diff --git a/superset/charts/data/api.py b/superset/charts/data/api.py
index 773229ad5f753..152383e0c66d4 100644
--- a/superset/charts/data/api.py
+++ b/superset/charts/data/api.py
@@ -41,6 +41,7 @@
 from superset.charts.schemas import ChartDataQueryContextSchema
 from superset.common.chart_data import ChartDataResultFormat, ChartDataResultType
 from superset.connectors.base.models import BaseDatasource
+from superset.dao.exceptions import DatasourceNotFound
 from superset.exceptions import QueryObjectValidationError
 from superset.extensions import event_logger
 from superset.utils.async_query_manager import AsyncQueryTokenException
@@ -141,6 +142,8 @@ def get_data(self, pk: int) -> Response:
             query_context = self._create_query_context_from_form(json_body)
             command = ChartDataCommand(query_context)
             command.validate()
+        except DatasourceNotFound as error:
+            return self.response_404()
         except QueryObjectValidationError as error:
             return self.response_400(message=error.message)
         except ValidationError as error:
@@ -229,6 +232,8 @@ def data(self) -> Response:
             query_context = self._create_query_context_from_form(json_body)
             command = ChartDataCommand(query_context)
             command.validate()
+        except DatasourceNotFound as error:
+            return self.response_404()
         except QueryObjectValidationError as error:
             return self.response_400(message=error.message)
         except ValidationError as error: