diff --git a/config/test.exs b/config/test.exs
index 900b6fd..6b0105e 100644
--- a/config/test.exs
+++ b/config/test.exs
@@ -45,6 +45,11 @@ config :amqpx,
       handler_module: Amqpx.Test.Support.HandleRejectionConsumer,
       backoff: 10
     },
+    %{
+      handler_module: Amqpx.Test.Support.NoRequeueConsumer,
+      backoff: 10,
+      requeue_on_reject: false
+    },
     %{
       handler_module: Amqpx.Test.Support.ConsumerConnectionTwo,
       connection_name: ConnectionTwo
@@ -97,6 +102,17 @@ config :amqpx, Amqpx.Test.Support.HandleRejectionConsumer, %{
   ]
 }
 
+config :amqpx, Amqpx.Test.Support.NoRequeueConsumer, %{
+  queue: "test-no-requeue",
+  exchanges: [
+    %{
+      name: "topic-no-requeue",
+      type: :topic,
+      routing_keys: ["amqpx.test-no-requeue"]
+    }
+  ]
+}
+
 config :amqpx, Amqpx.Test.Support.ConsumerConnectionTwo, %{
   queue: "connection-two",
   exchanges: [
diff --git a/lib/amqp/gen/consumer.ex b/lib/amqp/gen/consumer.ex
index 037e123..3c9f334 100644
--- a/lib/amqp/gen/consumer.ex
+++ b/lib/amqp/gen/consumer.ex
@@ -13,7 +13,8 @@ defmodule Amqpx.Gen.Consumer do
     :handler_state,
     prefetch_count: 50,
     backoff: 5_000,
-    connection_name: Amqpx.Gen.ConnectionManager
+    connection_name: Amqpx.Gen.ConnectionManager,
+    requeue_on_reject: true
   ]
 
   @type state() :: %__MODULE__{}
@@ -191,7 +192,8 @@ defmodule Amqpx.Gen.Consumer do
          %__MODULE__{
            handler_module: handler_module,
            handler_state: handler_state,
-           backoff: backoff
+           backoff: backoff,
+           requeue_on_reject: requeue_on_reject
          } = state
        ) do
     {:ok, handler_state} = handler_module.handle_message(message, meta, handler_state)
@@ -206,13 +208,13 @@ defmodule Amqpx.Gen.Consumer do
 
         is_message_to_reject =
           function_exported?(handler_module, :handle_message_rejection, 2) &&
-            redelivered
+            (!requeue_on_reject || (redelivered && requeue_on_reject))
 
         if is_message_to_reject do
           handler_module.handle_message_rejection(message, e)
         end
 
-        Basic.reject(state.channel, tag, requeue: !redelivered)
+        Basic.reject(state.channel, tag, requeue: requeue_on_reject && !redelivered)
       end)
 
       state
diff --git a/test/gen_test.exs b/test/gen_test.exs
index a00f72c..df027e8 100644
--- a/test/gen_test.exs
+++ b/test/gen_test.exs
@@ -4,6 +4,7 @@ defmodule Amqpx.Test.AmqpxTest do
   alias Amqpx.Test.Support.Consumer1
   alias Amqpx.Test.Support.Consumer2
   alias Amqpx.Test.Support.HandleRejectionConsumer
+  alias Amqpx.Test.Support.NoRequeueConsumer
   alias Amqpx.Test.Support.ConsumerConnectionTwo
   alias Amqpx.Test.Support.Producer1
   alias Amqpx.Test.Support.Producer2
@@ -96,17 +97,93 @@ defmodule Amqpx.Test.AmqpxTest do
 
   test "e2e: should handle message rejected when handle message fails" do
     test_pid = self()
-    error_message = "test_error"
 
     with_mock(HandleRejectionConsumer,
-      handle_message: fn _, _, _ -> raise error_message end,
-      handle_message_rejection: fn _, error -> send(test_pid, {:ok, error.message}) end
+      handle_message: fn _, _, _ ->
+        mock_called =
+          case Process.get(:times_mock_called) do
+            nil -> 1
+            n -> n + 1
+          end
+
+        Process.put(:times_mock_called, mock_called)
+
+        raise "test_error ##{mock_called}"
+      end,
+      handle_message_rejection: fn _, error ->
+        send(test_pid, {:ok, error.message})
+      end
     ) do
       publish_result =
         Amqpx.Gen.Producer.publish("topic-rejection", "amqpx.test-rejection", "some-message", redeliver: false)
 
       assert publish_result == :ok
-      assert_receive {:ok, ^error_message}, 1_000
+
+      # ensure handle_message_rejection is called only the second time
+      assert_receive {:ok, "test_error #2"}, 1_000
+    end
+  end
+
+  test "e2e: messages should not be re-enqueued when re-enqueue option is disabled" do
+    test_pid = self()
+    error_message = "test_error"
+
+    with_mock(NoRequeueConsumer,
+      handle_message: fn _, _, _ ->
+        mock_called =
+          case Process.get(:times_mock_called) do
+            nil -> 1
+            n -> n + 1
+          end
+
+        Process.put(:times_mock_called, mock_called)
+
+        send(test_pid, {:handled_message, mock_called})
+        raise error_message
+      end,
+      handle_message_rejection: fn _, _ -> :ok end
+    ) do
+      :ok = Amqpx.Gen.Producer.publish("topic-no-requeue", "amqpx.test-no-requeue", "some-message", redeliver: false)
+      assert_receive {:handled_message, 1}
+      refute_receive {:handled_message, 2}
+    end
+  end
+
+  test "e2e: handle_message_reject should be called upon first time when re-enqueue option is disabled" do
+    test_pid = self()
+    error_message = "test-error-requeue"
+
+    with_mock(NoRequeueConsumer,
+      handle_message: fn _, _, _ ->
+        mock_called =
+          case Process.get(:times_mock_handle_message_called) do
+            nil -> 1
+            n -> n + 1
+          end
+
+        Process.put(:times_mock_handle_message_called, mock_called)
+
+        raise "#{error_message} ##{mock_called}"
+      end,
+      handle_message_rejection: fn _, error ->
+        mock_called =
+          case Process.get(:times_mock_handle_message_rejection_called) do
+            nil -> 1
+            n -> n + 1
+          end
+
+        Process.put(:times_mock_handle_message_rejection_called, mock_called)
+
+        send(test_pid, {:handled_message, {error.message, mock_called}})
+        :ok
+      end
+    ) do
+      :ok = Amqpx.Gen.Producer.publish("topic-no-requeue", "amqpx.test-no-requeue", "some-message", redeliver: false)
+
+      # ensure the handle_message_rejection is called exactly one time after the handle_message call.
+      err_msg = {"#{error_message} #1", 1}
+      assert_receive {:handled_message, ^err_msg}
+      refute_receive {:handled_message, _}, 1_000
     end
   end
 
diff --git a/test/support/consumer/consumer_no_requeue.ex b/test/support/consumer/consumer_no_requeue.ex
new file mode 100644
index 0000000..26be4b9
--- /dev/null
+++ b/test/support/consumer/consumer_no_requeue.ex
@@ -0,0 +1,21 @@
+defmodule Amqpx.Test.Support.NoRequeueConsumer do
+  @moduledoc nil
+  @behaviour Amqpx.Gen.Consumer
+
+  alias Amqpx.Basic
+  alias Amqpx.Helper
+
+  def setup(channel) do
+    Helper.declare(channel, Application.fetch_env!(:amqpx, __MODULE__))
+    Basic.consume(channel, Application.fetch_env!(:amqpx, __MODULE__)[:queue], self())
+    {:ok, %{}}
+  end
+
+  def handle_message_rejection(_msg, _err) do
+    :ok
+  end
+
+  def handle_message(_payload, _meta, _state) do
+    raise "test error"
+  end
+end