diff --git a/extensions/datasource/deployment/src/main/java/io/quarkus/datasource/deployment/devservices/DevServicesDatasourceProcessor.java b/extensions/datasource/deployment/src/main/java/io/quarkus/datasource/deployment/devservices/DevServicesDatasourceProcessor.java
index b254874043b5d..92f016d6f93b0 100644
--- a/extensions/datasource/deployment/src/main/java/io/quarkus/datasource/deployment/devservices/DevServicesDatasourceProcessor.java
+++ b/extensions/datasource/deployment/src/main/java/io/quarkus/datasource/deployment/devservices/DevServicesDatasourceProcessor.java
@@ -6,6 +6,7 @@
 import java.util.HashMap;
 import java.util.List;
 import java.util.Map;
+import java.util.NoSuchElementException;
 import java.util.Objects;
 import java.util.Optional;
 import java.util.Set;
@@ -51,7 +52,25 @@ public class DevServicesDatasourceProcessor {
 
     // list of devservices properties we should not check for restart
     // see issue #30390
-    private static final Set<String> EXCLUDED_PROPERTIES = Set.of("quarkus.datasource.devservices.enabled");
+    private static final Set<String> EXCLUDED_RESTART_PROPERTIES = Set.of();
+
+    /**
+     * Properties that if modified will trigger a datasource dev service restart
+     */
+    private static final Set<String> RESTART_TRIGGERING_PROPERTIES = Set.of("db-kind",
+            "db-version",
+            "devservices.command",
+            "devservices.container-env.",
+            "devservices.container-properties.",
+            "devservices.db-name",
+            "devservices.image-name",
+            "devservices.init-script-path",
+            "devservices.port",
+            "devservices.properties.",
+            "devservices.reuse",
+            "devservices.volumes.",
+            "password",
+            "username");
 
     static volatile List<RunningDevService> databases;
 
@@ -78,14 +97,10 @@ DevServicesDatasourceResultBuildItem launchDatabases(
         //if not and the DB's have already started we just return
         if (databases != null) {
             boolean restartRequired = false;
-            Map<String, String> newDatasourceConfigs = ConfigProvider.getConfig()
-                    .unwrap(SmallRyeConfig.class)
-                    .getOptionalValues("quarkus.datasource",
-                            String.class, String.class)
-                    .orElse(Map.of());
+            Map<String, String> newDatasourceConfigs = getRestartTriggeringPropertiesValues();
             for (Map.Entry<String, String> entry : cachedProperties.entrySet()) {
                 String newValue = newDatasourceConfigs.get(entry.getKey());
-                if (!Objects.equals(entry.getValue(), trim(newValue))) {
+                if (!Objects.equals(entry.getValue(), newValue)) {
                     restartRequired = true;
                     break;
                 }
@@ -174,17 +189,47 @@ public void run() {
             closeBuildItem.addCloseTask(closeTask, true);
         }
         databases = runningDevServices;
-        cachedProperties = ConfigProvider.getConfig()
-                .unwrap(SmallRyeConfig.class)
-                .getOptionalValues("quarkus.datasource", String.class, String.class)
-                .orElse(Map.of());
+        cachedProperties = getRestartTriggeringPropertiesValues();
         for (RunningDevService database : databases) {
             devServicesResultBuildItemBuildProducer.produce(database.toBuildItem());
         }
         return new DevServicesDatasourceResultBuildItem(results);
     }
 
-    private String trim(String optional) {
+    /**
+     * Returns a map of properties that are can trigger a datasource dev service restart if modified.
+     * It excludes EXCLUDED_PROPERTIES and includes only RESTART_TRIGGERING_PROPERTIES.
+     * If a property ends with {@code .} then it will also trigger a restart on any sub properties change
+     */
+    private static Map<String, String> getRestartTriggeringPropertiesValues() {
+        Map<String, String> datasourceProperties;
+        try {
+            datasourceProperties = ConfigProvider.getConfig()
+                    .unwrap(SmallRyeConfig.class)
+                    .getOptionalValues("quarkus.datasource",
+                            String.class,
+                            String.class)
+                    .orElse(Map.of());
+        } catch (NoSuchElementException e) {
+            log.error("Could not get datasource properties", e);
+            datasourceProperties = Map.of();
+        }
+        Map<String, String> filteredProperties = new HashMap<>();
+        for (var entry : datasourceProperties.entrySet()) {
+            if (!EXCLUDED_RESTART_PROPERTIES.contains(entry.getKey())) {
+                for (String property : RESTART_TRIGGERING_PROPERTIES) {
+                    if (property.endsWith(".") && entry.getKey().contains(property) || entry.getKey()
+                            .endsWith(property)) {
+                        filteredProperties.put(entry.getKey(), trim(entry.getValue()));
+                        break;
+                    }
+                }
+            }
+        }
+        return filteredProperties;
+    }
+
+    private static String trim(String optional) {
         if (optional == null) {
             return null;
         }