diff --git a/extensions/hibernate-orm/deployment/src/main/java/io/quarkus/hibernate/orm/deployment/HibernateOrmProcessor.java b/extensions/hibernate-orm/deployment/src/main/java/io/quarkus/hibernate/orm/deployment/HibernateOrmProcessor.java
index 73ddc379f4f241..9b9636a16dc123 100644
--- a/extensions/hibernate-orm/deployment/src/main/java/io/quarkus/hibernate/orm/deployment/HibernateOrmProcessor.java
+++ b/extensions/hibernate-orm/deployment/src/main/java/io/quarkus/hibernate/orm/deployment/HibernateOrmProcessor.java
@@ -103,6 +103,7 @@
 import io.quarkus.deployment.builditem.RunTimeConfigurationDefaultBuildItem;
 import io.quarkus.deployment.builditem.ServiceStartBuildItem;
 import io.quarkus.deployment.builditem.SystemPropertyBuildItem;
+import io.quarkus.deployment.builditem.TransformedClassesBuildItem;
 import io.quarkus.deployment.builditem.nativeimage.NativeImageProxyDefinitionBuildItem;
 import io.quarkus.deployment.builditem.nativeimage.NativeImageResourceBuildItem;
 import io.quarkus.deployment.builditem.nativeimage.ReflectiveClassBuildItem;
@@ -143,7 +144,9 @@
 import io.quarkus.runtime.configuration.ConfigUtils;
 import io.quarkus.runtime.configuration.ConfigurationException;
 import net.bytebuddy.description.type.TypeDescription;
+import net.bytebuddy.dynamic.ClassFileLocator;
 import net.bytebuddy.dynamic.DynamicType;
+import net.bytebuddy.pool.TypePool;
 
 /**
  * Simulacrum of JPA bootstrap.
@@ -496,6 +499,7 @@ public void defineJpaEntities(
     public ProxyDefinitionsBuildItem pregenProxies(
             JpaModelBuildItem jpaModel,
             JpaModelIndexBuildItem indexBuildItem,
+            TransformedClassesBuildItem transformedClassesBuildItem,
             List<PersistenceUnitDescriptorBuildItem> persistenceUnitDescriptorBuildItems,
             BuildProducer<GeneratedClassBuildItem> generatedClassBuildItemBuildProducer,
             LiveReloadBuildItem liveReloadBuildItem) {
@@ -508,7 +512,8 @@ public ProxyDefinitionsBuildItem pregenProxies(
             managedClassAndPackageNames.addAll(pud.getManagedClassNames());
         }
         PreGeneratedProxies proxyDefinitions = generatedProxies(managedClassAndPackageNames,
-                indexBuildItem.getIndex(), generatedClassBuildItemBuildProducer, liveReloadBuildItem);
+                indexBuildItem.getIndex(), transformedClassesBuildItem,
+                generatedClassBuildItemBuildProducer, liveReloadBuildItem);
         return new ProxyDefinitionsBuildItem(proxyDefinitions);
     }
 
@@ -708,7 +713,6 @@ public HibernateModelClassCandidatesForFieldAccessBuildItem candidatesForFieldAc
     @Record(STATIC_INIT)
     public void build(HibernateOrmRecorder recorder, HibernateOrmConfig hibernateOrmConfig,
             BuildProducer<JpaModelPersistenceUnitMappingBuildItem> jpaModelPersistenceUnitMapping,
-            BuildProducer<BeanContainerListenerBuildItem> buildProducer,
             BuildProducer<SyntheticBeanBuildItem> syntheticBeans,
             List<PersistenceUnitDescriptorBuildItem> descriptors,
             JpaModelBuildItem jpaModel) throws Exception {
@@ -1481,6 +1485,7 @@ private static MultiTenancyStrategy getMultiTenancyStrategy(Optional<String> mul
     }
 
     private PreGeneratedProxies generatedProxies(Set<String> managedClassAndPackageNames, IndexView combinedIndex,
+            TransformedClassesBuildItem transformedClassesBuildItem,
             BuildProducer<GeneratedClassBuildItem> generatedClassBuildItemBuildProducer,
             LiveReloadBuildItem liveReloadBuildItem) {
         ProxyCache proxyCache = liveReloadBuildItem.getContextObject(ProxyCache.class);
@@ -1505,7 +1510,9 @@ private PreGeneratedProxies generatedProxies(Set<String> managedClassAndPackageN
             }
             proxyAnnotations.put(i.target().asClass().name().toString(), proxyClass.asClass().name().toString());
         }
-        try (ProxyBuildingHelper proxyHelper = new ProxyBuildingHelper(Thread.currentThread().getContextClassLoader())) {
+        TypePool transformedClassesTypePool = createTransformedClassesTypePool(transformedClassesBuildItem,
+                managedClassAndPackageNames);
+        try (ProxyBuildingHelper proxyHelper = new ProxyBuildingHelper(transformedClassesTypePool)) {
             for (String managedClassOrPackageName : managedClassAndPackageNames) {
                 CachedProxy result;
                 if (proxyCache.cache.containsKey(managedClassOrPackageName)
@@ -1552,6 +1559,27 @@ private PreGeneratedProxies generatedProxies(Set<String> managedClassAndPackageN
         return preGeneratedProxies;
     }
 
+    // Creates a TypePool that is aware of class transformations applied to entity classes,
+    // so that ByteBuddy can take these transformations into account.
+    // This is especially important when getters/setters are added to entity classes,
+    // because we want those methods to be overridden in proxies to trigger proxy initialization.
+    private TypePool createTransformedClassesTypePool(TransformedClassesBuildItem transformedClassesBuildItem,
+            Set<String> entityClasses) {
+        Map<String, byte[]> transformedClasses = new HashMap<>();
+        for (Set<TransformedClassesBuildItem.TransformedClass> transformedClassSet : transformedClassesBuildItem
+                .getTransformedClassesByJar().values()) {
+            for (TransformedClassesBuildItem.TransformedClass transformedClass : transformedClassSet) {
+                String className = transformedClass.getClassName();
+                if (entityClasses.contains(className)) {
+                    transformedClasses.put(className, transformedClass.getData());
+                }
+            }
+        }
+        return TypePool.Default.of(new ClassFileLocator.Compound(
+                new ClassFileLocator.Simple(transformedClasses),
+                ClassFileLocator.ForClassLoader.of(Thread.currentThread().getContextClassLoader())));
+    }
+
     private boolean isModified(String entity, Set<String> changedClasses, IndexView index) {
         if (changedClasses.contains(entity)) {
             return true;
diff --git a/extensions/hibernate-orm/deployment/src/main/java/io/quarkus/hibernate/orm/deployment/ProxyBuildingHelper.java b/extensions/hibernate-orm/deployment/src/main/java/io/quarkus/hibernate/orm/deployment/ProxyBuildingHelper.java
index 3419488fa8a2cd..dc6c27bd947fbf 100644
--- a/extensions/hibernate-orm/deployment/src/main/java/io/quarkus/hibernate/orm/deployment/ProxyBuildingHelper.java
+++ b/extensions/hibernate-orm/deployment/src/main/java/io/quarkus/hibernate/orm/deployment/ProxyBuildingHelper.java
@@ -1,13 +1,18 @@
 package io.quarkus.hibernate.orm.deployment;
 
-import java.lang.reflect.Modifier;
+import java.util.ArrayList;
+import java.util.List;
 import java.util.Set;
 
 import org.hibernate.bytecode.internal.bytebuddy.BytecodeProviderImpl;
 import org.hibernate.proxy.pojo.bytebuddy.ByteBuddyProxyHelper;
 
 import net.bytebuddy.ClassFileVersion;
+import net.bytebuddy.description.type.TypeDefinition;
+import net.bytebuddy.description.type.TypeDescription;
 import net.bytebuddy.dynamic.DynamicType;
+import net.bytebuddy.matcher.ElementMatchers;
+import net.bytebuddy.pool.TypePool;
 
 /**
  * Makes it slightly more readable to interact with the Hibernate
@@ -15,22 +20,21 @@
  */
 final class ProxyBuildingHelper implements AutoCloseable {
 
-    private final ClassLoader contextClassLoader;
+    private final TypePool typePool;
     private ByteBuddyProxyHelper byteBuddyProxyHelper;
     private BytecodeProviderImpl bytecodeProvider;
 
-    public ProxyBuildingHelper(ClassLoader contextClassLoader) {
-        this.contextClassLoader = contextClassLoader;
+    public ProxyBuildingHelper(TypePool typePool) {
+        this.typePool = typePool;
     }
 
     public DynamicType.Unloaded<?> buildUnloadedProxy(String mappedClassName, Set<String> interfaceNames) {
-        final Class[] interfaces = new Class[interfaceNames.size()];
+        List<TypeDefinition> interfaces = new ArrayList<>();
         int i = 0;
         for (String name : interfaceNames) {
-            interfaces[i++] = uninitializedClass(name);
+            interfaces.add(typePool.describe(name).resolve());
         }
-        final Class<?> mappedClass = uninitializedClass(mappedClassName);
-        return getByteBuddyProxyHelper().buildUnloadedProxy(mappedClass, interfaces);
+        return getByteBuddyProxyHelper().buildUnloadedProxy(typePool, typePool.describe(mappedClassName).resolve(), interfaces);
     }
 
     private ByteBuddyProxyHelper getByteBuddyProxyHelper() {
@@ -43,32 +47,20 @@ private ByteBuddyProxyHelper getByteBuddyProxyHelper() {
         return this.byteBuddyProxyHelper;
     }
 
-    private Class<?> uninitializedClass(String entity) {
-        try {
-            return Class.forName(entity, false, contextClassLoader);
-        } catch (ClassNotFoundException e) {
-            throw new RuntimeException(e);
-        }
-    }
-
     public boolean isProxiable(String managedClassOrPackageName) {
-        Class<?> mappedClass;
-        try {
-            mappedClass = Class.forName(managedClassOrPackageName, false, contextClassLoader);
-        } catch (ClassNotFoundException e) {
+        TypePool.Resolution mappedClassResolution = typePool.describe(managedClassOrPackageName);
+        if (!mappedClassResolution.isResolved()) {
             // Probably a package name - consider it's not proxiable.
             return false;
         }
 
-        if (Modifier.isFinal(mappedClass.getModifiers())) {
-            return false;
-        }
-        try {
-            mappedClass.getDeclaredConstructor();
-        } catch (NoSuchMethodException e) {
-            return false;
-        }
-        return true;
+        TypeDescription mappedClass = mappedClassResolution.resolve();
+
+        return !mappedClass.isFinal()
+                && !mappedClass.getDeclaredMethods()
+                        .filter(ElementMatchers.isConstructor()
+                                .and(ElementMatchers.takesNoArguments()))
+                        .isEmpty();
     }
 
     @Override