diff --git a/misc/build_wheel.py b/misc/build_wheel.py
new file mode 100644
index 000000000000..13633405bf77
--- /dev/null
+++ b/misc/build_wheel.py
@@ -0,0 +1,131 @@
+"""Script to build compiled binary wheels that can be uploaded to PyPI.
+
+The main GitHub workflow where this script is used:
+https://github.com/mypyc/mypy_mypyc-wheels/blob/master/.github/workflows/build.yml
+
+This uses cibuildwheel (https://github.com/joerick/cibuildwheel) to
+build the wheels.
+
+Usage:
+
+  build_wheel_ci.py --python-version <python-version> \
+                    --output-dir <dir>
+
+Wheels for the given Python version will be created in the given directory.
+Python version is in form "39".
+
+This works on macOS, Windows and Linux.
+
+You can test locally by using --extra-opts. macOS example:
+
+  mypy/misc/build_wheel_ci.py --python-version 39 --output-dir out --extra-opts="--platform macos"
+
+Other supported values for platform: linux, windows
+"""
+
+import argparse
+import os
+import subprocess
+import sys
+from typing import Dict
+
+# Clang package we use on Linux
+LLVM_URL = 'https://github.com/mypyc/mypy_mypyc-wheels/releases/download/llvm/llvm-centos-5.tar.gz'
+
+# Mypy repository root
+ROOT_DIR = os.path.dirname(os.path.dirname(__file__))
+
+
+def create_environ(python_version: str) -> Dict[str, str]:
+    """Set up environment variables for cibuildwheel."""
+    env = os.environ.copy()
+
+    env['CIBW_BUILD'] = "cp{}-*".format(python_version)
+
+    # Don't build 32-bit wheels
+    env['CIBW_SKIP'] = "*-manylinux_i686 *-win32"
+
+    env['CIBW_BUILD_VERBOSITY'] = '1'
+
+    # mypy's isolated builds don't specify the requirements mypyc needs, so install
+    # requirements and don't use isolated builds. we need to use build-requirements.txt
+    # with recent mypy commits to get stub packages needed for compilation.
+    #
+    # TODO: remove use of mypy-requirements.txt once we no longer need to support
+    #       building pre modular typeshed releases
+    env['CIBW_BEFORE_BUILD'] = """
+      pip install -r {package}/mypy-requirements.txt &&
+      (pip install -r {package}/build-requirements.txt || true)
+    """.replace('\n', ' ')
+
+    # download a copy of clang to use to compile on linux. this was probably built in 2018,
+    # speeds up compilation 2x
+    env['CIBW_BEFORE_BUILD_LINUX'] = """
+      (cd / && curl -L %s | tar xzf -) &&
+      pip install -r {package}/mypy-requirements.txt &&
+      (pip install -r {package}/build-requirements.txt || true)
+    """.replace('\n', ' ') % LLVM_URL
+
+    # the double negative is counterintuitive, https://github.com/pypa/pip/issues/5735
+    env['CIBW_ENVIRONMENT'] = 'MYPY_USE_MYPYC=1 MYPYC_OPT_LEVEL=3 PIP_NO_BUILD_ISOLATION=no'
+    env['CIBW_ENVIRONMENT_LINUX'] = (
+        'MYPY_USE_MYPYC=1 MYPYC_OPT_LEVEL=3 PIP_NO_BUILD_ISOLATION=no ' +
+        'CC=/opt/llvm/bin/clang'
+    )
+    env['CIBW_ENVIRONMENT_WINDOWS'] = (
+        'MYPY_USE_MYPYC=1 MYPYC_OPT_LEVEL=2 PIP_NO_BUILD_ISOLATION=no'
+    )
+
+    # lxml is slow to build wheels for new releases, so allow installing reqs to fail
+    # if we failed to install lxml, we'll skip tests, but allow the build to succeed
+    env['CIBW_BEFORE_TEST'] = (
+        'pip install -r {project}/mypy/test-requirements.txt || true'
+    )
+
+    # pytest looks for configuration files in the parent directories of where the tests live.
+    # since we are trying to run the tests from their installed location, we copy those into
+    # the venv. Ew ew ew.
+    env['CIBW_TEST_COMMAND'] = """
+      ( ! pip list | grep lxml ) || (
+      DIR=$(python -c 'import mypy, os; dn = os.path.dirname; print(dn(dn(mypy.__path__[0])))')
+      && TEST_DIR=$(python -c 'import mypy.test; print(mypy.test.__path__[0])')
+      && cp '{project}/mypy/pytest.ini' '{project}/mypy/conftest.py' $DIR
+      && MYPY_TEST_PREFIX='{project}/mypy' pytest $TEST_DIR
+      )
+    """.replace('\n', ' ')
+
+    # i ran into some flaky tests on windows, so only run testcheck. it looks like we
+    # previously didn't run any tests on windows wheels, so this is a net win.
+    env['CIBW_TEST_COMMAND_WINDOWS'] = """
+      bash -c "
+      ( ! pip list | grep lxml ) || (
+      DIR=$(python -c 'import mypy, os; dn = os.path.dirname; print(dn(dn(mypy.__path__[0])))')
+      && TEST_DIR=$(python -c 'import mypy.test; print(mypy.test.__path__[0])')
+      && cp '{project}/mypy/pytest.ini' '{project}/mypy/conftest.py' $DIR
+      && MYPY_TEST_PREFIX='{project}/mypy' pytest $TEST_DIR/testcheck.py
+      )
+      "
+    """.replace('\n', ' ')
+    return env
+
+
+def main() -> None:
+    parser = argparse.ArgumentParser()
+    parser.add_argument('--python-version', required=True, metavar='XY',
+                        help='Python version (e.g. 38 or 39)')
+    parser.add_argument('--output-dir', required=True, metavar='DIR',
+                        help='Output directory for created wheels')
+    parser.add_argument('--extra-opts', default='', metavar='OPTIONS',
+                        help='Extra options passed to cibuildwheel verbatim')
+    args = parser.parse_args()
+    python_version = args.python_version
+    output_dir = args.output_dir
+    extra_opts = args.extra_opts
+    environ = create_environ(python_version)
+    script = 'python -m cibuildwheel {} --output-dir {} {}'.format(extra_opts, output_dir,
+                                                                   ROOT_DIR)
+    subprocess.check_call(script, shell=True, env=environ)
+
+
+if __name__ == '__main__':
+    main()