diff --git a/content/en/docs/kubernetes/operator/automatic.md b/content/en/docs/kubernetes/operator/automatic.md
index 3fe3c12a41f6..00bd1227fa36 100644
--- a/content/en/docs/kubernetes/operator/automatic.md
+++ b/content/en/docs/kubernetes/operator/automatic.md
@@ -300,6 +300,32 @@ spec:
         value: http,nestjs-core # comma-separated list of the instrumentation package names without the `@opentelemetry/instrumentation-` prefix.
 ```
 
+To keep all default libraries and disable only specific instrumentation
+libraries you can use the `OTEL_NODE_DISABLED_INSTRUMENTATIONS` environment
+variable. For details, see
+[Excluding instrumentation libraries](/docs/zero-code/js/configuration/#excluding-instrumentation-libraries).
+
+```yaml
+apiVersion: opentelemetry.io/v1alpha1
+kind: Instrumentation
+# ... other fields skipped from this example
+spec:
+  # ... other fields skipped from this example
+  nodejs:
+    env:
+      - name: OTEL_NODE_DISABLED_INSTRUMENTATIONS
+        value: fs,grpc # comma-separated list of the instrumentation package names without the `@opentelemetry/instrumentation-` prefix.
+```
+
+{{% alert title="Note" color="info" %}}
+
+If both environment variables are set, `OTEL_NODE_ENABLED_INSTRUMENTATIONS` is
+applied first, and then `OTEL_NODE_DISABLED_INSTRUMENTATIONS` is applied to that
+list. Therefore, if the same instrumentation is included in both lists, that
+instrumentation will be disabled.
+
+{{% /alert %}}
+
 #### Learn more {#js-learn-more}
 
 For more details, see
diff --git a/content/en/docs/zero-code/js/configuration.md b/content/en/docs/zero-code/js/configuration.md
index 0511991b6373..3bf7fc47cf99 100644
--- a/content/en/docs/zero-code/js/configuration.md
+++ b/content/en/docs/zero-code/js/configuration.md
@@ -45,17 +45,22 @@ For example, to only enable the `env` and `host` detectors, you can set:
 OTEL_NODE_RESOURCE_DETECTORS=env,host
 ```
 
-### Excluding instrumentation libraries
+## Excluding instrumentation libraries
 
 By default, all
 [supported instrumentation libraries](https://github.com/open-telemetry/opentelemetry-js-contrib/blob/main/metapackages/auto-instrumentations-node/README.md#supported-instrumentations)
-are enabled, but you can use the environment variable
-`OTEL_NODE_ENABLED_INSTRUMENTATIONS` to enable only certain instrumentations by
-providing a comma-separated list of the instrumentation library names without
-the `@opentelemetry/instrumentation-` prefix.
+are enabled, but you can use environment variables to enable or disable specific
+instrumentations.
+
+### Enable specific instrumentations
+
+Use the environment variable `OTEL_NODE_ENABLED_INSTRUMENTATIONS` to enable only
+certain instrumentations by providing a comma-separated list of the
+instrumentation library names without the `@opentelemetry/instrumentation-`
+prefix.
 
 For example, to enable only
-[@opentelemetry/instrumentation-http](https://github.com/open-telemetry/opentelemetry-js/tree/main/packages/opentelemetry-instrumentation-http)
+[@opentelemetry/instrumentation-http](https://github.com/open-telemetry/opentelemetry-js/tree/main/experimental/packages/opentelemetry-instrumentation-http)
 and
 [@opentelemetry/instrumentation-express](https://github.com/open-telemetry/opentelemetry-js-contrib/tree/main/plugins/node/opentelemetry-instrumentation-express)
 instrumentations:
@@ -63,3 +68,29 @@ instrumentations:
 ```shell
 OTEL_NODE_ENABLED_INSTRUMENTATIONS="http,express"
 ```
+
+### Disable specific instrumentations
+
+Use the environment variable `OTEL_NODE_DISABLED_INSTRUMENTATIONS` to keep the
+fully enabled list and only disable certain instrumentations by providing a
+comma-separated list of the instrumentation library names without the
+`@opentelemetry/instrumentation-` prefix.
+
+For example, to disable only
+[@opentelemetry/instrumentation-fs](https://github.com/open-telemetry/opentelemetry-js-contrib/tree/main/plugins/node/instrumentation-fs)
+and
+[@opentelemetry/instrumentation-grpc](https://github.com/open-telemetry/opentelemetry-js/tree/main/experimental/packages/opentelemetry-instrumentation-grpc)
+instrumentations:
+
+```shell
+OTEL_NODE_DISABLED_INSTRUMENTATIONS="fs,grpc"
+```
+
+{{% alert title="Note" color="info" %}}
+
+If both environment variables are set, `OTEL_NODE_ENABLED_INSTRUMENTATIONS` is
+applied first, and then `OTEL_NODE_DISABLED_INSTRUMENTATIONS` is applied to that
+list. Therefore, if the same instrumentation is included in both lists, that
+instrumentation will be disabled.
+
+{{% /alert %}}