diff --git a/CHANGELOG.md b/CHANGELOG.md
index 2358664bdf4..bfbbe3d2ca4 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -19,6 +19,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
   ([#2976](https://github.com/open-telemetry/opentelemetry-python/pull/2976))
 - [exporter/opentelemetry-exporter-otlp-proto-http] Add OTLPMetricExporter
   ([#2891](https://github.com/open-telemetry/opentelemetry-python/pull/2891))
+- Fix a bug with exporter retries for with newer versions of the backoff library
+  ([#2980](https://github.com/open-telemetry/opentelemetry-python/pull/2980))
 
 ## [1.13.0-0.34b0](https://github.com/open-telemetry/opentelemetry-python/releases/tag/v1.13.0) - 2022-09-26
 
@@ -90,7 +92,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
   ([#2726](https://github.com/open-telemetry/opentelemetry-python/pull/2726))
 - fix: frozenset object has no attribute items
   ([#2727](https://github.com/open-telemetry/opentelemetry-python/pull/2727))
-- fix: create suppress HTTP instrumentation key in opentelemetry context 
+- fix: create suppress HTTP instrumentation key in opentelemetry context
   ([#2729](https://github.com/open-telemetry/opentelemetry-python/pull/2729))
 - Support logs SDK auto instrumentation enable/disable with env
   ([#2728](https://github.com/open-telemetry/opentelemetry-python/pull/2728))
diff --git a/exporter/opentelemetry-exporter-otlp-proto-grpc/src/opentelemetry/exporter/otlp/proto/grpc/exporter.py b/exporter/opentelemetry-exporter-otlp-proto-grpc/src/opentelemetry/exporter/otlp/proto/grpc/exporter.py
index 4405bcad68b..aef66b79dec 100644
--- a/exporter/opentelemetry-exporter-otlp-proto-grpc/src/opentelemetry/exporter/otlp/proto/grpc/exporter.py
+++ b/exporter/opentelemetry-exporter-otlp-proto-grpc/src/opentelemetry/exporter/otlp/proto/grpc/exporter.py
@@ -25,7 +25,7 @@
 from urllib.parse import urlparse
 from opentelemetry.sdk.trace import ReadableSpan
 
-from backoff import expo
+import backoff
 from google.rpc.error_details_pb2 import RetryInfo
 from grpc import (
     ChannelCredentials,
@@ -183,6 +183,19 @@ def _get_credentials(creds, environ_key):
     return ssl_channel_credentials()
 
 
+# Work around API change between backoff 1.x and 2.x. Since 2.0.0 the backoff
+# wait generator API requires a first .send(None) before reading the backoff
+# values from the generator.
+_is_backoff_v2 = next(backoff.expo()) is None
+
+
+def _expo(*args, **kwargs):
+    gen = backoff.expo(*args, **kwargs)
+    if _is_backoff_v2:
+        gen.send(None)
+    return gen
+
+
 # pylint: disable=no-member
 class OTLPExporterMixin(
     ABC, Generic[SDKDataT, ExportServiceRequestT, ExportResultT]
@@ -296,7 +309,7 @@ def _export(
         # expo returns a generator that yields delay values which grow
         # exponentially. Once delay is greater than max_value, the yielded
         # value will remain constant.
-        for delay in expo(max_value=max_value):
+        for delay in _expo(max_value=max_value):
 
             if delay == max_value:
                 return self._result.FAILURE
diff --git a/exporter/opentelemetry-exporter-otlp-proto-grpc/tests/logs/test_otlp_logs_exporter.py b/exporter/opentelemetry-exporter-otlp-proto-grpc/tests/logs/test_otlp_logs_exporter.py
index a9c63eaa0a0..07616090837 100644
--- a/exporter/opentelemetry-exporter-otlp-proto-grpc/tests/logs/test_otlp_logs_exporter.py
+++ b/exporter/opentelemetry-exporter-otlp-proto-grpc/tests/logs/test_otlp_logs_exporter.py
@@ -251,7 +251,7 @@ def test_otlp_exporter_endpoint(self, mock_secure, mock_insecure):
             )
             mock_method.reset_mock()
 
-    @patch("opentelemetry.exporter.otlp.proto.grpc.exporter.expo")
+    @patch("opentelemetry.exporter.otlp.proto.grpc.exporter._expo")
     @patch("opentelemetry.exporter.otlp.proto.grpc.exporter.sleep")
     def test_unavailable(self, mock_sleep, mock_expo):
 
@@ -265,7 +265,7 @@ def test_unavailable(self, mock_sleep, mock_expo):
         )
         mock_sleep.assert_called_with(1)
 
-    @patch("opentelemetry.exporter.otlp.proto.grpc.exporter.expo")
+    @patch("opentelemetry.exporter.otlp.proto.grpc.exporter._expo")
     @patch("opentelemetry.exporter.otlp.proto.grpc.exporter.sleep")
     def test_unavailable_delay(self, mock_sleep, mock_expo):
 
diff --git a/exporter/opentelemetry-exporter-otlp-proto-grpc/tests/metrics/test_otlp_metrics_exporter.py b/exporter/opentelemetry-exporter-otlp-proto-grpc/tests/metrics/test_otlp_metrics_exporter.py
index 262e26ed637..0e3e26b7476 100644
--- a/exporter/opentelemetry-exporter-otlp-proto-grpc/tests/metrics/test_otlp_metrics_exporter.py
+++ b/exporter/opentelemetry-exporter-otlp-proto-grpc/tests/metrics/test_otlp_metrics_exporter.py
@@ -449,7 +449,7 @@ def test_otlp_exporter_endpoint(self, mock_secure, mock_insecure):
             )
             mock_method.reset_mock()
 
-    @patch("opentelemetry.exporter.otlp.proto.grpc.exporter.expo")
+    @patch("opentelemetry.exporter.otlp.proto.grpc.exporter._expo")
     @patch("opentelemetry.exporter.otlp.proto.grpc.exporter.sleep")
     def test_unavailable(self, mock_sleep, mock_expo):
 
@@ -464,7 +464,7 @@ def test_unavailable(self, mock_sleep, mock_expo):
         )
         mock_sleep.assert_called_with(1)
 
-    @patch("opentelemetry.exporter.otlp.proto.grpc.exporter.expo")
+    @patch("opentelemetry.exporter.otlp.proto.grpc.exporter._expo")
     @patch("opentelemetry.exporter.otlp.proto.grpc.exporter.sleep")
     def test_unavailable_delay(self, mock_sleep, mock_expo):
 
diff --git a/exporter/opentelemetry-exporter-otlp-proto-grpc/tests/test_otlp_exporter_mixin.py b/exporter/opentelemetry-exporter-otlp-proto-grpc/tests/test_otlp_exporter_mixin.py
index 3f44ef228ee..81a874af705 100644
--- a/exporter/opentelemetry-exporter-otlp-proto-grpc/tests/test_otlp_exporter_mixin.py
+++ b/exporter/opentelemetry-exporter-otlp-proto-grpc/tests/test_otlp_exporter_mixin.py
@@ -56,7 +56,7 @@ def test_environ_to_compression(self):
             with self.assertRaises(InvalidCompressionValueException):
                 environ_to_compression("test_invalid")
 
-    @patch("opentelemetry.exporter.otlp.proto.grpc.exporter.expo")
+    @patch("opentelemetry.exporter.otlp.proto.grpc.exporter._expo")
     def test_export_warning(self, mock_expo):
 
         mock_expo.configure_mock(**{"return_value": [0]})
diff --git a/exporter/opentelemetry-exporter-otlp-proto-grpc/tests/test_otlp_trace_exporter.py b/exporter/opentelemetry-exporter-otlp-proto-grpc/tests/test_otlp_trace_exporter.py
index a5cb4e699a6..cfb286edee0 100644
--- a/exporter/opentelemetry-exporter-otlp-proto-grpc/tests/test_otlp_trace_exporter.py
+++ b/exporter/opentelemetry-exporter-otlp-proto-grpc/tests/test_otlp_trace_exporter.py
@@ -436,7 +436,23 @@ def test_otlp_headers(self, mock_ssl_channel, mock_secure):
         # pylint: disable=protected-access
         self.assertIsNone(exporter._headers, None)
 
-    @patch("opentelemetry.exporter.otlp.proto.grpc.exporter.expo")
+    @patch("opentelemetry.exporter.otlp.proto.grpc.exporter.backoff")
+    @patch("opentelemetry.exporter.otlp.proto.grpc.exporter.sleep")
+    def test_handles_backoff_v2_api(self, mock_sleep, mock_backoff):
+        # In backoff ~= 2.0.0 the first value yielded from expo is None.
+        def generate_delays(*args, **kwargs):
+            yield None
+            yield 1
+
+        mock_backoff.expo.configure_mock(**{"side_effect": generate_delays})
+
+        add_TraceServiceServicer_to_server(
+            TraceServiceServicerUNAVAILABLE(), self.server
+        )
+        self.exporter.export([self.span])
+        mock_sleep.assert_called_once_with(1)
+
+    @patch("opentelemetry.exporter.otlp.proto.grpc.exporter._expo")
     @patch("opentelemetry.exporter.otlp.proto.grpc.exporter.sleep")
     def test_unavailable(self, mock_sleep, mock_expo):
 
@@ -450,7 +466,7 @@ def test_unavailable(self, mock_sleep, mock_expo):
         )
         mock_sleep.assert_called_with(1)
 
-    @patch("opentelemetry.exporter.otlp.proto.grpc.exporter.expo")
+    @patch("opentelemetry.exporter.otlp.proto.grpc.exporter._expo")
     @patch("opentelemetry.exporter.otlp.proto.grpc.exporter.sleep")
     def test_unavailable_delay(self, mock_sleep, mock_expo):
 
diff --git a/exporter/opentelemetry-exporter-otlp-proto-http/pyproject.toml b/exporter/opentelemetry-exporter-otlp-proto-http/pyproject.toml
index edfc307c174..a89e7fa1884 100644
--- a/exporter/opentelemetry-exporter-otlp-proto-http/pyproject.toml
+++ b/exporter/opentelemetry-exporter-otlp-proto-http/pyproject.toml
@@ -34,7 +34,9 @@ dependencies = [
 ]
 
 [project.optional-dependencies]
-test = []
+test = [
+  "responses == 0.22.0",
+]
 
 [project.entry-points.opentelemetry_traces_exporter]
 otlp_proto_http = "opentelemetry.exporter.otlp.proto.http.trace_exporter:OTLPSpanExporter"
diff --git a/exporter/opentelemetry-exporter-otlp-proto-http/src/opentelemetry/exporter/otlp/proto/http/_log_exporter/__init__.py b/exporter/opentelemetry-exporter-otlp-proto-http/src/opentelemetry/exporter/otlp/proto/http/_log_exporter/__init__.py
index a74f849f406..580e084f4f9 100644
--- a/exporter/opentelemetry-exporter-otlp-proto-http/src/opentelemetry/exporter/otlp/proto/http/_log_exporter/__init__.py
+++ b/exporter/opentelemetry-exporter-otlp-proto-http/src/opentelemetry/exporter/otlp/proto/http/_log_exporter/__init__.py
@@ -20,8 +20,8 @@
 from typing import Dict, Optional, Sequence
 from time import sleep
 
+import backoff
 import requests
-from backoff import expo
 
 from opentelemetry.sdk.environment_variables import (
     OTEL_EXPORTER_OTLP_CERTIFICATE,
@@ -53,6 +53,18 @@
 DEFAULT_LOGS_EXPORT_PATH = "v1/logs"
 DEFAULT_TIMEOUT = 10  # in seconds
 
+# Work around API change between backoff 1.x and 2.x. Since 2.0.0 the backoff
+# wait generator API requires a first .send(None) before reading the backoff
+# values from the generator.
+_is_backoff_v2 = next(backoff.expo()) is None
+
+
+def _expo(*args, **kwargs):
+    gen = backoff.expo(*args, **kwargs)
+    if _is_backoff_v2:
+        gen.send(None)
+    return gen
+
 
 class OTLPLogExporter(LogExporter):
 
@@ -122,7 +134,7 @@ def export(self, batch: Sequence[LogData]) -> LogExportResult:
 
         serialized_data = _ProtobufEncoder.serialize(batch)
 
-        for delay in expo(max_value=self._MAX_RETRY_TIMEOUT):
+        for delay in _expo(max_value=self._MAX_RETRY_TIMEOUT):
 
             if delay == self._MAX_RETRY_TIMEOUT:
                 return LogExportResult.FAILURE
diff --git a/exporter/opentelemetry-exporter-otlp-proto-http/src/opentelemetry/exporter/otlp/proto/http/metric_exporter/__init__.py b/exporter/opentelemetry-exporter-otlp-proto-http/src/opentelemetry/exporter/otlp/proto/http/metric_exporter/__init__.py
index 1423c31238f..c83ca00e06c 100644
--- a/exporter/opentelemetry-exporter-otlp-proto-http/src/opentelemetry/exporter/otlp/proto/http/metric_exporter/__init__.py
+++ b/exporter/opentelemetry-exporter-otlp-proto-http/src/opentelemetry/exporter/otlp/proto/http/metric_exporter/__init__.py
@@ -66,8 +66,8 @@
 from opentelemetry.sdk.resources import Resource as SDKResource
 from opentelemetry.util.re import parse_headers
 
+import backoff
 import requests
-from backoff import expo
 
 _logger = logging.getLogger(__name__)
 
@@ -77,6 +77,18 @@
 DEFAULT_METRICS_EXPORT_PATH = "v1/metrics"
 DEFAULT_TIMEOUT = 10  # in seconds
 
+# Work around API change between backoff 1.x and 2.x. Since 2.0.0 the backoff
+# wait generator API requires a first .send(None) before reading the backoff
+# values from the generator.
+_is_backoff_v2 = next(backoff.expo()) is None
+
+
+def _expo(*args, **kwargs):
+    gen = backoff.expo(*args, **kwargs)
+    if _is_backoff_v2:
+        gen.send(None)
+    return gen
+
 
 class OTLPMetricExporter(MetricExporter):
 
@@ -319,7 +331,7 @@ def export(
         **kwargs,
     ) -> MetricExportResult:
         serialized_data = self._translate_data(metrics_data)
-        for delay in expo(max_value=self._MAX_RETRY_TIMEOUT):
+        for delay in _expo(max_value=self._MAX_RETRY_TIMEOUT):
 
             if delay == self._MAX_RETRY_TIMEOUT:
                 return MetricExportResult.FAILURE
diff --git a/exporter/opentelemetry-exporter-otlp-proto-http/src/opentelemetry/exporter/otlp/proto/http/trace_exporter/__init__.py b/exporter/opentelemetry-exporter-otlp-proto-http/src/opentelemetry/exporter/otlp/proto/http/trace_exporter/__init__.py
index a65bc44320f..9dc3b65014d 100644
--- a/exporter/opentelemetry-exporter-otlp-proto-http/src/opentelemetry/exporter/otlp/proto/http/trace_exporter/__init__.py
+++ b/exporter/opentelemetry-exporter-otlp-proto-http/src/opentelemetry/exporter/otlp/proto/http/trace_exporter/__init__.py
@@ -20,8 +20,8 @@
 from typing import Dict, Optional
 from time import sleep
 
+import backoff
 import requests
-from backoff import expo
 
 from opentelemetry.sdk.environment_variables import (
     OTEL_EXPORTER_OTLP_TRACES_CERTIFICATE,
@@ -54,6 +54,18 @@
 DEFAULT_TRACES_EXPORT_PATH = "v1/traces"
 DEFAULT_TIMEOUT = 10  # in seconds
 
+# Work around API change between backoff 1.x and 2.x. Since 2.0.0 the backoff
+# wait generator API requires a first .send(None) before reading the backoff
+# values from the generator.
+_is_backoff_v2 = next(backoff.expo()) is None
+
+
+def _expo(*args, **kwargs):
+    gen = backoff.expo(*args, **kwargs)
+    if _is_backoff_v2:
+        gen.send(None)
+    return gen
+
 
 class OTLPSpanExporter(SpanExporter):
 
@@ -133,7 +145,7 @@ def export(self, spans) -> SpanExportResult:
 
         serialized_data = _ProtobufEncoder.serialize(spans)
 
-        for delay in expo(max_value=self._MAX_RETRY_TIMEOUT):
+        for delay in _expo(max_value=self._MAX_RETRY_TIMEOUT):
 
             if delay == self._MAX_RETRY_TIMEOUT:
                 return SpanExportResult.FAILURE
diff --git a/exporter/opentelemetry-exporter-otlp-proto-http/tests/metrics/test_otlp_metrics_exporter.py b/exporter/opentelemetry-exporter-otlp-proto-http/tests/metrics/test_otlp_metrics_exporter.py
index e4665a47fc3..74ba53b3c59 100644
--- a/exporter/opentelemetry-exporter-otlp-proto-http/tests/metrics/test_otlp_metrics_exporter.py
+++ b/exporter/opentelemetry-exporter-otlp-proto-http/tests/metrics/test_otlp_metrics_exporter.py
@@ -16,6 +16,7 @@
 from unittest.mock import patch
 
 import requests
+import responses
 
 from opentelemetry.exporter.otlp.proto.http import Compression
 from opentelemetry.exporter.otlp.proto.http.metric_exporter import (
@@ -269,3 +270,30 @@ def test_serialization(self, mock_post):
             verify=exporter._certificate_file,
             timeout=exporter._timeout,
         )
+
+    @responses.activate
+    @patch("opentelemetry.exporter.otlp.proto.http.metric_exporter.backoff")
+    @patch("opentelemetry.exporter.otlp.proto.http.metric_exporter.sleep")
+    def test_handles_backoff_v2_api(self, mock_sleep, mock_backoff):
+        # In backoff ~= 2.0.0 the first value yielded from expo is None.
+        def generate_delays(*args, **kwargs):
+            yield None
+            yield 1
+
+        mock_backoff.expo.configure_mock(**{"side_effect": generate_delays})
+
+        # return a retryable error
+        responses.add(
+            responses.POST,
+            "http://metrics.example.com/export",
+            json={"error": "something exploded"},
+            status=500,
+        )
+
+        exporter = OTLPMetricExporter(
+            endpoint="http://metrics.example.com/export"
+        )
+        metrics_data = self.metrics["sum_int"]
+
+        exporter.export(metrics_data)
+        mock_sleep.assert_called_once_with(1)
diff --git a/exporter/opentelemetry-exporter-otlp-proto-http/tests/test_proto_log_exporter.py b/exporter/opentelemetry-exporter-otlp-proto-http/tests/test_proto_log_exporter.py
index 2063820b5d2..d94ddfb8f7c 100644
--- a/exporter/opentelemetry-exporter-otlp-proto-http/tests/test_proto_log_exporter.py
+++ b/exporter/opentelemetry-exporter-otlp-proto-http/tests/test_proto_log_exporter.py
@@ -19,6 +19,7 @@
 from unittest.mock import MagicMock, patch
 
 import requests
+import responses
 
 from opentelemetry.exporter.otlp.proto.http import Compression
 from opentelemetry.exporter.otlp.proto.http._log_exporter import (
@@ -159,6 +160,31 @@ def test_serialize(self):
             expected_encoding.SerializeToString(),
         )
 
+    @responses.activate
+    @patch("opentelemetry.exporter.otlp.proto.http._log_exporter.backoff")
+    @patch("opentelemetry.exporter.otlp.proto.http._log_exporter.sleep")
+    def test_handles_backoff_v2_api(self, mock_sleep, mock_backoff):
+        # In backoff ~= 2.0.0 the first value yielded from expo is None.
+        def generate_delays(*args, **kwargs):
+            yield None
+            yield 1
+
+        mock_backoff.expo.configure_mock(**{"side_effect": generate_delays})
+
+        # return a retryable error
+        responses.add(
+            responses.POST,
+            "http://logs.example.com/export",
+            json={"error": "something exploded"},
+            status=500,
+        )
+
+        exporter = OTLPLogExporter(endpoint="http://logs.example.com/export")
+        logs = self._get_sdk_log_data()
+
+        exporter.export(logs)
+        mock_sleep.assert_called_once_with(1)
+
     @staticmethod
     def _get_sdk_log_data() -> List[LogData]:
         log1 = LogData(
diff --git a/exporter/opentelemetry-exporter-otlp-proto-http/tests/test_proto_span_exporter.py b/exporter/opentelemetry-exporter-otlp-proto-http/tests/test_proto_span_exporter.py
index 73e54e86c0b..c7ff9a15dde 100644
--- a/exporter/opentelemetry-exporter-otlp-proto-http/tests/test_proto_span_exporter.py
+++ b/exporter/opentelemetry-exporter-otlp-proto-http/tests/test_proto_span_exporter.py
@@ -13,9 +13,11 @@
 # limitations under the License.
 
 import unittest
-from unittest.mock import patch
+from collections import OrderedDict
+from unittest.mock import Mock, patch
 
 import requests
+import responses
 
 from opentelemetry.exporter.otlp.proto.http import Compression
 from opentelemetry.exporter.otlp.proto.http.trace_exporter import (
@@ -37,6 +39,7 @@
     OTEL_EXPORTER_OTLP_TRACES_HEADERS,
     OTEL_EXPORTER_OTLP_TRACES_TIMEOUT,
 )
+from opentelemetry.sdk.trace import _Span
 
 OS_ENV_ENDPOINT = "os.env.base"
 OS_ENV_CERTIFICATE = "os/env/base.crt"
@@ -188,3 +191,40 @@ def test_headers_parse_from_env(self):
                 cm.records[0].message,
                 "Header doesn't match the format: missingValue.",
             )
+
+    # pylint: disable=no-self-use
+    @responses.activate
+    @patch("opentelemetry.exporter.otlp.proto.http.trace_exporter.backoff")
+    @patch("opentelemetry.exporter.otlp.proto.http.trace_exporter.sleep")
+    def test_handles_backoff_v2_api(self, mock_sleep, mock_backoff):
+        # In backoff ~= 2.0.0 the first value yielded from expo is None.
+        def generate_delays(*args, **kwargs):
+            yield None
+            yield 1
+
+        mock_backoff.expo.configure_mock(**{"side_effect": generate_delays})
+
+        # return a retryable error
+        responses.add(
+            responses.POST,
+            "http://traces.example.com/export",
+            json={"error": "something exploded"},
+            status=500,
+        )
+
+        exporter = OTLPSpanExporter(
+            endpoint="http://traces.example.com/export"
+        )
+        span = _Span(
+            "abc",
+            context=Mock(
+                **{
+                    "trace_state": OrderedDict([("a", "b"), ("c", "d")]),
+                    "span_id": 10217189687419569865,
+                    "trace_id": 67545097771067222548457157018666467027,
+                }
+            ),
+        )
+
+        exporter.export([span])
+        mock_sleep.assert_called_once_with(1)
diff --git a/tox.ini b/tox.ini
index 1a24186fbd7..2248ab1e427 100644
--- a/tox.ini
+++ b/tox.ini
@@ -137,7 +137,7 @@ commands_pre =
   exporter-otlp-proto-grpc: pip install {toxinidir}/exporter/opentelemetry-exporter-otlp-proto-grpc
 
   exporter-otlp-proto-http: pip install {toxinidir}/opentelemetry-proto
-  exporter-otlp-proto-http: pip install {toxinidir}/exporter/opentelemetry-exporter-otlp-proto-http
+  exporter-otlp-proto-http: pip install {toxinidir}/exporter/opentelemetry-exporter-otlp-proto-http[test]
 
   exporter-jaeger-combined: pip install {toxinidir}/exporter/opentelemetry-exporter-jaeger-proto-grpc {toxinidir}/exporter/opentelemetry-exporter-jaeger-thrift {toxinidir}/exporter/opentelemetry-exporter-jaeger
   exporter-jaeger-proto-grpc: pip install {toxinidir}/exporter/opentelemetry-exporter-jaeger-proto-grpc