diff --git a/test-framework/common/src/main/java/io/quarkus/test/common/TestResourceManager.java b/test-framework/common/src/main/java/io/quarkus/test/common/TestResourceManager.java
index 8521d7407200a..d5f606290bebe 100644
--- a/test-framework/common/src/main/java/io/quarkus/test/common/TestResourceManager.java
+++ b/test-framework/common/src/main/java/io/quarkus/test/common/TestResourceManager.java
@@ -319,13 +319,15 @@ private Set<TestResourceClassEntry> uniqueTestResourceClassEntries(Path testClas
      * Allows Quarkus to extra basic information about which test resources a test class will require
      */
     public static Set<TestResourceManager.TestResourceComparisonInfo> testResourceComparisonInfo(Class<?> testClass,
-            Path testClassLocation) {
+            Path testClassLocation, List<TestResourceClassEntry> entriesFromProfile) {
         Set<TestResourceClassEntry> uniqueEntries = getUniqueTestResourceClassEntries(testClass, testClassLocation, null);
-        if (uniqueEntries.isEmpty()) {
+        if (uniqueEntries.isEmpty() && entriesFromProfile.isEmpty()) {
             return Collections.emptySet();
         }
-        Set<TestResourceManager.TestResourceComparisonInfo> result = new HashSet<>(uniqueEntries.size());
-        for (TestResourceClassEntry entry : uniqueEntries) {
+        Set<TestResourceClassEntry> allEntries = new HashSet<>(uniqueEntries);
+        allEntries.addAll(entriesFromProfile);
+        Set<TestResourceManager.TestResourceComparisonInfo> result = new HashSet<>(allEntries.size());
+        for (TestResourceClassEntry entry : allEntries) {
             Map<String, String> args = new HashMap<>(entry.args);
             if (entry.configAnnotation != null) {
                 args.put("configAnnotation", entry.configAnnotation.annotationType().getName());
diff --git a/test-framework/junit5/src/main/java/io/quarkus/test/junit/QuarkusIntegrationTestExtension.java b/test-framework/junit5/src/main/java/io/quarkus/test/junit/QuarkusIntegrationTestExtension.java
index 1dd9e846a844f..84f460e27704e 100644
--- a/test-framework/junit5/src/main/java/io/quarkus/test/junit/QuarkusIntegrationTestExtension.java
+++ b/test-framework/junit5/src/main/java/io/quarkus/test/junit/QuarkusIntegrationTestExtension.java
@@ -153,7 +153,8 @@ private QuarkusTestExtensionState ensureStarted(ExtensionContext extensionContex
         // we reload the test resources if we changed test class and if we had or will have per-test test resources
         boolean reloadTestResources = false;
         if ((state == null && !failedBoot) || wrongProfile || (reloadTestResources = isNewTestClass
-                && TestResourceUtil.testResourcesRequireReload(state, extensionContext.getRequiredTestClass()))) {
+                && TestResourceUtil.testResourcesRequireReload(state, extensionContext.getRequiredTestClass(),
+                        selectedProfile))) {
             if (wrongProfile || reloadTestResources) {
                 if (state != null) {
                     try {
diff --git a/test-framework/junit5/src/main/java/io/quarkus/test/junit/QuarkusMainTestExtension.java b/test-framework/junit5/src/main/java/io/quarkus/test/junit/QuarkusMainTestExtension.java
index 71776250160ec..107c2f9b60b81 100644
--- a/test-framework/junit5/src/main/java/io/quarkus/test/junit/QuarkusMainTestExtension.java
+++ b/test-framework/junit5/src/main/java/io/quarkus/test/junit/QuarkusMainTestExtension.java
@@ -67,7 +67,8 @@ private void ensurePrepared(ExtensionContext extensionContext, Class<? extends Q
         // we reload the test resources if we changed test class and if we had or will have per-test test resources
         boolean isNewTestClass = !Objects.equals(extensionContext.getRequiredTestClass(), currentJUnitTestClass);
         if (wrongProfile || (isNewTestClass
-                && TestResourceUtil.testResourcesRequireReload(state, extensionContext.getRequiredTestClass()))) {
+                && TestResourceUtil.testResourcesRequireReload(state, extensionContext.getRequiredTestClass(),
+                        profile))) {
             if (state != null) {
                 try {
                     state.close();
diff --git a/test-framework/junit5/src/main/java/io/quarkus/test/junit/QuarkusTestExtension.java b/test-framework/junit5/src/main/java/io/quarkus/test/junit/QuarkusTestExtension.java
index 91da01372bb78..8d54d14d94074 100644
--- a/test-framework/junit5/src/main/java/io/quarkus/test/junit/QuarkusTestExtension.java
+++ b/test-framework/junit5/src/main/java/io/quarkus/test/junit/QuarkusTestExtension.java
@@ -579,7 +579,8 @@ private QuarkusTestExtensionState ensureStarted(ExtensionContext extensionContex
         // we reload the test resources if we changed test class and the new test class is not a nested class, and if we had or will have per-test test resources
         boolean reloadTestResources = false;
         if ((state == null && !failedBoot) || wrongProfile || (reloadTestResources = isNewTestClass
-                && TestResourceUtil.testResourcesRequireReload(state, extensionContext.getRequiredTestClass()))) {
+                && TestResourceUtil.testResourcesRequireReload(state, extensionContext.getRequiredTestClass(),
+                        selectedProfile))) {
             if (wrongProfile || reloadTestResources) {
                 if (state != null) {
                     try {
diff --git a/test-framework/junit5/src/main/java/io/quarkus/test/junit/TestResourceUtil.java b/test-framework/junit5/src/main/java/io/quarkus/test/junit/TestResourceUtil.java
index eb1fea1f4ff62..56e751b2d307a 100644
--- a/test-framework/junit5/src/main/java/io/quarkus/test/junit/TestResourceUtil.java
+++ b/test-framework/junit5/src/main/java/io/quarkus/test/junit/TestResourceUtil.java
@@ -31,9 +31,19 @@ private TestResourceUtil() {
      * This is where we decide if the test resources of the current state vs the ones required by the next test class
      * to be executed require a Quarkus restart.
      */
-    static boolean testResourcesRequireReload(QuarkusTestExtensionState state, Class<?> nextTestClass) {
+    static boolean testResourcesRequireReload(QuarkusTestExtensionState state, Class<?> nextTestClass,
+            Class<? extends QuarkusTestProfile> nextTestClassProfile) {
+        QuarkusTestProfile profileInstance = null;
+        if (nextTestClassProfile != null) {
+            try {
+                profileInstance = nextTestClassProfile.getConstructor().newInstance();
+            } catch (Exception e) {
+                throw new RuntimeException(e);
+            }
+        }
         Set<TestResourceManager.TestResourceComparisonInfo> existingTestResources = existingTestResources(state);
-        Set<TestResourceManager.TestResourceComparisonInfo> nextTestResources = nextTestResources(nextTestClass);
+        Set<TestResourceManager.TestResourceComparisonInfo> nextTestResources = nextTestResources(nextTestClass,
+                profileInstance);
 
         return TestResourceManager.testResourcesRequireReload(existingTestResources, nextTestResources);
     }
@@ -54,9 +64,20 @@ static Set<TestResourceManager.TestResourceComparisonInfo> existingTestResources
         return Collections.emptySet();
     }
 
-    static Set<TestResourceManager.TestResourceComparisonInfo> nextTestResources(Class<?> requiredTestClass) {
+    static Set<TestResourceManager.TestResourceComparisonInfo> nextTestResources(Class<?> requiredTestClass,
+            QuarkusTestProfile profileInstance) {
+
+        List<TestResourceManager.TestResourceClassEntry> entriesFromProfile = Collections.emptyList();
+        if (profileInstance != null) {
+            entriesFromProfile = new ArrayList<>(profileInstance.testResources().size());
+            for (QuarkusTestProfile.TestResourceEntry entry : profileInstance.testResources()) {
+                entriesFromProfile.add(new TestResourceManager.TestResourceClassEntry(entry.getClazz(), entry.getArgs(), null,
+                        entry.isParallel(), TestResourceScope.MATCHING_RESOURCES));
+            }
+        }
+
         return TestResourceManager
-                .testResourceComparisonInfo(requiredTestClass, getTestClassesLocation(requiredTestClass));
+                .testResourceComparisonInfo(requiredTestClass, getTestClassesLocation(requiredTestClass), entriesFromProfile);
     }
 
     /**
@@ -92,7 +113,7 @@ static <T> List<T> copyEntriesFromProfile(
                     T instance = (T) testResourceClassEntryConstructor.newInstance(
                             Class.forName(testResource.getClazz().getName(), true, classLoader), testResource.getArgs(),
                             null, testResource.isParallel(),
-                            Enum.valueOf(testResourceScopeClass, TestResourceScope.RESTRICTED_TO_CLASS.name()));
+                            Enum.valueOf(testResourceScopeClass, TestResourceScope.MATCHING_RESOURCES.name()));
                     result.add(instance);
                 }