diff --git a/news/7718.bugfix b/news/7718.bugfix
new file mode 100644
index 00000000000..5abcce69a83
--- /dev/null
+++ b/news/7718.bugfix
@@ -0,0 +1,2 @@
+Correctly detect global site-packages availability of virtual environments
+created by PyPA’s virtualenv>=20.0.
diff --git a/src/pip/_internal/utils/virtualenv.py b/src/pip/_internal/utils/virtualenv.py
index d81e6ac54bb..596a69a7dad 100644
--- a/src/pip/_internal/utils/virtualenv.py
+++ b/src/pip/_internal/utils/virtualenv.py
@@ -105,11 +105,12 @@ def virtualenv_no_global():
     # type: () -> bool
     """Returns a boolean, whether running in venv with no system site-packages.
     """
+    # PEP 405 compliance needs to be checked first since virtualenv >=20 would
+    # return True for both checks, but is only able to use the PEP 405 config.
+    if _running_under_venv():
+        return _no_global_under_venv()
 
     if _running_under_regular_virtualenv():
         return _no_global_under_regular_virtualenv()
 
-    if _running_under_venv():
-        return _no_global_under_venv()
-
     return False