjusttext = ">=0.7.3"
 toytree = "^2.0.1"
 arviz = ">=0.14"