diff --git a/CHANGELOG.md b/CHANGELOG.md
index 0a1039f83a..33f83bb0ae 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -46,6 +46,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
   ([#3022](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/3022))
 - Replace all instrumentor unit test `assertEqualSpanInstrumentationInfo` calls with `assertEqualSpanInstrumentationScope` calls
   ([#3037](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/3037))
+- `opentelemetry-instrumentation-sqlalchemy` Fixes engines from `sqlalchemy.engine_from_config` not being fully instrumented
+  ([#2816](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2816))
 - `opentelemetry-instrumentation-sqlalchemy`: Fix a remaining memory leak in EngineTracer
   ([#3053](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/3053))
 
diff --git a/instrumentation/opentelemetry-instrumentation-sqlalchemy/src/opentelemetry/instrumentation/sqlalchemy/__init__.py b/instrumentation/opentelemetry-instrumentation-sqlalchemy/src/opentelemetry/instrumentation/sqlalchemy/__init__.py
index 9889e18b5a..4182c0034e 100644
--- a/instrumentation/opentelemetry-instrumentation-sqlalchemy/src/opentelemetry/instrumentation/sqlalchemy/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-sqlalchemy/src/opentelemetry/instrumentation/sqlalchemy/__init__.py
@@ -181,6 +181,18 @@ def _instrument(self, **kwargs):
                 tracer, connections_usage, enable_commenter, commenter_options
             ),
         )
+        # sqlalchemy.engine.create is not present in earlier versions of sqlalchemy (which we support)
+        if parse_version(sqlalchemy.__version__).release >= (1, 4):
+            _w(
+                "sqlalchemy.engine.create",
+                "create_engine",
+                _wrap_create_engine(
+                    tracer,
+                    connections_usage,
+                    enable_commenter,
+                    commenter_options,
+                ),
+            )
         _w(
             "sqlalchemy.engine.base",
             "Engine.connect",
@@ -224,6 +236,8 @@ def _instrument(self, **kwargs):
     def _uninstrument(self, **kwargs):
         unwrap(sqlalchemy, "create_engine")
         unwrap(sqlalchemy.engine, "create_engine")
+        if parse_version(sqlalchemy.__version__).release >= (1, 4):
+            unwrap(sqlalchemy.engine.create, "create_engine")
         unwrap(Engine, "connect")
         if parse_version(sqlalchemy.__version__).release >= (1, 4):
             unwrap(sqlalchemy.ext.asyncio, "create_async_engine")
diff --git a/instrumentation/opentelemetry-instrumentation-sqlalchemy/tests/test_sqlalchemy.py b/instrumentation/opentelemetry-instrumentation-sqlalchemy/tests/test_sqlalchemy.py
index 18b9fa65f7..27a253decb 100644
--- a/instrumentation/opentelemetry-instrumentation-sqlalchemy/tests/test_sqlalchemy.py
+++ b/instrumentation/opentelemetry-instrumentation-sqlalchemy/tests/test_sqlalchemy.py
@@ -182,6 +182,17 @@ def test_create_engine_wrapper(self):
             "opentelemetry.instrumentation.sqlalchemy",
         )
 
+    def test_instrument_engine_from_config(self):
+        SQLAlchemyInstrumentor().instrument()
+        from sqlalchemy import engine_from_config  # pylint: disable-all
+
+        engine = engine_from_config({"sqlalchemy.url": "sqlite:///:memory:"})
+        cnx = engine.connect()
+        cnx.execute(text("SELECT	1 + 1;")).fetchall()
+        spans = self.memory_exporter.get_finished_spans()
+
+        self.assertEqual(len(spans), 2)
+
     def test_create_engine_wrapper_enable_commenter(self):
         logging.getLogger("sqlalchemy.engine").setLevel(logging.INFO)
         SQLAlchemyInstrumentor().instrument(