diff --git a/packages/opentelemetry-propagator-jaeger/src/JaegerPropagator.ts b/packages/opentelemetry-propagator-jaeger/src/JaegerPropagator.ts
index f3a739f4b9..18cf2cee59 100644
--- a/packages/opentelemetry-propagator-jaeger/src/JaegerPropagator.ts
+++ b/packages/opentelemetry-propagator-jaeger/src/JaegerPropagator.ts
@@ -25,10 +25,10 @@ import {
   TraceFlags,
 } from '@opentelemetry/api';
 import { isTracingSuppressed } from '@opentelemetry/core';
+import { JaegerPropagatorConfig } from './types';
 
 export const UBER_TRACE_ID_HEADER = 'uber-trace-id';
 export const UBER_BAGGAGE_HEADER_PREFIX = 'uberctx';
-const UBER_BAGGAGE_HEADER_REGEX = /^uberctx-(.+)/i;
 
 /**
  * Propagates {@link SpanContext} through Trace Context format propagation.
@@ -47,12 +47,18 @@ const UBER_BAGGAGE_HEADER_REGEX = /^uberctx-(.+)/i;
  */
 export class JaegerPropagator implements TextMapPropagator {
   private readonly _jaegerTraceHeader: string;
-
-  /**
-   * @param {string} [customTraceHeader="uber-trace-id"] - HTTP header to inject\extract trace from.
-   **/
-  constructor(customTraceHeader?: string) {
-    this._jaegerTraceHeader = customTraceHeader || UBER_TRACE_ID_HEADER;
+  private readonly _jaegerBaggageHeaderPrefix: string;
+
+  constructor(customTraceHeader?: string)
+  constructor(config?: JaegerPropagatorConfig)
+  constructor(config?: JaegerPropagatorConfig | string) {
+    if (typeof config === 'string') {
+      this._jaegerTraceHeader = config;
+      this._jaegerBaggageHeaderPrefix = UBER_BAGGAGE_HEADER_PREFIX;
+    } else {
+      this._jaegerTraceHeader = config?.customTraceHeader || UBER_TRACE_ID_HEADER;
+      this._jaegerBaggageHeaderPrefix = config?.customBaggageHeaderPrefix || UBER_BAGGAGE_HEADER_PREFIX;
+    }
   }
 
   inject(context: Context, carrier: unknown, setter: TextMapSetter): void {
@@ -74,7 +80,7 @@ export class JaegerPropagator implements TextMapPropagator {
       for (const [key, entry] of baggage.getAllEntries()) {
         setter.set(
           carrier,
-          `${UBER_BAGGAGE_HEADER_PREFIX}-${key}`,
+          `${this._jaegerBaggageHeaderPrefix}-${key}`,
           encodeURIComponent(entry.value)
         );
       }
@@ -88,11 +94,11 @@ export class JaegerPropagator implements TextMapPropagator {
       : uberTraceIdHeader;
     const baggageValues = getter
       .keys(carrier)
-      .filter(key => UBER_BAGGAGE_HEADER_REGEX.test(key))
+      .filter(key => key.startsWith(`${this._jaegerBaggageHeaderPrefix}-`))
       .map(key => {
         const value = getter.get(carrier, key);
         return {
-          key: key.substring(UBER_BAGGAGE_HEADER_PREFIX.length + 1),
+          key: key.substring(this._jaegerBaggageHeaderPrefix.length + 1),
           value: Array.isArray(value) ? value[0] : value,
         };
       });
diff --git a/packages/opentelemetry-propagator-jaeger/src/types.ts b/packages/opentelemetry-propagator-jaeger/src/types.ts
new file mode 100644
index 0000000000..c6bb9879e1
--- /dev/null
+++ b/packages/opentelemetry-propagator-jaeger/src/types.ts
@@ -0,0 +1,20 @@
+/*
+ * Copyright The OpenTelemetry Authors
+ *
+ * Licensed under the Apache License, Version 2.0 (the "License");
+ * you may not use this file except in compliance with the License.
+ * You may obtain a copy of the License at
+ *
+ *      https://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+export interface JaegerPropagatorConfig {
+  customTraceHeader?: string,
+  customBaggageHeaderPrefix?: string,
+}
diff --git a/packages/opentelemetry-propagator-jaeger/test/JaegerPropagator.test.ts b/packages/opentelemetry-propagator-jaeger/test/JaegerPropagator.test.ts
index 93836c84c9..be93f05194 100644
--- a/packages/opentelemetry-propagator-jaeger/test/JaegerPropagator.test.ts
+++ b/packages/opentelemetry-propagator-jaeger/test/JaegerPropagator.test.ts
@@ -34,7 +34,12 @@ import {
 describe('JaegerPropagator', () => {
   const jaegerPropagator = new JaegerPropagator();
   const customHeader = 'new-header';
+  const customBaggageHeaderPrefix = 'custom-baggage-header-prefix';
   const customJaegerPropagator = new JaegerPropagator(customHeader);
+  const customJaegerPropagatorWithConfig = new JaegerPropagator({
+    customTraceHeader: customHeader,
+    customBaggageHeaderPrefix,
+  });
   let carrier: { [key: string]: unknown };
 
   beforeEach(() => {
@@ -114,6 +119,28 @@ describe('JaegerPropagator', () => {
         encodeURIComponent('%id%')
       );
     });
+
+    it('should propagate baggage with custom prefix with url encoded values', () => {
+      const baggage = propagation.createBaggage({
+        test: {
+          value: '1',
+        },
+        myuser: {
+          value: '%id%',
+        },
+      });
+
+      customJaegerPropagatorWithConfig.inject(
+        propagation.setBaggage(ROOT_CONTEXT, baggage),
+        carrier,
+        defaultTextMapSetter
+      );
+      assert.strictEqual(carrier[`${customBaggageHeaderPrefix}-test`], '1');
+      assert.strictEqual(
+        carrier[`${customBaggageHeaderPrefix}-myuser`],
+        encodeURIComponent('%id%')
+      );
+    });
   });
 
   describe('.extract()', () => {
@@ -215,6 +242,21 @@ describe('JaegerPropagator', () => {
       assert(secondEntry.value === '%id%');
     });
 
+    it('should extract baggage with custom prefix from carrier', () => {
+      carrier[`${customBaggageHeaderPrefix}-test`] = 'value';
+      carrier[`${customBaggageHeaderPrefix}-myuser`] = '%25id%25';
+      const extractedBaggage = propagation.getBaggage(
+        customJaegerPropagatorWithConfig.extract(ROOT_CONTEXT, carrier, defaultTextMapGetter)
+      );
+
+      const firstEntry = extractedBaggage?.getEntry('test');
+      assert(typeof firstEntry !== 'undefined');
+      assert(firstEntry.value === 'value');
+      const secondEntry = extractedBaggage?.getEntry('myuser');
+      assert(typeof secondEntry !== 'undefined');
+      assert(secondEntry.value === '%id%');
+    });
+
     it('should extract baggage from carrier and not override current one', () => {
       carrier[`${UBER_BAGGAGE_HEADER_PREFIX}-test`] = 'value';
       carrier[`${UBER_BAGGAGE_HEADER_PREFIX}-myuser`] = '%25id%25';
@@ -266,6 +308,9 @@ describe('JaegerPropagator', () => {
     it('returns the customized header if customized', () => {
       assert.deepStrictEqual(customJaegerPropagator.fields(), [customHeader]);
     });
+    it('returns the customized header if customized with config', () => {
+      assert.deepStrictEqual(customJaegerPropagatorWithConfig.fields(), [customHeader]);
+    });
   });
 
   it('should fail gracefully on bad responses from getter', () => {