diff --git a/.github/workflows/benchmarks.yml b/.github/workflows/benchmarks.yml
index aa909250ad8..0c06f8b741f 100644
--- a/.github/workflows/benchmarks.yml
+++ b/.github/workflows/benchmarks.yml
@@ -7,14 +7,14 @@ on:
 jobs:
   sdk-benchmarks:
     env:
-      py311: "3.11"
+      py312: "3.12"
       RUN_MATRIX_COMBINATION: ${{ matrix.python-version }}-sdk-${{ matrix.os }}
     runs-on: self-hosted
     strategy:
       # Ensures the entire test matrix is run, even if one permutation fails
       fail-fast: false
       matrix:
-        python-version: [py311]
+        python-version: [py312]
         os: [ubuntu-20.04, windows-2019]
     steps:
     - name: Checkout Core Repo @ SHA - ${{ github.sha }}
diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
index 47339d80579..696232b5558 100644
--- a/.github/workflows/test.yml
+++ b/.github/workflows/test.yml
@@ -31,6 +31,7 @@ jobs:
       py39: 3.9
       py310: "3.10"
       py311: "3.11"
+      py312: "3.12"
       pypy3: pypy-3.8
       RUN_MATRIX_COMBINATION: ${{ matrix.python-version }}-${{ matrix.package }}-${{
         matrix.os }}
@@ -38,7 +39,7 @@ jobs:
     strategy:
       fail-fast: false  # ensures the entire test matrix is run, even if one permutation fails
       matrix:
-        python-version: [py38, py39, py310, py311, pypy3]
+        python-version: [py38, py39, py310, py311, py312, pypy3]
         package:
           - "api"
           - "sdk"
diff --git a/.pre-commit-config.yaml b/.pre-commit-config.yaml
index cbdffe129b2..b01b7ce4d7b 100644
--- a/.pre-commit-config.yaml
+++ b/.pre-commit-config.yaml
@@ -3,7 +3,7 @@ repos:
     rev: 24.3.0
     hooks:
       - id: black
-        language_version: python3.11
+        language_version: python3.12
   - repo: https://github.com/pycqa/isort
     rev: 5.12.0
     hooks:
diff --git a/CHANGELOG.md b/CHANGELOG.md
index 242e82a3240..2c495129ea7 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -7,6 +7,9 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 
 ## Unreleased
 
+- Add Python 3.12 to tox
+  ([#3616](https://github.com/open-telemetry/opentelemetry-python/pull/3616))
+
 ## Version 1.25.0/0.46b0 (2024-05-30)
 
 - Fix class BoundedAttributes to have RLock rather than Lock
diff --git a/CONTRIBUTING.md b/CONTRIBUTING.md
index ec155c5e72c..3b085e95033 100644
--- a/CONTRIBUTING.md
+++ b/CONTRIBUTING.md
@@ -54,7 +54,7 @@ You can run `tox` with the following arguments:
   under multiple Python versions
 - `tox -e docs` to regenerate the API docs
 - `tox -e opentelemetry-api` and `tox -e opentelemetry-sdk` to run the API and SDK unit tests
-- `tox -e py311-opentelemetry-api` to e.g. run the API unit tests under a specific
+- `tox -e py312-opentelemetry-api` to e.g. run the API unit tests under a specific
   Python version
 - `tox -e spellcheck` to run a spellcheck on all the code
 - `tox -e lint` to run lint checks on all code
diff --git a/docs/examples/error_handler/error_handler_0/pyproject.toml b/docs/examples/error_handler/error_handler_0/pyproject.toml
index 7869303c110..fb8c889e61f 100644
--- a/docs/examples/error_handler/error_handler_0/pyproject.toml
+++ b/docs/examples/error_handler/error_handler_0/pyproject.toml
@@ -22,6 +22,7 @@ classifiers = [
   "Programming Language :: Python :: 3.9",
   "Programming Language :: Python :: 3.10",
   "Programming Language :: Python :: 3.11",
+  "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
   "opentelemetry-sdk ~= 1.3",
diff --git a/docs/examples/error_handler/error_handler_1/pyproject.toml b/docs/examples/error_handler/error_handler_1/pyproject.toml
index b2e04d4a676..5f72ff58480 100644
--- a/docs/examples/error_handler/error_handler_1/pyproject.toml
+++ b/docs/examples/error_handler/error_handler_1/pyproject.toml
@@ -22,6 +22,7 @@ classifiers = [
   "Programming Language :: Python :: 3.9",
   "Programming Language :: Python :: 3.10",
   "Programming Language :: Python :: 3.11",
+  "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
   "opentelemetry-sdk ~= 1.3",
diff --git a/exporter/opentelemetry-exporter-opencensus/pyproject.toml b/exporter/opentelemetry-exporter-opencensus/pyproject.toml
index 98a2b49cc0d..04af7aca18e 100644
--- a/exporter/opentelemetry-exporter-opencensus/pyproject.toml
+++ b/exporter/opentelemetry-exporter-opencensus/pyproject.toml
@@ -24,6 +24,7 @@ classifiers = [
   "Programming Language :: Python :: 3.9",
   "Programming Language :: Python :: 3.10",
   "Programming Language :: Python :: 3.11",
+  "Programming Language :: Python :: 3.12",
   "Typing :: Typed",
 ]
 dependencies = [
diff --git a/exporter/opentelemetry-exporter-otlp-proto-common/pyproject.toml b/exporter/opentelemetry-exporter-otlp-proto-common/pyproject.toml
index 8adb298346e..a9bdec583b2 100644
--- a/exporter/opentelemetry-exporter-otlp-proto-common/pyproject.toml
+++ b/exporter/opentelemetry-exporter-otlp-proto-common/pyproject.toml
@@ -24,6 +24,7 @@ classifiers = [
   "Programming Language :: Python :: 3.9",
   "Programming Language :: Python :: 3.10",
   "Programming Language :: Python :: 3.11",
+  "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
   "opentelemetry-proto == 1.26.0.dev",
diff --git a/exporter/opentelemetry-exporter-otlp-proto-grpc/pyproject.toml b/exporter/opentelemetry-exporter-otlp-proto-grpc/pyproject.toml
index db4639e6016..3f1735799ac 100644
--- a/exporter/opentelemetry-exporter-otlp-proto-grpc/pyproject.toml
+++ b/exporter/opentelemetry-exporter-otlp-proto-grpc/pyproject.toml
@@ -24,6 +24,7 @@ classifiers = [
   "Programming Language :: Python :: 3.9",
   "Programming Language :: Python :: 3.10",
   "Programming Language :: Python :: 3.11",
+  "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
   "Deprecated >= 1.2.6",
diff --git a/exporter/opentelemetry-exporter-otlp-proto-http/pyproject.toml b/exporter/opentelemetry-exporter-otlp-proto-http/pyproject.toml
index ab56683b8bd..47a7ceae847 100644
--- a/exporter/opentelemetry-exporter-otlp-proto-http/pyproject.toml
+++ b/exporter/opentelemetry-exporter-otlp-proto-http/pyproject.toml
@@ -24,6 +24,7 @@ classifiers = [
   "Programming Language :: Python :: 3.9",
   "Programming Language :: Python :: 3.10",
   "Programming Language :: Python :: 3.11",
+  "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
   "Deprecated >= 1.2.6",
diff --git a/exporter/opentelemetry-exporter-otlp/pyproject.toml b/exporter/opentelemetry-exporter-otlp/pyproject.toml
index 9493120a7ae..04967c702a3 100644
--- a/exporter/opentelemetry-exporter-otlp/pyproject.toml
+++ b/exporter/opentelemetry-exporter-otlp/pyproject.toml
@@ -24,6 +24,7 @@ classifiers = [
   "Programming Language :: Python :: 3.9",
   "Programming Language :: Python :: 3.10",
   "Programming Language :: Python :: 3.11",
+  "Programming Language :: Python :: 3.12",
   "Typing :: Typed",
 ]
 dependencies = [
diff --git a/exporter/opentelemetry-exporter-prometheus/pyproject.toml b/exporter/opentelemetry-exporter-prometheus/pyproject.toml
index 969b5067092..914a848caf9 100644
--- a/exporter/opentelemetry-exporter-prometheus/pyproject.toml
+++ b/exporter/opentelemetry-exporter-prometheus/pyproject.toml
@@ -24,6 +24,7 @@ classifiers = [
   "Programming Language :: Python :: 3.9",
   "Programming Language :: Python :: 3.10",
   "Programming Language :: Python :: 3.11",
+  "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
diff --git a/exporter/opentelemetry-exporter-zipkin-json/pyproject.toml b/exporter/opentelemetry-exporter-zipkin-json/pyproject.toml
index f2657001e22..70b4f72ea48 100644
--- a/exporter/opentelemetry-exporter-zipkin-json/pyproject.toml
+++ b/exporter/opentelemetry-exporter-zipkin-json/pyproject.toml
@@ -24,6 +24,7 @@ classifiers = [
   "Programming Language :: Python :: 3.9",
   "Programming Language :: Python :: 3.10",
   "Programming Language :: Python :: 3.11",
+  "Programming Language :: Python :: 3.12",
   "Typing :: Typed",
 ]
 dependencies = [
diff --git a/exporter/opentelemetry-exporter-zipkin-proto-http/pyproject.toml b/exporter/opentelemetry-exporter-zipkin-proto-http/pyproject.toml
index 4795ce04250..3ece52427ff 100644
--- a/exporter/opentelemetry-exporter-zipkin-proto-http/pyproject.toml
+++ b/exporter/opentelemetry-exporter-zipkin-proto-http/pyproject.toml
@@ -24,6 +24,7 @@ classifiers = [
   "Programming Language :: Python :: 3.9",
   "Programming Language :: Python :: 3.10",
   "Programming Language :: Python :: 3.11",
+  "Programming Language :: Python :: 3.12",
   "Typing :: Typed",
 ]
 dependencies = [
diff --git a/exporter/opentelemetry-exporter-zipkin/pyproject.toml b/exporter/opentelemetry-exporter-zipkin/pyproject.toml
index fc9e3e4ee96..fce1da40e30 100644
--- a/exporter/opentelemetry-exporter-zipkin/pyproject.toml
+++ b/exporter/opentelemetry-exporter-zipkin/pyproject.toml
@@ -24,6 +24,7 @@ classifiers = [
   "Programming Language :: Python :: 3.9",
   "Programming Language :: Python :: 3.10",
   "Programming Language :: Python :: 3.11",
+  "Programming Language :: Python :: 3.12",
   "Typing :: Typed",
 ]
 dependencies = [
diff --git a/opentelemetry-api/pyproject.toml b/opentelemetry-api/pyproject.toml
index ade38a1ceef..d6946e69def 100644
--- a/opentelemetry-api/pyproject.toml
+++ b/opentelemetry-api/pyproject.toml
@@ -22,6 +22,7 @@ classifiers = [
     "Programming Language :: Python :: 3.9",
     "Programming Language :: Python :: 3.10",
     "Programming Language :: Python :: 3.11",
+    "Programming Language :: Python :: 3.12",
     "Typing :: Typed",
 ]
 dependencies = [
diff --git a/opentelemetry-proto/pyproject.toml b/opentelemetry-proto/pyproject.toml
index 0e0c1331196..c8af4c5797d 100644
--- a/opentelemetry-proto/pyproject.toml
+++ b/opentelemetry-proto/pyproject.toml
@@ -23,6 +23,7 @@ classifiers = [
   "Programming Language :: Python :: 3.9",
   "Programming Language :: Python :: 3.10",
   "Programming Language :: Python :: 3.11",
+  "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
   "protobuf>=3.19, < 5.0",
diff --git a/opentelemetry-sdk/pyproject.toml b/opentelemetry-sdk/pyproject.toml
index 6ba709e629c..30b1c00de06 100644
--- a/opentelemetry-sdk/pyproject.toml
+++ b/opentelemetry-sdk/pyproject.toml
@@ -23,6 +23,7 @@ classifiers = [
   "Programming Language :: Python :: 3.9",
   "Programming Language :: Python :: 3.10",
   "Programming Language :: Python :: 3.11",
+  "Programming Language :: Python :: 3.12",
   "Typing :: Typed",
 ]
 dependencies = [
diff --git a/opentelemetry-semantic-conventions/pyproject.toml b/opentelemetry-semantic-conventions/pyproject.toml
index eb7dbcbfa16..ef6c56597b9 100644
--- a/opentelemetry-semantic-conventions/pyproject.toml
+++ b/opentelemetry-semantic-conventions/pyproject.toml
@@ -23,6 +23,7 @@ classifiers = [
   "Programming Language :: Python :: 3.9",
   "Programming Language :: Python :: 3.10",
   "Programming Language :: Python :: 3.11",
+  "Programming Language :: Python :: 3.12",
 ]
 
 dependencies = [
diff --git a/propagator/opentelemetry-propagator-b3/pyproject.toml b/propagator/opentelemetry-propagator-b3/pyproject.toml
index 1f158285e5b..f8abf0bc3ce 100644
--- a/propagator/opentelemetry-propagator-b3/pyproject.toml
+++ b/propagator/opentelemetry-propagator-b3/pyproject.toml
@@ -23,6 +23,7 @@ classifiers = [
   "Programming Language :: Python :: 3.9",
   "Programming Language :: Python :: 3.10",
   "Programming Language :: Python :: 3.11",
+  "Programming Language :: Python :: 3.12",
   "Typing :: Typed",
 ]
 dependencies = [
diff --git a/propagator/opentelemetry-propagator-jaeger/pyproject.toml b/propagator/opentelemetry-propagator-jaeger/pyproject.toml
index 9586fdf4745..9bdf0513b02 100644
--- a/propagator/opentelemetry-propagator-jaeger/pyproject.toml
+++ b/propagator/opentelemetry-propagator-jaeger/pyproject.toml
@@ -23,6 +23,7 @@ classifiers = [
   "Programming Language :: Python :: 3.9",
   "Programming Language :: Python :: 3.10",
   "Programming Language :: Python :: 3.11",
+  "Programming Language :: Python :: 3.12",
   "Typing :: Typed",
 ]
 dependencies = [
diff --git a/shim/opentelemetry-opencensus-shim/pyproject.toml b/shim/opentelemetry-opencensus-shim/pyproject.toml
index 02485dcade9..b4fdfb6e9f8 100644
--- a/shim/opentelemetry-opencensus-shim/pyproject.toml
+++ b/shim/opentelemetry-opencensus-shim/pyproject.toml
@@ -23,6 +23,7 @@ classifiers = [
   "Programming Language :: Python :: 3.9",
   "Programming Language :: Python :: 3.10",
   "Programming Language :: Python :: 3.11",
+  "Programming Language :: Python :: 3.12",
   "Typing :: Typed",
 ]
 dependencies = [
diff --git a/shim/opentelemetry-opentracing-shim/pyproject.toml b/shim/opentelemetry-opentracing-shim/pyproject.toml
index a9869f57f7d..0345178f903 100644
--- a/shim/opentelemetry-opentracing-shim/pyproject.toml
+++ b/shim/opentelemetry-opentracing-shim/pyproject.toml
@@ -23,6 +23,7 @@ classifiers = [
   "Programming Language :: Python :: 3.9",
   "Programming Language :: Python :: 3.10",
   "Programming Language :: Python :: 3.11",
+  "Programming Language :: Python :: 3.12",
   "Typing :: Typed",
 ]
 dependencies = [
diff --git a/tests/opentelemetry-test-utils/pyproject.toml b/tests/opentelemetry-test-utils/pyproject.toml
index b56e274f422..74314eb542a 100644
--- a/tests/opentelemetry-test-utils/pyproject.toml
+++ b/tests/opentelemetry-test-utils/pyproject.toml
@@ -22,6 +22,8 @@ classifiers = [
   "Programming Language :: Python :: 3.8",
   "Programming Language :: Python :: 3.9",
   "Programming Language :: Python :: 3.10",
+  "Programming Language :: Python :: 3.11",
+  "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
   "asgiref ~= 3.0",
diff --git a/tox.ini b/tox.ini
index 7c18460b19a..312e217fdae 100644
--- a/tox.ini
+++ b/tox.ini
@@ -5,80 +5,80 @@ skip_missing_interpreters = True
 envlist =
     ; Environments are organized by individual package, allowing
     ; for specifying supported Python versions per package.
-    py3{8,9,10,11}-opentelemetry-api
+    py3{8,9,10,11,12}-opentelemetry-api
     pypy3-opentelemetry-api
 
     ; The numbers at the end of the environment names
     ; below mean these dependencies are being used:
     ; 0: protobuf==3.20.3
     ; 1: protobuf==4.25.3
-    py3{8,9,10,11}-opentelemetry-protobuf-{0,1}
+    py3{8,9,10,11,12}-opentelemetry-protobuf-{0,1}
     pypy3-opentelemetry-protobuf-{0,1}
 
-    py3{8,9,10,11}-opentelemetry-sdk
+    py3{8,9,10,11,12}-opentelemetry-sdk
     pypy3-opentelemetry-sdk
 
-    py3{8,9,10,11}-opentelemetry-semantic-conventions
+    py3{8,9,10,11,12}-opentelemetry-semantic-conventions
     pypy3-opentelemetry-semantic-conventions
 
     ; docs/getting-started
-    py3{8,9,10,11}-opentelemetry-getting-started
+    py3{8,9,10,11,12}-opentelemetry-getting-started
     pypy3-opentelemetry-getting-started
 
-    py3{8,9,10,11}-opentelemetry-opentracing-shim
+    py3{8,9,10,11,12}-opentelemetry-opentracing-shim
     pypy3-opentelemetry-opentracing-shim
 
-    py3{8,9,10,11}-opentelemetry-opencensus-shim
+    py3{8,9,10,11,12}-opentelemetry-opencensus-shim
     ; opencensus-shim intentionally excluded from pypy3 (grpcio install fails)
 
-    py3{8,9,10,11}-opentelemetry-exporter-opencensus
+    py3{8,9,10,11,12}-opentelemetry-exporter-opencensus
     ; exporter-opencensus intentionally excluded from pypy3
 
     ; The numbers at the end of the environment names
     ; below mean these dependencies are being used:
     ; 0: protobuf==3.20.3
     ; 1: protobuf==4.25.3
-    py3{8,9,10,11}-opentelemetry-exporter-otlp-proto-common-{0,1}
+    py3{8,9,10,11,12}-opentelemetry-exporter-otlp-proto-common-{0,1}
     pypy3-opentelemetry-exporter-otlp-proto-common-{0,1}
 
     ; opentelemetry-exporter-otlp
-    py3{8,9,10,11}-opentelemetry-exporter-otlp-combined
+    py3{8,9,10,11,12}-opentelemetry-exporter-otlp-combined
     ; intentionally excluded from pypy3
 
     ; The numbers at the end of the environment names
     ; below mean these dependencies are being used:
     ; 0: protobuf==3.20.3
     ; 1: protobuf==4.25.3
-    py3{8,9,10,11}-opentelemetry-exporter-otlp-proto-grpc-{0,1}
+    py3{8,9,10,11,12}-opentelemetry-exporter-otlp-proto-grpc-{0,1}
     ; intentionally excluded from pypy3
 
     ; The numbers at the end of the environment names
     ; below mean these dependencies are being used:
     ; 0: protobuf==3.20.3
     ; 1: protobuf==4.25.3
-    py3{8,9,10,11}-opentelemetry-exporter-otlp-proto-http-{0,1}
+    py3{8,9,10,11,12}-opentelemetry-exporter-otlp-proto-http-{0,1}
     pypy3-opentelemetry-exporter-otlp-proto-http-{0,1}
 
-    py3{8,9,10,11}-opentelemetry-exporter-prometheus
+    py3{8,9,10,11,12}-opentelemetry-exporter-prometheus
     pypy3-opentelemetry-exporter-prometheus
 
     ; opentelemetry-exporter-zipkin
-    py3{8,9,10,11}-opentelemetry-exporter-zipkin-combined
+    py3{8,9,10,11,12}-opentelemetry-exporter-zipkin-combined
     pypy3-opentelemetry-exporter-zipkin-combined
 
-    py3{8,9,10,11}-opentelemetry-exporter-zipkin-proto-http
+    py3{8,9,10,11,12}-opentelemetry-exporter-zipkin-proto-http
     pypy3-opentelemetry-exporter-zipkin-proto-http
 
-    py3{8,9,10,11}-opentelemetry-exporter-zipkin-json
+    py3{8,9,10,11,12}-opentelemetry-exporter-zipkin-json
     pypy3-opentelemetry-exporter-zipkin-json
 
-    py3{8,9,10,11}-opentelemetry-propagator-b3
+    py3{8,9,10,11,12}-opentelemetry-propagator-b3
     pypy3-opentelemetry-propagator-b3
 
-    py3{8,9,10,11}-opentelemetry-propagator-jaeger
+    py3{8,9,10,11,12}-opentelemetry-propagator-jaeger
     pypy3-opentelemetry-propagator-jaeger
 
-    py3{8,9,10,11}-opentelemetry-test-utils
+    py3{8,9,10,11,12}-opentelemetry-test-utils
     pypy3-opentelemetry-test-utils
 
     lint