diff --git a/.pre-commit-config.yaml b/.pre-commit-config.yaml
index c199640e2..247a7357c 100644
--- a/.pre-commit-config.yaml
+++ b/.pre-commit-config.yaml
@@ -1,6 +1,6 @@
 repos:
 - repo: https://github.com/pre-commit/pre-commit-hooks
-  rev: v3.1.0
+  rev: v3.2.0
   hooks:
   - id: check-ast
   - id: check-builtin-literals
@@ -25,7 +25,7 @@ repos:
   - id: seed-isort-config
     args: [--application-directories, '.:src']
 - repo: https://github.com/pre-commit/mirrors-isort
-  rev: v5.2.0
+  rev: v5.2.2
   hooks:
   - id: isort
 - repo: https://github.com/ambv/black
diff --git a/docs/changelog/1915.bugfix.rst b/docs/changelog/1915.bugfix.rst
new file mode 100644
index 000000000..eb537b13a
--- /dev/null
+++ b/docs/changelog/1915.bugfix.rst
@@ -0,0 +1 @@
+Upgrade pip to ``20.2.1`` and setuptools to ``49.2.1`` - by :user:`gaborbernat`.
diff --git a/src/virtualenv/seed/wheels/embed/__init__.py b/src/virtualenv/seed/wheels/embed/__init__.py
index fcdfa19f3..a65c7eab7 100644
--- a/src/virtualenv/seed/wheels/embed/__init__.py
+++ b/src/virtualenv/seed/wheels/embed/__init__.py
@@ -6,33 +6,33 @@
 BUNDLE_FOLDER = Path(__file__).absolute().parent
 BUNDLE_SUPPORT = {
     "3.10": {
-        "pip": "pip-20.2-py2.py3-none-any.whl",
-        "setuptools": "setuptools-49.2.0-py3-none-any.whl",
+        "pip": "pip-20.2.1-py2.py3-none-any.whl",
+        "setuptools": "setuptools-49.2.1-py3-none-any.whl",
         "wheel": "wheel-0.34.2-py2.py3-none-any.whl",
     },
     "3.9": {
-        "pip": "pip-20.2-py2.py3-none-any.whl",
-        "setuptools": "setuptools-49.2.0-py3-none-any.whl",
+        "pip": "pip-20.2.1-py2.py3-none-any.whl",
+        "setuptools": "setuptools-49.2.1-py3-none-any.whl",
         "wheel": "wheel-0.34.2-py2.py3-none-any.whl",
     },
     "3.8": {
-        "pip": "pip-20.2-py2.py3-none-any.whl",
-        "setuptools": "setuptools-49.2.0-py3-none-any.whl",
+        "pip": "pip-20.2.1-py2.py3-none-any.whl",
+        "setuptools": "setuptools-49.2.1-py3-none-any.whl",
         "wheel": "wheel-0.34.2-py2.py3-none-any.whl",
     },
     "3.7": {
-        "pip": "pip-20.2-py2.py3-none-any.whl",
-        "setuptools": "setuptools-49.2.0-py3-none-any.whl",
+        "pip": "pip-20.2.1-py2.py3-none-any.whl",
+        "setuptools": "setuptools-49.2.1-py3-none-any.whl",
         "wheel": "wheel-0.34.2-py2.py3-none-any.whl",
     },
     "3.6": {
-        "pip": "pip-20.2-py2.py3-none-any.whl",
-        "setuptools": "setuptools-49.2.0-py3-none-any.whl",
+        "pip": "pip-20.2.1-py2.py3-none-any.whl",
+        "setuptools": "setuptools-49.2.1-py3-none-any.whl",
         "wheel": "wheel-0.34.2-py2.py3-none-any.whl",
     },
     "3.5": {
-        "pip": "pip-20.2-py2.py3-none-any.whl",
-        "setuptools": "setuptools-49.2.0-py3-none-any.whl",
+        "pip": "pip-20.2.1-py2.py3-none-any.whl",
+        "setuptools": "setuptools-49.2.1-py3-none-any.whl",
         "wheel": "wheel-0.34.2-py2.py3-none-any.whl",
     },
     "3.4": {
@@ -41,7 +41,7 @@
         "wheel": "wheel-0.33.6-py2.py3-none-any.whl",
     },
     "2.7": {
-        "pip": "pip-20.2-py2.py3-none-any.whl",
+        "pip": "pip-20.2.1-py2.py3-none-any.whl",
         "setuptools": "setuptools-44.1.1-py2.py3-none-any.whl",
         "wheel": "wheel-0.34.2-py2.py3-none-any.whl",
     },
diff --git a/src/virtualenv/seed/wheels/embed/pip-20.2-py2.py3-none-any.whl b/src/virtualenv/seed/wheels/embed/pip-20.2.1-py2.py3-none-any.whl
similarity index 92%
rename from src/virtualenv/seed/wheels/embed/pip-20.2-py2.py3-none-any.whl
rename to src/virtualenv/seed/wheels/embed/pip-20.2.1-py2.py3-none-any.whl
index ce0ef7565..3d0d3f8ae 100644
Binary files a/src/virtualenv/seed/wheels/embed/pip-20.2-py2.py3-none-any.whl and b/src/virtualenv/seed/wheels/embed/pip-20.2.1-py2.py3-none-any.whl differ
diff --git a/src/virtualenv/seed/wheels/embed/setuptools-49.2.0-py3-none-any.whl b/src/virtualenv/seed/wheels/embed/setuptools-49.2.1-py3-none-any.whl
similarity index 93%
rename from src/virtualenv/seed/wheels/embed/setuptools-49.2.0-py3-none-any.whl
rename to src/virtualenv/seed/wheels/embed/setuptools-49.2.1-py3-none-any.whl
index 25e5ef38a..308e2f2ed 100644
Binary files a/src/virtualenv/seed/wheels/embed/setuptools-49.2.0-py3-none-any.whl and b/src/virtualenv/seed/wheels/embed/setuptools-49.2.1-py3-none-any.whl differ