diff --git a/extensions/grpc-common/deployment/src/main/java/io/quarkus/grpc/common/deployment/GrpcCommonProcessor.java b/extensions/grpc-common/deployment/src/main/java/io/quarkus/grpc/common/deployment/GrpcCommonProcessor.java
index 477ad5690a4a6..82d43e7c7919f 100644
--- a/extensions/grpc-common/deployment/src/main/java/io/quarkus/grpc/common/deployment/GrpcCommonProcessor.java
+++ b/extensions/grpc-common/deployment/src/main/java/io/quarkus/grpc/common/deployment/GrpcCommonProcessor.java
@@ -75,7 +75,8 @@ NativeImageConfigBuildItem nativeImageConfiguration() {
                 .addRuntimeInitializedClass("io.grpc.netty.Utils")
                 .addRuntimeInitializedClass("io.grpc.netty.NettyServerBuilder")
                 .addRuntimeInitializedClass("io.grpc.netty.NettyChannelBuilder")
-                .addRuntimeInitializedClass("io.grpc.internal.RetriableStream");
+                .addRuntimeInitializedClass("io.grpc.internal.RetriableStream")
+                .addRuntimeReinitializedClass("com.google.protobuf.UnsafeUtil");
         return builder.build();
     }
 
diff --git a/extensions/grpc-common/runtime/pom.xml b/extensions/grpc-common/runtime/pom.xml
index 540731e0cc3b0..6f988e789e581 100644
--- a/extensions/grpc-common/runtime/pom.xml
+++ b/extensions/grpc-common/runtime/pom.xml
@@ -99,9 +99,28 @@
             <groupId>io.quarkus</groupId>
             <artifactId>quarkus-vertx</artifactId>
         </dependency>
+        <dependency>
+            <groupId>io.grpc</groupId>
+            <artifactId>grpc-core</artifactId>
+            <exclusions>
+                <exclusion>
+                    <groupId>com.google.code.findbugs</groupId>
+                    <artifactId>jsr305</artifactId>
+                </exclusion>
+                <exclusion>
+                    <groupId>org.codehaus.mojo</groupId>
+                    <artifactId>animal-sniffer-annotations</artifactId>
+                </exclusion>
+                <exclusion>
+                    <groupId>com.google.android</groupId>
+                    <artifactId>annotations</artifactId>
+                </exclusion>
+            </exclusions>
+        </dependency>
         <dependency>
             <groupId>org.graalvm.nativeimage</groupId>
             <artifactId>svm</artifactId>
+            <scope>provided</scope>
         </dependency>
     </dependencies>
 
diff --git a/extensions/grpc-common/runtime/src/main/java/io/quarkus/grpc/common/runtime/graal/GrpcSubstitutions.java b/extensions/grpc-common/runtime/src/main/java/io/quarkus/grpc/common/runtime/graal/GrpcSubstitutions.java
index 349eb09e264b8..1cdaed9d44fc5 100644
--- a/extensions/grpc-common/runtime/src/main/java/io/quarkus/grpc/common/runtime/graal/GrpcSubstitutions.java
+++ b/extensions/grpc-common/runtime/src/main/java/io/quarkus/grpc/common/runtime/graal/GrpcSubstitutions.java
@@ -2,6 +2,7 @@
 
 import static io.grpc.InternalServiceProviders.getCandidatesViaHardCoded;
 
+import java.lang.reflect.Field;
 import java.util.ArrayList;
 import java.util.Collections;
 import java.util.Comparator;
@@ -12,6 +13,8 @@
 import com.oracle.svm.core.annotate.Substitute;
 import com.oracle.svm.core.annotate.TargetClass;
 
+import sun.misc.Unsafe;
+
 @SuppressWarnings("unused")
 @TargetClass(className = "io.grpc.ServiceProviders")
 final class Target_io_grpc_ServiceProviders { // NOSONAR
@@ -79,6 +82,20 @@ interface Target_io_grpc_ServiceProviders_PriorityAccessor<T> { // NOSONAR
     int getPriority(T provider);
 }
 
+@TargetClass(className = "com.google.protobuf.UnsafeUtil")
+final class Target_com_google_protobuf_UnsafeUtil {
+    @Substitute
+    static sun.misc.Unsafe getUnsafe() {
+        try {
+            Field theUnsafe = Unsafe.class.getDeclaredField("theUnsafe");
+            theUnsafe.setAccessible(true);
+            return (Unsafe) theUnsafe.get(null);
+        } catch (Exception e) {
+            throw new RuntimeException(e);
+        }
+    }
+}
+
 @SuppressWarnings("unused")
 class GrpcSubstitutions {
 }