diff --git a/extensions/jdbc/jdbc-mysql/runtime/src/main/java/io/quarkus/jdbc/mysql/runtime/graal/com/mysql/cj/jdbc/MySQLJDBCSubstitutions.java b/extensions/jdbc/jdbc-mysql/runtime/src/main/java/io/quarkus/jdbc/mysql/runtime/graal/com/mysql/cj/jdbc/MySQLJDBCSubstitutions.java
new file mode 100644
index 00000000000000..1a8d2bf9b78347
--- /dev/null
+++ b/extensions/jdbc/jdbc-mysql/runtime/src/main/java/io/quarkus/jdbc/mysql/runtime/graal/com/mysql/cj/jdbc/MySQLJDBCSubstitutions.java
@@ -0,0 +1,29 @@
+package io.quarkus.jdbc.mysql.runtime.graal.com.mysql.cj.jdbc;
+
+import java.sql.SQLException;
+
+import com.oracle.svm.core.annotate.Substitute;
+import com.oracle.svm.core.annotate.TargetClass;
+
+@TargetClass(className = "com.mysql.cj.jdbc.ConnectionGroupManager")
+final class ConnectionGroupManager {
+
+    @Substitute
+    public static void registerJmx() throws SQLException {
+
+    }
+
+}
+
+@TargetClass(className = "com.mysql.cj.jdbc.jmx.ReplicationGroupManager")
+final class ReplicationGroupManager {
+
+    @Substitute
+    public synchronized void registerJmx() throws SQLException {
+
+    }
+
+}
+
+class MySQLJDBCSubstitutions {
+}