diff --git a/experimental/CHANGELOG.md b/experimental/CHANGELOG.md
index 2e6ac3fbc6..b21634b9b2 100644
--- a/experimental/CHANGELOG.md
+++ b/experimental/CHANGELOG.md
@@ -17,6 +17,7 @@ All notable changes to experimental packages in this project will be documented
     * (internal) OTLPExporterBrowserBase: `RequestType` has been replaced by a `ResponseType` type-argument
     * (internal) OTLPExporterNodeBase: `ServiceRequest` has been replaced by a `ServiceResponse` type-argument
     * (internal) the `@opentelemetry/otlp-exporter-proto-base` package has been removed, and will from now on be deprecated in `npm`
+* fix(instrumentation)!: remove unused supportedVersions from Instrumentation interface [#4694](https://github.com/open-telemetry/opentelemetry-js/pull/4694) @blumamir
 
 ### :rocket: (Enhancement)
 
diff --git a/experimental/packages/opentelemetry-instrumentation/src/types.ts b/experimental/packages/opentelemetry-instrumentation/src/types.ts
index 3adc03921d..0445192de1 100644
--- a/experimental/packages/opentelemetry-instrumentation/src/types.ts
+++ b/experimental/packages/opentelemetry-instrumentation/src/types.ts
@@ -54,14 +54,6 @@ export interface Instrumentation<
 
   /** Method to get instrumentation config  */
   getConfig(): ConfigType;
-
-  /**
-   * Contains all supported versions.
-   * All versions must be compatible with [semver](https://semver.org/spec/v2.0.0.html) format.
-   * If the version is not supported, we won't apply instrumentation patch (see `enable` method).
-   * If omitted, all versions of the module will be patched.
-   */
-  supportedVersions?: string[];
 }
 
 /**
@@ -102,8 +94,6 @@ export interface InstrumentationModuleFile {
   /** Method to patch the instrumentation  */
   patch(moduleExports: unknown, moduleVersion?: string): unknown;
 
-  /** Method to patch the instrumentation  */
-
   /** Method to unpatch the instrumentation  */
   unpatch(moduleExports?: unknown, moduleVersion?: string): void;
 }