The unregister in remove is being passed the wrong value.

[cnobile2012]

I've copied the method in the issue so it is obvious what I found. The call to the epoll().unregister() is being passed the source not the file descriptor or in your case the fileno integer value. This is most likely not blowing up because the source is actually a long int (memory address) itself, but nothing is getting unregistered either. The Python docs indicate that both register and unregister should take as their 1st argument fd (file descriptor).

    def remove(self, source):
        """Removes an event source from the Selector.

        Arguments:
        source -- the event source to remove.
        """
        fileno = source.fileno()
        self._get_epoll().unregister(source)
        del self._sources[fileno]