diff --git a/pkg/cluster/spec/monitoring.go b/pkg/cluster/spec/monitoring.go
index 38d77430f4..58f50721a1 100644
--- a/pkg/cluster/spec/monitoring.go
+++ b/pkg/cluster/spec/monitoring.go
@@ -17,6 +17,7 @@ import (
 	"context"
 	"crypto/tls"
 	"fmt"
+	"os"
 	"path"
 	"path/filepath"
 	"reflect"
@@ -29,6 +30,7 @@ import (
 	"github.com/pingcap/tiup/pkg/cluster/template/scripts"
 	"github.com/pingcap/tiup/pkg/meta"
 	"github.com/pingcap/tiup/pkg/set"
+	"gopkg.in/yaml.v3"
 )
 
 // PrometheusSpec represents the Prometheus Server topology specification in topology.yaml
@@ -51,6 +53,7 @@ type PrometheusSpec struct {
 	Arch                  string                 `yaml:"arch,omitempty"`
 	OS                    string                 `yaml:"os,omitempty"`
 	RuleDir               string                 `yaml:"rule_dir,omitempty" validate:"rule_dir:editable"`
+	AdditionalScrapeConf  map[string]interface{} `yaml:"additional_scrape_conf,omitempty" validate:"additional_scrape_conf:ignore"`
 }
 
 // Remote prometheus remote config
@@ -336,6 +339,12 @@ func (i *MonitorInstance) InitConfig(
 	if err := cfig.ConfigToFile(fp); err != nil {
 		return err
 	}
+	if spec.AdditionalScrapeConf != nil {
+		err = mergeAdditionalScrapeConf(fp, spec.AdditionalScrapeConf)
+		if err != nil {
+			return err
+		}
+	}
 	dst = filepath.Join(paths.Deploy, "conf", "prometheus.yml")
 	if err := e.Transfer(ctx, fp, dst, false, 0, false); err != nil {
 		return err
@@ -428,3 +437,26 @@ func (i *MonitorInstance) ScaleConfig(
 	i.topo = topo
 	return i.InitConfig(ctx, e, clusterName, clusterVersion, deployUser, paths)
 }
+
+func mergeAdditionalScrapeConf(source string, addition map[string]interface{}) error {
+	var result map[string]interface{}
+	bytes, err := os.ReadFile(source)
+	if err != nil {
+		return err
+	}
+	err = yaml.Unmarshal(bytes, &result)
+	if err != nil {
+		return err
+	}
+
+	for _, job := range result["scrape_configs"].([]interface{}) {
+		for k, v := range addition {
+			job.(map[string]interface{})[k] = v
+		}
+	}
+	bytes, err = yaml.Marshal(result)
+	if err != nil {
+		return err
+	}
+	return os.WriteFile(source, bytes, 0644)
+}
diff --git a/pkg/cluster/spec/monitoring_test.go b/pkg/cluster/spec/monitoring_test.go
index ae3d0a07c1..a0a85dfb2a 100644
--- a/pkg/cluster/spec/monitoring_test.go
+++ b/pkg/cluster/spec/monitoring_test.go
@@ -15,6 +15,7 @@ package spec
 
 import (
 	"context"
+	"fmt"
 	"os"
 	"os/user"
 	"path"
@@ -25,6 +26,7 @@ import (
 	"github.com/pingcap/tiup/pkg/cluster/executor"
 	"github.com/pingcap/tiup/pkg/meta"
 	"github.com/stretchr/testify/assert"
+	"gopkg.in/yaml.v3"
 )
 
 func TestLocalRuleDirs(t *testing.T) {
@@ -128,3 +130,95 @@ groups:
 		assert.NoFileExists(t, path.Join(deployDir, "conf", f.Name()))
 	}
 }
+
+func TestMergeAdditionalScrapeConf(t *testing.T) {
+	file, err := os.CreateTemp("", "tiup-cluster-spec-test")
+	if err != nil {
+		panic(fmt.Sprintf("create temp file: %s", err))
+	}
+	defer os.Remove(file.Name())
+
+	_, err = file.WriteString(`---
+global:
+  scrape_interval:     15s # By default, scrape targets every 15 seconds.
+  evaluation_interval: 15s # By default, scrape targets every 15 seconds.
+  # scrape_timeout is set to the global default (10s).
+  external_labels:
+    cluster: 'test'
+    monitor: "prometheus"
+
+scrape_configs:
+  - job_name: "tidb"
+    honor_labels: true # don't overwrite job & instance labels
+    static_configs:
+    - targets:
+      - '192.168.122.215:10080'
+  - job_name: "tikv"
+    honor_labels: true # don't overwrite job & instance labels
+    static_configs:
+    - targets:
+      - '192.168.122.25:20180'`)
+	assert.Nil(t, err)
+
+	expected := `global:
+    evaluation_interval: 15s
+    external_labels:
+        cluster: test
+        monitor: prometheus
+    scrape_interval: 15s
+scrape_configs:
+    - honor_labels: true
+      job_name: tidb
+      metric_relabel_configs:
+        - action: drop
+          regex: tikv_thread_nonvoluntary_context_switches|tikv_thread_voluntary_context_switches|tikv_threads_io_bytes_total
+          separator: ;
+          source_labels:
+            - __name__
+        - action: drop
+          regex: tikv_thread_cpu_seconds_total;(tokio|rocksdb).+
+          separator: ;
+          source_labels:
+            - __name__
+            - name
+      static_configs:
+        - targets:
+            - 192.168.122.215:10080
+    - honor_labels: true
+      job_name: tikv
+      metric_relabel_configs:
+        - action: drop
+          regex: tikv_thread_nonvoluntary_context_switches|tikv_thread_voluntary_context_switches|tikv_threads_io_bytes_total
+          separator: ;
+          source_labels:
+            - __name__
+        - action: drop
+          regex: tikv_thread_cpu_seconds_total;(tokio|rocksdb).+
+          separator: ;
+          source_labels:
+            - __name__
+            - name
+      static_configs:
+        - targets:
+            - 192.168.122.25:20180
+`
+
+	var addition map[string]interface{}
+	err = yaml.Unmarshal([]byte(`metric_relabel_configs:
+  - source_labels: [__name__]
+    separator: ;
+    regex: tikv_thread_nonvoluntary_context_switches|tikv_thread_voluntary_context_switches|tikv_threads_io_bytes_total
+    action: drop
+  - source_labels: [__name__,name]
+    separator: ;
+    regex: tikv_thread_cpu_seconds_total;(tokio|rocksdb).+
+    action: drop`), &addition)
+	assert.Nil(t, err)
+
+	err = mergeAdditionalScrapeConf(file.Name(), addition)
+	assert.Nil(t, err)
+	result, err := os.ReadFile(file.Name())
+	assert.Nil(t, err)
+
+	assert.Equal(t, expected, string(result))
+}