diff --git a/extensions/resteasy-classic/rest-client/runtime/src/main/java/io/quarkus/restclient/runtime/QuarkusProxyInvocationHandler.java b/extensions/resteasy-classic/rest-client/runtime/src/main/java/io/quarkus/restclient/runtime/QuarkusProxyInvocationHandler.java
new file mode 100644
index 0000000000000..2eba8ce96542c
--- /dev/null
+++ b/extensions/resteasy-classic/rest-client/runtime/src/main/java/io/quarkus/restclient/runtime/QuarkusProxyInvocationHandler.java
@@ -0,0 +1,296 @@
+package io.quarkus.restclient.runtime;
+
+import java.lang.annotation.Annotation;
+import java.lang.reflect.InvocationHandler;
+import java.lang.reflect.InvocationTargetException;
+import java.lang.reflect.Method;
+import java.lang.reflect.Modifier;
+import java.lang.reflect.ParameterizedType;
+import java.lang.reflect.Type;
+import java.util.ArrayList;
+import java.util.Collections;
+import java.util.HashMap;
+import java.util.List;
+import java.util.Map;
+import java.util.Set;
+import java.util.concurrent.CompletionException;
+import java.util.concurrent.atomic.AtomicBoolean;
+import java.util.stream.Collectors;
+
+import jakarta.enterprise.context.spi.CreationalContext;
+import jakarta.enterprise.inject.spi.BeanManager;
+import jakarta.enterprise.inject.spi.CDI;
+import jakarta.enterprise.inject.spi.InterceptionType;
+import jakarta.enterprise.inject.spi.Interceptor;
+import jakarta.ws.rs.ProcessingException;
+import jakarta.ws.rs.client.ResponseProcessingException;
+import jakarta.ws.rs.ext.ParamConverter;
+import jakarta.ws.rs.ext.ParamConverterProvider;
+
+import org.jboss.logging.Logger;
+import org.jboss.resteasy.client.jaxrs.ResteasyClient;
+import org.jboss.resteasy.microprofile.client.ExceptionMapping;
+import org.jboss.resteasy.microprofile.client.InvocationContextImpl;
+import org.jboss.resteasy.microprofile.client.RestClientProxy;
+import org.jboss.resteasy.microprofile.client.header.ClientHeaderFillingException;
+
+/**
+ * Quarkus version of {@link org.jboss.resteasy.microprofile.client.ProxyInvocationHandler} retaining the ability to
+ * create a custom interceptor chain and invoke it manually.
+ * <p/>
+ * This is needed due to changes in https://github.com/resteasy/resteasy-microprofile/pull/182
+ * <p/>
+ * In theory, it could be improved by pre-generating proxies for {@code @RegisterRestClient} interfaces and registering
+ * them as standard beans with all their interceptor bindings.
+ */
+public class QuarkusProxyInvocationHandler implements InvocationHandler {
+
+    private static final Logger LOGGER = Logger.getLogger(QuarkusProxyInvocationHandler.class);
+    public static final Type[] NO_TYPES = {};
+
+    private final Object target;
+
+    private final Set<Object> providerInstances;
+
+    private final Map<Method, List<InvocationContextImpl.InterceptorInvocation>> interceptorChains;
+
+    private final ResteasyClient client;
+
+    private final CreationalContext<?> creationalContext;
+
+    private final AtomicBoolean closed;
+
+    public QuarkusProxyInvocationHandler(final Class<?> restClientInterface,
+            final Object target,
+            final Set<Object> providerInstances,
+            final ResteasyClient client, final BeanManager beanManager) {
+        this.target = target;
+        this.providerInstances = providerInstances;
+        this.client = client;
+        this.closed = new AtomicBoolean();
+        if (beanManager != null) {
+            this.creationalContext = beanManager.createCreationalContext(null);
+            this.interceptorChains = initInterceptorChains(beanManager, creationalContext, restClientInterface);
+        } else {
+            this.creationalContext = null;
+            this.interceptorChains = Collections.emptyMap();
+        }
+    }
+
+    @Override
+    public Object invoke(Object proxy, Method method, Object[] args) throws Throwable {
+        if (RestClientProxy.class.equals(method.getDeclaringClass())) {
+            return invokeRestClientProxyMethod(proxy, method, args);
+        }
+        // Autocloseable/Closeable
+        if (method.getName().equals("close") && (args == null || args.length == 0)) {
+            close();
+            return null;
+        }
+        if (closed.get()) {
+            throw new IllegalStateException("RestClientProxy is closed");
+        }
+
+        boolean replacementNeeded = false;
+        Object[] argsReplacement = args != null ? new Object[args.length] : null;
+        Annotation[][] parameterAnnotations = method.getParameterAnnotations();
+
+        if (args != null) {
+            for (Object p : providerInstances) {
+                if (p instanceof ParamConverterProvider) {
+
+                    int index = 0;
+                    for (Object arg : args) {
+                        // ParamConverter's are not allowed to be passed null values. If we have a null value do not process
+                        // it through the provider.
+                        if (arg == null) {
+                            continue;
+                        }
+
+                        if (parameterAnnotations[index].length > 0) { // does a parameter converter apply?
+                            ParamConverter<?> converter = ((ParamConverterProvider) p).getConverter(arg.getClass(), null,
+                                    parameterAnnotations[index]);
+                            if (converter != null) {
+                                Type[] genericTypes = getGenericTypes(converter.getClass());
+                                if (genericTypes.length == 1) {
+
+                                    // minimum supported types
+                                    switch (genericTypes[0].getTypeName()) {
+                                        case "java.lang.String":
+                                            @SuppressWarnings("unchecked")
+                                            ParamConverter<String> stringConverter = (ParamConverter<String>) converter;
+                                            argsReplacement[index] = stringConverter.toString((String) arg);
+                                            replacementNeeded = true;
+                                            break;
+                                        case "java.lang.Integer":
+                                            @SuppressWarnings("unchecked")
+                                            ParamConverter<Integer> intConverter = (ParamConverter<Integer>) converter;
+                                            argsReplacement[index] = intConverter.toString((Integer) arg);
+                                            replacementNeeded = true;
+                                            break;
+                                        case "java.lang.Boolean":
+                                            @SuppressWarnings("unchecked")
+                                            ParamConverter<Boolean> boolConverter = (ParamConverter<Boolean>) converter;
+                                            argsReplacement[index] = boolConverter.toString((Boolean) arg);
+                                            replacementNeeded = true;
+                                            break;
+                                        default:
+                                            continue;
+                                    }
+                                }
+                            }
+                        } else {
+                            argsReplacement[index] = arg;
+                        }
+                        index++;
+                    }
+                }
+            }
+        }
+
+        if (replacementNeeded) {
+            args = argsReplacement;
+        }
+
+        List<InvocationContextImpl.InterceptorInvocation> chain = interceptorChains.get(method);
+        if (chain != null) {
+            // Invoke business method interceptors
+            return new InvocationContextImpl(target, method, args, chain).proceed();
+        } else {
+            try {
+                return method.invoke(target, args);
+            } catch (InvocationTargetException e) {
+                Throwable cause = e.getCause();
+                if (cause instanceof CompletionException) {
+                    cause = cause.getCause();
+                }
+                if (cause instanceof ExceptionMapping.HandlerException) {
+                    ((ExceptionMapping.HandlerException) cause).mapException(method);
+                    // no applicable exception mapper found or applicable mapper returned null
+                    return null;
+                }
+                if (cause instanceof ResponseProcessingException) {
+                    ResponseProcessingException rpe = (ResponseProcessingException) cause;
+                    cause = rpe.getCause();
+                    if (cause instanceof RuntimeException) {
+                        throw cause;
+                    }
+                } else {
+                    if (cause instanceof ProcessingException &&
+                            cause.getCause() instanceof ClientHeaderFillingException) {
+                        throw cause.getCause().getCause();
+                    }
+                    if (cause instanceof RuntimeException) {
+                        throw cause;
+                    }
+                }
+                throw e;
+            }
+        }
+    }
+
+    private Object invokeRestClientProxyMethod(Object proxy, Method method, Object[] args) {
+        switch (method.getName()) {
+            case "getClient":
+                return client;
+            case "close":
+                close();
+                return null;
+            default:
+                throw new IllegalStateException("Unsupported RestClientProxy method: " + method);
+        }
+    }
+
+    private void close() {
+        if (closed.compareAndSet(false, true)) {
+            if (creationalContext != null) {
+                creationalContext.release();
+            }
+            client.close();
+        }
+    }
+
+    private Type[] getGenericTypes(Class<?> aClass) {
+        Type[] genericInterfaces = aClass.getGenericInterfaces();
+        Type[] genericTypes = NO_TYPES;
+        for (Type genericInterface : genericInterfaces) {
+            if (genericInterface instanceof ParameterizedType) {
+                genericTypes = ((ParameterizedType) genericInterface).getActualTypeArguments();
+            }
+        }
+        return genericTypes;
+    }
+
+    private static List<Annotation> getBindings(Annotation[] annotations, BeanManager beanManager) {
+        if (annotations.length == 0) {
+            return Collections.emptyList();
+        }
+        List<Annotation> bindings = new ArrayList<>();
+        for (Annotation annotation : annotations) {
+            if (beanManager.isInterceptorBinding(annotation.annotationType())) {
+                bindings.add(annotation);
+            }
+        }
+        return bindings;
+    }
+
+    private static BeanManager getBeanManager(Class<?> restClientInterface) {
+        try {
+            CDI<Object> current = CDI.current();
+            return current != null ? current.getBeanManager() : null;
+        } catch (IllegalStateException e) {
+            LOGGER.warnf("CDI container is not available - interceptor bindings declared on %s will be ignored",
+                    restClientInterface.getSimpleName());
+            return null;
+        }
+    }
+
+    private static Map<Method, List<InvocationContextImpl.InterceptorInvocation>> initInterceptorChains(
+            BeanManager beanManager, CreationalContext<?> creationalContext, Class<?> restClientInterface) {
+
+        Map<Method, List<InvocationContextImpl.InterceptorInvocation>> chains = new HashMap<>();
+        // Interceptor as a key in a map is not entirely correct (custom interceptors) but should work in most cases
+        Map<Interceptor<?>, Object> interceptorInstances = new HashMap<>();
+
+        List<Annotation> classLevelBindings = getBindings(restClientInterface.getAnnotations(), beanManager);
+
+        for (Method method : restClientInterface.getMethods()) {
+            if (method.isDefault() || Modifier.isStatic(method.getModifiers())) {
+                continue;
+            }
+            List<Annotation> methodLevelBindings = getBindings(method.getAnnotations(), beanManager);
+
+            if (!classLevelBindings.isEmpty() || !methodLevelBindings.isEmpty()) {
+
+                Annotation[] interceptorBindings = merge(methodLevelBindings, classLevelBindings);
+
+                List<Interceptor<?>> interceptors = beanManager.resolveInterceptors(InterceptionType.AROUND_INVOKE,
+                        interceptorBindings);
+                if (!interceptors.isEmpty()) {
+                    List<InvocationContextImpl.InterceptorInvocation> chain = new ArrayList<>();
+                    for (Interceptor<?> interceptor : interceptors) {
+                        chain.add(new InvocationContextImpl.InterceptorInvocation(interceptor,
+                                interceptorInstances.computeIfAbsent(interceptor,
+                                        i -> beanManager.getReference(i, i.getBeanClass(), creationalContext))));
+                    }
+                    chains.put(method, chain);
+                }
+            }
+        }
+        return chains.isEmpty() ? Collections.emptyMap() : chains;
+    }
+
+    private static Annotation[] merge(List<Annotation> methodLevelBindings, List<Annotation> classLevelBindings) {
+        Set<Class<? extends Annotation>> types = methodLevelBindings.stream()
+                .map(a -> a.annotationType())
+                .collect(Collectors.toSet());
+        List<Annotation> merged = new ArrayList<>(methodLevelBindings);
+        for (Annotation annotation : classLevelBindings) {
+            if (!types.contains(annotation.annotationType())) {
+                merged.add(annotation);
+            }
+        }
+        return merged.toArray(new Annotation[] {});
+    }
+
+}
diff --git a/extensions/resteasy-classic/rest-client/runtime/src/main/java/io/quarkus/restclient/runtime/QuarkusRestClientBuilder.java b/extensions/resteasy-classic/rest-client/runtime/src/main/java/io/quarkus/restclient/runtime/QuarkusRestClientBuilder.java
index 3c26f09ba35e9..ead9b44944922 100644
--- a/extensions/resteasy-classic/rest-client/runtime/src/main/java/io/quarkus/restclient/runtime/QuarkusRestClientBuilder.java
+++ b/extensions/resteasy-classic/rest-client/runtime/src/main/java/io/quarkus/restclient/runtime/QuarkusRestClientBuilder.java
@@ -73,7 +73,6 @@
 import org.jboss.resteasy.microprofile.client.DefaultResponseExceptionMapper;
 import org.jboss.resteasy.microprofile.client.ExceptionMapping;
 import org.jboss.resteasy.microprofile.client.MethodInjectionFilter;
-import org.jboss.resteasy.microprofile.client.ProxyInvocationHandler;
 import org.jboss.resteasy.microprofile.client.RestClientListeners;
 import org.jboss.resteasy.microprofile.client.RestClientProxy;
 import org.jboss.resteasy.microprofile.client.async.AsyncInterceptorRxInvokerProvider;
@@ -363,7 +362,7 @@ public <T> T build(Class<T> aClass, ClientHttpEngine httpEngine)
 
         final BeanManager beanManager = getBeanManager();
         T proxy = (T) Proxy.newProxyInstance(classLoader, interfaces,
-                new ProxyInvocationHandler(aClass, actualClient, getLocalProviderInstances(), client));
+                new QuarkusProxyInvocationHandler(aClass, actualClient, getLocalProviderInstances(), client, beanManager));
         ClientHeaderProviders.registerForClass(aClass, proxy, beanManager);
         return proxy;
     }