diff --git a/extensions/resteasy-reactive/rest-jackson/deployment/src/main/java/io/quarkus/resteasy/reactive/jackson/deployment/processor/ResteasyReactiveJacksonProcessor.java b/extensions/resteasy-reactive/rest-jackson/deployment/src/main/java/io/quarkus/resteasy/reactive/jackson/deployment/processor/ResteasyReactiveJacksonProcessor.java
index 9fa08c45b54d2..8debcec04ede8 100644
--- a/extensions/resteasy-reactive/rest-jackson/deployment/src/main/java/io/quarkus/resteasy/reactive/jackson/deployment/processor/ResteasyReactiveJacksonProcessor.java
+++ b/extensions/resteasy-reactive/rest-jackson/deployment/src/main/java/io/quarkus/resteasy/reactive/jackson/deployment/processor/ResteasyReactiveJacksonProcessor.java
@@ -72,7 +72,6 @@
 import io.quarkus.resteasy.reactive.jackson.EnableSecureSerialization;
 import io.quarkus.resteasy.reactive.jackson.SecureField;
 import io.quarkus.resteasy.reactive.jackson.runtime.ResteasyReactiveServerJacksonRecorder;
-import io.quarkus.resteasy.reactive.jackson.runtime.mappers.DefaultMismatchedInputException;
 import io.quarkus.resteasy.reactive.jackson.runtime.mappers.NativeInvalidDefinitionExceptionMapper;
 import io.quarkus.resteasy.reactive.jackson.runtime.security.RolesAllowedConfigExpStorage;
 import io.quarkus.resteasy.reactive.jackson.runtime.security.SecurityCustomSerialization;
@@ -108,6 +107,7 @@ public class ResteasyReactiveJacksonProcessor {
     private static final String[] EMPTY_STRING_ARRAY = new String[0];
     private static final List<String> HANDLED_MEDIA_TYPES = List.of(MediaType.APPLICATION_JSON, APPLICATION_NDJSON,
             APPLICATION_STREAM_JSON);
+    public static final String DEFAULT_MISMATCHED_INPUT_EXCEPTION = "io.quarkus.resteasy.reactive.jackson.runtime.mappers.DefaultMismatchedInputException";
 
     @BuildStep
     void feature(BuildProducer<FeatureBuildItem> feature) {
@@ -130,9 +130,16 @@ ReinitializeVertxJsonBuildItem vertxJson() {
     }
 
     @BuildStep
-    ExceptionMapperBuildItem exceptionMappers() {
-        return new ExceptionMapperBuildItem(DefaultMismatchedInputException.class.getName(),
-                MismatchedInputException.class.getName(), Priorities.USER + 100, false);
+    void exceptionMappers(BuildProducer<ExceptionMapperBuildItem> producer) {
+        try {
+            Thread.currentThread().getContextClassLoader().loadClass(DEFAULT_MISMATCHED_INPUT_EXCEPTION);
+        } catch (NoClassDefFoundError | ClassNotFoundException e) {
+            // the class is not available, likely due to quarkus.class-loading.removed-resources."io.quarkus\:quarkus-rest-jackson"=io/quarkus/resteasy/reactive/jackson/runtime/mappers/DefaultMismatchedInputException.class
+            return;
+        }
+
+        producer.produce(new ExceptionMapperBuildItem(DEFAULT_MISMATCHED_INPUT_EXCEPTION,
+                MismatchedInputException.class.getName(), Priorities.USER + 100, false));
     }
 
     @BuildStep
diff --git a/extensions/resteasy-reactive/rest-jackson/deployment/src/test/java/io/quarkus/resteasy/reactive/jackson/deployment/test/ExceptionInReaderWithExcludedBuiltInAndIncludedCustomMapperTest.java b/extensions/resteasy-reactive/rest-jackson/deployment/src/test/java/io/quarkus/resteasy/reactive/jackson/deployment/test/ExceptionInReaderWithExcludedBuiltInAndIncludedCustomMapperTest.java
new file mode 100644
index 0000000000000..e0ca92a987963
--- /dev/null
+++ b/extensions/resteasy-reactive/rest-jackson/deployment/src/test/java/io/quarkus/resteasy/reactive/jackson/deployment/test/ExceptionInReaderWithExcludedBuiltInAndIncludedCustomMapperTest.java
@@ -0,0 +1,46 @@
+package io.quarkus.resteasy.reactive.jackson.deployment.test;
+
+import java.util.function.Supplier;
+
+import jakarta.ws.rs.core.Response;
+import jakarta.ws.rs.ext.ExceptionMapper;
+import jakarta.ws.rs.ext.Provider;
+
+import org.jboss.shrinkwrap.api.ShrinkWrap;
+import org.jboss.shrinkwrap.api.spec.JavaArchive;
+import org.junit.jupiter.api.Test;
+import org.junit.jupiter.api.extension.RegisterExtension;
+
+import com.fasterxml.jackson.databind.DatabindException;
+
+import io.quarkus.test.QuarkusUnitTest;
+import io.restassured.RestAssured;
+
+public class ExceptionInReaderWithExcludedBuiltInAndIncludedCustomMapperTest {
+
+    @RegisterExtension
+    static QuarkusUnitTest test = new QuarkusUnitTest()
+            .setArchiveProducer(new Supplier<>() {
+                @Override
+                public JavaArchive get() {
+                    return ShrinkWrap.create(JavaArchive.class)
+                            .addClasses(FroMage.class, FroMageEndpoint.class, DatabindExceptionMapper.class);
+                }
+            }).overrideConfigKey("quarkus.class-loading.removed-resources.\"io.quarkus\\:quarkus-rest-jackson\"",
+                    "io/quarkus/resteasy/reactive/jackson/runtime/mappers/DefaultMismatchedInputException.class");
+
+    @Test
+    public void test() {
+        RestAssured.with().contentType("application/json").body("{\"name\": \"brie\"}").put("/fromage")
+                .then().statusCode(999);
+    }
+
+    @Provider
+    public static class DatabindExceptionMapper implements ExceptionMapper<DatabindException> {
+
+        @Override
+        public Response toResponse(DatabindException exception) {
+            return Response.status(999).build();
+        }
+    }
+}
diff --git a/extensions/resteasy-reactive/rest-jackson/runtime/src/main/java/io/quarkus/resteasy/reactive/jackson/runtime/mappers/DefaultMismatchedInputException.java b/extensions/resteasy-reactive/rest-jackson/runtime/src/main/java/io/quarkus/resteasy/reactive/jackson/runtime/mappers/DefaultMismatchedInputException.java
index 54783b513b961..151ab715d69c4 100644
--- a/extensions/resteasy-reactive/rest-jackson/runtime/src/main/java/io/quarkus/resteasy/reactive/jackson/runtime/mappers/DefaultMismatchedInputException.java
+++ b/extensions/resteasy-reactive/rest-jackson/runtime/src/main/java/io/quarkus/resteasy/reactive/jackson/runtime/mappers/DefaultMismatchedInputException.java
@@ -10,6 +10,7 @@
 
 import io.quarkus.runtime.LaunchMode;
 
+@SuppressWarnings("unused")
 public class DefaultMismatchedInputException
         implements ExceptionMapper<com.fasterxml.jackson.databind.exc.MismatchedInputException> {