diff --git a/compiler/rustc_trait_selection/src/solve/alias_relate.rs b/compiler/rustc_trait_selection/src/solve/alias_relate.rs
index 43e61de955af7..b77a7de7e3738 100644
--- a/compiler/rustc_trait_selection/src/solve/alias_relate.rs
+++ b/compiler/rustc_trait_selection/src/solve/alias_relate.rs
@@ -16,9 +16,12 @@
 //! relate them structurally.
 
 use super::EvalCtxt;
+use rustc_data_structures::fx::FxHashSet;
 use rustc_infer::infer::InferCtxt;
+use rustc_middle::traits::query::NoSolution;
 use rustc_middle::traits::solve::{Certainty, Goal, QueryResult};
-use rustc_middle::ty;
+use rustc_middle::ty::{self, Ty, TyCtxt};
+use rustc_middle::ty::{TypeSuperVisitable, TypeVisitable, TypeVisitableExt, TypeVisitor};
 
 impl<'tcx> EvalCtxt<'_, InferCtxt<'tcx>> {
     #[instrument(level = "trace", skip(self), ret)]
@@ -29,6 +32,12 @@ impl<'tcx> EvalCtxt<'_, InferCtxt<'tcx>> {
         let tcx = self.tcx();
         let Goal { param_env, predicate: (lhs, rhs, direction) } = goal;
 
+        if self.alias_cannot_name_placeholder_in_rigid(param_env, lhs, rhs)
+            || self.alias_cannot_name_placeholder_in_rigid(param_env, rhs, lhs)
+        {
+            return Err(NoSolution);
+        }
+
         // Structurally normalize the lhs.
         let lhs = if let Some(alias) = lhs.to_alias_term() {
             let term = self.next_term_infer_of_kind(lhs);
@@ -84,3 +93,105 @@ impl<'tcx> EvalCtxt<'_, InferCtxt<'tcx>> {
         }
     }
 }
+
+enum IgnoreAliases {
+    Yes,
+    No,
+}
+
+impl<'tcx> EvalCtxt<'_, InferCtxt<'tcx>> {
+    /// In case a rigid term refers to a placeholder which is not referenced by the
+    /// alias, the alias cannot be normalized to that rigid term unless it contains
+    /// either inference variables or these placeholders are referenced in a term
+    /// of a `Projection`-clause in the environment.
+    fn alias_cannot_name_placeholder_in_rigid(
+        &mut self,
+        param_env: ty::ParamEnv<'tcx>,
+        rigid_term: ty::Term<'tcx>,
+        alias: ty::Term<'tcx>,
+    ) -> bool {
+        // Check that the rigid term is actually rigid.
+        if rigid_term.to_alias_term().is_some() || alias.to_alias_term().is_none() {
+            return false;
+        }
+
+        // If the alias has any type or const inference variables,
+        // do not try to apply the fast path as these inference variables
+        // may resolve to something containing placeholders.
+        if alias.has_non_region_infer() {
+            return false;
+        }
+
+        let mut referenced_placeholders =
+            self.collect_placeholders_in_term(rigid_term, IgnoreAliases::Yes);
+        for clause in param_env.caller_bounds() {
+            match clause.kind().skip_binder() {
+                ty::ClauseKind::Projection(ty::ProjectionPredicate { term, .. }) => {
+                    if term.has_non_region_infer() {
+                        return false;
+                    }
+
+                    let env_term_placeholders =
+                        self.collect_placeholders_in_term(term, IgnoreAliases::No);
+                    #[allow(rustc::potential_query_instability)]
+                    referenced_placeholders.retain(|p| !env_term_placeholders.contains(p));
+                }
+                ty::ClauseKind::Trait(_)
+                | ty::ClauseKind::TypeOutlives(_)
+                | ty::ClauseKind::RegionOutlives(_)
+                | ty::ClauseKind::ConstArgHasType(..)
+                | ty::ClauseKind::WellFormed(_)
+                | ty::ClauseKind::ConstEvaluatable(_) => continue,
+            }
+        }
+
+        if referenced_placeholders.is_empty() {
+            return false;
+        }
+
+        let alias_placeholders = self.collect_placeholders_in_term(alias, IgnoreAliases::No);
+        // If the rigid term references a placeholder not mentioned by the alias,
+        // they can never unify.
+        !referenced_placeholders.is_subset(&alias_placeholders)
+    }
+
+    fn collect_placeholders_in_term(
+        &mut self,
+        term: ty::Term<'tcx>,
+        ignore_aliases: IgnoreAliases,
+    ) -> FxHashSet<ty::Term<'tcx>> {
+        // Fast path to avoid walking the term.
+        if !term.has_placeholders() {
+            return Default::default();
+        }
+
+        struct PlaceholderCollector<'tcx> {
+            ignore_aliases: IgnoreAliases,
+            placeholders: FxHashSet<ty::Term<'tcx>>,
+        }
+        impl<'tcx> TypeVisitor<TyCtxt<'tcx>> for PlaceholderCollector<'tcx> {
+            type Result = ();
+
+            fn visit_ty(&mut self, t: Ty<'tcx>) {
+                match t.kind() {
+                    ty::Placeholder(_) => drop(self.placeholders.insert(t.into())),
+                    ty::Alias(..) if matches!(self.ignore_aliases, IgnoreAliases::Yes) => {}
+                    _ => t.super_visit_with(self),
+                }
+            }
+
+            fn visit_const(&mut self, ct: ty::Const<'tcx>) {
+                match ct.kind() {
+                    ty::ConstKind::Placeholder(_) => drop(self.placeholders.insert(ct.into())),
+                    ty::ConstKind::Unevaluated(_) | ty::ConstKind::Expr(_)
+                        if matches!(self.ignore_aliases, IgnoreAliases::Yes) => {}
+                    _ => ct.super_visit_with(self),
+                }
+            }
+        }
+
+        let mut visitor = PlaceholderCollector { ignore_aliases, placeholders: Default::default() };
+        term.visit_with(&mut visitor);
+        visitor.placeholders
+    }
+}