diff --git a/go.mod b/go.mod
index b2bd664da13f3..c4b668a81dcf1 100644
--- a/go.mod
+++ b/go.mod
@@ -45,7 +45,7 @@ require (
 	github.com/pingcap/failpoint v0.0.0-20210316064728-7acb0f0a3dfd
 	github.com/pingcap/fn v0.0.0-20200306044125-d5540d389059
 	github.com/pingcap/goleveldb v0.0.0-20191226122134-f82aafb29989
-	github.com/pingcap/kvproto v0.0.0-20210429093846-65f54a202d7e
+	github.com/pingcap/kvproto v0.0.0-20210507054410-a8152f8a876c
 	github.com/pingcap/log v0.0.0-20210317133921-96f4fcab92a4
 	github.com/pingcap/parser v0.0.0-20210513020953-ae2c4497c07b
 	github.com/pingcap/sysutil v0.0.0-20210315073920-cc0985d983a3
diff --git a/go.sum b/go.sum
index c42d129ae5b8b..212917e414404 100644
--- a/go.sum
+++ b/go.sum
@@ -436,8 +436,8 @@ github.com/pingcap/goleveldb v0.0.0-20191226122134-f82aafb29989/go.mod h1:O17Xtb
 github.com/pingcap/kvproto v0.0.0-20191211054548-3c6b38ea5107/go.mod h1:WWLmULLO7l8IOcQG+t+ItJ3fEcrL5FxF0Wu+HrMy26w=
 github.com/pingcap/kvproto v0.0.0-20200411081810-b85805c9476c/go.mod h1:IOdRDPLyda8GX2hE/jO7gqaCV/PNFh8BZQCQZXfIOqI=
 github.com/pingcap/kvproto v0.0.0-20210219064844-c1844a4775d6/go.mod h1:IOdRDPLyda8GX2hE/jO7gqaCV/PNFh8BZQCQZXfIOqI=
-github.com/pingcap/kvproto v0.0.0-20210429093846-65f54a202d7e h1:oUMZ6X/Kpaoxfejh9/jQ+4UZ5xk9MRYcouWJ0oXRKNE=
-github.com/pingcap/kvproto v0.0.0-20210429093846-65f54a202d7e/go.mod h1:IOdRDPLyda8GX2hE/jO7gqaCV/PNFh8BZQCQZXfIOqI=
+github.com/pingcap/kvproto v0.0.0-20210507054410-a8152f8a876c h1:cy87vgUJT0U4JuxC7R14PuwBrabI9fDawYhyKTbjOBQ=
+github.com/pingcap/kvproto v0.0.0-20210507054410-a8152f8a876c/go.mod h1:IOdRDPLyda8GX2hE/jO7gqaCV/PNFh8BZQCQZXfIOqI=
 github.com/pingcap/log v0.0.0-20191012051959-b742a5d432e9/go.mod h1:4rbK1p9ILyIfb6hU7OG2CiWSqMXnp3JMbiaVJ6mvoY8=
 github.com/pingcap/log v0.0.0-20200511115504-543df19646ad/go.mod h1:4rbK1p9ILyIfb6hU7OG2CiWSqMXnp3JMbiaVJ6mvoY8=
 github.com/pingcap/log v0.0.0-20201112100606-8f1e84a3abc8/go.mod h1:4rbK1p9ILyIfb6hU7OG2CiWSqMXnp3JMbiaVJ6mvoY8=
diff --git a/store/copr/batch_coprocessor.go b/store/copr/batch_coprocessor.go
index 4bec370a9a4d5..bf8d1b7c893e0 100644
--- a/store/copr/batch_coprocessor.go
+++ b/store/copr/batch_coprocessor.go
@@ -406,6 +406,20 @@ func (b *batchCopIterator) handleBatchCopResponse(bo *backoffer, response *copro
 		return errors.Trace(err)
 	}
 
+	if len(response.RetryRegions) > 0 {
+		logutil.BgLogger().Info("multiple regions are stale and need to be refreshed", zap.Int("region size", len(response.RetryRegions)))
+		for idx, retry := range response.RetryRegions {
+			id := tikv.NewRegionVerID(retry.Id, retry.RegionEpoch.ConfVer, retry.RegionEpoch.Version)
+			logutil.BgLogger().Info("invalid region because tiflash detected stale region", zap.String("region id", id.String()))
+			b.store.GetRegionCache().InvalidateCachedRegionWithReason(id, tikv.EpochNotMatch)
+			if idx >= 10 {
+				logutil.BgLogger().Info("stale regions are too many, so we omit the rest ones")
+				break
+			}
+		}
+		return
+	}
+
 	resp := batchCopResponse{
 		pbResp: response,
 		detail: new(CopRuntimeStats),
diff --git a/store/mockstore/unistore/tikv/server.go b/store/mockstore/unistore/tikv/server.go
index f571ff4fe963f..adf3049330897 100644
--- a/store/mockstore/unistore/tikv/server.go
+++ b/store/mockstore/unistore/tikv/server.go
@@ -845,6 +845,11 @@ func (svr *Server) ReadIndex(context.Context, *kvrpcpb.ReadIndexRequest) (*kvrpc
 	return &kvrpcpb.ReadIndexResponse{}, nil
 }
 
+// GetLockWaitInfo implements implements the tikvpb.TikvServer interface.
+func (svr *Server) GetLockWaitInfo(ctx context.Context, _ *kvrpcpb.GetLockWaitInfoRequest) (*kvrpcpb.GetLockWaitInfoResponse, error) {
+	return &kvrpcpb.GetLockWaitInfoResponse{}, nil
+}
+
 // transaction debugger commands.
 
 // MvccGetByKey implements implements the tikvpb.TikvServer interface.
diff --git a/store/tikv/region_request_test.go b/store/tikv/region_request_test.go
index 9c5172e52f372..8d531ee209a78 100644
--- a/store/tikv/region_request_test.go
+++ b/store/tikv/region_request_test.go
@@ -462,6 +462,10 @@ func (s *mockTikvGrpcServer) SplitRegion(context.Context, *kvrpcpb.SplitRegionRe
 	return nil, errors.New("unreachable")
 }
 
+func (s *mockTikvGrpcServer) GetLockWaitInfo(context.Context, *kvrpcpb.GetLockWaitInfoRequest) (*kvrpcpb.GetLockWaitInfoResponse, error) {
+	return nil, errors.New("unreachable")
+}
+
 func (s *mockTikvGrpcServer) CoprocessorStream(*coprocessor.Request, tikvpb.Tikv_CoprocessorStreamServer) error {
 	return errors.New("unreachable")
 }