diff --git a/integration-tests/main/src/test/java/io/quarkus/it/main/QuarkusTestNestedWithTestProfileTestCase.java b/integration-tests/main/src/test/java/io/quarkus/it/main/QuarkusTestNestedWithTestProfileTestCase.java
new file mode 100644
index 0000000000000..ea34887a78915
--- /dev/null
+++ b/integration-tests/main/src/test/java/io/quarkus/it/main/QuarkusTestNestedWithTestProfileTestCase.java
@@ -0,0 +1,83 @@
+package io.quarkus.it.main;
+
+import static org.hamcrest.Matchers.is;
+
+import java.util.Collections;
+import java.util.Map;
+
+import org.junit.jupiter.api.Assertions;
+import org.junit.jupiter.api.Nested;
+import org.junit.jupiter.api.Tag;
+import org.junit.jupiter.api.Test;
+
+import io.quarkus.test.junit.QuarkusTest;
+import io.quarkus.test.junit.QuarkusTestProfile;
+import io.quarkus.test.junit.TestProfile;
+import io.restassured.RestAssured;
+
+@QuarkusTest
+@Tag("nested")
+@TestProfile(QuarkusTestNestedWithTestProfileTestCase.OuterProfile.class)
+public class QuarkusTestNestedWithTestProfileTestCase {
+
+    private static final int TEST_PORT_FROM_PROFILE = 7777;
+
+    @Nested
+    class NestedCase {
+
+        @Test
+        void testProfileFromNested() {
+            Assertions.assertEquals(TEST_PORT_FROM_PROFILE, RestAssured.port);
+            RestAssured.when()
+                    .get("/greeting/Stu")
+                    .then()
+                    .statusCode(200)
+                    .body(is("OuterProfile Stu"));
+        }
+    }
+
+    @Nested
+    @TestProfile(QuarkusTestNestedWithTestProfileTestCase.ModernEnglishProfile.class)
+    class ModernEnglishCase {
+
+        @Test
+        void testProfileFromNested() {
+            RestAssured.when()
+                    .get("/greeting/Stu")
+                    .then()
+                    .statusCode(200)
+                    .body(is("Hey Stu"));
+        }
+    }
+
+    public static class OuterProfile implements QuarkusTestProfile {
+
+        @Override
+        public Map<String, String> getConfigOverrides() {
+            return Collections.singletonMap("quarkus.http.test-port", "" + TEST_PORT_FROM_PROFILE);
+        }
+
+        @Override
+        public String[] commandLineParameters() {
+            return new String[] { "OuterProfile" };
+        }
+
+        @Override
+        public boolean runMainMethod() {
+            return true;
+        }
+    }
+
+    public static class ModernEnglishProfile implements QuarkusTestProfile {
+
+        @Override
+        public String[] commandLineParameters() {
+            return new String[] { "Hey" };
+        }
+
+        @Override
+        public boolean runMainMethod() {
+            return true;
+        }
+    }
+}
diff --git a/test-framework/junit5/src/main/java/io/quarkus/test/junit/AbstractJvmQuarkusTestExtension.java b/test-framework/junit5/src/main/java/io/quarkus/test/junit/AbstractJvmQuarkusTestExtension.java
index 970242d209c98..3ec62a44e2ea8 100644
--- a/test-framework/junit5/src/main/java/io/quarkus/test/junit/AbstractJvmQuarkusTestExtension.java
+++ b/test-framework/junit5/src/main/java/io/quarkus/test/junit/AbstractJvmQuarkusTestExtension.java
@@ -184,12 +184,17 @@ protected PrepareResult createAugmentor(ExtensionContext context, Class<? extend
     }
 
     protected Class<? extends QuarkusTestProfile> getQuarkusTestProfile(ExtensionContext extensionContext) {
-        TestProfile annotation = extensionContext.getRequiredTestClass().getAnnotation(TestProfile.class);
-        Class<? extends QuarkusTestProfile> selectedProfile = null;
-        if (annotation != null) {
-            selectedProfile = annotation.value();
+        Class<?> testClass = extensionContext.getRequiredTestClass();
+        while (testClass != null) {
+            TestProfile annotation = testClass.getAnnotation(TestProfile.class);
+            if (annotation != null) {
+                return annotation.value();
+            }
+
+            testClass = testClass.getEnclosingClass();
         }
-        return selectedProfile;
+
+        return null;
     }
 
     protected static boolean hasPerTestResources(ExtensionContext extensionContext) {