diff --git a/pytest_django/plugin.py b/pytest_django/plugin.py
index 4c403da9e..3f499715b 100644
--- a/pytest_django/plugin.py
+++ b/pytest_django/plugin.py
@@ -263,9 +263,10 @@ def pytest_configure():
 def _classmethod_is_defined_at_leaf(cls, method_name):
     super_method = None
 
-    for base_cls in cls.__bases__:
+    for base_cls in cls.__mro__[1:]:  # pragma: no branch
         if hasattr(base_cls, method_name):
             super_method = getattr(base_cls, method_name)
+            break
 
     assert super_method is not None, (
         '%s could not be found in base class' % method_name)
diff --git a/tests/test_unittest.py b/tests/test_unittest.py
index d4ecbc381..98699ab80 100644
--- a/tests/test_unittest.py
+++ b/tests/test_unittest.py
@@ -176,6 +176,34 @@ def test_bar21(self):
         ])
         assert result.ret == 0
 
+    def test_setUpClass_mixin(self, django_testdir):
+        django_testdir.create_test_module('''
+            from django.test import TestCase
+
+            class TheMixin(object):
+                @classmethod
+                def setUpClass(cls):
+                    super(TheMixin, cls).setUpClass()
+
+
+            class TestFoo(TheMixin, TestCase):
+                def test_foo(self):
+                    pass
+
+
+            class TestBar(TheMixin, TestCase):
+                def test_bar(self):
+                    pass
+        ''')
+
+        result = django_testdir.runpytest_subprocess('-v', '-s', '--pdb')
+        result.stdout.fnmatch_lines([
+            "*TestFoo::test_foo Creating test database for*",
+            "PASSED",
+            "*TestBar::test_bar PASSED*",
+        ])
+        assert result.ret == 0
+
     def test_setUpClass_skip(self, django_testdir):
         django_testdir.create_test_module('''
             from django.test import TestCase