diff --git a/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/headers/UriUserInfoTest.java b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/headers/UriUserInfoTest.java
new file mode 100644
index 0000000000000..63a52d6e85207
--- /dev/null
+++ b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/headers/UriUserInfoTest.java
@@ -0,0 +1,84 @@
+package io.quarkus.rest.client.reactive.headers;
+
+import static org.assertj.core.api.Assertions.assertThat;
+
+import java.net.URI;
+import java.util.Base64;
+
+import javax.ws.rs.GET;
+import javax.ws.rs.HeaderParam;
+import javax.ws.rs.Path;
+import javax.ws.rs.core.UriBuilder;
+
+import org.eclipse.microprofile.rest.client.RestClientBuilder;
+import org.eclipse.microprofile.rest.client.annotation.ClientHeaderParam;
+import org.junit.jupiter.api.Test;
+import org.junit.jupiter.api.extension.RegisterExtension;
+
+import io.quarkus.test.QuarkusUnitTest;
+import io.quarkus.test.common.http.TestHTTPResource;
+
+public class UriUserInfoTest {
+
+    @RegisterExtension
+    static final QuarkusUnitTest config = new QuarkusUnitTest()
+            .withApplicationRoot((jar) -> jar.addClasses(TestResource.class));
+
+    @TestHTTPResource
+    URI baseUri;
+
+    @Test
+    void noUserInfo() {
+        Client client = RestClientBuilder.newBuilder().baseUri(baseUri).build(Client.class);
+        assertThat(client.call()).isNullOrEmpty();
+    }
+
+    @Test
+    void withUserInfo() {
+        Client client = RestClientBuilder.newBuilder().baseUri(UriBuilder.fromUri(baseUri).userInfo("foo:bar").build())
+                .build(Client.class);
+        assertThat(client.call()).isEqualTo("foo:bar");
+    }
+
+    @Test
+    void userInfoOverridesClientHeaderParamAnnotation() {
+        Client client = RestClientBuilder.newBuilder().baseUri(UriBuilder.fromUri(baseUri).userInfo("foo:bar").build())
+                .build(Client.class);
+        assertThat(client.call2()).isEqualTo("foo:bar");
+    }
+
+    @Test
+    void userInfoDoesNotOverrideHeaderParamAnnotation() {
+        Client client = RestClientBuilder.newBuilder().baseUri(UriBuilder.fromUri(baseUri).userInfo("foo:bar").build())
+                .build(Client.class);
+        assertThat(client.call3("Basic " + Base64.getEncoder().encodeToString(("user:pass").getBytes())))
+                .isEqualTo("user:pass");
+    }
+
+    @Path("/test")
+    public static class TestResource {
+
+        @GET
+        @Path("/credentials")
+        public String credentials(@HeaderParam("Authorization") String authorization) {
+            if ((authorization == null) || authorization.isEmpty()) {
+                return null;
+            }
+            return new String(Base64.getDecoder().decode(authorization.substring("Basic ".length())));
+        }
+    }
+
+    @Path("/test/credentials")
+    public interface Client {
+
+        @GET
+        String call();
+
+        @ClientHeaderParam(name = "Authorization", value = "whatever")
+        @GET
+        String call2();
+
+        @GET
+        String call3(@HeaderParam("Authorization") String authorization);
+    }
+}
diff --git a/independent-projects/resteasy-reactive/client/runtime/src/main/java/org/jboss/resteasy/reactive/client/impl/AsyncInvokerImpl.java b/independent-projects/resteasy-reactive/client/runtime/src/main/java/org/jboss/resteasy/reactive/client/impl/AsyncInvokerImpl.java
index 64a44c7c08c48..8708360ffce7a 100644
--- a/independent-projects/resteasy-reactive/client/runtime/src/main/java/org/jboss/resteasy/reactive/client/impl/AsyncInvokerImpl.java
+++ b/independent-projects/resteasy-reactive/client/runtime/src/main/java/org/jboss/resteasy/reactive/client/impl/AsyncInvokerImpl.java
@@ -2,6 +2,7 @@
 
 import java.lang.reflect.Type;
 import java.net.URI;
+import java.util.Base64;
 import java.util.HashMap;
 import java.util.Map;
 import java.util.concurrent.CompletableFuture;
@@ -14,6 +15,7 @@
 import javax.ws.rs.client.Entity;
 import javax.ws.rs.client.InvocationCallback;
 import javax.ws.rs.core.GenericType;
+import javax.ws.rs.core.HttpHeaders;
 import javax.ws.rs.core.Response;
 
 import org.jboss.resteasy.reactive.RestResponse;
@@ -45,12 +47,30 @@ public AsyncInvokerImpl(ClientImpl restClient, HttpClient httpClient, URI uri, R
         this.httpClient = httpClient;
         this.uri = uri;
         this.requestSpec = new RequestSpec(requestSpec);
+        addUserInfoIfNecessary(this.uri, this.requestSpec);
         this.configuration = configuration;
         this.properties = new HashMap<>(properties);
         this.handlerChain = handlerChain;
         this.requestContext = requestContext;
     }
 
+    private void addUserInfoIfNecessary(URI uri, RequestSpec requestSpec) {
+        String userInfo = uri.getUserInfo();
+        if (userInfo == null) {
+            return;
+        }
+        String[] parts = userInfo.split(":");
+        if (parts.length != 2) {
+            return;
+        }
+        ClientRequestHeaders specHeaders = requestSpec.headers;
+        String authorizationHeader = specHeaders.getHeader(HttpHeaders.AUTHORIZATION);
+        if (authorizationHeader == null) {
+            specHeaders.header(HttpHeaders.AUTHORIZATION,
+                    "Basic " + Base64.getEncoder().encodeToString((parts[0] + ":" + parts[1]).getBytes()));
+        }
+    }
+
     public Map<String, Object> getProperties() {
         return properties;
     }