diff --git a/instrumentation/src/java/org/oppia/android/instrumentation/testing/EndToEndTestHelper.kt b/instrumentation/src/java/org/oppia/android/instrumentation/testing/EndToEndTestHelper.kt
index 776b59a704b..3074b255a1e 100644
--- a/instrumentation/src/java/org/oppia/android/instrumentation/testing/EndToEndTestHelper.kt
+++ b/instrumentation/src/java/org/oppia/android/instrumentation/testing/EndToEndTestHelper.kt
@@ -49,16 +49,32 @@ object EndToEndTestHelper {
     wait(Until.hasObject(By.text(text)), TRANSITION_TIMEOUT_SECONDS)
   }
 
+  /** Waits for the view with given content description to appear. */
+  fun UiDevice.waitForDesc(text: String) {
+    wait(Until.hasObject(By.desc(text)), TRANSITION_TIMEOUT_SECONDS)
+  }
+
   /** Return the UiObject with the given text. */
-  fun UiDevice.findObjectByText(text: String): UiObject2? {
+  fun UiDevice.findObjectByText(text: String): UiObject2 {
     waitForText(text)
-    return findObject(By.text(text))
+    return checkNotNull(findObject(By.text(text)))
   }
 
   /** Returns the UiObject for the given resourceId. */
-  fun UiDevice.findObjectByRes(resourceId: String): UiObject2? {
+  fun UiDevice.findObjectByRes(resourceId: String): UiObject2 {
     waitForRes(resourceId)
-    return findObject(By.res("$OPPIA_PACKAGE:id/$resourceId"))
+    return checkNotNull(findObject(By.res("$OPPIA_PACKAGE:id/$resourceId")))
+  }
+
+  /** Returns the UiObject for the given resourceId. */
+  fun UiObject2.findObjectByRes(resourceId: String): UiObject2 {
+    return checkNotNull(findObject(By.res("$OPPIA_PACKAGE:id/$resourceId")))
+  }
+
+  /** Returns the UiObject for the given content description. */
+  fun UiDevice.findObjectByDesc(text: String): UiObject2 {
+    waitForDesc(text)
+    return checkNotNull(findObject(By.desc(text)))
   }
 
   /** Performs a scroll until the view with the give text is visible. */
diff --git a/instrumentation/src/javatests/org/oppia/android/instrumentation/player/ExplorationPlayerTest.kt b/instrumentation/src/javatests/org/oppia/android/instrumentation/player/ExplorationPlayerTest.kt
index a6d16c181c0..4bf77e7610b 100644
--- a/instrumentation/src/javatests/org/oppia/android/instrumentation/player/ExplorationPlayerTest.kt
+++ b/instrumentation/src/javatests/org/oppia/android/instrumentation/player/ExplorationPlayerTest.kt
@@ -4,7 +4,9 @@ import androidx.test.platform.app.InstrumentationRegistry
 import androidx.test.uiautomator.UiDevice
 import com.google.common.truth.Truth.assertThat
 import org.junit.Before
+import org.junit.Ignore
 import org.junit.Test
+import org.oppia.android.instrumentation.testing.EndToEndTestHelper.findObjectByDesc
 import org.oppia.android.instrumentation.testing.EndToEndTestHelper.findObjectByRes
 import org.oppia.android.instrumentation.testing.EndToEndTestHelper.findObjectByText
 import org.oppia.android.instrumentation.testing.EndToEndTestHelper.scrollRecyclerViewTextIntoView
@@ -23,22 +25,162 @@ class ExplorationPlayerTest {
   }
 
   @Test
-  fun testExploration_prototypeExploration_toolbarTitle_isDisplayedSuccessfully() {
+  fun testPlayExploration_prototypeExploration_playedFullyThrough_finishesSuccessfully() {
     navigateToPrototypeExploration()
-    assertThat(device.findObjectByRes("exploration_toolbar_title")).isNotNull()
+
+    // Play through all interactions.
+    playContinueInteraction()
+    playFractionInputInteraction()
+    playMultipleChoiceIntearction1()
+    playMultipleChoiceIntearction2()
+    playItemSelectionInteraction()
+    playNumericInputInteraction()
+    playRatioInputInteraction()
+    playTextInputInteraction()
+    playDragAndDropInteraction()
+    playDragDropMergeInteraction()
+    playEndExplorationInteraction()
+
+    // Assert Topic Completed.
+    scrollRecyclerViewTextIntoView("Chapter 1: Prototype Exploration")
+    val chapterCompletedTick = device.findObjectByText(
+      "Chapter 1: Prototype Exploration"
+    ).parent.findObjectByRes("chapter_completed_tick")
+    assertThat(chapterCompletedTick).isNotNull()
+  }
+
+  // TODO(#3697): Update e2e tests when backend support is introduced.
+  @Test
+  @Ignore("Need backend connection support to test the ImageRegionSelectionInteraction")
+  fun testPlayExploration_imageRegionInteractionExp_playedFullyThrough_finishesSuccessfully() {
+    navigateToImageRegionSelectionInteraction()
+
+    // Image Region Selection Interaction.
+    val imageSelectionView = device.findObjectByRes("interaction_container_frame_layout")
+    device.waitForRes("image_click_interaction_image_view")
+    // TODO(#3712): Use content description to fetch the image region.
+    imageSelectionView.children.get(2).click()
+    device.findObjectByText("SUBMIT").click()
+    device.findObjectByText("CONTINUE").click()
+
+    // End Exploration.
+    playEndExplorationInteraction()
+
+    // Assert Topic Completed.
+    scrollRecyclerViewTextIntoView("Chapter 2: Image Region Selection Exploration")
+    val chapterCompletedTick = device.findObjectByText(
+      "Chapter 2: Image Region Selection Exploration"
+    ).parent.findObjectByRes("chapter_completed_tick")
+    assertThat(chapterCompletedTick).isNotNull()
   }
 
   /** Navigates and opens the Prototype Exploration using the admin profile. */
   private fun navigateToPrototypeExploration() {
-    device.findObjectByRes("skip_text_view")?.click()
-    device.findObjectByRes("get_started_button")?.click()
+    device.findObjectByRes("skip_text_view").click()
+    device.findObjectByRes("get_started_button").click()
+    device.waitForRes("profile_select_text")
+    device.findObjectByText("Admin").click()
+    scrollRecyclerViewTextIntoView("First Test Topic")
+    device.findObjectByText("First Test Topic").click()
+    device.findObjectByText("LESSONS").click()
+    device.findObjectByText("First Story").click()
+    scrollRecyclerViewTextIntoView("Chapter 1: Prototype Exploration")
+    device.findObjectByText("Chapter 1: Prototype Exploration").click()
+  }
+
+  private fun completePrototypeExploration() {
+    playContinueInteraction()
+    playFractionInputInteraction()
+    playMultipleChoiceIntearction1()
+    playMultipleChoiceIntearction2()
+    playItemSelectionInteraction()
+    playNumericInputInteraction()
+    playRatioInputInteraction()
+    playTextInputInteraction()
+    playDragAndDropInteraction()
+    playDragDropMergeInteraction()
+    playEndExplorationInteraction()
+  }
+
+  private fun playContinueInteraction() {
+    device.findObjectByText("CONTINUE").click()
+  }
+
+  private fun playFractionInputInteraction() {
+    device.findObjectByRes("fraction_input_interaction_view").text = "1/2"
+    device.findObjectByText("SUBMIT").click()
+    playContinueInteraction()
+  }
+
+  private fun playMultipleChoiceIntearction1() {
+    device.findObjectByText("Eagle").click()
+    playContinueInteraction()
+  }
+
+  private fun playMultipleChoiceIntearction2() {
+    device.findObjectByText("Green").click()
+    playContinueInteraction()
+  }
+
+  private fun playItemSelectionInteraction() {
+    device.findObjectByText("Red").click()
+    device.findObjectByText("Green").click()
+    device.findObjectByText("Blue").click()
+    device.findObjectByText("SUBMIT").click()
+    playContinueInteraction()
+  }
+
+  private fun playNumericInputInteraction() {
+    device.findObjectByRes("numeric_input_interaction_view").text = "121"
+    device.findObjectByText("SUBMIT").click()
+    playContinueInteraction()
+  }
+
+  private fun playRatioInputInteraction() {
+    device.findObjectByRes("ratio_input_interaction_view").text = "4:5"
+    device.findObjectByText("SUBMIT").click()
+    playContinueInteraction()
+  }
+
+  private fun playTextInputInteraction() {
+    device.findObjectByRes("text_input_interaction_view").text = "Finnish"
+    device.findObjectByText("SUBMIT").click()
+    playContinueInteraction()
+  }
+
+  private fun playDragAndDropInteraction() {
+    device.findObjectByDesc("Move item down to 2").click()
+    device.findObjectByDesc("Move item down to 3").click()
+    device.findObjectByDesc("Move item down to 4").click()
+    device.findObjectByText("SUBMIT").click()
+    playContinueInteraction()
+  }
+
+  private fun playDragDropMergeInteraction() {
+    device.findObjectByDesc("Link to item 2").click()
+    device.findObjectByDesc("Move item down to 3").click()
+    device.findObjectByText("SUBMIT").click()
+    playContinueInteraction()
+  }
+
+  private fun playEndExplorationInteraction() {
+    device.findObjectByText("RETURN TO TOPIC").click()
+  }
+
+  /** Navigates and opens the Image Region Selection Exploration using the admin profile. */
+  private fun navigateToImageRegionSelectionInteraction() {
+    device.findObjectByRes("skip_text_view").click()
+    device.findObjectByRes("get_started_button").click()
     device.waitForRes("profile_select_text")
-    device.findObjectByText("Admin")?.click()
+    device.findObjectByText("Admin").click()
     scrollRecyclerViewTextIntoView("First Test Topic")
-    device.findObjectByText("First Test Topic")?.click()
-    device.findObjectByText("LESSONS")?.click()
-    device.findObjectByText("First Story")?.click()
+    device.findObjectByText("First Test Topic").click()
+    device.findObjectByText("LESSONS").click()
+    device.findObjectByText("First Story").click()
     scrollRecyclerViewTextIntoView("Chapter 1: Prototype Exploration")
-    device.findObjectByText("Chapter 1: Prototype Exploration")?.click()
+    device.findObjectByText("Chapter 1: Prototype Exploration").click()
+    completePrototypeExploration()
+    scrollRecyclerViewTextIntoView("Chapter 2: Image Region Selection Exploration")
+    device.findObjectByText("Chapter 2: Image Region Selection Exploration").click()
   }
 }