diff --git a/executor/set_test.go b/executor/set_test.go
index 05b20812e75a2..c3e2ec3a8626a 100644
--- a/executor/set_test.go
+++ b/executor/set_test.go
@@ -517,6 +517,17 @@ func (s *testSerialSuite1) TestSetVar(c *C) {
 	tk.MustExec("SET GLOBAL tidb_enable_extended_stats = off")
 	tk.MustQuery("select @@global.tidb_enable_extended_stats").Check(testkit.Rows("0"))
 
+	tk.MustExec("SET SESSION tidb_enable_tiflash_fallback_tikv = on")
+	tk.MustQuery("select @@session.tidb_enable_tiflash_fallback_tikv").Check(testkit.Rows("1"))
+	tk.MustExec("SET SESSION tidb_enable_tiflash_fallback_tikv = off")
+	tk.MustQuery("select @@session.tidb_enable_tiflash_fallback_tikv").Check(testkit.Rows("0"))
+	tk.MustExec("SET GLOBAL tidb_enable_tiflash_fallback_tikv = on")
+	tk.MustQuery("select @@global.tidb_enable_tiflash_fallback_tikv").Check(testkit.Rows("1"))
+	tk.MustExec("SET GLOBAL tidb_enable_tiflash_fallback_tikv = off")
+	tk.MustQuery("select @@global.tidb_enable_tiflash_fallback_tikv").Check(testkit.Rows("0"))
+	c.Assert(tk.ExecToErr("SET SESSION tidb_enable_tiflash_fallback_tikv = 123"), NotNil)
+	c.Assert(tk.ExecToErr("SET GLOBAL tidb_enable_tiflash_fallback_tikv = 321"), NotNil)
+
 	// Test issue #22145
 	tk.MustExec(`set global sync_relay_log = "'"`)
 
diff --git a/server/conn.go b/server/conn.go
index cecc23d6dab5b..6479e0d065566 100644
--- a/server/conn.go
+++ b/server/conn.go
@@ -72,6 +72,7 @@ import (
 	"github.com/pingcap/tidb/sessionctx"
 	"github.com/pingcap/tidb/sessionctx/stmtctx"
 	"github.com/pingcap/tidb/sessionctx/variable"
+	"github.com/pingcap/tidb/store/tikv"
 	"github.com/pingcap/tidb/tablecodec"
 	"github.com/pingcap/tidb/util/arena"
 	"github.com/pingcap/tidb/util/chunk"
@@ -1457,14 +1458,31 @@ func (cc *clientConn) handleQuery(ctx context.Context, sql string) (err error) {
 	if len(pointPlans) > 0 {
 		defer cc.ctx.ClearValue(plannercore.PointPlanKey)
 	}
+	var retryable bool
 	for i, stmt := range stmts {
 		if len(pointPlans) > 0 {
 			// Save the point plan in Session so we don't need to build the point plan again.
 			cc.ctx.SetValue(plannercore.PointPlanKey, plannercore.PointPlanVal{Plan: pointPlans[i]})
 		}
-		err = cc.handleStmt(ctx, stmt, parserWarns, i == len(stmts)-1)
+		retryable, err = cc.handleStmt(ctx, stmt, parserWarns, i == len(stmts)-1)
 		if err != nil {
-			break
+			if cc.ctx.GetSessionVars().EnableTiFlashFallbackTiKV && errors.ErrorEqual(err, tikv.ErrTiFlashServerTimeout) && retryable {
+				// When the TiFlash server seems down, we append a warning to remind the user to check the status of the TiFlash
+				// server and fallback to TiKV.
+				warns := append(parserWarns, stmtctx.SQLWarn{Level: stmtctx.WarnLevelError, Err: err})
+				func() {
+					delete(cc.ctx.GetSessionVars().IsolationReadEngines, kv.TiFlash)
+					defer func() {
+						cc.ctx.GetSessionVars().IsolationReadEngines[kv.TiFlash] = struct{}{}
+					}()
+					_, err = cc.handleStmt(ctx, stmt, warns, i == len(stmts)-1)
+				}()
+				if err != nil {
+					break
+				}
+			} else {
+				break
+			}
 		}
 	}
 	if err != nil {
@@ -1567,7 +1585,9 @@ func (cc *clientConn) prefetchPointPlanKeys(ctx context.Context, stmts []ast.Stm
 	return pointPlans, nil
 }
 
-func (cc *clientConn) handleStmt(ctx context.Context, stmt ast.StmtNode, warns []stmtctx.SQLWarn, lastStmt bool) error {
+// The first return value indicates whether the call of handleStmt has no side effect and can be retried to correct error.
+// Currently the first return value is used to fallback to TiKV when TiFlash is down.
+func (cc *clientConn) handleStmt(ctx context.Context, stmt ast.StmtNode, warns []stmtctx.SQLWarn, lastStmt bool) (bool, error) {
 	ctx = context.WithValue(ctx, execdetails.StmtExecDetailKey, &execdetails.StmtExecDetails{})
 	reg := trace.StartRegion(ctx, "ExecuteStmt")
 	rs, err := cc.ctx.ExecuteStmt(ctx, stmt)
@@ -1578,7 +1598,7 @@ func (cc *clientConn) handleStmt(ctx context.Context, stmt ast.StmtNode, warns [
 		defer terror.Call(rs.Close)
 	}
 	if err != nil {
-		return err
+		return true, err
 	}
 
 	if lastStmt {
@@ -1593,12 +1613,12 @@ func (cc *clientConn) handleStmt(ctx context.Context, stmt ast.StmtNode, warns [
 	if rs != nil {
 		connStatus := atomic.LoadInt32(&cc.status)
 		if connStatus == connStatusShutdown {
-			return executor.ErrQueryInterrupted
+			return false, executor.ErrQueryInterrupted
 		}
 
-		err = cc.writeResultset(ctx, rs, false, status, 0)
+		retryable, err := cc.writeResultset(ctx, rs, false, status, 0)
 		if err != nil {
-			return err
+			return retryable, err
 		}
 	} else {
 		handled, err := cc.handleQuerySpecial(ctx, status)
@@ -1609,10 +1629,10 @@ func (cc *clientConn) handleStmt(ctx context.Context, stmt ast.StmtNode, warns [
 			}
 		}
 		if err != nil {
-			return err
+			return false, err
 		}
 	}
-	return nil
+	return false, nil
 }
 
 func (cc *clientConn) handleQuerySpecial(ctx context.Context, status uint16) (bool, error) {
@@ -1678,7 +1698,10 @@ func (cc *clientConn) handleFieldList(ctx context.Context, sql string) (err erro
 // If binary is true, the data would be encoded in BINARY format.
 // serverStatus, a flag bit represents server information.
 // fetchSize, the desired number of rows to be fetched each time when client uses cursor.
-func (cc *clientConn) writeResultset(ctx context.Context, rs ResultSet, binary bool, serverStatus uint16, fetchSize int) (runErr error) {
+// retryable indicates whether the call of writeResultset has no side effect and can be retried to correct error. The call
+// has side effect in cursor mode or once data has been sent to client. Currently retryable is used to fallback to TiKV when
+// TiFlash is down.
+func (cc *clientConn) writeResultset(ctx context.Context, rs ResultSet, binary bool, serverStatus uint16, fetchSize int) (retryable bool, runErr error) {
 	defer func() {
 		// close ResultSet when cursor doesn't exist
 		r := recover()
@@ -1699,13 +1722,13 @@ func (cc *clientConn) writeResultset(ctx context.Context, rs ResultSet, binary b
 	if mysql.HasCursorExistsFlag(serverStatus) {
 		err = cc.writeChunksWithFetchSize(ctx, rs, serverStatus, fetchSize)
 	} else {
-		err = cc.writeChunks(ctx, rs, binary, serverStatus)
+		retryable, err = cc.writeChunks(ctx, rs, binary, serverStatus)
 	}
 	if err != nil {
-		return err
+		return retryable, err
 	}
 
-	return cc.flush(ctx)
+	return false, cc.flush(ctx)
 }
 
 func (cc *clientConn) writeColumnInfo(columns []*ColumnInfo, serverStatus uint16) error {
@@ -1727,10 +1750,12 @@ func (cc *clientConn) writeColumnInfo(columns []*ColumnInfo, serverStatus uint16
 // writeChunks writes data from a Chunk, which filled data by a ResultSet, into a connection.
 // binary specifies the way to dump data. It throws any error while dumping data.
 // serverStatus, a flag bit represents server information
-func (cc *clientConn) writeChunks(ctx context.Context, rs ResultSet, binary bool, serverStatus uint16) error {
+// The first return value indicates whether error occurs at the first call of ResultSet.Next.
+func (cc *clientConn) writeChunks(ctx context.Context, rs ResultSet, binary bool, serverStatus uint16) (bool, error) {
 	data := cc.alloc.AllocWithLen(4, 1024)
 	req := rs.NewChunk()
 	gotColumnInfo := false
+	firstNext := true
 	var stmtDetail *execdetails.StmtExecDetails
 	stmtDetailRaw := ctx.Value(execdetails.StmtExecDetailKey)
 	if stmtDetailRaw != nil {
@@ -1741,15 +1766,16 @@ func (cc *clientConn) writeChunks(ctx context.Context, rs ResultSet, binary bool
 		// Here server.tidbResultSet implements Next method.
 		err := rs.Next(ctx, req)
 		if err != nil {
-			return err
+			return firstNext, err
 		}
+		firstNext = false
 		if !gotColumnInfo {
 			// We need to call Next before we get columns.
 			// Otherwise, we will get incorrect columns info.
 			columns := rs.Columns()
 			err = cc.writeColumnInfo(columns, serverStatus)
 			if err != nil {
-				return err
+				return false, err
 			}
 			gotColumnInfo = true
 		}
@@ -1768,11 +1794,11 @@ func (cc *clientConn) writeChunks(ctx context.Context, rs ResultSet, binary bool
 			}
 			if err != nil {
 				reg.End()
-				return err
+				return false, err
 			}
 			if err = cc.writePacket(data); err != nil {
 				reg.End()
-				return err
+				return false, err
 			}
 		}
 		reg.End()
@@ -1780,7 +1806,7 @@ func (cc *clientConn) writeChunks(ctx context.Context, rs ResultSet, binary bool
 			stmtDetail.WriteSQLRespDuration += time.Since(start)
 		}
 	}
-	return cc.writeEOF(serverStatus)
+	return false, cc.writeEOF(serverStatus)
 }
 
 // writeChunksWithFetchSize writes data from a Chunk, which filled data by a ResultSet, into a connection.
@@ -1873,7 +1899,7 @@ func (cc *clientConn) writeMultiResultset(ctx context.Context, rss []ResultSet,
 		if !lastRs {
 			status |= mysql.ServerMoreResultsExists
 		}
-		if err := cc.writeResultset(ctx, rs, binary, status, 0); err != nil {
+		if _, err := cc.writeResultset(ctx, rs, binary, status, 0); err != nil {
 			return err
 		}
 	}
diff --git a/server/conn_stmt.go b/server/conn_stmt.go
index 9de3c4cc47822..762a5be52cf39 100644
--- a/server/conn_stmt.go
+++ b/server/conn_stmt.go
@@ -46,9 +46,11 @@ import (
 	"github.com/pingcap/errors"
 	"github.com/pingcap/parser/mysql"
 	"github.com/pingcap/parser/terror"
+	"github.com/pingcap/tidb/kv"
 	"github.com/pingcap/tidb/metrics"
 	plannercore "github.com/pingcap/tidb/planner/core"
 	"github.com/pingcap/tidb/sessionctx/stmtctx"
+	"github.com/pingcap/tidb/store/tikv"
 	"github.com/pingcap/tidb/types"
 	"github.com/pingcap/tidb/util/execdetails"
 	"github.com/pingcap/tidb/util/hack"
@@ -192,12 +194,31 @@ func (cc *clientConn) handleStmtExecute(ctx context.Context, data []byte) (err e
 		}
 	}
 	ctx = context.WithValue(ctx, execdetails.StmtExecDetailKey, &execdetails.StmtExecDetails{})
+	retryable, err := cc.executePreparedStmtAndWriteResult(ctx, stmt, args, useCursor)
+	if cc.ctx.GetSessionVars().EnableTiFlashFallbackTiKV && err != nil && errors.ErrorEqual(err, tikv.ErrTiFlashServerTimeout) && retryable {
+		// When the TiFlash server seems down, we append a warning to remind the user to check the status of the TiFlash
+		// server and fallback to TiKV.
+		prevErr := err
+		delete(cc.ctx.GetSessionVars().IsolationReadEngines, kv.TiFlash)
+		defer func() {
+			cc.ctx.GetSessionVars().IsolationReadEngines[kv.TiFlash] = struct{}{}
+		}()
+		_, err = cc.executePreparedStmtAndWriteResult(ctx, stmt, args, useCursor)
+		// We append warning after the retry because `ResetContextOfStmt` may be called during the retry, which clears warnings.
+		cc.ctx.GetSessionVars().StmtCtx.AppendError(prevErr)
+	}
+	return err
+}
+
+// The first return value indicates whether the call of executePreparedStmtAndWriteResult has no side effect and can be retried
+// to correct error. Currently the first return value is used to fallback to TiKV when TiFlash is down.
+func (cc *clientConn) executePreparedStmtAndWriteResult(ctx context.Context, stmt PreparedStatement, args []types.Datum, useCursor bool) (bool, error) {
 	rs, err := stmt.Execute(ctx, args)
 	if err != nil {
-		return errors.Annotate(err, cc.preparedStmt2String(stmtID))
+		return true, errors.Annotate(err, cc.preparedStmt2String(uint32(stmt.ID())))
 	}
 	if rs == nil {
-		return cc.writeOK(ctx)
+		return false, cc.writeOK(ctx)
 	}
 
 	// if the client wants to use cursor
@@ -207,20 +228,20 @@ func (cc *clientConn) handleStmtExecute(ctx context.Context, data []byte) (err e
 		stmt.StoreResultSet(rs)
 		err = cc.writeColumnInfo(rs.Columns(), mysql.ServerStatusCursorExists)
 		if err != nil {
-			return err
+			return false, err
 		}
 		if cl, ok := rs.(fetchNotifier); ok {
 			cl.OnFetchReturned()
 		}
 		// explicitly flush columnInfo to client.
-		return cc.flush(ctx)
+		return false, cc.flush(ctx)
 	}
 	defer terror.Call(rs.Close)
-	err = cc.writeResultset(ctx, rs, true, 0, 0)
+	retryable, err := cc.writeResultset(ctx, rs, true, 0, 0)
 	if err != nil {
-		return errors.Annotate(err, cc.preparedStmt2String(stmtID))
+		return retryable, errors.Annotate(err, cc.preparedStmt2String(uint32(stmt.ID())))
 	}
-	return nil
+	return false, nil
 }
 
 // maxFetchSize constants
@@ -252,7 +273,7 @@ func (cc *clientConn) handleStmtFetch(ctx context.Context, data []byte) (err err
 			strconv.FormatUint(uint64(stmtID), 10), "stmt_fetch_rs"), cc.preparedStmt2String(stmtID))
 	}
 
-	err = cc.writeResultset(ctx, rs, true, mysql.ServerStatusCursorExists, int(fetchSize))
+	_, err = cc.writeResultset(ctx, rs, true, mysql.ServerStatusCursorExists, int(fetchSize))
 	if err != nil {
 		return errors.Annotate(err, cc.preparedStmt2String(stmtID))
 	}
diff --git a/server/conn_test.go b/server/conn_test.go
index 54971486981b0..8a54c13ff7dfc 100644
--- a/server/conn_test.go
+++ b/server/conn_test.go
@@ -23,6 +23,7 @@ import (
 
 	. "github.com/pingcap/check"
 	"github.com/pingcap/failpoint"
+	"github.com/pingcap/parser/model"
 	"github.com/pingcap/parser/mysql"
 	"github.com/pingcap/tidb/domain"
 	"github.com/pingcap/tidb/executor"
@@ -710,3 +711,49 @@ func (ts *ConnTestSuite) TestPrefetchPointKeys(c *C) {
 	tk.MustExec("commit")
 	tk.MustQuery("select * from prefetch").Check(testkit.Rows("1 1 3", "2 2 6", "3 3 5"))
 }
+
+func (ts *ConnTestSuite) TestFallbackToTiKVWhenTiFlashIsDown(c *C) {
+	c.Assert(failpoint.Enable("github.com/pingcap/tidb/store/tikv/errorMockTiFlashServerTimeout", "return(true)"), IsNil)
+	cc := &clientConn{
+		alloc: arena.NewAllocator(1024),
+		pkt: &packetIO{
+			bufWriter: bufio.NewWriter(bytes.NewBuffer(nil)),
+		},
+	}
+	tk := testkit.NewTestKitWithInit(c, ts.store)
+	cc.ctx = &TiDBContext{Session: tk.Se, stmts: make(map[int]*TiDBStatement)}
+
+	tk.MustExec("set @@session.tidb_enable_tiflash_fallback_tikv = 1")
+	tk.MustExec("drop table if exists t")
+	tk.MustExec("create table t (a int, b int)")
+	tk.MustExec("insert into t values (3, 4), (6, 7), (9, 10)")
+
+	// Create virtual tiflash replica info.
+	dom := domain.GetDomain(tk.Se)
+	is := dom.InfoSchema()
+	db, exists := is.SchemaByName(model.NewCIStr("test"))
+	c.Assert(exists, IsTrue)
+	for _, tblInfo := range db.Tables {
+		if tblInfo.Name.L == "t" {
+			tblInfo.TiFlashReplica = &model.TiFlashReplicaInfo{
+				Count:     1,
+				Available: true,
+			}
+		}
+	}
+
+	tk.MustQuery("explain select sum(a) from t").Check(testkit.Rows(
+		"StreamAgg_20 1.00 root  funcs:sum(Column#6)->Column#4",
+		"└─TableReader_21 1.00 root  data:StreamAgg_8",
+		"  └─StreamAgg_8 1.00 cop[tiflash]  funcs:sum(test.t.a)->Column#6",
+		"    └─TableFullScan_19 10000.00 cop[tiflash] table:t keep order:false, stats:pseudo"))
+
+	ctx := context.Background()
+	c.Assert(cc.handleQuery(ctx, "select sum(a) from t"), IsNil)
+	tk.MustQuery("show warnings").Check(testkit.Rows("Error 9012 TiFlash server timeout"))
+	c.Assert(cc.handleStmtPrepare(ctx, "select sum(a) from t"), IsNil)
+	c.Assert(cc.handleStmtExecute(ctx, []byte{0x1, 0x0, 0x0, 0x0, 0x0, 0x1, 0x0, 0x0, 0x0}), IsNil)
+	tk.MustQuery("show warnings").Check(testkit.Rows("Error 9012 TiFlash server timeout"))
+
+	c.Assert(failpoint.Disable("github.com/pingcap/tidb/store/tikv/errorMockTiFlashServerTimeout"), IsNil)
+}
diff --git a/session/session.go b/session/session.go
index 474c24d5d3efb..6287c5df35a40 100644
--- a/session/session.go
+++ b/session/session.go
@@ -2640,6 +2640,7 @@ var builtinGlobalVariable = []string{
 	variable.TiDBTrackAggregateMemoryUsage,
 	variable.TiDBMultiStatementMode,
 	variable.TiDBEnableExchangePartition,
+	variable.TiDBEnableTiFlashFallbackTiKV,
 }
 
 var (
diff --git a/sessionctx/variable/session.go b/sessionctx/variable/session.go
index 38b8c5767e2c0..e763e10aed6b2 100644
--- a/sessionctx/variable/session.go
+++ b/sessionctx/variable/session.go
@@ -809,6 +809,9 @@ type SessionVars struct {
 
 	// TiDBEnableExchangePartition indicates whether to enable exchange partition
 	TiDBEnableExchangePartition bool
+
+	// EnableTiFlashFallbackTiKV indicates whether to fallback to TiKV when TiFlash is unavailable.
+	EnableTiFlashFallbackTiKV bool
 }
 
 // CheckAndGetTxnScope will return the transaction scope we should use in the current session.
@@ -967,6 +970,7 @@ func NewSessionVars() *SessionVars {
 		GuaranteeLinearizability:    DefTiDBGuaranteeLinearizability,
 		AnalyzeVersion:              DefTiDBAnalyzeVersion,
 		EnableIndexMergeJoin:        DefTiDBEnableIndexMergeJoin,
+		EnableTiFlashFallbackTiKV:   DefTiDBEnableTiFlashFallbackTiKV,
 	}
 	vars.KVVars = kv.NewVariables(&vars.Killed)
 	vars.Concurrency = Concurrency{
@@ -1697,6 +1701,8 @@ func (s *SessionVars) SetSystemVar(name string, val string) error {
 		s.MultiStatementMode = TiDBOptMultiStmt(val)
 	case TiDBEnableExchangePartition:
 		s.TiDBEnableExchangePartition = TiDBOptOn(val)
+	case TiDBEnableTiFlashFallbackTiKV:
+		s.EnableTiFlashFallbackTiKV = TiDBOptOn(val)
 	}
 	s.systems[name] = val
 	return nil
diff --git a/sessionctx/variable/sysvar.go b/sessionctx/variable/sysvar.go
index efd2a64a03653..b128ecd4276e3 100644
--- a/sessionctx/variable/sysvar.go
+++ b/sessionctx/variable/sysvar.go
@@ -659,6 +659,7 @@ var defaultSysVars = []*SysVar{
 	{Scope: ScopeGlobal | ScopeSession, Name: TiDBEnableFastAnalyze, Value: BoolToOnOff(DefTiDBUseFastAnalyze), Type: TypeBool},
 	{Scope: ScopeGlobal | ScopeSession, Name: TiDBSkipIsolationLevelCheck, Value: BoolToOnOff(DefTiDBSkipIsolationLevelCheck), Type: TypeBool},
 	{Scope: ScopeGlobal | ScopeSession, Name: TiDBEnableRateLimitAction, Value: BoolToOnOff(DefTiDBEnableRateLimitAction), Type: TypeBool},
+	{Scope: ScopeGlobal | ScopeSession, Name: TiDBEnableTiFlashFallbackTiKV, Value: BoolToOnOff(DefTiDBEnableTiFlashFallbackTiKV), Type: TypeBool},
 	/* The following variable is defined as session scope but is actually server scope. */
 	{Scope: ScopeSession, Name: TiDBGeneralLog, Value: BoolToOnOff(DefTiDBGeneralLog), Type: TypeBool},
 	{Scope: ScopeSession, Name: TiDBPProfSQLCPU, Value: strconv.Itoa(DefTiDBPProfSQLCPU), Type: TypeInt, MinValue: 0, MaxValue: 1},
diff --git a/sessionctx/variable/tidb_vars.go b/sessionctx/variable/tidb_vars.go
index 898d65747b562..7fd20780907e4 100644
--- a/sessionctx/variable/tidb_vars.go
+++ b/sessionctx/variable/tidb_vars.go
@@ -523,6 +523,9 @@ const (
 
 	// TiDBEnableExchangePartition indicates whether to enable exchange partition.
 	TiDBEnableExchangePartition = "tidb_enable_exchange_partition"
+
+	// TiDBEnableTiFlashFallbackTiKV indicates whether to fallback to TiKV when TiFlash is unavailable.
+	TiDBEnableTiFlashFallbackTiKV = "tidb_enable_tiflash_fallback_tikv"
 )
 
 // TiDB vars that have only global scope
@@ -663,6 +666,7 @@ const (
 	DefTiDBEnableIndexMergeJoin        = false
 	DefTiDBTrackAggregateMemoryUsage   = false
 	DefTiDBEnableExchangePartition     = false
+	DefTiDBEnableTiFlashFallbackTiKV   = false
 )
 
 // Process global variables.
diff --git a/sessionctx/variable/varsutil_test.go b/sessionctx/variable/varsutil_test.go
index c5b56363c3338..0c70f77a79ad9 100644
--- a/sessionctx/variable/varsutil_test.go
+++ b/sessionctx/variable/varsutil_test.go
@@ -105,6 +105,7 @@ func (s *testVarsutilSuite) TestNewSessionVars(c *C) {
 	c.Assert(vars.ShardAllocateStep, Equals, int64(DefTiDBShardAllocateStep))
 	c.Assert(vars.EnableChangeColumnType, Equals, DefTiDBChangeColumnType)
 	c.Assert(vars.AnalyzeVersion, Equals, DefTiDBAnalyzeVersion)
+	c.Assert(vars.EnableTiFlashFallbackTiKV, Equals, DefTiDBEnableTiFlashFallbackTiKV)
 
 	assertFieldsGreaterThanZero(c, reflect.ValueOf(vars.MemQuota))
 	assertFieldsGreaterThanZero(c, reflect.ValueOf(vars.BatchSize))
diff --git a/store/tikv/batch_coprocessor.go b/store/tikv/batch_coprocessor.go
index 39d4e9f6ba8c7..ba597fa346981 100644
--- a/store/tikv/batch_coprocessor.go
+++ b/store/tikv/batch_coprocessor.go
@@ -21,6 +21,7 @@ import (
 	"time"
 
 	"github.com/pingcap/errors"
+	"github.com/pingcap/failpoint"
 	"github.com/pingcap/kvproto/pkg/coprocessor"
 	"github.com/pingcap/kvproto/pkg/kvrpcpb"
 	"github.com/pingcap/kvproto/pkg/metapb"
@@ -146,6 +147,15 @@ func buildBatchCopTasks(bo *Backoffer, cache *RegionCache, ranges *KeyRanges, st
 		if needRetry {
 			// Backoff once for each retry.
 			err = bo.Backoff(BoRegionMiss, errors.New("Cannot find region with TiFlash peer"))
+			// Actually ErrRegionUnavailable would be thrown out rather than ErrTiFlashServerTimeout. However, since currently
+			// we don't have MockTiFlash, we inject ErrTiFlashServerTimeout to simulate the situation that TiFlash is down.
+			if storeType == kv.TiFlash {
+				failpoint.Inject("errorMockTiFlashServerTimeout", func(val failpoint.Value) {
+					if val.(bool) {
+						failpoint.Return(nil, errors.Trace(ErrTiFlashServerTimeout))
+					}
+				})
+			}
 			if err != nil {
 				return nil, errors.Trace(err)
 			}