diff --git a/src/components/radio-button/radio-button-group/radio-button-group.ts b/src/components/radio-button/radio-button-group/radio-button-group.ts
index b90c98bce0..5b6e041c19 100644
--- a/src/components/radio-button/radio-button-group/radio-button-group.ts
+++ b/src/components/radio-button/radio-button-group/radio-button-group.ts
@@ -2,7 +2,7 @@ import { CSSResultGroup, html, LitElement, nothing, PropertyValues, TemplateResu
 import { customElement, property, state } from 'lit/decorators.js';
 
 import { isArrowKeyPressed, getNextElementIndex, interactivityChecker } from '../../core/a11y';
-import { toggleDatasetEntry, setAttribute } from '../../core/dom';
+import { toggleDatasetEntry, setAttribute, isValidAttribute } from '../../core/dom';
 import {
   createNamedSlotState,
   HandlerRepository,
@@ -241,7 +241,12 @@ export class SbbRadioButtonGroupElement extends LitElement {
   }
 
   private _getRadioTabIndex(radio: SbbRadioButtonElement): number {
-    return (radio.checked || this._hasSelectionPanel) && !radio.disabled && !this.disabled ? 0 : -1;
+    const isSelected: boolean = radio.checked && !radio.disabled && !this.disabled;
+    const isParentPanelWithContent: boolean =
+      radio.parentElement.nodeName === 'SBB-SELECTION-PANEL' &&
+      isValidAttribute(radio.parentElement, 'data-has-content');
+
+    return isSelected || (this._hasSelectionPanel && isParentPanelWithContent) ? 0 : -1;
   }
 
   private _handleKeyDown(evt: KeyboardEvent): void {
@@ -262,17 +267,14 @@ export class SbbRadioButtonGroupElement extends LitElement {
       return;
     }
 
-    let current: number;
-    let nextIndex: number;
-
-    if (this._hasSelectionPanel) {
-      current = enabledRadios.findIndex((e: SbbRadioButtonElement) => e === evt.target);
-      nextIndex = getNextElementIndex(evt, current, enabledRadios.length);
-    } else {
-      const checked: number = enabledRadios.findIndex(
-        (radio: SbbRadioButtonElement) => radio.checked,
-      );
-      nextIndex = getNextElementIndex(evt, checked, enabledRadios.length);
+    const current: number = enabledRadios.findIndex((e: SbbRadioButtonElement) => e === evt.target);
+    const nextIndex: number = getNextElementIndex(evt, current, enabledRadios.length);
+
+    // Selection on arrow keypress is allowed only if all the selection-panels have no content.
+    const allPanelsHaveNoContent: boolean = (
+      Array.from(this.querySelectorAll?.('sbb-selection-panel')) || []
+    ).every((e) => !isValidAttribute(e, 'data-has-content'));
+    if (!this._hasSelectionPanel || (this._hasSelectionPanel && allPanelsHaveNoContent)) {
       enabledRadios[nextIndex].select();
     }
 
diff --git a/src/components/selection-panel/selection-panel.e2e.ts b/src/components/selection-panel/selection-panel.e2e.ts
index 381582680c..8ff7e00370 100644
--- a/src/components/selection-panel/selection-panel.e2e.ts
+++ b/src/components/selection-panel/selection-panel.e2e.ts
@@ -231,6 +231,64 @@ describe('sbb-selection-panel', () => {
     });
   });
 
+  describe('with radio group with no slotted content', () => {
+    it('focus selected, the focus and select on keyboard navigation', async () => {
+      await fixture(html`
+        <sbb-radio-button-group id="group-no-content" name="input-group-name" value="Value 2">
+          <sbb-selection-panel disable-animation id="no-content-1">
+            <sbb-radio-button id="input-no-content-1" value="Value 1">Value one</sbb-radio-button>
+          </sbb-selection-panel>
+          <sbb-selection-panel disable-animation id="no-content-2">
+            <sbb-radio-button id="input-no-content-2" value="Value 2">Value two</sbb-radio-button>
+          </sbb-selection-panel>
+          <sbb-selection-panel disable-animation id="no-content-3">
+            <sbb-radio-button id="input-no-content-3" value="Value 3" disabled
+              >Value three</sbb-radio-button
+            >
+          </sbb-selection-panel>
+          <sbb-selection-panel disable-animation id="no-content-4">
+            <sbb-radio-button id="input-no-content-4" value="Value 4">Value four</sbb-radio-button>
+          </sbb-selection-panel>
+        </sbb-radio-button-group>
+      `);
+      const wrapperNoContent = document.querySelector('#group-no-content');
+      const firstInputNoContent: SbbRadioButtonElement =
+        document.querySelector('#input-no-content-1');
+      const secondInputNoContent: SbbRadioButtonElement =
+        document.querySelector('#input-no-content-2');
+      const fourthInputNoContent: SbbRadioButtonElement =
+        document.querySelector('#input-no-content-4');
+
+      await sendKeys({ down: 'Tab' });
+      await waitForLitRender(wrapperNoContent);
+      expect(document.activeElement.id).to.be.equal(secondInputNoContent.id);
+
+      await sendKeys({ down: 'ArrowUp' });
+      await waitForLitRender(wrapperNoContent);
+      expect(document.activeElement.id).to.be.equal(firstInputNoContent.id);
+      expect(secondInputNoContent).not.to.have.attribute('checked');
+      expect(firstInputNoContent).to.have.attribute('checked');
+
+      await sendKeys({ down: 'ArrowRight' });
+      await waitForLitRender(wrapperNoContent);
+      expect(document.activeElement.id).to.be.equal(secondInputNoContent.id);
+      expect(firstInputNoContent).not.to.have.attribute('checked');
+      expect(secondInputNoContent).to.have.attribute('checked');
+
+      await sendKeys({ down: 'ArrowDown' });
+      await waitForLitRender(wrapperNoContent);
+      expect(document.activeElement.id).to.be.equal(fourthInputNoContent.id);
+      expect(secondInputNoContent).not.to.have.attribute('checked');
+      expect(fourthInputNoContent).to.have.attribute('checked');
+
+      await sendKeys({ down: 'ArrowLeft' });
+      await waitForLitRender(wrapperNoContent);
+      expect(document.activeElement.id).to.be.equal(secondInputNoContent.id);
+      expect(fourthInputNoContent).not.to.have.attribute('checked');
+      expect(secondInputNoContent).to.have.attribute('checked');
+    });
+  });
+
   describe('with nested radio buttons', () => {
     let nestedElement: SbbRadioButtonGroupElement;
 
diff --git a/src/components/selection-panel/selection-panel.stories.ts b/src/components/selection-panel/selection-panel.stories.ts
index fb0e370572..d9217676dc 100644
--- a/src/components/selection-panel/selection-panel.stories.ts
+++ b/src/components/selection-panel/selection-panel.stories.ts
@@ -472,6 +472,31 @@ const WithNoContentTemplate = ({
   </sbb-selection-panel>
 `;
 
+const WithNoContentGroupTemplate = ({
+  checkedInput,
+  disabledInput,
+  ...args
+}: Args): TemplateResult => html`
+  <sbb-radio-button-group orientation="vertical" horizontal-from="large">
+    <sbb-selection-panel ${sbbSpread(args)}>
+      ${cardBadge()}
+      <sbb-radio-button value="Value one" ?disabled=${disabledInput}>
+        Value one ${suffixAndSubtext()}
+      </sbb-radio-button>
+    </sbb-selection-panel>
+    <sbb-selection-panel ${sbbSpread(args)}>
+      ${cardBadge()}
+      <sbb-radio-button value="Value two" ?checked=${checkedInput}>
+        Value two ${suffixAndSubtext()}
+      </sbb-radio-button>
+    </sbb-selection-panel>
+    <sbb-selection-panel ${sbbSpread(args)}>
+      ${cardBadge()}
+      <sbb-radio-button value="Value three"> Value three ${suffixAndSubtext()} </sbb-radio-button>
+    </sbb-selection-panel>
+  </sbb-radio-button-group>
+`;
+
 export const WithCheckbox: StoryObj = {
   render: WithCheckboxTemplate,
   argTypes: basicArgTypes,
@@ -665,6 +690,12 @@ export const WithNoContentCheckedDisabled: StoryObj = {
   args: { ...basicArgs, checkedInput: true, disabledInput: true },
 };
 
+export const WithNoContentGroup: StoryObj = {
+  render: WithNoContentGroupTemplate,
+  argTypes: basicArgTypes,
+  args: { ...basicArgs, checkedInput: true },
+};
+
 export const TicketsOptionsExample: StoryObj = {
   render: TicketsOptionsExampleTemplate,
   argTypes: basicArgTypes,