diff --git a/dev-requirements.txt b/dev-requirements.txt
index 22595d5af2b..44e20801416 100644
--- a/dev-requirements.txt
+++ b/dev-requirements.txt
@@ -1,7 +1,7 @@
 pylint==2.11.0
 flake8~=3.7
 isort~=5.8
-black~=21.7b0
+black~=22.1.0
 httpretty~=1.0
 mypy==0.812
 sphinx~=3.5.4
diff --git a/exporter/opentelemetry-exporter-jaeger-proto-grpc/src/opentelemetry/exporter/jaeger/proto/grpc/translate/__init__.py b/exporter/opentelemetry-exporter-jaeger-proto-grpc/src/opentelemetry/exporter/jaeger/proto/grpc/translate/__init__.py
index 65eef76d0fa..3eb59755c96 100644
--- a/exporter/opentelemetry-exporter-jaeger-proto-grpc/src/opentelemetry/exporter/jaeger/proto/grpc/translate/__init__.py
+++ b/exporter/opentelemetry-exporter-jaeger-proto-grpc/src/opentelemetry/exporter/jaeger/proto/grpc/translate/__init__.py
@@ -39,7 +39,7 @@
 
 def _nsec_to_usec_round(nsec: int) -> int:
     """Round nanoseconds to microseconds"""
-    return (nsec + 500) // 10 ** 3
+    return (nsec + 500) // 10**3
 
 
 def _convert_int_to_i64(val):
diff --git a/exporter/opentelemetry-exporter-jaeger-proto-grpc/tests/test_jaeger_exporter_protobuf.py b/exporter/opentelemetry-exporter-jaeger-proto-grpc/tests/test_jaeger_exporter_protobuf.py
index 4448b2c838c..926bbff085e 100644
--- a/exporter/opentelemetry-exporter-jaeger-proto-grpc/tests/test_jaeger_exporter_protobuf.py
+++ b/exporter/opentelemetry-exporter-jaeger-proto-grpc/tests/test_jaeger_exporter_protobuf.py
@@ -108,13 +108,13 @@ def test_translate_to_jaeger(self):
         parent_id = 0x1111111111111111
         other_id = 0x2222222222222222
 
-        base_time = 683647322 * 10 ** 9  # in ns
+        base_time = 683647322 * 10**9  # in ns
         start_times = (
             base_time,
-            base_time + 150 * 10 ** 6,
-            base_time + 300 * 10 ** 6,
+            base_time + 150 * 10**6,
+            base_time + 300 * 10**6,
         )
-        durations = (50 * 10 ** 6, 100 * 10 ** 6, 200 * 10 ** 6)
+        durations = (50 * 10**6, 100 * 10**6, 200 * 10**6)
         end_times = (
             start_times[0] + durations[0],
             start_times[1] + durations[1],
@@ -139,7 +139,7 @@ def test_translate_to_jaeger(self):
             ]
         )
 
-        event_timestamp = base_time + 50 * 10 ** 6
+        event_timestamp = base_time + 50 * 10**6
         # pylint:disable=protected-access
         event_timestamp_proto = (
             pb_translator._proto_timestamp_from_epoch_nanos(event_timestamp)
diff --git a/exporter/opentelemetry-exporter-jaeger-thrift/src/opentelemetry/exporter/jaeger/thrift/translate/__init__.py b/exporter/opentelemetry-exporter-jaeger-thrift/src/opentelemetry/exporter/jaeger/thrift/translate/__init__.py
index f21ede6f8b4..1649b000e91 100644
--- a/exporter/opentelemetry-exporter-jaeger-thrift/src/opentelemetry/exporter/jaeger/thrift/translate/__init__.py
+++ b/exporter/opentelemetry-exporter-jaeger-thrift/src/opentelemetry/exporter/jaeger/thrift/translate/__init__.py
@@ -36,7 +36,7 @@
 
 def _nsec_to_usec_round(nsec: int) -> int:
     """Round nanoseconds to microseconds"""
-    return (nsec + 500) // 10 ** 3
+    return (nsec + 500) // 10**3
 
 
 def _convert_int_to_i64(val):
diff --git a/exporter/opentelemetry-exporter-jaeger-thrift/tests/test_jaeger_exporter_thrift.py b/exporter/opentelemetry-exporter-jaeger-thrift/tests/test_jaeger_exporter_thrift.py
index 8a30527eebc..8bd3e3e359d 100644
--- a/exporter/opentelemetry-exporter-jaeger-thrift/tests/test_jaeger_exporter_thrift.py
+++ b/exporter/opentelemetry-exporter-jaeger-thrift/tests/test_jaeger_exporter_thrift.py
@@ -230,13 +230,13 @@ def test_translate_to_jaeger(self):
         parent_id = 0x1111111111111111
         other_id = 0x2222222222222222
 
-        base_time = 683647322 * 10 ** 9  # in ns
+        base_time = 683647322 * 10**9  # in ns
         start_times = (
             base_time,
-            base_time + 150 * 10 ** 6,
-            base_time + 300 * 10 ** 6,
+            base_time + 150 * 10**6,
+            base_time + 300 * 10**6,
         )
-        durations = (50 * 10 ** 6, 100 * 10 ** 6, 200 * 10 ** 6)
+        durations = (50 * 10**6, 100 * 10**6, 200 * 10**6)
         end_times = (
             start_times[0] + durations[0],
             start_times[1] + durations[1],
@@ -259,7 +259,7 @@ def test_translate_to_jaeger(self):
             "key_float": 0.3,
         }
 
-        event_timestamp = base_time + 50 * 10 ** 6
+        event_timestamp = base_time + 50 * 10**6
         event = trace.Event(
             name="event0",
             timestamp=event_timestamp,
@@ -338,8 +338,8 @@ def test_translate_to_jaeger(self):
                 traceIdLow=trace_id_low,
                 spanId=span_id,
                 parentSpanId=parent_id,
-                startTime=start_times[0] // 10 ** 3,
-                duration=durations[0] // 10 ** 3,
+                startTime=start_times[0] // 10**3,
+                duration=durations[0] // 10**3,
                 flags=0,
                 tags=[
                     jaeger.Tag(
@@ -394,7 +394,7 @@ def test_translate_to_jaeger(self):
                 ],
                 logs=[
                     jaeger.Log(
-                        timestamp=event_timestamp // 10 ** 3,
+                        timestamp=event_timestamp // 10**3,
                         fields=[
                             jaeger.Tag(
                                 key="annotation_bool",
@@ -426,8 +426,8 @@ def test_translate_to_jaeger(self):
                 traceIdLow=trace_id_low,
                 spanId=parent_id,
                 parentSpanId=0,
-                startTime=start_times[1] // 10 ** 3,
-                duration=durations[1] // 10 ** 3,
+                startTime=start_times[1] // 10**3,
+                duration=durations[1] // 10**3,
                 flags=0,
                 tags=default_tags,
             ),
@@ -437,8 +437,8 @@ def test_translate_to_jaeger(self):
                 traceIdLow=trace_id_low,
                 spanId=other_id,
                 parentSpanId=0,
-                startTime=start_times[2] // 10 ** 3,
-                duration=durations[2] // 10 ** 3,
+                startTime=start_times[2] // 10**3,
+                duration=durations[2] // 10**3,
                 flags=0,
                 tags=[
                     jaeger.Tag(
diff --git a/exporter/opentelemetry-exporter-opencensus/tests/test_otcollector_trace_exporter.py b/exporter/opentelemetry-exporter-opencensus/tests/test_otcollector_trace_exporter.py
index cd4dcb1a08c..fa546cde7a2 100644
--- a/exporter/opentelemetry-exporter-opencensus/tests/test_otcollector_trace_exporter.py
+++ b/exporter/opentelemetry-exporter-opencensus/tests/test_otcollector_trace_exporter.py
@@ -84,13 +84,13 @@ def test_translate_to_collector(self):
         trace_id = 0x6E0C63257DE34C926F9EFCD03927272E
         span_id = 0x34BF92DEEFC58C92
         parent_id = 0x1111111111111111
-        base_time = 683647322 * 10 ** 9  # in ns
+        base_time = 683647322 * 10**9  # in ns
         start_times = (
             base_time,
-            base_time + 150 * 10 ** 6,
-            base_time + 300 * 10 ** 6,
+            base_time + 150 * 10**6,
+            base_time + 300 * 10**6,
         )
-        durations = (50 * 10 ** 6, 100 * 10 ** 6, 200 * 10 ** 6)
+        durations = (50 * 10**6, 100 * 10**6, 200 * 10**6)
         end_times = (
             start_times[0] + durations[0],
             start_times[1] + durations[1],
@@ -114,7 +114,7 @@ def test_translate_to_collector(self):
             "annotation_string": "annotation_test",
             "key_float": 0.3,
         }
-        event_timestamp = base_time + 50 * 10 ** 6
+        event_timestamp = base_time + 50 * 10**6
         event = trace.Event(
             name="event0",
             timestamp=event_timestamp,
diff --git a/exporter/opentelemetry-exporter-otlp-proto-http/tests/test_protobuf_encoder.py b/exporter/opentelemetry-exporter-otlp-proto-http/tests/test_protobuf_encoder.py
index f2d2445677c..a6ebc051452 100644
--- a/exporter/opentelemetry-exporter-otlp-proto-http/tests/test_protobuf_encoder.py
+++ b/exporter/opentelemetry-exporter-otlp-proto-http/tests/test_protobuf_encoder.py
@@ -80,18 +80,18 @@ def test_content_type(self):
     def get_exhaustive_otel_span_list() -> List[SDKSpan]:
         trace_id = 0x3E0C63257DE34C926F9EFCD03927272E
 
-        base_time = 683647322 * 10 ** 9  # in ns
+        base_time = 683647322 * 10**9  # in ns
         start_times = (
             base_time,
-            base_time + 150 * 10 ** 6,
-            base_time + 300 * 10 ** 6,
-            base_time + 400 * 10 ** 6,
+            base_time + 150 * 10**6,
+            base_time + 300 * 10**6,
+            base_time + 400 * 10**6,
         )
         end_times = (
-            start_times[0] + (50 * 10 ** 6),
-            start_times[1] + (100 * 10 ** 6),
-            start_times[2] + (200 * 10 ** 6),
-            start_times[3] + (300 * 10 ** 6),
+            start_times[0] + (50 * 10**6),
+            start_times[1] + (100 * 10**6),
+            start_times[2] + (200 * 10**6),
+            start_times[3] + (300 * 10**6),
         )
 
         parent_span_context = SDKSpanContext(
@@ -114,7 +114,7 @@ def get_exhaustive_otel_span_list() -> List[SDKSpan]:
             events=(
                 SDKEvent(
                     name="event0",
-                    timestamp=base_time + 50 * 10 ** 6,
+                    timestamp=base_time + 50 * 10**6,
                     attributes={
                         "annotation_bool": True,
                         "annotation_string": "annotation_test",
diff --git a/exporter/opentelemetry-exporter-zipkin-json/src/opentelemetry/exporter/zipkin/encoder/__init__.py b/exporter/opentelemetry-exporter-zipkin-json/src/opentelemetry/exporter/zipkin/encoder/__init__.py
index 07ad735ece8..5353a896cf8 100644
--- a/exporter/opentelemetry-exporter-zipkin-json/src/opentelemetry/exporter/zipkin/encoder/__init__.py
+++ b/exporter/opentelemetry-exporter-zipkin-json/src/opentelemetry/exporter/zipkin/encoder/__init__.py
@@ -256,7 +256,7 @@ def _nsec_to_usec_round(nsec: int) -> int:
         Timestamp in zipkin spans is int of microseconds.
         See: https://zipkin.io/pages/instrumenting.html
         """
-        return (nsec + 500) // 10 ** 3
+        return (nsec + 500) // 10**3
 
 
 class JsonEncoder(Encoder):
diff --git a/exporter/opentelemetry-exporter-zipkin-json/tests/encoder/common_tests.py b/exporter/opentelemetry-exporter-zipkin-json/tests/encoder/common_tests.py
index a04148b6ea4..8eaa5b1563b 100644
--- a/exporter/opentelemetry-exporter-zipkin-json/tests/encoder/common_tests.py
+++ b/exporter/opentelemetry-exporter-zipkin-json/tests/encoder/common_tests.py
@@ -96,15 +96,15 @@ def test_constructor_max_tag_value_length(self):
             )
 
         def test_nsec_to_usec_round(self):
-            base_time_nsec = 683647322 * 10 ** 9
+            base_time_nsec = 683647322 * 10**9
             for nsec in (
                 base_time_nsec,
-                base_time_nsec + 150 * 10 ** 6,
-                base_time_nsec + 300 * 10 ** 6,
-                base_time_nsec + 400 * 10 ** 6,
+                base_time_nsec + 150 * 10**6,
+                base_time_nsec + 300 * 10**6,
+                base_time_nsec + 400 * 10**6,
             ):
                 self.assertEqual(
-                    (nsec + 500) // 10 ** 3,
+                    (nsec + 500) // 10**3,
                     self.get_encoder_default()._nsec_to_usec_round(nsec),
                 )
 
@@ -168,8 +168,8 @@ def test_get_parent_id_from_span_context(self):
         def get_data_for_max_tag_length_test(
             max_tag_length: int,
         ) -> (trace._Span, Dict):
-            start_time = 683647322 * 10 ** 9  # in ns
-            duration = 50 * 10 ** 6
+            start_time = 683647322 * 10**9  # in ns
+            duration = 50 * 10**6
             end_time = start_time + duration
 
             span = trace._Span(
@@ -332,18 +332,18 @@ def get_data_for_max_tag_length_test(
         def get_exhaustive_otel_span_list() -> List[trace._Span]:
             trace_id = 0x6E0C63257DE34C926F9EFCD03927272E
 
-            base_time = 683647322 * 10 ** 9  # in ns
+            base_time = 683647322 * 10**9  # in ns
             start_times = (
                 base_time,
-                base_time + 150 * 10 ** 6,
-                base_time + 300 * 10 ** 6,
-                base_time + 400 * 10 ** 6,
+                base_time + 150 * 10**6,
+                base_time + 300 * 10**6,
+                base_time + 400 * 10**6,
             )
             end_times = (
-                start_times[0] + (50 * 10 ** 6),
-                start_times[1] + (100 * 10 ** 6),
-                start_times[2] + (200 * 10 ** 6),
-                start_times[3] + (300 * 10 ** 6),
+                start_times[0] + (50 * 10**6),
+                start_times[1] + (100 * 10**6),
+                start_times[2] + (200 * 10**6),
+                start_times[3] + (300 * 10**6),
             )
 
             parent_span_context = trace_api.SpanContext(
@@ -366,7 +366,7 @@ def get_exhaustive_otel_span_list() -> List[trace._Span]:
                 events=(
                     trace.Event(
                         name="event0",
-                        timestamp=base_time + 50 * 10 ** 6,
+                        timestamp=base_time + 50 * 10**6,
                         attributes={
                             "annotation_bool": True,
                             "annotation_string": "annotation_test",
@@ -429,14 +429,14 @@ def get_exhaustive_otel_span_list() -> List[trace._Span]:
     # pylint: disable=W0223
     class CommonJsonEncoderTest(CommonEncoderTest, abc.ABC):
         def test_encode_trace_id(self):
-            for trace_id in (1, 1024, 2 ** 32, 2 ** 64, 2 ** 65):
+            for trace_id in (1, 1024, 2**32, 2**64, 2**65):
                 self.assertEqual(
                     format(trace_id, "032x"),
                     self.get_encoder_default()._encode_trace_id(trace_id),
                 )
 
         def test_encode_span_id(self):
-            for span_id in (1, 1024, 2 ** 8, 2 ** 16, 2 ** 32, 2 ** 64):
+            for span_id in (1, 1024, 2**8, 2**16, 2**32, 2**64):
                 self.assertEqual(
                     format(span_id, "016x"),
                     self.get_encoder_default()._encode_span_id(span_id),
diff --git a/exporter/opentelemetry-exporter-zipkin-json/tests/encoder/test_v1_json.py b/exporter/opentelemetry-exporter-zipkin-json/tests/encoder/test_v1_json.py
index a7e0480f0e2..b099040acc9 100644
--- a/exporter/opentelemetry-exporter-zipkin-json/tests/encoder/test_v1_json.py
+++ b/exporter/opentelemetry-exporter-zipkin-json/tests/encoder/test_v1_json.py
@@ -48,13 +48,13 @@ def test_encode(self):
                     otel_spans[0].context.span_id
                 ),
                 "name": otel_spans[0].name,
-                "timestamp": otel_spans[0].start_time // 10 ** 3,
-                "duration": (otel_spans[0].end_time // 10 ** 3)
-                - (otel_spans[0].start_time // 10 ** 3),
+                "timestamp": otel_spans[0].start_time // 10**3,
+                "duration": (otel_spans[0].end_time // 10**3)
+                - (otel_spans[0].start_time // 10**3),
                 "annotations": [
                     {
                         "timestamp": otel_spans[0].events[0].timestamp
-                        // 10 ** 3,
+                        // 10**3,
                         "value": json.dumps(
                             {
                                 "event0": {
@@ -101,9 +101,9 @@ def test_encode(self):
                     otel_spans[1].context.span_id
                 ),
                 "name": otel_spans[1].name,
-                "timestamp": otel_spans[1].start_time // 10 ** 3,
-                "duration": (otel_spans[1].end_time // 10 ** 3)
-                - (otel_spans[1].start_time // 10 ** 3),
+                "timestamp": otel_spans[1].start_time // 10**3,
+                "duration": (otel_spans[1].end_time // 10**3)
+                - (otel_spans[1].start_time // 10**3),
                 "binaryAnnotations": [
                     {
                         "key": "key_resource",
@@ -128,9 +128,9 @@ def test_encode(self):
                     otel_spans[2].context.span_id
                 ),
                 "name": otel_spans[2].name,
-                "timestamp": otel_spans[2].start_time // 10 ** 3,
-                "duration": (otel_spans[2].end_time // 10 ** 3)
-                - (otel_spans[2].start_time // 10 ** 3),
+                "timestamp": otel_spans[2].start_time // 10**3,
+                "duration": (otel_spans[2].end_time // 10**3)
+                - (otel_spans[2].start_time // 10**3),
                 "binaryAnnotations": [
                     {
                         "key": "key_string",
@@ -150,9 +150,9 @@ def test_encode(self):
                     otel_spans[3].context.span_id
                 ),
                 "name": otel_spans[3].name,
-                "timestamp": otel_spans[3].start_time // 10 ** 3,
-                "duration": (otel_spans[3].end_time // 10 ** 3)
-                - (otel_spans[3].start_time // 10 ** 3),
+                "timestamp": otel_spans[3].start_time // 10**3,
+                "duration": (otel_spans[3].end_time // 10**3)
+                - (otel_spans[3].start_time // 10**3),
                 "binaryAnnotations": [
                     {
                         "key": NAME_KEY,
@@ -177,8 +177,8 @@ def test_encode_id_zero_padding(self):
         trace_id = 0x0E0C63257DE34C926F9EFCD03927272E
         span_id = 0x04BF92DEEFC58C92
         parent_id = 0x0AAAAAAAAAAAAAAA
-        start_time = 683647322 * 10 ** 9  # in ns
-        duration = 50 * 10 ** 6
+        start_time = 683647322 * 10**9  # in ns
+        duration = 50 * 10**6
         end_time = start_time + duration
 
         otel_span = trace._Span(
diff --git a/exporter/opentelemetry-exporter-zipkin-json/tests/encoder/test_v2_json.py b/exporter/opentelemetry-exporter-zipkin-json/tests/encoder/test_v2_json.py
index 2898604a25b..9ceb9383fd6 100644
--- a/exporter/opentelemetry-exporter-zipkin-json/tests/encoder/test_v2_json.py
+++ b/exporter/opentelemetry-exporter-zipkin-json/tests/encoder/test_v2_json.py
@@ -48,9 +48,9 @@ def test_encode(self):
                     otel_spans[0].context.span_id
                 ),
                 "name": otel_spans[0].name,
-                "timestamp": otel_spans[0].start_time // 10 ** 3,
-                "duration": (otel_spans[0].end_time // 10 ** 3)
-                - (otel_spans[0].start_time // 10 ** 3),
+                "timestamp": otel_spans[0].start_time // 10**3,
+                "duration": (otel_spans[0].end_time // 10**3)
+                - (otel_spans[0].start_time // 10**3),
                 "localEndpoint": local_endpoint,
                 "kind": span_kind,
                 "tags": {
@@ -62,7 +62,7 @@ def test_encode(self):
                 "annotations": [
                     {
                         "timestamp": otel_spans[0].events[0].timestamp
-                        // 10 ** 3,
+                        // 10**3,
                         "value": json.dumps(
                             {
                                 "event0": {
@@ -86,9 +86,9 @@ def test_encode(self):
                     otel_spans[1].context.span_id
                 ),
                 "name": otel_spans[1].name,
-                "timestamp": otel_spans[1].start_time // 10 ** 3,
-                "duration": (otel_spans[1].end_time // 10 ** 3)
-                - (otel_spans[1].start_time // 10 ** 3),
+                "timestamp": otel_spans[1].start_time // 10**3,
+                "duration": (otel_spans[1].end_time // 10**3)
+                - (otel_spans[1].start_time // 10**3),
                 "localEndpoint": local_endpoint,
                 "kind": span_kind,
                 "tags": {
@@ -103,9 +103,9 @@ def test_encode(self):
                     otel_spans[2].context.span_id
                 ),
                 "name": otel_spans[2].name,
-                "timestamp": otel_spans[2].start_time // 10 ** 3,
-                "duration": (otel_spans[2].end_time // 10 ** 3)
-                - (otel_spans[2].start_time // 10 ** 3),
+                "timestamp": otel_spans[2].start_time // 10**3,
+                "duration": (otel_spans[2].end_time // 10**3)
+                - (otel_spans[2].start_time // 10**3),
                 "localEndpoint": local_endpoint,
                 "kind": span_kind,
                 "tags": {
@@ -119,9 +119,9 @@ def test_encode(self):
                     otel_spans[3].context.span_id
                 ),
                 "name": otel_spans[3].name,
-                "timestamp": otel_spans[3].start_time // 10 ** 3,
-                "duration": (otel_spans[3].end_time // 10 ** 3)
-                - (otel_spans[3].start_time // 10 ** 3),
+                "timestamp": otel_spans[3].start_time // 10**3,
+                "duration": (otel_spans[3].end_time // 10**3)
+                - (otel_spans[3].start_time // 10**3),
                 "localEndpoint": local_endpoint,
                 "kind": span_kind,
                 "tags": {NAME_KEY: "name", VERSION_KEY: "version"},
@@ -137,8 +137,8 @@ def test_encode_id_zero_padding(self):
         trace_id = 0x0E0C63257DE34C926F9EFCD03927272E
         span_id = 0x04BF92DEEFC58C92
         parent_id = 0x0AAAAAAAAAAAAAAA
-        start_time = 683647322 * 10 ** 9  # in ns
-        duration = 50 * 10 ** 6
+        start_time = 683647322 * 10**9  # in ns
+        duration = 50 * 10**6
         end_time = start_time + duration
 
         otel_span = trace._Span(
diff --git a/exporter/opentelemetry-exporter-zipkin-proto-http/tests/encoder/common_tests.py b/exporter/opentelemetry-exporter-zipkin-proto-http/tests/encoder/common_tests.py
index a04148b6ea4..8eaa5b1563b 100644
--- a/exporter/opentelemetry-exporter-zipkin-proto-http/tests/encoder/common_tests.py
+++ b/exporter/opentelemetry-exporter-zipkin-proto-http/tests/encoder/common_tests.py
@@ -96,15 +96,15 @@ def test_constructor_max_tag_value_length(self):
             )
 
         def test_nsec_to_usec_round(self):
-            base_time_nsec = 683647322 * 10 ** 9
+            base_time_nsec = 683647322 * 10**9
             for nsec in (
                 base_time_nsec,
-                base_time_nsec + 150 * 10 ** 6,
-                base_time_nsec + 300 * 10 ** 6,
-                base_time_nsec + 400 * 10 ** 6,
+                base_time_nsec + 150 * 10**6,
+                base_time_nsec + 300 * 10**6,
+                base_time_nsec + 400 * 10**6,
             ):
                 self.assertEqual(
-                    (nsec + 500) // 10 ** 3,
+                    (nsec + 500) // 10**3,
                     self.get_encoder_default()._nsec_to_usec_round(nsec),
                 )
 
@@ -168,8 +168,8 @@ def test_get_parent_id_from_span_context(self):
         def get_data_for_max_tag_length_test(
             max_tag_length: int,
         ) -> (trace._Span, Dict):
-            start_time = 683647322 * 10 ** 9  # in ns
-            duration = 50 * 10 ** 6
+            start_time = 683647322 * 10**9  # in ns
+            duration = 50 * 10**6
             end_time = start_time + duration
 
             span = trace._Span(
@@ -332,18 +332,18 @@ def get_data_for_max_tag_length_test(
         def get_exhaustive_otel_span_list() -> List[trace._Span]:
             trace_id = 0x6E0C63257DE34C926F9EFCD03927272E
 
-            base_time = 683647322 * 10 ** 9  # in ns
+            base_time = 683647322 * 10**9  # in ns
             start_times = (
                 base_time,
-                base_time + 150 * 10 ** 6,
-                base_time + 300 * 10 ** 6,
-                base_time + 400 * 10 ** 6,
+                base_time + 150 * 10**6,
+                base_time + 300 * 10**6,
+                base_time + 400 * 10**6,
             )
             end_times = (
-                start_times[0] + (50 * 10 ** 6),
-                start_times[1] + (100 * 10 ** 6),
-                start_times[2] + (200 * 10 ** 6),
-                start_times[3] + (300 * 10 ** 6),
+                start_times[0] + (50 * 10**6),
+                start_times[1] + (100 * 10**6),
+                start_times[2] + (200 * 10**6),
+                start_times[3] + (300 * 10**6),
             )
 
             parent_span_context = trace_api.SpanContext(
@@ -366,7 +366,7 @@ def get_exhaustive_otel_span_list() -> List[trace._Span]:
                 events=(
                     trace.Event(
                         name="event0",
-                        timestamp=base_time + 50 * 10 ** 6,
+                        timestamp=base_time + 50 * 10**6,
                         attributes={
                             "annotation_bool": True,
                             "annotation_string": "annotation_test",
@@ -429,14 +429,14 @@ def get_exhaustive_otel_span_list() -> List[trace._Span]:
     # pylint: disable=W0223
     class CommonJsonEncoderTest(CommonEncoderTest, abc.ABC):
         def test_encode_trace_id(self):
-            for trace_id in (1, 1024, 2 ** 32, 2 ** 64, 2 ** 65):
+            for trace_id in (1, 1024, 2**32, 2**64, 2**65):
                 self.assertEqual(
                     format(trace_id, "032x"),
                     self.get_encoder_default()._encode_trace_id(trace_id),
                 )
 
         def test_encode_span_id(self):
-            for span_id in (1, 1024, 2 ** 8, 2 ** 16, 2 ** 32, 2 ** 64):
+            for span_id in (1, 1024, 2**8, 2**16, 2**32, 2**64):
                 self.assertEqual(
                     format(span_id, "016x"),
                     self.get_encoder_default()._encode_span_id(span_id),
diff --git a/exporter/opentelemetry-exporter-zipkin-proto-http/tests/encoder/test_v2_protobuf.py b/exporter/opentelemetry-exporter-zipkin-proto-http/tests/encoder/test_v2_protobuf.py
index 787566e7109..4ba1ea220a2 100644
--- a/exporter/opentelemetry-exporter-zipkin-proto-http/tests/encoder/test_v2_protobuf.py
+++ b/exporter/opentelemetry-exporter-zipkin-proto-http/tests/encoder/test_v2_protobuf.py
@@ -33,14 +33,14 @@ def get_encoder(*args, **kwargs) -> ProtobufEncoder:
         return ProtobufEncoder(*args, **kwargs)
 
     def test_encode_trace_id(self):
-        for trace_id in (1, 1024, 2 ** 32, 2 ** 64, 2 ** 127):
+        for trace_id in (1, 1024, 2**32, 2**64, 2**127):
             self.assertEqual(
                 self.get_encoder_default()._encode_trace_id(trace_id),
                 trace_id.to_bytes(length=16, byteorder="big", signed=False),
             )
 
     def test_encode_span_id(self):
-        for span_id in (1, 1024, 2 ** 8, 2 ** 16, 2 ** 32, 2 ** 63):
+        for span_id in (1, 1024, 2**8, 2**16, 2**32, 2**63):
             self.assertEqual(
                 self.get_encoder_default()._encode_span_id(span_id),
                 span_id.to_bytes(length=8, byteorder="big", signed=False),
diff --git a/opentelemetry-api/src/opentelemetry/trace/span.py b/opentelemetry-api/src/opentelemetry/trace/span.py
index 23eac7337ed..228e505281c 100644
--- a/opentelemetry-api/src/opentelemetry/trace/span.py
+++ b/opentelemetry-api/src/opentelemetry/trace/span.py
@@ -387,8 +387,8 @@ def values(self) -> typing.ValuesView[str]:
 
 
 DEFAULT_TRACE_STATE = TraceState.get_default()
-_TRACE_ID_MAX_VALUE = 2 ** 128 - 1
-_SPAN_ID_MAX_VALUE = 2 ** 64 - 1
+_TRACE_ID_MAX_VALUE = 2**128 - 1
+_SPAN_ID_MAX_VALUE = 2**64 - 1
 
 
 class SpanContext(
diff --git a/opentelemetry-sdk/src/opentelemetry/sdk/util/instrumentation.py b/opentelemetry-sdk/src/opentelemetry/sdk/util/instrumentation.py
index 7f565ba8ea3..d634e1b8330 100644
--- a/opentelemetry-sdk/src/opentelemetry/sdk/util/instrumentation.py
+++ b/opentelemetry-sdk/src/opentelemetry/sdk/util/instrumentation.py
@@ -40,15 +40,11 @@ def __hash__(self):
         return hash((self._name, self._version, self._schema_url))
 
     def __eq__(self, value):
-        return (
-            type(value) is type(self)
-            and (
-                self._name,
-                self._version,
-                self._schema_url,
-            )
-            == (value._name, value._version, value._schema_url)
-        )
+        return type(value) is type(self) and (
+            self._name,
+            self._version,
+            self._schema_url,
+        ) == (value._name, value._version, value._schema_url)
 
     def __lt__(self, value):
         if type(value) is not type(self):
diff --git a/opentelemetry-sdk/tests/trace/test_sampling.py b/opentelemetry-sdk/tests/trace/test_sampling.py
index ba6c5f5636a..c5f922c8e5c 100644
--- a/opentelemetry-sdk/tests/trace/test_sampling.py
+++ b/opentelemetry-sdk/tests/trace/test_sampling.py
@@ -255,7 +255,7 @@ def test_probability_sampler_limits(self):
         # Sample one of every 2^64 (= 5e-20) traces. This is the lowest
         # possible meaningful sampling rate, only traces with trace ID 0x0
         # should get sampled.
-        almost_always_off = sampling.TraceIdRatioBased(2 ** -64)
+        almost_always_off = sampling.TraceIdRatioBased(2**-64)
         self.assertTrue(
             almost_always_off.should_sample(
                 None, 0x0, "span name"
@@ -267,7 +267,7 @@ def test_probability_sampler_limits(self):
             ).decision.is_sampled()
         )
         self.assertEqual(
-            sampling.TraceIdRatioBased.get_bound_for_rate(2 ** -64), 0x1
+            sampling.TraceIdRatioBased.get_bound_for_rate(2**-64), 0x1
         )
 
         # Sample every trace with trace ID less than 0xffffffffffffffff. In
@@ -278,7 +278,7 @@ def test_probability_sampler_limits(self):
         #
         #     1 - sys.float_info.epsilon
 
-        almost_always_on = sampling.TraceIdRatioBased(1 - 2 ** -64)
+        almost_always_on = sampling.TraceIdRatioBased(1 - 2**-64)
         self.assertTrue(
             almost_always_on.should_sample(
                 None, 0xFFFFFFFFFFFFFFFE, "span name"
diff --git a/scripts/eachdist.py b/scripts/eachdist.py
index 58064a7400d..427f990fe18 100755
--- a/scripts/eachdist.py
+++ b/scripts/eachdist.py
@@ -630,7 +630,7 @@ def update_dependencies(targets, version, packages):
         update_files(
             targets,
             "setup.cfg",
-            fr"({basename(pkg)}.*)==(.*)",
+            rf"({basename(pkg)}.*)==(.*)",
             r"\1== " + version,
         )
 
diff --git a/tests/opentelemetry-test-utils/setup.cfg b/tests/opentelemetry-test-utils/setup.cfg
index cf5220fc3b8..dc2c84d6d47 100644
--- a/tests/opentelemetry-test-utils/setup.cfg
+++ b/tests/opentelemetry-test-utils/setup.cfg
@@ -42,7 +42,7 @@ install_requires =
     opentelemetry-sdk ~= 1.3
 
 [options.extras_require]
-test = flask~=1.0
+test = flask~=2.0
 
 [options.packages.find]
 where = src