diff --git a/pkgs/development/compilers/llvm/git/compiler-rt/default.nix b/pkgs/development/compilers/llvm/git/compiler-rt/default.nix
index 1abb0a4116558..53c0924a07c56 100644
--- a/pkgs/development/compilers/llvm/git/compiler-rt/default.nix
+++ b/pkgs/development/compilers/llvm/git/compiler-rt/default.nix
@@ -66,6 +66,9 @@ stdenv.mkDerivation {
     "-DDARWIN_macosx_OVERRIDE_SDK_VERSION=ON"
     "-DDARWIN_osx_ARCHS=${stdenv.hostPlatform.darwinArch}"
     "-DDARWIN_osx_BUILTIN_ARCHS=${stdenv.hostPlatform.darwinArch}"
+    # `COMPILER_RT_DEFAULT_TARGET_ONLY` does not apply to Darwin:
+    # https://github.com/llvm/llvm-project/blob/27ef42bec80b6c010b7b3729ed0528619521a690/compiler-rt/cmake/base-config-ix.cmake#L153
+    "-DCOMPILER_RT_ENABLE_IOS=OFF"
   ];
 
   outputs = [ "out" "dev" ];