diff --git a/extensions/jdbc/jdbc-mssql/runtime/src/main/java/io/quarkus/jdbc/mssql/runtime/graal/com/microsoft/sqlserver/jdbc/SQLServerJDBCSubstitutions.java b/extensions/jdbc/jdbc-mssql/runtime/src/main/java/io/quarkus/jdbc/mssql/runtime/graal/com/microsoft/sqlserver/jdbc/SQLServerJDBCSubstitutions.java
index dbb21c9ab934e..b5da254262cee 100644
--- a/extensions/jdbc/jdbc-mssql/runtime/src/main/java/io/quarkus/jdbc/mssql/runtime/graal/com/microsoft/sqlserver/jdbc/SQLServerJDBCSubstitutions.java
+++ b/extensions/jdbc/jdbc-mssql/runtime/src/main/java/io/quarkus/jdbc/mssql/runtime/graal/com/microsoft/sqlserver/jdbc/SQLServerJDBCSubstitutions.java
@@ -8,6 +8,8 @@
 
 import com.microsoft.sqlserver.jdbc.SQLServerException;
 import com.microsoft.sqlserver.jdbc.SQLServerStatement;
+import com.oracle.svm.core.annotate.AlwaysInline;
+import com.oracle.svm.core.annotate.Delete;
 import com.oracle.svm.core.annotate.Substitute;
 import com.oracle.svm.core.annotate.TargetClass;
 
@@ -60,6 +62,50 @@ static KeyManager[] getKeyManagerFromFile(String certPath, String keyPath, Strin
     }
 }
 
+@TargetClass(className = "com.microsoft.sqlserver.jdbc.SQLServerLexer")
+@Delete //Deleting this one explicitly, so to help with maintenance with the substitutions of SQLServerFMTQuery
+final class SQLServerLexerRemove {
+
+}
+
+/**
+ * This will make sure the ANTLR4 Lexer included in the driver is not reachable; this was mostly
+ * prevented by not allowing to explicitly set the useFmtOnly connection property, but this code
+ * path would also get activated on very old SQL Server versions being detected on a connection.
+ * Since that's not a constant that the compiler can rely on, we need one more substitution.
+ */
+@TargetClass(className = "com.microsoft.sqlserver.jdbc.SQLServerFMTQuery")
+final class SQLServerFMTQuery {
+
+    @Substitute
+    SQLServerFMTQuery(String userSql) throws SQLServerException {
+        throw new IllegalStateException("It is not supported to connect to SQL Server versions older than 2012");
+    }
+
+}
+
+/**
+ * This substitution is not strictly necessary, but it helps by providing a better error message to our users.
+ */
+@TargetClass(className = "com.microsoft.sqlserver.jdbc.SQLServerPreparedStatement")
+final class DisableFMTRemove {
+
+    @Substitute
+    @AlwaysInline("We need this to be constant folded")
+    public final boolean getUseFmtOnly() throws SQLServerException {
+        return false;//Important for this to be disabled via a constant
+    }
+
+    @Substitute
+    public final void setUseFmtOnly(boolean useFmtOnly) throws SQLServerException {
+        if (useFmtOnly) {
+            throw new IllegalStateException(
+                    "It is not possible to enable the useFmtOnly option on Quarkus: this option is only useful on SQL Server version 2008 (which is not supported) and introduces several other problems.");
+        }
+    }
+
+}
+
 class SQLServerJDBCSubstitutions {
 
 }