diff --git a/thirdparty/CMakeLists.txt b/thirdparty/CMakeLists.txt
index a65fdb2e56680d..d35947dca9e38b 100644
--- a/thirdparty/CMakeLists.txt
+++ b/thirdparty/CMakeLists.txt
@@ -158,7 +158,7 @@ if(NGRAPH_PDPD_FRONTEND_ENABLE OR NGRAPH_ONNX_IMPORT_ENABLE)
         if(NGRAPH_USE_SYSTEM_PROTOBUF)
             set(link_type INTERFACE)
         endif()
-        if(CMAKE_COMPILER_IS_GNUCXX OR CMAKE_CXX_COMPILER_ID MATCHES "^(Apple)?Clang$")
+        if(CMAKE_COMPILER_IS_GNUCXX OR OV_COMPILER_IS_CLANG)
             target_compile_options(${target} ${link_type} -Wno-undef)
         endif()
     endforeach()
diff --git a/thirdparty/protobuf/CMakeLists.txt b/thirdparty/protobuf/CMakeLists.txt
index c4d6fe26bc2af6..f3cec9914a16f5 100644
--- a/thirdparty/protobuf/CMakeLists.txt
+++ b/thirdparty/protobuf/CMakeLists.txt
@@ -63,6 +63,8 @@ if(CMAKE_COMPILER_IS_GNUCXX OR OV_COMPILER_IS_CLANG)
     if(TARGET libprotoc)
         list(APPEND _proto_libs libprotoc)
         target_compile_options(libprotoc PRIVATE -Wno-all -Wno-unused-variable)
+        # libprotobuf is always built for protoc
+        target_compile_options(libprotobuf PUBLIC -Wno-undef)
     endif()
     set_target_properties(${_proto_libs} PROPERTIES
         CXX_VISIBILITY_PRESET default