diff --git a/.pre-commit-config.yaml b/.pre-commit-config.yaml
index 266e5a015e408..25fafb7800bb4 100644
--- a/.pre-commit-config.yaml
+++ b/.pre-commit-config.yaml
@@ -93,7 +93,19 @@ repos:
         pass_filenames: false
         types: [python]
         stages: [manual]
-        additional_dependencies: ['pyright@1.1.248']
+        additional_dependencies: &pyright_dependencies
+        - pyright@1.1.253
+-   repo: local
+    hooks:
+    -   id: pyright_reportGeneralTypeIssues
+        name: pyright reportGeneralTypeIssues
+        entry: pyright --skipunannotated -p pyright_reportGeneralTypeIssues.json
+        # note: assumes python env is setup and activated
+        language: node
+        pass_filenames: false
+        types: [python]
+        stages: [manual]
+        additional_dependencies: *pyright_dependencies
 -   repo: local
     hooks:
     -   id: mypy
diff --git a/pandas/_libs/lib.pyi b/pandas/_libs/lib.pyi
index d4a766f7086af..02f021128cbed 100644
--- a/pandas/_libs/lib.pyi
+++ b/pandas/_libs/lib.pyi
@@ -4,6 +4,7 @@
 from typing import (
     Any,
     Callable,
+    Final,
     Generator,
     Hashable,
     Literal,
@@ -26,7 +27,7 @@ from enum import Enum
 class _NoDefault(Enum):
     no_default = ...
 
-no_default = _NoDefault.no_default
+no_default: Final = _NoDefault.no_default
 NoDefault = Literal[_NoDefault.no_default]
 
 i8max: int
diff --git a/pandas/util/_doctools.py b/pandas/util/_doctools.py
index 18fb9a7e055b5..cb4ceb052a8e0 100644
--- a/pandas/util/_doctools.py
+++ b/pandas/util/_doctools.py
@@ -1,5 +1,7 @@
 from __future__ import annotations
 
+from typing import Iterable
+
 import numpy as np
 
 import pandas as pd
@@ -41,7 +43,7 @@ def _get_cells(self, left, right, vertical) -> tuple[int, int]:
             hcells = sum([self._shape(df)[1] for df in left] + [self._shape(right)[1]])
         return hcells, vcells
 
-    def plot(self, left, right, labels=None, vertical: bool = True):
+    def plot(self, left, right, labels: Iterable[str] = (), vertical: bool = True):
         """
         Plot left / right DataFrames in specified layout.
 
diff --git a/pyright_reportGeneralTypeIssues.json b/pyright_reportGeneralTypeIssues.json
new file mode 100644
index 0000000000000..22d607eb958e1
--- /dev/null
+++ b/pyright_reportGeneralTypeIssues.json
@@ -0,0 +1,127 @@
+# this becomes obsolete when reportGeneralTypeIssues can be enabled in pyproject.toml
+{
+    "typeCheckingMode": "off",
+    "reportGeneralTypeIssues": true,
+    "include":
+      [
+        "pandas",
+        "typings"
+      ],
+    "exclude":
+      [
+        # exclude tests
+        "pandas/tests",
+        # and all files that currently don't pass
+        "pandas/_config/config.py",
+        "pandas/core/algorithms.py",
+        "pandas/core/apply.py",
+        "pandas/core/array_algos/take.py",
+        "pandas/core/arrays/_mixins.py",
+        "pandas/core/arrays/_ranges.py",
+        "pandas/core/arrays/arrow/array.py",
+        "pandas/core/arrays/base.py",
+        "pandas/core/arrays/boolean.py",
+        "pandas/core/arrays/categorical.py",
+        "pandas/core/arrays/datetimelike.py",
+        "pandas/core/arrays/datetimes.py",
+        "pandas/core/arrays/interval.py",
+        "pandas/core/arrays/masked.py",
+        "pandas/core/arrays/numeric.py",
+        "pandas/core/arrays/period.py",
+        "pandas/core/arrays/sparse/array.py",
+        "pandas/core/arrays/sparse/dtype.py",
+        "pandas/core/arrays/string_.py",
+        "pandas/core/arrays/string_arrow.py",
+        "pandas/core/arrays/timedeltas.py",
+        "pandas/core/common.py",
+        "pandas/core/computation/align.py",
+        "pandas/core/construction.py",
+        "pandas/core/describe.py",
+        "pandas/core/dtypes/base.py",
+        "pandas/core/dtypes/cast.py",
+        "pandas/core/dtypes/common.py",
+        "pandas/core/dtypes/concat.py",
+        "pandas/core/dtypes/dtypes.py",
+        "pandas/core/frame.py",
+        "pandas/core/generic.py",
+        "pandas/core/groupby/generic.py",
+        "pandas/core/groupby/groupby.py",
+        "pandas/core/groupby/grouper.py",
+        "pandas/core/groupby/ops.py",
+        "pandas/core/indexers/objects.py",
+        "pandas/core/indexers/utils.py",
+        "pandas/core/indexes/base.py",
+        "pandas/core/indexes/category.py",
+        "pandas/core/indexes/datetimelike.py",
+        "pandas/core/indexes/datetimes.py",
+        "pandas/core/indexes/extension.py",
+        "pandas/core/indexes/interval.py",
+        "pandas/core/indexes/multi.py",
+        "pandas/core/indexes/numeric.py",
+        "pandas/core/indexes/period.py",
+        "pandas/core/indexes/range.py",
+        "pandas/core/indexing.py",
+        "pandas/core/internals/api.py",
+        "pandas/core/internals/array_manager.py",
+        "pandas/core/internals/base.py",
+        "pandas/core/internals/blocks.py",
+        "pandas/core/internals/concat.py",
+        "pandas/core/internals/construction.py",
+        "pandas/core/internals/managers.py",
+        "pandas/core/missing.py",
+        "pandas/core/nanops.py",
+        "pandas/core/resample.py",
+        "pandas/core/reshape/concat.py",
+        "pandas/core/reshape/merge.py",
+        "pandas/core/reshape/pivot.py",
+        "pandas/core/reshape/reshape.py",
+        "pandas/core/reshape/tile.py",
+        "pandas/core/series.py",
+        "pandas/core/sorting.py",
+        "pandas/core/strings/accessor.py",
+        "pandas/core/tools/datetimes.py",
+        "pandas/core/tools/timedeltas.py",
+        "pandas/core/util/hashing.py",
+        "pandas/core/util/numba_.py",
+        "pandas/core/window/ewm.py",
+        "pandas/core/window/expanding.py",
+        "pandas/core/window/rolling.py",
+        "pandas/io/common.py",
+        "pandas/io/excel/_base.py",
+        "pandas/io/excel/_odfreader.py",
+        "pandas/io/excel/_odswriter.py",
+        "pandas/io/excel/_openpyxl.py",
+        "pandas/io/excel/_pyxlsb.py",
+        "pandas/io/excel/_xlrd.py",
+        "pandas/io/formats/csvs.py",
+        "pandas/io/formats/excel.py",
+        "pandas/io/formats/format.py",
+        "pandas/io/formats/info.py",
+        "pandas/io/formats/printing.py",
+        "pandas/io/formats/style.py",
+        "pandas/io/formats/style_render.py",
+        "pandas/io/formats/xml.py",
+        "pandas/io/json/_json.py",
+        "pandas/io/parquet.py",
+        "pandas/io/parsers/arrow_parser_wrapper.py",
+        "pandas/io/parsers/base_parser.py",
+        "pandas/io/parsers/c_parser_wrapper.py",
+        "pandas/io/parsers/python_parser.py",
+        "pandas/io/parsers/readers.py",
+        "pandas/io/pytables.py",
+        "pandas/io/sas/sas7bdat.py",
+        "pandas/io/sas/sasreader.py",
+        "pandas/io/sql.py",
+        "pandas/io/stata.py",
+        "pandas/io/xml.py",
+        "pandas/plotting/_core.py",
+        "pandas/plotting/_matplotlib/converter.py",
+        "pandas/plotting/_matplotlib/core.py",
+        "pandas/plotting/_matplotlib/hist.py",
+        "pandas/plotting/_matplotlib/misc.py",
+        "pandas/plotting/_matplotlib/style.py",
+        "pandas/plotting/_matplotlib/timeseries.py",
+        "pandas/plotting/_matplotlib/tools.py",
+        "pandas/tseries/frequencies.py",
+      ],
+}
diff --git a/typings/numba.pyi b/typings/numba.pyi
index f877cbf339a8b..36cccb894049b 100644
--- a/typings/numba.pyi
+++ b/typings/numba.pyi
@@ -12,9 +12,7 @@ from pandas._typing import F
 
 def __getattr__(name: str) -> Any: ...  # incomplete
 @overload
-def jit(
-    signature_or_function: F = ...,
-) -> F: ...
+def jit(signature_or_function: F) -> F: ...
 @overload
 def jit(
     signature_or_function: str