diff --git a/kokoro/linux/dockerfile/test/python310/Dockerfile b/kokoro/linux/dockerfile/test/python310/Dockerfile
new file mode 100644
index 0000000000000..e16e93b3b2465
--- /dev/null
+++ b/kokoro/linux/dockerfile/test/python310/Dockerfile
@@ -0,0 +1,31 @@
+FROM python:3.10-buster
+
+# Install dependencies.  We start with the basic ones require to build protoc
+# and the C++ build
+RUN apt-get update && apt-get install -y \
+  autoconf \
+  autotools-dev \
+  build-essential \
+  bzip2 \
+  ccache \
+  curl \
+  gcc \
+  git \
+  libc6 \
+  libc6-dbg \
+  libc6-dev \
+  libgtest-dev \
+  libtool \
+  make \
+  parallel \
+  time \
+  wget \
+  && apt-get clean \
+  && rm -rf /var/lib/apt/lists/*
+
+# Install Python libraries.
+RUN python -m pip install --no-cache-dir --upgrade \
+  pip \
+  setuptools \
+  tox \
+  wheel
diff --git a/kokoro/linux/python310/build.sh b/kokoro/linux/python310/build.sh
new file mode 100755
index 0000000000000..0d8a2c9c6d497
--- /dev/null
+++ b/kokoro/linux/python310/build.sh
@@ -0,0 +1,18 @@
+#!/bin/bash
+#
+# This is the top-level script we give to Kokoro as the entry point for
+# running the "pull request" project:
+#
+# This script selects a specific Dockerfile (for building a Docker image) and
+# a script to run inside that image.  Then we delegate to the general
+# build_and_run_docker.sh script.
+
+# Change to repo root
+cd $(dirname $0)/../../..
+
+export DOCKERHUB_ORGANIZATION=protobuftesting
+export DOCKERFILE_DIR=kokoro/linux/dockerfile/test/python310
+export DOCKER_RUN_SCRIPT=kokoro/linux/pull_request_in_docker.sh
+export OUTPUT_DIR=testoutput
+export TEST_SET="python310"
+./kokoro/linux/build_and_run_docker.sh
diff --git a/kokoro/linux/python310/continuous.cfg b/kokoro/linux/python310/continuous.cfg
new file mode 100644
index 0000000000000..6ec74d8597e81
--- /dev/null
+++ b/kokoro/linux/python310/continuous.cfg
@@ -0,0 +1,11 @@
+# Config file for running tests in Kokoro
+
+# Location of the build script in repository
+build_file: "protobuf/kokoro/linux/python310/build.sh"
+timeout_mins: 120
+
+action {
+  define_artifacts {
+    regex: "**/sponge_log.xml"
+  }
+}
diff --git a/kokoro/linux/python310/presubmit.cfg b/kokoro/linux/python310/presubmit.cfg
new file mode 100644
index 0000000000000..6ec74d8597e81
--- /dev/null
+++ b/kokoro/linux/python310/presubmit.cfg
@@ -0,0 +1,11 @@
+# Config file for running tests in Kokoro
+
+# Location of the build script in repository
+build_file: "protobuf/kokoro/linux/python310/build.sh"
+timeout_mins: 120
+
+action {
+  define_artifacts {
+    regex: "**/sponge_log.xml"
+  }
+}
diff --git a/kokoro/linux/python310_cpp/build.sh b/kokoro/linux/python310_cpp/build.sh
new file mode 100755
index 0000000000000..2903a2d9c2dd4
--- /dev/null
+++ b/kokoro/linux/python310_cpp/build.sh
@@ -0,0 +1,18 @@
+#!/bin/bash
+#
+# This is the top-level script we give to Kokoro as the entry point for
+# running the "pull request" project:
+#
+# This script selects a specific Dockerfile (for building a Docker image) and
+# a script to run inside that image.  Then we delegate to the general
+# build_and_run_docker.sh script.
+
+# Change to repo root
+cd $(dirname $0)/../../..
+
+export DOCKERHUB_ORGANIZATION=protobuftesting
+export DOCKERFILE_DIR=kokoro/linux/dockerfile/test/python310
+export DOCKER_RUN_SCRIPT=kokoro/linux/pull_request_in_docker.sh
+export OUTPUT_DIR=testoutput
+export TEST_SET="python310_cpp"
+./kokoro/linux/build_and_run_docker.sh
diff --git a/kokoro/linux/python310_cpp/continuous.cfg b/kokoro/linux/python310_cpp/continuous.cfg
new file mode 100644
index 0000000000000..7ec844196e240
--- /dev/null
+++ b/kokoro/linux/python310_cpp/continuous.cfg
@@ -0,0 +1,11 @@
+# Config file for running tests in Kokoro
+
+# Location of the build script in repository
+build_file: "protobuf/kokoro/linux/python310_cpp/build.sh"
+timeout_mins: 120
+
+action {
+  define_artifacts {
+    regex: "**/sponge_log.xml"
+  }
+}
diff --git a/kokoro/linux/python310_cpp/presubmit.cfg b/kokoro/linux/python310_cpp/presubmit.cfg
new file mode 100644
index 0000000000000..7ec844196e240
--- /dev/null
+++ b/kokoro/linux/python310_cpp/presubmit.cfg
@@ -0,0 +1,11 @@
+# Config file for running tests in Kokoro
+
+# Location of the build script in repository
+build_file: "protobuf/kokoro/linux/python310_cpp/build.sh"
+timeout_mins: 120
+
+action {
+  define_artifacts {
+    regex: "**/sponge_log.xml"
+  }
+}
diff --git a/kokoro/release/python/linux/build_artifacts.sh b/kokoro/release/python/linux/build_artifacts.sh
index 2407a302c7879..31da562814410 100755
--- a/kokoro/release/python/linux/build_artifacts.sh
+++ b/kokoro/release/python/linux/build_artifacts.sh
@@ -61,7 +61,9 @@ build_artifact_version 3.6
 build_artifact_version 3.7
 build_artifact_version 3.8
 build_artifact_version 3.9
+build_artifact_version 3.10
 
 build_crosscompiled_aarch64_artifact_version 3.7
 build_crosscompiled_aarch64_artifact_version 3.8
 build_crosscompiled_aarch64_artifact_version 3.9
+build_crosscompiled_aarch64_artifact_version 3.10
diff --git a/kokoro/release/python/macos/build_artifacts.sh b/kokoro/release/python/macos/build_artifacts.sh
index fbbd650b71c7f..75644539fa057 100755
--- a/kokoro/release/python/macos/build_artifacts.sh
+++ b/kokoro/release/python/macos/build_artifacts.sh
@@ -55,3 +55,4 @@ build_artifact_version 3.6
 build_artifact_version 3.7
 build_artifact_version 3.8
 build_artifact_version 3.9
+build_artifact_version 3.10
diff --git a/kokoro/release/python/windows/build_artifacts.bat b/kokoro/release/python/windows/build_artifacts.bat
index 340bda8dd9cef..ac466a901d3c2 100644
--- a/kokoro/release/python/windows/build_artifacts.bat
+++ b/kokoro/release/python/windows/build_artifacts.bat
@@ -73,6 +73,16 @@ SET PYTHON_VERSION=3.9
 SET PYTHON_ARCH=64
 CALL build_single_artifact.bat || goto :error
 
+SET PYTHON=C:\python310_32bit
+SET PYTHON_VERSION=3.10
+SET PYTHON_ARCH=32
+CALL build_single_artifact.bat || goto :error
+
+SET PYTHON=C:\python310
+SET PYTHON_VERSION=3.10
+SET PYTHON_ARCH=64
+CALL build_single_artifact.bat || goto :error
+
 goto :EOF
 
 :error
diff --git a/kokoro/release/python/windows/build_single_artifact.bat b/kokoro/release/python/windows/build_single_artifact.bat
index 920f9c83a8bf1..8d3cd0c9d8ee9 100644
--- a/kokoro/release/python/windows/build_single_artifact.bat
+++ b/kokoro/release/python/windows/build_single_artifact.bat
@@ -24,6 +24,12 @@ if %PYTHON%==C:\python39_32bit set vcplatform=Win32
 if %PYTHON%==C:\python39 set generator=Visual Studio 14 Win64
 if %PYTHON%==C:\python39 set vcplatform=x64
 
+if %PYTHON%==C:\python310_32bit set generator=Visual Studio 14
+if %PYTHON%==C:\python310_32bit set vcplatform=Win32
+
+if %PYTHON%==C:\python310 set generator=Visual Studio 14 Win64
+if %PYTHON%==C:\python310 set vcplatform=x64
+
 REM Prepend newly installed Python to the PATH of this build (this cannot be
 REM done from inside the powershell script as it would require to restart
 REM the parent CMD process).
diff --git a/kokoro/release/python/windows/install_python_interpreters.ps1 b/kokoro/release/python/windows/install_python_interpreters.ps1
index b63259a829848..f193eedeb0e9c 100644
--- a/kokoro/release/python/windows/install_python_interpreters.ps1
+++ b/kokoro/release/python/windows/install_python_interpreters.ps1
@@ -95,3 +95,20 @@ $Python39x64Config = @{
     PythonInstallerHash = "b61a33dc28f13b561452f3089c87eb63"
 }
 Install-Python @Python39x64Config
+
+# Python 3.10
+$Python39x86Config = @{
+    PythonVersion = "3.10.0"
+    PythonInstaller = "python-3.10.0"
+    PythonInstallPath = "C:\python310_32bit"
+    PythonInstallerHash = "6de353f2f7422aa030d4ccc788ffa75e"
+}
+Install-Python @Python310x86Config
+
+$Python39x64Config = @{
+    PythonVersion = "3.10.0"
+    PythonInstaller = "python-3.10.0-amd64"
+    PythonInstallPath = "C:\python310"
+    PythonInstallerHash = "39135519b044757f0a3b09d63612b0da"
+}
+Install-Python @Python310x64Config
diff --git a/python/setup.py b/python/setup.py
index ab42b6fe173da..77d9cd1f6ce13 100755
--- a/python/setup.py
+++ b/python/setup.py
@@ -287,11 +287,12 @@ def get_option_from_sys_argv(option_str):
       classifiers=[
           "Programming Language :: Python",
           "Programming Language :: Python :: 3",
-          "Programming Language :: Python :: 3.3",
-          "Programming Language :: Python :: 3.4",
           "Programming Language :: Python :: 3.5",
           "Programming Language :: Python :: 3.6",
           "Programming Language :: Python :: 3.7",
+          "Programming Language :: Python :: 3.8",
+          "Programming Language :: Python :: 3.9",
+          "Programming Language :: Python :: 3.10",
       ],
       namespace_packages=['google'],
       packages=find_packages(
diff --git a/python/tox.ini b/python/tox.ini
index 88dd842e82198..7142b86f0fdf0 100644
--- a/python/tox.ini
+++ b/python/tox.ini
@@ -1,6 +1,6 @@
 [tox]
 envlist =
-    py{35,36,37,38,39}-{cpp,python}
+    py{35,36,37,38,39,310}-{cpp,python}
 
 [testenv]
 usedevelop=true
@@ -14,7 +14,7 @@ setenv =
 commands =
     python setup.py -q build_py
     python: python setup.py -q build
-    py{35,36,37,38,39}-cpp: python setup.py -q build --cpp_implementation --warnings_as_errors --compile_static_extension
+    py{35,36,37,38,39,310}-cpp: python setup.py -q build --cpp_implementation --warnings_as_errors --compile_static_extension
     python: python setup.py -q test -q
     cpp: python setup.py -q test -q --cpp_implementation
     python: python setup.py -q test_conformance
diff --git a/tests.sh b/tests.sh
index fcfb75f865eba..176bc5f2bc6ec 100755
--- a/tests.sh
+++ b/tests.sh
@@ -375,6 +375,10 @@ build_python39() {
   build_python_version py39-python
 }
 
+build_python310() {
+  build_python_version py310-python
+}
+
 build_python_cpp() {
   internal_build_cpp
   export LD_LIBRARY_PATH=../src/.libs # for Linux
@@ -427,6 +431,11 @@ build_python39_cpp() {
   build_python_cpp_version py39-cpp
 }
 
+build_python310_cpp() {
+  build_python_cpp_version py310-cpp
+}
+
+
 build_ruby23() {
   internal_build_cpp  # For conformance tests.
   cd ruby && bash travis-test.sh ruby-2.3.8 && cd ..