diff --git a/extensions/smallrye-openapi/deployment/src/main/java/io/quarkus/smallrye/openapi/deployment/SmallRyeOpenApiProcessor.java b/extensions/smallrye-openapi/deployment/src/main/java/io/quarkus/smallrye/openapi/deployment/SmallRyeOpenApiProcessor.java
index 4e50a3ad5ace5a..3c927c2563aea9 100644
--- a/extensions/smallrye-openapi/deployment/src/main/java/io/quarkus/smallrye/openapi/deployment/SmallRyeOpenApiProcessor.java
+++ b/extensions/smallrye-openapi/deployment/src/main/java/io/quarkus/smallrye/openapi/deployment/SmallRyeOpenApiProcessor.java
@@ -67,6 +67,7 @@
 import io.quarkus.deployment.builditem.GeneratedResourceBuildItem;
 import io.quarkus.deployment.builditem.HotDeploymentWatchedFileBuildItem;
 import io.quarkus.deployment.builditem.LaunchModeBuildItem;
+import io.quarkus.deployment.builditem.RunTimeConfigBuilderBuildItem;
 import io.quarkus.deployment.builditem.ShutdownContextBuildItem;
 import io.quarkus.deployment.builditem.nativeimage.NativeImageResourceBuildItem;
 import io.quarkus.deployment.builditem.nativeimage.ReflectiveClassBuildItem;
@@ -79,6 +80,7 @@
 import io.quarkus.resteasy.server.common.spi.AllowedJaxRsAnnotationPrefixBuildItem;
 import io.quarkus.resteasy.server.common.spi.ResteasyJaxrsConfigBuildItem;
 import io.quarkus.runtime.LaunchMode;
+import io.quarkus.runtime.configuration.ConfigBuilder;
 import io.quarkus.runtime.util.ClassPathUtils;
 import io.quarkus.security.Authenticated;
 import io.quarkus.smallrye.openapi.common.deployment.SmallRyeOpenApiConfig;
@@ -89,6 +91,7 @@
 import io.quarkus.smallrye.openapi.deployment.spi.AddToOpenAPIDefinitionBuildItem;
 import io.quarkus.smallrye.openapi.deployment.spi.IgnoreStaticDocumentBuildItem;
 import io.quarkus.smallrye.openapi.deployment.spi.OpenApiDocumentBuildItem;
+import io.quarkus.smallrye.openapi.runtime.OpenApiConfigMapping;
 import io.quarkus.smallrye.openapi.runtime.OpenApiConstants;
 import io.quarkus.smallrye.openapi.runtime.OpenApiDocumentService;
 import io.quarkus.smallrye.openapi.runtime.OpenApiRecorder;
@@ -103,6 +106,7 @@
 import io.quarkus.vertx.http.deployment.RouteBuildItem;
 import io.quarkus.vertx.http.deployment.SecurityInformationBuildItem;
 import io.quarkus.vertx.http.deployment.devmode.NotFoundPageDisplayableEndpointBuildItem;
+import io.smallrye.config.SmallRyeConfigBuilder;
 import io.smallrye.openapi.api.OpenApiConfig;
 import io.smallrye.openapi.api.OpenApiConfigImpl;
 import io.smallrye.openapi.api.OpenApiDocument;
@@ -173,11 +177,15 @@ void contributeClassesToIndex(BuildProducer<AdditionalIndexedClassesBuildItem> a
 
     @BuildStep
     void registerNativeImageResources(BuildProducer<ServiceProviderBuildItem> serviceProvider) {
-        // To map from smallrye and mp config to quarkus
-        serviceProvider.produce(ServiceProviderBuildItem.allProvidersFromClassPath(OpenApiConfigMapping.class.getName()));
         serviceProvider.produce(ServiceProviderBuildItem.allProvidersFromClassPath(OASFactoryResolver.class.getName()));
     }
 
+    @BuildStep
+    void runtimeOnly(BuildProducer<RunTimeConfigBuilderBuildItem> runTimeConfigBuilder) {
+        // To map from smallrye and mp config to quarkus
+        runTimeConfigBuilder.produce(new RunTimeConfigBuilderBuildItem(RuntimeOnlyBuilder.class.getName()));
+    }
+
     @BuildStep
     void configFiles(BuildProducer<HotDeploymentWatchedFileBuildItem> watchedFiles,
             SmallRyeOpenApiConfig openApiConfig,
@@ -1113,4 +1121,11 @@ private OASFilter filter(OpenApiConfig openApiConfig) {
         return OpenApiProcessor.getFilter(openApiConfig,
                 Thread.currentThread().getContextClassLoader());
     }
+
+    public static class RuntimeOnlyBuilder implements ConfigBuilder {
+        @Override
+        public SmallRyeConfigBuilder configBuilder(final SmallRyeConfigBuilder builder) {
+            return builder.withInterceptors(new OpenApiConfigMapping());
+        }
+    }
 }
diff --git a/extensions/smallrye-openapi/deployment/src/main/resources/META-INF/services/io.smallrye.config.ConfigSourceInterceptor b/extensions/smallrye-openapi/deployment/src/main/resources/META-INF/services/io.smallrye.config.ConfigSourceInterceptor
deleted file mode 100644
index aa926ba3f79c03..00000000000000
--- a/extensions/smallrye-openapi/deployment/src/main/resources/META-INF/services/io.smallrye.config.ConfigSourceInterceptor
+++ /dev/null
@@ -1 +0,0 @@
-io.quarkus.smallrye.openapi.deployment.OpenApiConfigMapping
diff --git a/extensions/smallrye-openapi/deployment/src/main/java/io/quarkus/smallrye/openapi/deployment/OpenApiConfigMapping.java b/extensions/smallrye-openapi/runtime/src/main/java/io/quarkus/smallrye/openapi/runtime/OpenApiConfigMapping.java
similarity index 99%
rename from extensions/smallrye-openapi/deployment/src/main/java/io/quarkus/smallrye/openapi/deployment/OpenApiConfigMapping.java
rename to extensions/smallrye-openapi/runtime/src/main/java/io/quarkus/smallrye/openapi/runtime/OpenApiConfigMapping.java
index d25441c5cd6114..cc788f25f18ec3 100644
--- a/extensions/smallrye-openapi/deployment/src/main/java/io/quarkus/smallrye/openapi/deployment/OpenApiConfigMapping.java
+++ b/extensions/smallrye-openapi/runtime/src/main/java/io/quarkus/smallrye/openapi/runtime/OpenApiConfigMapping.java
@@ -1,4 +1,4 @@
-package io.quarkus.smallrye.openapi.deployment;
+package io.quarkus.smallrye.openapi.runtime;
 
 import java.util.Collections;
 import java.util.HashMap;
diff --git a/extensions/smallrye-openapi/runtime/src/main/java/io/quarkus/smallrye/openapi/runtime/OpenApiDocumentService.java b/extensions/smallrye-openapi/runtime/src/main/java/io/quarkus/smallrye/openapi/runtime/OpenApiDocumentService.java
index 203c05353a85af..7b107646d0c33c 100644
--- a/extensions/smallrye-openapi/runtime/src/main/java/io/quarkus/smallrye/openapi/runtime/OpenApiDocumentService.java
+++ b/extensions/smallrye-openapi/runtime/src/main/java/io/quarkus/smallrye/openapi/runtime/OpenApiDocumentService.java
@@ -5,11 +5,13 @@
 import java.nio.charset.StandardCharsets;
 
 import javax.enterprise.context.ApplicationScoped;
+import javax.enterprise.event.Observes;
 
 import org.eclipse.microprofile.config.Config;
 import org.eclipse.microprofile.openapi.OASFilter;
 import org.eclipse.microprofile.openapi.models.OpenAPI;
 
+import io.quarkus.runtime.ShutdownEvent;
 import io.smallrye.openapi.api.OpenApiConfig;
 import io.smallrye.openapi.api.OpenApiConfigImpl;
 import io.smallrye.openapi.api.OpenApiDocument;
@@ -24,13 +26,16 @@
 @ApplicationScoped
 public class OpenApiDocumentService implements OpenApiDocumentHolder {
 
+    private static final String OPENAPI_SERVERS = "mp.openapi.servers";
     private final OpenApiDocumentHolder documentHolder;
+    private final String previousOpenApiServersSystemPropertyValue;
 
     public OpenApiDocumentService(OASFilter autoSecurityFilter, Config config) {
 
         String servers = config.getOptionalValue("quarkus.smallrye-openapi.servers", String.class).orElse(null);
+        this.previousOpenApiServersSystemPropertyValue = System.getProperty(OPENAPI_SERVERS);
         if (servers != null && !servers.isEmpty()) {
-            System.setProperty("mp.openapi.servers", servers);
+            System.setProperty(OPENAPI_SERVERS, servers);
         }
 
         if (config.getOptionalValue("quarkus.smallrye-openapi.always-run-filter", Boolean.class).orElse(Boolean.FALSE)) {
@@ -40,6 +45,17 @@ public OpenApiDocumentService(OASFilter autoSecurityFilter, Config config) {
         }
     }
 
+    void reset(@Observes ShutdownEvent event) {
+        // Reset the value of the System property "mp.openapi.servers" to prevent side effects on tests since
+        // the value of System property "mp.openapi.servers" takes precedence over the value of
+        // "quarkus.smallrye-openapi.servers" due to the configuration mapping
+        if (previousOpenApiServersSystemPropertyValue == null) {
+            System.clearProperty(OPENAPI_SERVERS);
+        } else {
+            System.setProperty(OPENAPI_SERVERS, previousOpenApiServersSystemPropertyValue);
+        }
+    }
+
     public byte[] getJsonDocument() {
         return this.documentHolder.getJsonDocument();
     }