diff --git a/Lib/test/test_peg_generator/test_c_parser.py b/Lib/test/test_peg_generator/test_c_parser.py
index 0dffedca789c57..67bb8512118e3a 100644
--- a/Lib/test/test_peg_generator/test_c_parser.py
+++ b/Lib/test/test_peg_generator/test_c_parser.py
@@ -1,3 +1,4 @@
+import sysconfig
 import textwrap
 import unittest
 from distutils.tests.support import TempdirManager
@@ -8,6 +9,11 @@
 from test.support import os_helper
 from test.support.script_helper import assert_python_ok
 
+_py_cflags_nodist = sysconfig.get_config_var('PY_CFLAGS_NODIST')
+_pgo_flag = sysconfig.get_config_var('PGO_PROF_USE_FLAG')
+if _pgo_flag and _py_cflags_nodist and _pgo_flag in _py_cflags_nodist:
+    raise unittest.SkipTest("peg_generator test disabled under PGO build")
+
 test_tools.skip_if_missing("peg_generator")
 with test_tools.imports_under_tool("peg_generator"):
     from pegen.grammar_parser import GeneratedParser as GrammarParser