diff --git a/test-framework/junit5/src/main/java/io/quarkus/test/junit/NativeImageTest.java b/test-framework/junit5/src/main/java/io/quarkus/test/junit/NativeImageTest.java
index b53af9748d040..1bf824b77c9fa 100644
--- a/test-framework/junit5/src/main/java/io/quarkus/test/junit/NativeImageTest.java
+++ b/test-framework/junit5/src/main/java/io/quarkus/test/junit/NativeImageTest.java
@@ -29,4 +29,9 @@
 @ExtendWith({ DisabledOnNativeImageCondition.class, QuarkusTestExtension.class, NativeTestExtension.class })
 @Retention(RetentionPolicy.RUNTIME)
 public @interface NativeImageTest {
+    /**
+     * Allow to define system properties that will be passed to the native image that will be started by the tests.
+     * Properties defined in this field will have precedence over the ones defined in profiles shipped with the image.
+     */
+    String[] systemProperties() default {};
 }
diff --git a/test-framework/junit5/src/main/java/io/quarkus/test/junit/NativeTestExtension.java b/test-framework/junit5/src/main/java/io/quarkus/test/junit/NativeTestExtension.java
index c6d7775c12302..4d2baf19aebc9 100644
--- a/test-framework/junit5/src/main/java/io/quarkus/test/junit/NativeTestExtension.java
+++ b/test-framework/junit5/src/main/java/io/quarkus/test/junit/NativeTestExtension.java
@@ -3,6 +3,7 @@
 import java.io.Closeable;
 import java.io.IOException;
 import java.lang.reflect.Field;
+import java.util.HashMap;
 import java.util.List;
 import java.util.Map;
 import java.util.function.Function;
@@ -71,6 +72,11 @@ public void beforeAll(ExtensionContext extensionContext) throws Exception {
                 Map<String, String> systemProps = testResourceManager.start();
                 NativeImageLauncher launcher = new NativeImageLauncher(testClass);
                 launcher.addSystemProperties(systemProps);
+                systemProps = getAnnotationSystemProperties(testClass);
+                if (!systemProps.isEmpty()) {
+                    launcher.addSystemProperties(systemProps);
+                }
+
                 try {
                     launcher.start();
                 } catch (IOException e) {
@@ -109,7 +115,31 @@ private void ensureNoInjectAnnotationIsUsed(Class<?> testClass) {
             }
             current = current.getSuperclass();
         }
+    }
+
+    private Map<String, String> getAnnotationSystemProperties(Class<?> testClass) {
+        final Map<String, String> systemProps = new HashMap<>();
+        final NativeImageTest annotation = testClass.getAnnotation(NativeImageTest.class);
 
+        if (annotation != null && annotation.systemProperties().length > 0) {
+            for (String expression : annotation.systemProperties()) {
+                if (!expression.contains("=") || expression.startsWith("=")) {
+                    throw new JUnitException("Invalid system property '" + expression
+                            + "' passed to @NativeImageTest: it must be 'key=value'");
+                }
+                final int equalSignIndex = expression.indexOf('=');
+                final String key = expression.substring(0, equalSignIndex);
+
+                final String value;
+                if (expression.endsWith("=")) {
+                    value = "";
+                } else {
+                    value = expression.substring(equalSignIndex + 1);
+                }
+                systemProps.put(key, value);
+            }
+        }
+        return systemProps;
     }
 
     /**