diff --git a/extensions/jaxb/deployment/src/main/java/io/quarkus/jaxb/deployment/FilteredJaxbClassesToBeBoundBuildItem.java b/extensions/jaxb/deployment/src/main/java/io/quarkus/jaxb/deployment/FilteredJaxbClassesToBeBoundBuildItem.java
index 347e3cf661c6b..10e84bd9f104d 100644
--- a/extensions/jaxb/deployment/src/main/java/io/quarkus/jaxb/deployment/FilteredJaxbClassesToBeBoundBuildItem.java
+++ b/extensions/jaxb/deployment/src/main/java/io/quarkus/jaxb/deployment/FilteredJaxbClassesToBeBoundBuildItem.java
@@ -5,6 +5,7 @@
 import java.util.LinkedHashSet;
 import java.util.List;
 import java.util.Set;
+import java.util.function.Predicate;
 import java.util.stream.Collectors;
 
 import io.quarkus.builder.item.SimpleBuildItem;
@@ -33,11 +34,20 @@ public List<Class<?>> getClasses() {
 
     public static class Builder {
         private final Set<String> classNames = new LinkedHashSet<>();
-        private final Set<String> classNameExcludes = new LinkedHashSet<>();
+        private final Set<Predicate<String>> classNamePredicateExcludes = new LinkedHashSet<>();
 
         public Builder classNameExcludes(Collection<String> classNameExcludes) {
-            for (String className : classNameExcludes) {
-                this.classNameExcludes.add(className);
+            final String packMatch = ".*";
+
+            for (String classNameExclude : classNameExcludes) {
+                if (classNameExclude.endsWith(packMatch)) {
+                    // Package ends with ".*"
+                    final String packageName = classNameExclude.substring(0, classNameExclude.length() - packMatch.length());
+                    this.classNamePredicateExcludes.add((className) -> className.startsWith(packageName));
+                } else {
+                    // Standard class name
+                    this.classNamePredicateExcludes.add(classNameExclude::equals);
+                }
             }
             return this;
         }
@@ -51,7 +61,7 @@ public Builder classNames(Collection<String> classNames) {
 
         public FilteredJaxbClassesToBeBoundBuildItem build() {
             final List<Class<?>> classes = classNames.stream()
-                    .filter(className -> !this.classNameExcludes.contains(className))
+                    .filter(className -> this.classNamePredicateExcludes.stream().noneMatch(p -> p.test(className)))
                     .map(FilteredJaxbClassesToBeBoundBuildItem::getClassByName)
                     .filter(JaxbType::isValidType)
                     .collect(Collectors.toList());
diff --git a/extensions/jaxb/deployment/src/test/java/io/quarkus/jaxb/deployment/AbstractJaxbContextTest.java b/extensions/jaxb/deployment/src/test/java/io/quarkus/jaxb/deployment/AbstractJaxbContextTest.java
new file mode 100644
index 0000000000000..4e42f478435df
--- /dev/null
+++ b/extensions/jaxb/deployment/src/test/java/io/quarkus/jaxb/deployment/AbstractJaxbContextTest.java
@@ -0,0 +1,58 @@
+package io.quarkus.jaxb.deployment;
+
+import static org.assertj.core.api.Assertions.assertThat;
+
+import java.io.StringWriter;
+
+import jakarta.enterprise.context.control.ActivateRequestContext;
+import jakarta.inject.Inject;
+import jakarta.xml.bind.JAXBContext;
+import jakarta.xml.bind.JAXBException;
+import jakarta.xml.bind.Marshaller;
+import jakarta.xml.bind.Unmarshaller;
+
+import org.assertj.core.api.Assertions;
+import org.junit.jupiter.api.Test;
+
+public abstract class AbstractJaxbContextTest {
+
+    @Inject
+    JAXBContext jaxbContext;
+
+    @Inject
+    Marshaller marshaller;
+
+    @Inject
+    Unmarshaller unmarshaller;
+
+    @Test
+    @ActivateRequestContext
+    public void shouldInjectJaxbBeans() {
+        assertThat(jaxbContext).isNotNull();
+        assertThat(marshaller).isNotNull();
+        assertThat(unmarshaller).isNotNull();
+    }
+
+    @Test
+    @ActivateRequestContext
+    public void marshalModelOne() throws JAXBException {
+        io.quarkus.jaxb.deployment.one.Model model = new io.quarkus.jaxb.deployment.one.Model();
+        model.setName1("name1");
+
+        StringWriter sw = new StringWriter();
+        marshaller.marshal(model, sw);
+
+        assertThat(sw.toString()).isEqualTo("<?xml version=\"1.0\" encoding=\"UTF-8\" standalone=\"yes\"?>"
+                + "<model><name1>name1</name1></model>");
+    }
+
+    @Test
+    @ActivateRequestContext
+    public void marshalModelTwo() throws JAXBException {
+        io.quarkus.jaxb.deployment.two.Model model = new io.quarkus.jaxb.deployment.two.Model();
+        model.setName2("name2");
+        Assertions.assertThatExceptionOfType(JAXBException.class)
+                .isThrownBy(() -> marshaller.marshal(model, new StringWriter()))
+                .withMessage("class io.quarkus.jaxb.deployment.two.Model nor any of its super class is known to this context.");
+    }
+}
diff --git a/extensions/jaxb/deployment/src/test/java/io/quarkus/jaxb/deployment/ClassExcludeTest.java b/extensions/jaxb/deployment/src/test/java/io/quarkus/jaxb/deployment/ClassExcludeTest.java
new file mode 100644
index 0000000000000..f6859cccfec74
--- /dev/null
+++ b/extensions/jaxb/deployment/src/test/java/io/quarkus/jaxb/deployment/ClassExcludeTest.java
@@ -0,0 +1,17 @@
+package io.quarkus.jaxb.deployment;
+
+import org.junit.jupiter.api.extension.RegisterExtension;
+
+import io.quarkus.test.QuarkusUnitTest;
+
+public class ClassExcludeTest extends AbstractJaxbContextTest {
+
+    @RegisterExtension
+    static final QuarkusUnitTest config = new QuarkusUnitTest()
+            .withApplicationRoot((jar) -> jar
+                    .addClasses(
+                            io.quarkus.jaxb.deployment.one.Model.class,
+                            io.quarkus.jaxb.deployment.two.Model.class)
+                    .addPackage("io.quarkus.jaxb.deployment.info"))
+            .overrideConfigKey("quarkus.jaxb.exclude-classes", "io.quarkus.jaxb.deployment.two.Model");
+}
diff --git a/extensions/jaxb/deployment/src/test/java/io/quarkus/jaxb/deployment/PackageExcludeTest.java b/extensions/jaxb/deployment/src/test/java/io/quarkus/jaxb/deployment/PackageExcludeTest.java
new file mode 100644
index 0000000000000..b531ce48f6d45
--- /dev/null
+++ b/extensions/jaxb/deployment/src/test/java/io/quarkus/jaxb/deployment/PackageExcludeTest.java
@@ -0,0 +1,17 @@
+package io.quarkus.jaxb.deployment;
+
+import org.junit.jupiter.api.extension.RegisterExtension;
+
+import io.quarkus.test.QuarkusUnitTest;
+
+public class PackageExcludeTest extends AbstractJaxbContextTest {
+
+    @RegisterExtension
+    static final QuarkusUnitTest config = new QuarkusUnitTest()
+            .withApplicationRoot((jar) -> jar
+                    .addClasses(
+                            io.quarkus.jaxb.deployment.one.Model.class,
+                            io.quarkus.jaxb.deployment.two.Model.class)
+                    .addPackage("io.quarkus.jaxb.deployment.info"))
+            .overrideConfigKey("quarkus.jaxb.exclude-classes", "io.quarkus.jaxb.deployment.two.*");
+}
diff --git a/extensions/jaxb/runtime/src/main/java/io/quarkus/jaxb/runtime/JaxbConfig.java b/extensions/jaxb/runtime/src/main/java/io/quarkus/jaxb/runtime/JaxbConfig.java
index 2c48016a10824..bd2a0114e49e6 100644
--- a/extensions/jaxb/runtime/src/main/java/io/quarkus/jaxb/runtime/JaxbConfig.java
+++ b/extensions/jaxb/runtime/src/main/java/io/quarkus/jaxb/runtime/JaxbConfig.java
@@ -18,6 +18,8 @@ public class JaxbConfig {
 
     /**
      * Exclude classes to automatically be bound to the default JAXB context.
+     * Values with suffix {@code .*}, i.e. {@code org.acme.*}, are considered packages and exclude all classes that are members
+     * of these packages
      */
     @ConfigItem
     public Optional<List<String>> excludeClasses;