disease_target_evidence.json

{
  "$schema": "http://json-schema.org/draft-07/schema#",
  "title": "OpenTargets",
  "description": "OpenTargets evidence objects",
  "type": "object",
  "oneOf": [
    {
      "properties": {
        "datasourceId": {
          "const": "cancer_gene_census"
        },
        "allelicRequirements": {
          "$ref": "#/definitions/allelicRequirements"
        },
        "biosamplesFromSource": {
          "$ref": "#/definitions/biosamplesFromSource"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "diseaseFromSource": {
          "$ref": "#/definitions/diseaseFromSource"
        },
        "diseaseFromSourceId": {
          "$ref": "#/definitions/diseaseFromSourceId"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceMappedId"
        },
        "literature": {
          "$ref": "#/definitions/literature"
        },
        "mutatedSamples": {
          "$ref": "#/definitions/mutatedSamples"
        },
        "resourceScore": {
          "$ref": "#/definitions/resourceScore"
        },
        "studyId": {
          "$ref": "#/definitions/studyId"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        }
      },
      "required": [
        "datasourceId",
        "mutatedSamples",
        "resourceScore",
        "targetFromSourceId"
      ],
      "additionalProperties": false
    },
    {
      "properties": {
        "datasourceId": {
          "const": "cancer_biomarkers"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "biomarkerName": {
          "$ref": "#/definitions/biomarkerName"
        },
        "biomarkers": {
          "$ref": "#/definitions/biomarkers"
        },
        "confidence": {
          "$ref": "#/definitions/confidence"
        },
        "diseaseFromSource": {
          "$ref": "#/definitions/diseaseFromSource"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceMappedId"
        },
        "drugFromSource": {
          "$ref": "#/definitions/drugFromSource"
        },
        "drugId": {
          "$ref": "#/definitions/drugId"
        },
        "drugResponse": {
          "$ref": "#/definitions/drugResponse"
        },
        "literature": {
          "$ref": "#/definitions/literature"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        },
        "urls": {
          "$ref": "#/definitions/urls"
        }
      },
      "required": [
        "biomarkerName",
        "confidence",
        "datasourceId",
        "diseaseFromSource",
        "drugFromSource",
        "drugResponse",
        "targetFromSourceId"
      ],
      "additionalProperties": false
    },
    {
      "properties": {
        "datasourceId": {
          "const": "chembl"
        },
        "clinicalPhase": {
          "$ref": "#/definitions/clinicalPhase"
        },
        "clinicalStatus": {
          "$ref": "#/definitions/clinicalStatus"
        },
        "cohortPhenotypes": {
          "$ref": "#/definitions/cohortPhenotypes"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "diseaseFromSource": {
          "$ref": "#/definitions/diseaseFromSource"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceMappedId"
        },
        "drugId": {
          "$ref": "#/definitions/drugId"
        },
        "studyId": {
          "$ref": "#/definitions/studyId"
        },
        "studyStartDate": {
          "$ref": "#/definitions/studyStartDate"
        },
        "studyStopReason": {
          "$ref": "#/definitions/studyStopReason"
        },
        "studyStopReasonCategories": {
          "$ref": "#/definitions/studyStopReasonCategories"
        },
        "targetFromSource": {
          "$ref": "#/definitions/targetFromSourceId"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        },
        "urls": {
          "$ref": "#/definitions/urls"
        }
      },
      "required": [
        "clinicalPhase",
        "datasourceId",
        "drugId",
        "targetFromSource",
        "targetFromSourceId",
        "urls"
      ],
      "additionalProperties": false
    },
    {
      "properties": {
        "datasourceId": {
          "const": "clingen"
        },
        "allelicRequirements": {
          "$ref": "#/definitions/allelicRequirements"
        },
        "confidence": {
          "$ref": "#/definitions/confidence"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "diseaseFromSource": {
          "$ref": "#/definitions/diseaseFromSource"
        },
        "diseaseFromSourceId": {
          "$ref": "#/definitions/diseaseFromSourceId"
        },
        "studyId": {
          "$ref": "#/definitions/studyId"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceMappedId"
        },
        "urls": {
          "$ref": "#/definitions/urls"
        }
      },
      "required": [
        "allelicRequirements",
        "confidence",
        "diseaseFromSource",
        "datasourceId",
        "studyId",
        "targetFromSourceId",
        "urls"
      ],
      "additionalProperties": false
    },
    {
      "properties": {
        "datasourceId": {
          "const": "crispr"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "diseaseCellLines": {
          "$ref": "#/definitions/diseaseCellLines"
        },
        "diseaseFromSource": {
          "$ref": "#/definitions/diseaseFromSource"
        },
        "diseaseFromSourceId": {
          "$ref": "#/definitions/diseaseFromSourceId"
        },
        "literature": {
          "$ref": "#/definitions/literature"
        },
        "resourceScore": {
          "$ref": "#/definitions/resourceScore"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        },
        "targetFromSource": {
          "$ref": "#/definitions/targetFromSource"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceMappedId"
        }
      },
      "required": [
        "datasourceId",
        "diseaseCellLines",
        "diseaseFromSource",
        "resourceScore",
        "targetFromSourceId"
      ],
      "additionalProperties": false
    },
    {
      "properties": {
        "datasourceId": {
          "const": "crispr_screen"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "cellType": {
          "$ref": "#/definitions/cellType"
        },
        "diseaseFromSource": {
          "$ref": "#/definitions/diseaseFromSource"
        },
        "literature": {
          "$ref": "#/definitions/literature"
        },
        "resourceScore": {
          "$ref": "#/definitions/resourceScore"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceMappedId"
        },
        "projectId": {
          "$ref": "#/definitions/projectId"
        },
        "crisprScreenLibrary": {
          "$ref": "#/definitions/crisprScreenLibrary"
        },
        "studyOverview": {
          "$ref": "#/definitions/studyOverview"
        },
        "contrast": {
          "$ref": "#/definitions/contrast"
        },
        "statisticalTestTail": {
          "$ref": "#/definitions/statisticalTestTail"
        },
        "log2FoldChangeValue": {
          "$ref": "#/definitions/log2FoldChangeValue"
        },
        "studyId": {
          "$ref": "#/definitions/studyId"
        },
        "geneticBackground": {
          "$ref": "#/definitions/geneticBackground"
        }
      },
      "required": [
        "datasourceId",
        "datatypeId",
        "cellType",
        "diseaseFromSourceMappedId",
        "resourceScore",
        "targetFromSourceId",
        "contrast",
        "studyId"
      ],
      "additionalProperties": false
    },
    {
      "properties": {
        "datasourceId": {
          "const": "encore"
        },
        "biomarkerList": {
          "$ref": "#/definitions/biomarkerList"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "diseaseCellLines": {
          "$ref": "#/definitions/diseaseCellLines"
        },
        "diseaseFromSource": {
          "$ref": "#/definitions/diseaseFromSource"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceMappedId"
        },
        "geneInteractionType": {
          "$ref": "#/definitions/geneInteractionType"
        },
        "geneticInteractionFDR": {
          "$ref": "#/definitions/geneticInteractionFDR"
        },
        "statisticalMethod": {
          "$ref": "#/definitions/statisticalMethod"
        },
        "geneticInteractionPValue": {
          "$ref": "#/definitions/geneticInteractionPValue"
        },
        "geneticInteractionScore": {
          "$ref": "#/definitions/geneticInteractionScore"
        },
        "interactingTargetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        },
        "interactingTargetRole": {
          "$ref": "#/definitions/targetRole"
        },
        "phenotypicConsequenceFDR": {
          "$ref": "#/definitions/phenotypicConsequenceFDR"
        },
        "phenotypicConsequenceLogFoldChange": {
          "$ref": "#/definitions/phenotypicConsequenceLogFoldChange"
        },
        "phenotypicConsequencePValue": {
          "$ref": "#/definitions/phenotypicConsequencePValue"
        },
        "projectDescription": {
          "$ref": "#/definitions/projectDescription"
        },
        "projectId": {
          "$ref": "#/definitions/projectId"
        },
        "releaseDate": {
          "$ref": "#/definitions/releaseDate"
        },
        "releaseVersion": {
          "$ref": "#/definitions/releaseVersion"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        },
        "targetRole": {
          "$ref": "#/definitions/targetRole"
        },
        "warningMessage": {
          "$ref": "#/definitions/warningMessage"
        }
      },
      "required": [
        "datasourceId",
        "datatypeId",
        "diseaseFromSourceMappedId",
        "targetFromSourceId",
        "geneticInteractionScore"
      ],
      "additionalProperties": false
    },
    {
      "properties": {
        "datasourceId": {
          "const": "europepmc"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceId"
        },
        "literature": {
          "$ref": "#/definitions/literature"
        },
        "publicationYear": {
          "$ref": "#/definitions/publicationYear"
        },
        "resourceScore": {
          "$ref": "#/definitions/resourceScore"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        },
        "textMiningSentences": {
          "$ref": "#/definitions/textMiningSentences"
        },
        "pmcIds": {
          "$ref": "#/definitions/pmcIds"
        }
      },
      "required": [
        "datasourceId",
        "diseaseFromSourceMappedId",
        "publicationYear",
        "resourceScore",
        "targetFromSourceId",
        "textMiningSentences"
      ],
      "additionalProperties": false
    },
    {
      "properties": {
        "datasourceId": {
          "const": "eva"
        },
        "alleleOrigins": {
          "$ref": "#/definitions/alleleOrigins"
        },
        "allelicRequirements": {
          "$ref": "#/definitions/allelicRequirements"
        },
        "clinicalSignificances": {
          "$ref": "#/definitions/clinicalSignificances"
        },
        "cohortPhenotypes": {
          "$ref": "#/definitions/cohortPhenotypes"
        },
        "confidence": {
          "$ref": "#/definitions/confidence"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "diseaseFromSource": {
          "$ref": "#/definitions/diseaseFromSource"
        },
        "diseaseFromSourceId": {
          "$ref": "#/definitions/diseaseFromSourceId"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceMappedId"
        },
        "literature": {
          "$ref": "#/definitions/literature"
        },
        "studyId": {
          "$ref": "#/definitions/studyId"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        },
        "variantFunctionalConsequenceId": {
          "$ref": "#/definitions/variantFunctionalConsequenceId"
        },
        "variantHgvsId": {
          "$ref": "#/definitions/variantHgvsId"
        },
        "variantFromSourceId": {
          "$ref": "#/definitions/variantFromSourceId"
        },
        "variantId": {
          "$ref": "#/definitions/variantId"
        },
        "variantRsId": {
          "$ref": "#/definitions/variantRsId"
        },
        "releaseDate": {
          "$ref": "#/definitions/releaseDate"
        }
      },
      "required": [
        "clinicalSignificances",
        "cohortPhenotypes",
        "confidence",
        "datasourceId",
        "diseaseFromSource",
        "studyId",
        "targetFromSourceId",
        "variantFunctionalConsequenceId"
      ],
      "additionalProperties": false
    },
    {
      "properties": {
        "datasourceId": {
          "const": "eva_somatic"
        },
        "alleleOrigins": {
          "$ref": "#/definitions/alleleOrigins"
        },
        "allelicRequirements": {
          "$ref": "#/definitions/allelicRequirements"
        },
        "clinicalSignificances": {
          "$ref": "#/definitions/clinicalSignificances"
        },
        "cohortPhenotypes": {
          "$ref": "#/definitions/cohortPhenotypes"
        },
        "confidence": {
          "$ref": "#/definitions/confidence"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "diseaseFromSource": {
          "$ref": "#/definitions/diseaseFromSource"
        },
        "diseaseFromSourceId": {
          "$ref": "#/definitions/diseaseFromSourceId"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceMappedId"
        },
        "literature": {
          "$ref": "#/definitions/literature"
        },
        "studyId": {
          "$ref": "#/definitions/studyId"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        },
        "variantFunctionalConsequenceId": {
          "$ref": "#/definitions/variantFunctionalConsequenceId"
        },
        "variantHgvsId": {
          "$ref": "#/definitions/variantHgvsId"
        },
        "variantFromSourceId": {
          "$ref": "#/definitions/variantFromSourceId"
        },
        "variantId": {
          "$ref": "#/definitions/variantId"
        },
        "variantRsId": {
          "$ref": "#/definitions/variantRsId"
        },
        "releaseDate": {
          "$ref": "#/definitions/releaseDate"
        }
      },
      "required": [
        "alleleOrigins",
        "clinicalSignificances",
        "cohortPhenotypes",
        "confidence",
        "datasourceId",
        "diseaseFromSource",
        "studyId",
        "targetFromSourceId",
        "variantFunctionalConsequenceId"
      ],
      "additionalProperties": false
    },
    {
      "properties": {
        "datasourceId": {
          "const": "expression_atlas"
        },
        "biosamplesFromSource": {
          "$ref": "#/definitions/biosamplesFromSource"
        },
        "confidence": {
          "$ref": "#/definitions/confidence"
        },
        "contrast": {
          "$ref": "#/definitions/contrast"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "diseaseFromSource": {
          "$ref": "#/definitions/diseaseFromSource"
        },
        "diseaseFromSourceId": {
          "$ref": "#/definitions/diseaseFromSourceId"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceMappedId"
        },
        "literature": {
          "$ref": "#/definitions/literature"
        },
        "log2FoldChangePercentileRank": {
          "$ref": "#/definitions/log2FoldChangePercentileRank"
        },
        "log2FoldChangeValue": {
          "$ref": "#/definitions/log2FoldChangeValue"
        },
        "resourceScore": {
          "$ref": "#/definitions/resourceScore"
        },
        "studyId": {
          "$ref": "#/definitions/studyId"
        },
        "studyOverview": {
          "$ref": "#/definitions/studyOverview"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        }
      },
      "required": [
        "confidence",
        "contrast",
        "datasourceId",
        "log2FoldChangePercentileRank",
        "log2FoldChangeValue",
        "resourceScore",
        "studyId",
        "studyOverview",
        "targetFromSourceId"
      ],
      "additionalProperties": false
    },
    {
      "properties": {
        "datasourceId": {
          "const": "gene2phenotype"
        },
        "allelicRequirements": {
          "$ref": "#/definitions/allelicRequirements"
        },
        "confidence": {
          "$ref": "#/definitions/confidence"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "diseaseFromSource": {
          "$ref": "#/definitions/diseaseFromSource"
        },
        "diseaseFromSourceId": {
          "$ref": "#/definitions/diseaseFromSourceId"
        },
        "literature": {
          "$ref": "#/definitions/literature"
        },
        "studyId": {
          "$ref": "#/definitions/studyId"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceMappedId"
        },
        "variantFunctionalConsequenceId": {
          "$ref": "#/definitions/variantFunctionalConsequenceId"
        }
      },
      "required": [
        "confidence",
        "datasourceId",
        "diseaseFromSource",
        "studyId",
        "targetFromSourceId"
      ],
      "additionalProperties": false
    },
    {
      "properties": {
        "datasourceId": {
          "const": "gene_burden"
        },
        "allelicRequirements": {
          "$ref": "#/definitions/allelicRequirements"
        },
        "ancestry": {
          "$ref": "#/definitions/ancestry"
        },
        "ancestryId": {
          "$ref": "#/definitions/ancestryId"
        },
        "beta": {
          "$ref": "#/definitions/beta"
        },
        "betaConfidenceIntervalLower": {
          "$ref": "#/definitions/confidenceIntervalLower"
        },
        "betaConfidenceIntervalUpper": {
          "$ref": "#/definitions/confidenceIntervalUpper"
        },
        "cohortId": {
          "$ref": "#/definitions/cohortId"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "diseaseFromSource": {
          "$ref": "#/definitions/diseaseFromSource"
        },
        "diseaseFromSourceId": {
          "$ref": "#/definitions/diseaseFromSourceId"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceMappedId"
        },
        "literature": {
          "$ref": "#/definitions/literature"
        },
        "oddsRatio": {
          "$ref": "#/definitions/oddsRatio"
        },
        "oddsRatioConfidenceIntervalLower": {
          "$ref": "#/definitions/confidenceIntervalLower"
        },
        "oddsRatioConfidenceIntervalUpper": {
          "$ref": "#/definitions/confidenceIntervalUpper"
        },
        "projectId": {
          "$ref": "#/definitions/projectId"
        },
        "pValueMantissa": {
          "$ref": "#/definitions/pValueMantissa"
        },
        "pValueExponent": {
          "$ref": "#/definitions/pValueExponent"
        },
        "resourceScore": {
          "$ref": "#/definitions/resourceScore"
        },
        "releaseVersion": {
          "$ref": "#/definitions/releaseVersion"
        },
        "sex": {
          "$ref": "#/definitions/sex"
        },
        "statisticalMethod": {
          "$ref": "#/definitions/statisticalMethod"
        },
        "statisticalMethodOverview": {
          "$ref": "#/definitions/statisticalMethodOverview"
        },
        "studyCases": {
          "$ref": "#/definitions/studyCases"
        },
        "studyCasesWithQualifyingVariants": {
          "$ref": "#/definitions/studyCasesWithQualifyingVariants"
        },
        "studySampleSize": {
          "$ref": "#/definitions/studySampleSize"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        },
        "urls": {
          "$ref": "#/definitions/urls"
        }
      },
      "required": [
        "datasourceId",
        "pValueMantissa",
        "resourceScore",
        "statisticalMethod",
        "statisticalMethodOverview",
        "studySampleSize",
        "targetFromSourceId"
      ],
      "additionalProperties": false
    },
    {
      "properties": {
        "datasourceId": {
          "const": "genomics_england"
        },
        "allelicRequirements": {
          "$ref": "#/definitions/allelicRequirements"
        },
        "cohortPhenotypes": {
          "$ref": "#/definitions/cohortPhenotypes"
        },
        "confidence": {
          "$ref": "#/definitions/confidence"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "diseaseFromSource": {
          "$ref": "#/definitions/diseaseFromSource"
        },
        "diseaseFromSourceId": {
          "$ref": "#/definitions/diseaseFromSourceId"
        },
        "literature": {
          "$ref": "#/definitions/literature"
        },
        "studyId": {
          "$ref": "#/definitions/studyId"
        },
        "studyOverview": {
          "$ref": "#/definitions/studyOverview"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceMappedId"
        }
      },
      "required": [
        "cohortPhenotypes",
        "datasourceId",
        "studyId",
        "studyOverview",
        "targetFromSourceId"
      ],
      "additionalProperties": false
    },
    {
      "properties": {
        "datasourceId": {
          "const": "intogen"
        },
        "cohortDescription": {
          "$ref": "#/definitions/cohortDescription"
        },
        "cohortId": {
          "$ref": "#/definitions/cohortId"
        },
        "cohortShortName": {
          "$ref": "#/definitions/cohortShortName"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "diseaseFromSource": {
          "$ref": "#/definitions/diseaseFromSource"
        },
        "mutatedSamples": {
          "$ref": "#/definitions/mutatedSamples"
        },
        "resourceScore": {
          "$ref": "#/definitions/resourceScore"
        },
        "significantDriverMethods": {
          "$ref": "#/definitions/significantDriverMethods"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceMappedId"
        }
      },
      "required": [
        "cohortDescription",
        "cohortId",
        "cohortShortName",
        "datasourceId",
        "diseaseFromSource",
        "mutatedSamples",
        "targetFromSourceId"
      ],
      "additionalProperties": false
    },
    {
      "properties": {
        "datasourceId": {
          "const": "orphanet"
        },
        "alleleOrigins": {
          "$ref": "#/definitions/alleleOrigins"
        },
        "confidence": {
          "$ref": "#/definitions/confidence"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "diseaseFromSource": {
          "$ref": "#/definitions/diseaseFromSource"
        },
        "diseaseFromSourceId": {
          "$ref": "#/definitions/diseaseFromSourceId"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceMappedId"
        },
        "literature": {
          "$ref": "#/definitions/literature"
        },
        "targetFromSource": {
          "$ref": "#/definitions/targetFromSource"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        },
        "variantFunctionalConsequenceId": {
          "$ref": "#/definitions/variantFunctionalConsequenceId"
        }
      },
      "required": [
        "alleleOrigins",
        "confidence",
        "datasourceId",
        "diseaseFromSource",
        "targetFromSourceId"
      ],
      "additionalProperties": false
    },
    {
      "properties": {
        "datasourceId": {
          "const": "ot_crispr"
        },
        "cellLineBackground": {
          "$ref": "#/definitions/cellLineBackground"
        },
        "cellType": {
          "$ref": "#/definitions/cellType"
        },
        "contrast": {
          "$ref": "#/definitions/contrast"
        },
        "crisprScreenLibrary": {
          "$ref": "#/definitions/crisprScreenLibrary"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "statisticalTestTail": {
          "$ref": "#/definitions/statisticalTestTail"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceMappedId"
        },
        "geneticBackground": {
          "$ref": "#/definitions/geneticBackground"
        },
        "log2FoldChangeValue": {
          "$ref": "#/definitions/log2FoldChangeValue"
        },
        "projectDescription": {
          "$ref": "#/definitions/projectDescription"
        },
        "projectId": {
          "$ref": "#/definitions/projectId"
        },
        "releaseDate": {
          "$ref": "#/definitions/releaseDate"
        },
        "releaseVersion": {
          "$ref": "#/definitions/releaseVersion"
        },
        "resourceScore": {
          "$ref": "#/definitions/resourceScore"
        },
        "studyOverview": {
          "$ref": "#/definitions/studyOverview"
        },
        "studyId": {
          "$ref": "#/definitions/studyId"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        }
      },
      "required": [
        "datasourceId",
        "targetFromSourceId",
        "projectId",
        "projectDescription",
        "resourceScore",
        "studyId"
      ],
      "additionalProperties": false
    },
    {
      "properties": {
        "datasourceId": {
          "const": "ot_crispr_validation"
        },
        "biomarkerList": {
          "$ref": "#/definitions/biomarkerList"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "diseaseCellLines": {
          "$ref": "#/definitions/diseaseCellLines"
        },
        "diseaseFromSource": {
          "$ref": "#/definitions/diseaseFromSource"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceMappedId"
        },
        "projectId": {
          "$ref": "#/definitions/projectId"
        },
        "releaseDate": {
          "$ref": "#/definitions/releaseDate"
        },
        "releaseVersion": {
          "$ref": "#/definitions/releaseVersion"
        },
        "resourceScore": {
          "$ref": "#/definitions/resourceScore"
        },
        "studyOverview": {
          "$ref": "#/definitions/studyOverview"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        },
        "primaryProjectId": {
          "$ref": "#/definitions/projectId"
        },
        "primaryProjectHit": {
          "type": "boolean"
        },
        "assays": {
          "$ref": "#/definitions/assays"
        },
        "assessments": {
          "$ref": "#/definitions/assessments"
        }
      },
      "required": [
        "datasourceId",
        "datatypeId",
        "targetFromSourceId",
        "diseaseFromSourceMappedId"
      ],
      "additionalProperties": false
    },
    {
      "properties": {
        "datasourceId": {
          "const": "ot_genetics_portal"
        },
        "beta": {
          "$ref": "#/definitions/beta"
        },
        "oddsRatioConfidenceIntervalLower": {
          "$ref": "#/definitions/confidenceIntervalLower"
        },
        "oddsRatioConfidenceIntervalUpper": {
          "$ref": "#/definitions/confidenceIntervalUpper"
        },
        "betaConfidenceIntervalLower": {
          "$ref": "#/definitions/confidenceIntervalLower"
        },
        "betaConfidenceIntervalUpper": {
          "$ref": "#/definitions/confidenceIntervalUpper"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "diseaseFromSource": {
          "$ref": "#/definitions/diseaseFromSource"
        },
        "diseaseFromSourceId": {
          "$ref": "#/definitions/diseaseFromSourceId"
        },
        "literature": {
          "$ref": "#/definitions/literature"
        },
        "oddsRatio": {
          "$ref": "#/definitions/oddsRatio"
        },
        "projectId": {
          "$ref": "#/definitions/projectId"
        },
        "pValueExponent": {
          "$ref": "#/definitions/pValueExponent"
        },
        "pValueMantissa": {
          "$ref": "#/definitions/pValueMantissa"
        },
        "publicationFirstAuthor": {
          "$ref": "#/definitions/publicationFirstAuthor"
        },
        "publicationYear": {
          "$ref": "#/definitions/publicationYear"
        },
        "resourceScore": {
          "$ref": "#/definitions/resourceScore"
        },
        "studyId": {
          "$ref": "#/definitions/studyId"
        },
        "studySampleSize": {
          "$ref": "#/definitions/studySampleSize"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        },
        "variantFunctionalConsequenceId": {
          "$ref": "#/definitions/variantFunctionalConsequenceId"
        },
        "variantFunctionalConsequenceFromQtlId": {
          "$ref": "#/definitions/variantFunctionalConsequenceId"
        },
        "variantId": {
          "$ref": "#/definitions/variantId"
        },
        "variantRsId": {
          "$ref": "#/definitions/variantRsId"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceMappedId"
        }
      },
      "required": [
        "datasourceId",
        "diseaseFromSource",
        "projectId",
        "pValueExponent",
        "pValueMantissa",
        "resourceScore",
        "studyId",
        "targetFromSourceId",
        "variantFunctionalConsequenceId",
        "variantId"
      ],
      "additionalProperties": false
    },
    {
      "properties": {
        "datasourceId": {
          "const": "impc"
        },
        "biologicalModelAllelicComposition": {
          "$ref": "#/definitions/biologicalModelAllelicComposition"
        },
        "biologicalModelGeneticBackground": {
          "$ref": "#/definitions/biologicalModelGeneticBackground"
        },
        "biologicalModelId": {
          "$ref": "#/definitions/biologicalModelId"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "diseaseFromSource": {
          "$ref": "#/definitions/diseaseFromSource"
        },
        "diseaseFromSourceId": {
          "$ref": "#/definitions/diseaseFromSourceId"
        },
        "diseaseModelAssociatedHumanPhenotypes": {
          "$ref": "#/definitions/diseaseModelAssociatedHumanPhenotypes"
        },
        "diseaseModelAssociatedModelPhenotypes": {
          "$ref": "#/definitions/diseaseModelAssociatedModelPhenotypes"
        },
        "literature": {
          "$ref": "#/definitions/literature"
        },
        "resourceScore": {
          "$ref": "#/definitions/resourceScore"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        },
        "targetInModel": {
          "$ref": "#/definitions/targetInModel"
        },
        "targetInModelEnsemblId": {
          "$ref": "#/definitions/targetInModelEnsemblId"
        },
        "targetInModelMgiId": {
          "$ref": "#/definitions/targetInModelMgiId"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceMappedId"
        }
      },
      "required": [
        "biologicalModelAllelicComposition",
        "biologicalModelGeneticBackground",
        "datasourceId",
        "diseaseFromSource",
        "resourceScore",
        "targetFromSourceId",
        "targetInModel",
        "targetInModelMgiId"
      ],
      "additionalProperties": false
    },
    {
      "properties": {
        "datasourceId": {
          "const": "progeny"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "diseaseFromSource": {
          "$ref": "#/definitions/diseaseFromSource"
        },
        "diseaseFromSourceId": {
          "$ref": "#/definitions/diseaseFromSourceId"
        },
        "pathways": {
          "$ref": "#/definitions/pathways"
        },
        "resourceScore": {
          "$ref": "#/definitions/resourceScore"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceMappedId"
        }
      },
      "required": [
        "datasourceId",
        "diseaseFromSource",
        "pathways",
        "resourceScore",
        "targetFromSourceId"
      ],
      "additionalProperties": false
    },
    {
      "properties": {
        "datasourceId": {
          "const": "reactome"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "diseaseFromSource": {
          "$ref": "#/definitions/diseaseFromSource"
        },
        "diseaseFromSourceId": {
          "$ref": "#/definitions/diseaseFromSourceId"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceMappedId"
        },
        "variantFunctionalConsequenceId": {
          "$ref": "#/definitions/variantFunctionalConsequenceId"
        },
        "literature": {
          "$ref": "#/definitions/literature"
        },
        "pathways": {
          "$ref": "#/definitions/pathways"
        },
        "reactionId": {
          "$ref": "#/definitions/reactionId"
        },
        "reactionName": {
          "$ref": "#/definitions/reactionName"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        },
        "targetModulation": {
          "$ref": "#/definitions/targetModulation"
        },
        "variantAminoacidDescriptions": {
          "$ref": "#/definitions/variantAminoacidDescriptions"
        }
      },
      "required": [
        "datasourceId",
        "diseaseFromSource",
        "pathways",
        "targetFromSourceId"
      ],
      "additionalProperties": false
    },
    {
      "properties": {
        "datasourceId": {
          "const": "slapenrich"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "diseaseFromSource": {
          "$ref": "#/definitions/diseaseFromSource"
        },
        "diseaseFromSourceId": {
          "$ref": "#/definitions/diseaseFromSourceId"
        },
        "pathways": {
          "$ref": "#/definitions/pathways"
        },
        "resourceScore": {
          "$ref": "#/definitions/resourceScore"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceMappedId"
        }
      },
      "required": [
        "datasourceId",
        "diseaseFromSource",
        "pathways",
        "resourceScore",
        "targetFromSourceId"
      ],
      "additionalProperties": false
    },
    {
      "properties": {
        "datasourceId": {
          "const": "sysbio"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "diseaseFromSourceId": {
          "$ref": "#/definitions/diseaseFromSourceId"
        },
        "diseaseFromSource": {
          "$ref": "#/definitions/diseaseFromSource"
        },
        "literature": {
          "$ref": "#/definitions/literature"
        },
        "pathways": {
          "$ref": "#/definitions/pathways"
        },
        "resourceScore": {
          "$ref": "#/definitions/resourceScore"
        },
        "studyOverview": {
          "$ref": "#/definitions/studyOverview"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceMappedId"
        }
      },
      "required": [
        "datasourceId",
        "diseaseFromSource",
        "literature",
        "pathways",
        "resourceScore",
        "studyOverview",
        "targetFromSourceId"
      ],
      "additionalProperties": false
    },
    {
      "properties": {
        "datasourceId": {
          "const": "uniprot_literature"
        },
        "confidence": {
          "$ref": "#/definitions/confidence"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "diseaseFromSource": {
          "$ref": "#/definitions/diseaseFromSource"
        },
        "diseaseFromSourceId": {
          "$ref": "#/definitions/diseaseFromSourceId"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceMappedId"
        },
        "literature": {
          "$ref": "#/definitions/literature"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        },
        "targetModulation": {
          "$ref": "#/definitions/targetModulation"
        }
      },
      "required": [
        "confidence",
        "datasourceId",
        "diseaseFromSource",
        "literature",
        "targetFromSourceId",
        "targetModulation"
      ],
      "additionalProperties": false
    },
    {
      "properties": {
        "datasourceId": {
          "const": "uniprot_variants"
        },
        "datatypeId": {
          "$ref": "#/definitions/datatypeId"
        },
        "confidence": {
          "$ref": "#/definitions/confidence"
        },
        "diseaseFromSource": {
          "$ref": "#/definitions/diseaseFromSource"
        },
        "diseaseFromSourceId": {
          "$ref": "#/definitions/diseaseFromSourceId"
        },
        "diseaseFromSourceMappedId": {
          "$ref": "#/definitions/diseaseFromSourceMappedId"
        },
        "variantFunctionalConsequenceId": {
          "$ref": "#/definitions/variantFunctionalConsequenceId"
        },
        "literature": {
          "$ref": "#/definitions/literature"
        },
        "targetFromSourceId": {
          "$ref": "#/definitions/targetFromSourceId"
        },
        "targetModulation": {
          "$ref": "#/definitions/targetModulation"
        },
        "variantRsId": {
          "$ref": "#/definitions/variantRsId"
        },
        "variantId": {
          "$ref": "#/definitions/variantId"
        }
      },
      "required": [
        "confidence",
        "datasourceId",
        "diseaseFromSource",
        "literature",
        "targetFromSourceId",
        "targetModulation",
        "variantFunctionalConsequenceId",
        "variantRsId"
      ],
      "additionalProperties": false
    }
  ],
  "definitions": {
    "ancestry": {
      "type": "string",
      "description": "Genetic origin of a population.",
      "examples": [
        "EUR",
        "EAS"
      ]
    },
    "ancestryId": {
      "type": "string",
      "description": "Identifier of the ancestry in the HANCESTRO ontology",
      "examples": [
        "HANCESTRO_006"
      ],
      "pattern": "HANCESTRO_\\d+"
    },
    "alleleOrigins": {
      "type": "array",
      "description": "Origin of the variant allele",
      "items": {
        "type": "string"
      },
      "uniqueItems": true
    },
    "allelicRequirements": {
      "type": "array",
      "description": "Inheritance patterns",
      "items": {
        "type": "string"
      },
      "minItems": 1,
      "uniqueItems": true
    },
    "assays": {
      "type": "array",
      "description": "Assays used in the study",
      "items": {
        "type": "object",
        "description": "Description and result of one assay",
        "properties": {
          "shortName": {
            "type": "string",
            "description": "Short name of the assay.",
            "examples": [
              "CellTiter-Glo"
            ]
          },
          "description": {
            "type": "string",
            "description": "Description of the assay",
            "examples": [
              "Homogeneous method of quantifying the presence of ATP, an indicator of metabolically active cells, and using this as a proxy to determine the number of viable cells."
            ]
          },
          "isHit": {
            "type": "boolean",
            "description": "Indicating if the assay was positive or negative for the target",
            "enum": [
              true,
              false
            ]
          }
        },
        "required": [
          "shortName",
          "description",
          "isHit"
        ],
        "additionalProperties": false
      },
      "uniqueItems": true
    },
    "assessments": {
      "type": "array",
      "description": "List of assessments of a study.",
      "items": {
        "type": "string",
        "description": "Assessment of a study. In the context of Validation Lab, this is the assessment of the validation gene in a given cellular context.",
        "examples": [
          "Validated"
        ]
      }
    },
    "beta": {
      "type": "number",
      "description": "Effect size of numberic traits."
    },
    "biologicalModelAllelicComposition": {
      "type": "string",
      "description": "Allelic composition of the model organism",
      "examples": [
        "Lepr<tm1Jke>/Lepr<tm1Jke>"
      ]
    },
    "biologicalModelGeneticBackground": {
      "type": "string",
      "description": "Genetic background of the model organism",
      "examples": [
        "involves: 129X1/SvJ"
      ]
    },
    "biologicalModelId": {
      "type": "string",
      "description": "Identifier of the biological model (eg. in MGI).",
      "examples": [
        "MGI:5766745"
      ],
      "pattern": "^(MGI:)\\d+$"
    },
    "cellLineBackground": {
      "type": "string",
      "description": "Background of the derived cell lines.",
      "examples": [
        "KOLF2-C1"
      ]
    },
    "cellType": {
      "type": "string",
      "description": "The studied cell type. Preferably the cell line ontology label.",
      "examples": [
        "HaCaT keratinocytes",
        "iPSC derived cortical neurons"
      ]
    },
    "biomarkerName": {
      "type": "string",
      "description": "Altered characteristics that influences the disease process.",
      "examples": [
        "BRAF (V600E,V600D,V600K,V600M,V600G,V600R)"
      ]
    },
    "biomarkerList": {
      "type": "array",
      "description": "List of biomarkers associated with the biological model.",
      "items": {
        "type": "object",
        "description": "One biomarker for the model",
        "properties": {
          "name": {
            "type": "string",
            "description": "Short name of the biomarker.",
            "examples": [
              "MSI"
            ]
          },
          "description": {
            "type": "string",
            "description": "Description of the biomarker",
            "examples": [
              "Microsatellite instable"
            ]
          }
        },
        "required": [
          "name"
        ],
        "additionalProperties": false
      }
    },
    "biomarkers": {
      "type": "object",
      "description": "List of biomarkers.",
      "properties": {
        "geneticVariation": {
          "type": "array",
          "items": {
            "type": "object",
            "properties": {
              "name": {
                "type": "string",
                "examples": [
                  "BRAF:V600M"
                ]
              },
              "id": {
                "$ref": "#/definitions/variantId"
              },
              "functionalConsequenceId": {
                "$ref": "#/definitions/variantFunctionalConsequenceId"
              }
            },
            "required": [
              "name"
            ],
            "additionalProperties": false
          },
          "uniqueItems": true
        },
        "geneExpression": {
          "type": "array",
          "items": {
            "type": "object",
            "properties": {
              "name": {
                "type": "string",
                "description": "Raw gene expression annotation from the source",
                "examples": [
                  "ANXA1:over"
                ]
              },
              "id": {
                "type": "string",
                "description": "Gene Ontology (GO) identifiers of regulation or background expression processes.",
                "pattern": "^GO_\\d+",
                "examples": [
                  "GO_0010467"
                ]
              }
            },
            "required": [
              "name"
            ],
            "additionalProperties": false
          },
          "uniqueItems": true
        }
      },
      "additionalProperties": false
    },
    "clinicalPhase": {
      "type": "number",
      "description": "Phase of the clinical trial",
      "minimum": 0.5,
      "maximum": 4.0
    },
    "clinicalSignificances": {
      "type": "array",
      "description": "Standard terms to define clinical significance",
      "items": {
        "type": "string",
        "examples": [
          "pathogenic"
        ],
        "enum": [
          "affects",
          "association",
          "association not found",
          "benign",
          "confers sensitivity",
          "conflicting data from submitters",
          "conflicting interpretations of pathogenicity",
          "drug response",
          "established risk allele",
          "likely benign",
          "likely risk allele",
          "likely pathogenic",
          "low penetrance",
          "not provided",
          "other",
          "pathogenic",
          "protective",
          "risk factor",
          "uncertain risk allele",
          "uncertain significance"
        ]
      },
      "minItems": 1,
      "uniqueItems": true
    },
    "clinicalStatus": {
      "type": "string",
      "description": "Current stage of a clinical study",
      "examples": [
        "Enrolling by invitation"
      ],
      "enum": [
        "Suspended",
        "Unknown status",
        "Completed",
        "Enrolling by invitation",
        "Not yet recruiting",
        "Recruiting",
        "Terminated",
        "N/A",
        "Withdrawn",
        "Active, not recruiting"
      ]
    },
    "cohortDescription": {
      "type": "string",
      "description": "Description of the studied cohort",
      "examples": [
        "Prostate adenocarcinoma data from SU2C-PCF Dream Team"
      ]
    },
    "cohortId": {
      "type": "string",
      "description": "Identifier of the studied cohort",
      "examples": [
        "CBIOP_WXS_PRAD_SU2C_2019",
        "UK Biobank"
      ]
    },
    "cohortShortName": {
      "type": "string",
      "description": "Short name of the studied cohort",
      "examples": [
        "PRAD_SU2C_MET"
      ]
    },
    "cohortPhenotypes": {
      "type": "array",
      "description": "Clinical features/phenotypes observed in studied individuals",
      "items": {
        "type": "string",
        "examples": [
          "Anterior segment dysgenesis 5"
        ]
      },
      "uniqueItems": true
    },
    "confidence": {
      "type": "string",
      "description": "Confidence qualifier on the reported evidence"
    },
    "confidenceIntervalLower": {
      "type": "number",
      "description": "Lower value of the confidence interval"
    },
    "confidenceIntervalUpper": {
      "type": "number",
      "description": "Upper value of the confidence interval"
    },
    "contrast": {
      "type": "string",
      "description": "Experiment contrast",
      "examples": [
        "glioblastoma vs normal"
      ]
    },
    "crisprScreenLibrary": {
      "type": "string",
      "description": "The applied screening library in the CRISPR/CAS9 project.",
      "examples": [
        "Kosuke v1.1 (Behan et al., 2018)"
      ]
    },
    "datasourceId": {
      "type": "string"
    },
    "datatypeId": {
      "type": "string",
      "enum": [
        "affected_pathway",
        "literature",
        "rna_expression",
        "genetic_literature",
        "animal_model",
        "somatic_mutation",
        "known_drug",
        "genetic_association",
        "ot_partner",
        "ot_validation_lab"
      ]
    },
    "diseaseCellLines": {
      "type": "array",
      "description": "Cancer cell lines used to generate evidence",
      "items": {
        "type": "object",
        "properties": {
          "id": {
            "type": "string",
            "description": "Cell type identifier in cell ontology or in cell model database",
            "examples": [
              "SIDM01076"
            ]
          },
          "name": {
            "type": "string",
            "description": "Name of the cell model",
            "examples": [
              "BC-1"
            ]
          },
          "tissue": {
            "type": "string",
            "description": "Name of the tissue from which the cells were sampled",
            "examples": [
              "pancreas"
            ]
          },
          "tissueId": {
            "type": "string",
            "description": "UBERON identifier of the anatomical unit the cells were sampled.",
            "examples": [
              "UBERON_0000059"
            ],
            "pattern": "UBERON_\\d+"
          }
        },
        "additionalProperties": false
      },
      "uniqueItems": true
    },
    "diseaseFromSource": {
      "type": "string",
      "description": "Disease label from the original source",
      "examples": [
        "MYOPATHY, SPHEROID BODY"
      ]
    },
    "diseaseFromSourceId": {
      "type": "string",
      "description": "Disease ID from the original source",
      "examples": [
        "OMIM:182920"
      ]
    },
    "diseaseFromSourceMappedId": {
      "type": "string",
      "description": "Identifier of the disease in the EFO ontology",
      "pattern": "(^NCIT_C\\d+$|^Orphanet_\\d+$|^GO_\\d+$|^HP_\\d+$|^EFO_\\d+$|^MONDO_\\d+$|^DOID_\\d+$|^MP_\\d+$|^OTAR_\\d+$|^PATO_\\d+$|^CHEBI_\\d+$|^OAE_\\d+$|^MS_\\d+$|^OMIT_\\d+$|^SNOMED_\\d+$|^OBI_\\d+$|^NBO_\\d+$|^OBA_\\d+$|^OGMS_\\d+$)",
      "examples": [
        "EFO_0005537"
      ]
    },
    "diseaseModelAssociatedHumanPhenotypes": {
      "type": "array",
      "description": "Human phenotypes equivalent to those observed in animal models",
      "items": {
        "type": "object",
        "properties": {
          "id": {
            "type": "string",
            "pattern": "^HP:\\d+$"
          },
          "label": {
            "type": "string"
          }
        },
        "additionalProperties": false
      },
      "uniqueItems": true
    },
    "diseaseModelAssociatedModelPhenotypes": {
      "type": "array",
      "description": "Phenotypes observed in genetically-modified animal models",
      "items": {
        "type": "object",
        "properties": {
          "id": {
            "type": "string",
            "pattern": "^MP:\\d+$",
            "examples": [
              "MP:0002060"
            ]
          },
          "label": {
            "type": "string",
            "examples": [
              "abnormal skin morphology"
            ]
          }
        },
        "additionalProperties": false,
        "required": [
          "id"
        ]
      },
      "minItems": 1,
      "uniqueItems": true
    },
    "drugFromSource": {
      "type": "string",
      "description": "Drug name/family in resource of origin.",
      "examples": [
        "Imatinib"
      ]
    },
    "drugId": {
      "type": "string",
      "description": "Drug molecule ID",
      "pattern": "^(CHEMBL)\\d+$",
      "examples": [
        "CHEMBL1431",
        "CHEMBL803"
      ]
    },
    "falseDiscoveryRate": {
      "type": "number",
      "description": "False discovery rate (FDR) captures the rate of type I error.",
      "minimum": 0.0,
      "maximum": 1.0
    },
    "geneInteractionType": {
      "type": "string",
      "description": "Description of the interaction between the two genes.",
      "enum": [
        "cooperative",
        "additive",
        "antagonistic"
      ]
    },
    "geneticBackground": {
      "type": "string",
      "description": "Additional genetic background of the applied cell line in the CRISPR screen."
    },
    "geneticInteractionFDR": {
      "type": "number",
      "description": "False discovery rate of the genetic interaction test."
    },
    "geneticInteractionPValue": {
      "type": "number",
      "description": "P-value of the genetic interaction test."
    },
    "geneticInteractionScore": {
      "type": "number",
      "description": "The strength of the genetic interaction. Directionality is captured as well: antagonistics < 0 < cooperative."
    },
    "drugResponse": {
      "type": "string",
      "description": "Patterns of drug response.",
      "examples": [
        "Not Responsive"
      ]
    },
    "literature": {
      "type": "array",
      "description": "PubMed or preprint reference identifiers",
      "items": {
        "type": "string",
        "pattern": "(PPR)?\\d+"
      },
      "uniqueItems": true
    },
    "log2FoldChangePercentileRank": {
      "type": "integer",
      "description": "Percentile of top differentially regulated genes (transcripts) within experiment"
    },
    "log2FoldChangeValue": {
      "type": "number",
      "description": "Log2 fold expression change in contrast experiment"
    },
    "mutatedSamples": {
      "type": "array",
      "items": {
        "type": "object",
        "properties": {
          "functionalConsequenceId": {
            "$ref": "#/definitions/variantFunctionalConsequenceId"
          },
          "numberMutatedSamples": {
            "type": "integer",
            "description": "Number of cohort samples in which target is mutated with a mutation of any type",
            "exclusiveMinimum": 0
          },
          "numberSamplesTested": {
            "type": "integer",
            "description": "Number of cohort samples tested",
            "exclusiveMinimum": 0
          },
          "numberSamplesWithMutationType": {
            "type": "integer",
            "description": "Number of cohort samples in which target is mutated with a specific mutation type",
            "exclusiveMinimum": 0
          }
        },
        "additionalProperties": false
      },
      "uniqueItems": true
    },
    "oddsRatio": {
      "type": "number",
      "description": "Odds ratio (e.g GWAS association)"
    },
    "pathways": {
      "type": "array",
      "description": "List of pathways",
      "items": {
        "type": "object",
        "properties": {
          "id": {
            "type": "string",
            "description": "Reactome pathway identifier.",
            "pattern": "^(R-HSA-)\\d+$",
            "examples": [
              "R-HSA-4615885"
            ]
          },
          "name": {
            "type": "string",
            "description": "Pathway or gene set name",
            "examples": [
              "Chaperonin-mediated protein folding",
              "Signaling by FGFR3"
            ]
          }
        },
        "required": [
          "name"
        ],
        "additionalProperties": false
      },
      "minItems": 1,
      "uniqueItems": true
    },
    "phenotypicConsequenceFDR": {
      "type": "number",
      "description": "False discovery rate of the genetic test"
    },
    "phenotypicConsequenceLogFoldChange": {
      "type": "number",
      "description": "Log 2 fold change of the cell survival."
    },
    "phenotypicConsequencePValue": {
      "type": "number",
      "description": "P-value of the the cell survival test."
    },
    "pmcIds": {
      "type": "array",
      "description": "List of PubMed Central identifiers of full text publication.",
      "items": {
        "type": "string",
        "pattern": "^PMC\\d+$",
        "description": "Literature identifer in PubMed Central"
      },
      "minItems": 1,
      "uniqueItems": true
    },
    "projectId": {
      "type": "string",
      "description": "The identifer of the project that generated the data.",
      "examples": [
        "FINNGEN",
        "UKBB",
        "OTAR033"
      ]
    },
    "projectDescription": {
      "type": "string",
      "description": "Description of the project that generated the data."
    },
    "pValue": {
      "type": "number",
      "description": "p-value",
      "maximum": 1.0,
      "minimum": 0.0
    },
    "pValueExponent": {
      "type": "integer",
      "description": "p-value (e.g. GWAS association) exponent"
    },
    "pValueMantissa": {
      "type": "number",
      "description": "p-value (e.g. GWAS association) exponent",
      "minimum": 0.0
    },
    "publicationFirstAuthor": {
      "type": "string",
      "description": "First author of the publication",
      "examples": [
        "Davies G",
        "Kanai M",
        "Pirastu N",
        "Astle WJ",
        "Kichaev G"
      ]
    },
    "publicationYear": {
      "type": "integer",
      "description": "Year of publication",
      "pattern": "\\d{4}$"
    },
    "reactionId": {
      "type": "string",
      "description": "Pathway reaction ID",
      "pattern": "^(R-HSA-)\\d+$",
      "examples": [
        "R-HSA-9660615"
      ]
    },
    "reactionName": {
      "type": "string",
      "description": "Name corresponding to the reaction ID",
      "examples": [
        "Viral Protein Synthesis"
      ]
    },
    "releaseDate": {
      "type": "string",
      "description": "Date of the release of the data in a 'YYYY-MM-DD' format",
      "pattern": "(((19|20)([2468][048]|[13579][26]|0[48])|2000)[-]02[-]29|((19|20)[0-9]{2}[-](0[469]|11)[-](0[1-9]|[12][0-9]|30)|(19|20)[0-9]{2}[-](0[13578]|1[02])[-](0[1-9]|[12][0-9]|3[01])|(19|20)[0-9]{2}[-]02[-](0[1-9]|1[0-9]|2[0-8])))"
    },
    "releaseVersion": {
      "type": "string",
      "description": "Version of the release of the data"
    },
    "resourceScore": {
      "type": "number",
      "description": "Score provided by datasource indicating strength of target-disease association",
      "minimum": 0.0
    },
    "sex": {
      "type": "array",
      "description": "Sex of the population included in the analysis",
      "items": {
        "type": "string",
        "enum": [
          "men",
          "women"
        ]
      }
    },
    "significantDriverMethods": {
      "type": "array",
      "description": "Methods to detect cancer driver genes producing significant results",
      "items": {
        "type": "string",
        "examples": [
          "mutpanning"
        ],
        "enum": [
          "oncodriveclustl",
          "combination",
          "smregions",
          "mutpanning",
          "cbase",
          "hotmaps",
          "dndscv",
          "oncodrivefml"
        ]
      },
      "uniqueItems": true
    },
    "statisticalTestTail": {
      "type": "string",
      "description": "End of the distribution the target was picked from.",
      "enum": [
        "upper tail",
        "lower tail"
      ]
    },
    "statisticalMethod": {
      "type": "string",
      "description": "The statistical method used to calculate the association.",
      "examples": [
        "ADD-WGR-FIRTH_M3.0001",
        "ptv5pcnt"
      ]
    },
    "statisticalMethodOverview": {
      "type": "string",
      "description": "Overview of the statistical method used to calculate the association."
    },
    "studyCases": {
      "type": "integer",
      "description": "Number of cases in case-control study.",
      "exclusiveMinimum": 0
    },
    "studyCasesWithQualifyingVariants": {
      "type": "integer",
      "description": "Number of cases in case-control study that carry at least one allele of the qualifying variant."
    },
    "studyId": {
      "type": "string",
      "description": "Identifier of the study",
      "examples": [
        "GCST90083260"
      ]
    },
    "studyOverview": {
      "type": "string",
      "description": "Description of the study"
    },
    "studySampleSize": {
      "type": "integer",
      "description": "Sample size of study",
      "exclusiveMinimum": 0
    },
    "studyStartDate": {
      "type": "string",
      "format": "date",
      "description": "Start date of study in a YYYY-MM-DD format",
      "pattern": "(((19|20)([2468][048]|[13579][26]|0[48])|2000)[-]02[-]29|((19|20)[0-9]{2}[-](0[469]|11)[-](0[1-9]|[12][0-9]|30)|(19|20)[0-9]{2}[-](0[13578]|1[02])[-](0[1-9]|[12][0-9]|3[01])|(19|20)[0-9]{2}[-]02[-](0[1-9]|1[0-9]|2[0-8])))"
    },
    "studyStopReason": {
      "type": "string",
      "description": "Reason why a study has been stopped",
      "pattern": "^[^\\ ].*[^\\ ]$"
    },
    "studyStopReasonCategories": {
      "type": "array",
      "description": "Predicted reason(s) why the study has been stopped based on studyStopReason.",
      "items": {
        "type": "string",
        "enum": [
          "Insufficient enrollment",
          "Business or administrative",
          "Negative",
          "Logistics or resources",
          "Study design",
          "Invalid reason",
          "Study staff moved",
          "COVID-19",
          "Another study",
          "No context",
          "Safety or side effects",
          "Regulatory",
          "Interim analysis",
          "Success",
          "Met endpoint",
          "Ethical reason",
          "Insufficient data",
          "Uncategorised"
        ]
      },
      "uniqueItems": true
    },
    "targetFromSourceId": {
      "type": "string",
      "description": "Target ID in resource of origin (accepted sources include Ensembl gene ID, Uniprot ID, gene symbol), only capital letters are accepted.",
      "examples": [
        "BRCA1",
        "ENSG00000012048",
        "P38398"
      ],
      "pattern": "^[a-zA-Z0-9-.]+$"
    },
    "targetFromSource": {
      "type": "string",
      "description": "Target name/synonym or non HGNC symbol in resource of origin",
      "examples": [
        "3-mercaptopyruvate sulfurtransferase"
      ]
    },
    "targetInModelEnsemblId": {
      "type": "string",
      "description": "Target Ensembl ID in animal model",
      "pattern": "^(ENSMUSG)\\d+$",
      "examples": [
        "ENSMUSG00000014773"
      ]
    },
    "targetInModelMgiId": {
      "type": "string",
      "description": "Target MGI ID in animal model",
      "pattern": "^(MGI:)\\d+$",
      "examples": [
        "MGI:104659"
      ]
    },
    "targetInModel": {
      "type": "string",
      "description": "Target name/synonym in animal model",
      "examples": [
        "Dll1"
      ]
    },
    "targetModulation": {
      "type": "string",
      "description": "Description of target modulation event"
    },
    "targetRole": {
      "type": "string",
      "description": "Role of a target in the genetic interaction test.",
      "enum": [
        "library",
        "anchor",
        "gicontrols"
      ]
    },
    "textMiningSentences": {
      "type": "array",
      "items": {
        "type": "object",
        "properties": {
          "dEnd": {
            "type": "integer",
            "description": "Index position where disease name ends in sentence"
          },
          "dStart": {
            "type": "integer",
            "description": "Index position where disease name starts in sentence"
          },
          "section": {
            "type": "string",
            "description": "Section in which sentence occurs",
            "enum": [
              "title",
              "abstract",
              "intro",
              "case",
              "figure",
              "table",
              "discuss",
              "concl",
              "results",
              "appendix",
              "other"
            ]
          },
          "tEnd": {
            "type": "integer",
            "description": "Index position where target name ends in sentence"
          },
          "text": {
            "type": "string",
            "description": "Sentence text"
          },
          "tStart": {
            "type": "integer",
            "description": "Index position where target name starts in sentence"
          }
        },
        "required": [
          "dEnd",
          "dStart",
          "section",
          "tEnd",
          "text",
          "tStart"
        ],
        "additionalProperties": false
      },
      "uniqueItems": true
    },
    "biosamplesFromSource": {
      "type": "array",
      "description": "Identifier of the referenced biological material",
      "items": {
        "type": "string",
        "pattern": "(UBERON_\\d+|BTO_\\d+|EFO_\\d+|CL_\\d+)",
        "examples": [
          "UBERON_0002107",
          "BTO_0001202",
          "CL_0000019",
          "EFO_0000572"
        ]
      },
      "uniqueItems": true
    },
    "urls": {
      "type": "array",
      "description": "Reference to linked external resource (e.g. clinical trials, studies, package inserts, reports, etc.)",
      "items": {
        "type": "object",
        "properties": {
          "url": {
            "type": "string",
            "pattern": "https://|http://",
            "examples": [
              "https://clinicaltrials.gov/search?id=%22NCT01917656%22",
              "https://search.clinicalgenome.org/kb/gene-validity/d910a9d8-516e-443d-acba-8d61f7574792--2018-06-07T14:23:53"
            ]
          },
          "niceName": {
            "type": "string",
            "examples": [
              "Clinical Trials",
              "DailyMed",
              "FDA",
              "ATC"
            ]
          }
        },
        "additionalProperties": false
      },
      "uniqueItems": true
    },
    "variantFunctionalConsequenceId": {
      "type": "string",
      "description": "Sequence ontology (SO) identifier of the functional consequence of the variant",
      "pattern": "SO_\\d+",
      "examples": [
        "SO_0001628"
      ]
    },
    "variantHgvsId": {
      "type": "string",
      "description": "Identifier in HGVS notation of the disease-causing variant.",
      "examples": [
        "NC_000011.10:g.17605796C>T",
        "LRG_214t1:c.889-1633_7395-667del"
      ]
    },
    "variantFromSourceId": {
      "type": "string",
      "description": "Identifier of the disease-causing variant at source.",
      "examples": [
        "NC_000011.10:g.17605796C>T",
        "VCV000018397"
      ]
    },
    "variantId": {
      "type": "string",
      "description": "Identifier in CHROM_POS_REF_ALT notation of the disease-causing variant.",
      "pattern": "^([0-9XY]{1,2}|MT)_\\d+_[A-Z]+_[A-Z]+$",
      "examples": [
        "20_41203988_T_C",
        "MT_91234_C_W"
      ]
    },
    "variantRsId": {
      "type": "string",
      "description": "Variant reference SNP cluster ID (Rsid)",
      "pattern": "^rs[0-9]{1,}$",
      "examples": [
        "rs539139475"
      ]
    },
    "variantAminoacidDescriptions": {
      "type": "array",
      "description": "Descriptions of variant consequences at protein level",
      "items": {
        "type": "string",
        "examples": [
          "glycine 598 replaced with L-valine",
          "Deletion of residues 550 to 558"
        ]
      },
      "uniqueItems": true
    },
    "warningMessage": {
      "type": "string",
      "description": "Free text description of any concerns or warnings about the data."
    }
  }
}