diff --git a/instrumentation/elasticsearch/elasticsearch-api-client-7.16/javaagent/build.gradle.kts b/instrumentation/elasticsearch/elasticsearch-api-client-7.16/javaagent/build.gradle.kts
index 1a1cca49c0aa..42cd0bd1467c 100644
--- a/instrumentation/elasticsearch/elasticsearch-api-client-7.16/javaagent/build.gradle.kts
+++ b/instrumentation/elasticsearch/elasticsearch-api-client-7.16/javaagent/build.gradle.kts
@@ -6,7 +6,7 @@ muzzle {
   pass {
     group.set("co.elastic.clients")
     module.set("elasticsearch-java")
-    versions.set("[7.16,)")
+    versions.set("[7.16,8.10)") // 8.10+ has native, on-by-default opentelemetry instrumentation
     assertInverse.set(true)
   }
 }
@@ -23,6 +23,7 @@ dependencies {
   testImplementation("com.fasterxml.jackson.core:jackson-databind:2.14.2")
   testImplementation("org.testcontainers:elasticsearch")
 
+  // 8.10+ has native, on-by-default opentelemetry instrumentation
   latestDepTestLibrary("co.elastic.clients:elasticsearch-java:8.0.+")
 }
 
diff --git a/instrumentation/elasticsearch/elasticsearch-api-client-7.16/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/elasticsearch/apiclient/ElasticsearchApiClientInstrumentationModule.java b/instrumentation/elasticsearch/elasticsearch-api-client-7.16/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/elasticsearch/apiclient/ElasticsearchApiClientInstrumentationModule.java
index 31ab3e3b84b5..834be5b9e584 100644
--- a/instrumentation/elasticsearch/elasticsearch-api-client-7.16/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/elasticsearch/apiclient/ElasticsearchApiClientInstrumentationModule.java
+++ b/instrumentation/elasticsearch/elasticsearch-api-client-7.16/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/elasticsearch/apiclient/ElasticsearchApiClientInstrumentationModule.java
@@ -5,12 +5,15 @@
 
 package io.opentelemetry.javaagent.instrumentation.elasticsearch.apiclient;
 
+import static io.opentelemetry.javaagent.extension.matcher.AgentElementMatchers.hasClassesNamed;
 import static java.util.Arrays.asList;
+import static net.bytebuddy.matcher.ElementMatchers.not;
 
 import com.google.auto.service.AutoService;
 import io.opentelemetry.javaagent.extension.instrumentation.InstrumentationModule;
 import io.opentelemetry.javaagent.extension.instrumentation.TypeInstrumentation;
 import java.util.List;
+import net.bytebuddy.matcher.ElementMatcher;
 
 @AutoService(InstrumentationModule.class)
 public class ElasticsearchApiClientInstrumentationModule extends InstrumentationModule {
@@ -18,6 +21,15 @@ public ElasticsearchApiClientInstrumentationModule() {
     super("elasticsearch-api-client-7.16", "elasticsearch");
   }
 
+  @Override
+  public ElementMatcher.Junction<ClassLoader> classLoaderMatcher() {
+    // Since Elasticsearch client version 8.10, the ES client comes with a native OTel
+    // instrumentation
+    // that introduced the class `co.elastic.clients.transport.instrumentation.Instrumentation`.
+    // Disabling agent instrumentation for those cases.
+    return not(hasClassesNamed("co.elastic.clients.transport.instrumentation.Instrumentation"));
+  }
+
   @Override
   public List<TypeInstrumentation> typeInstrumentations() {
     return asList(
diff --git a/instrumentation/elasticsearch/elasticsearch-rest-7.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/elasticsearch/rest/v7_0/ElasticsearchRest7InstrumentationModule.java b/instrumentation/elasticsearch/elasticsearch-rest-7.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/elasticsearch/rest/v7_0/ElasticsearchRest7InstrumentationModule.java
index 81001ea209e0..2546a5cac39b 100644
--- a/instrumentation/elasticsearch/elasticsearch-rest-7.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/elasticsearch/rest/v7_0/ElasticsearchRest7InstrumentationModule.java
+++ b/instrumentation/elasticsearch/elasticsearch-rest-7.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/elasticsearch/rest/v7_0/ElasticsearchRest7InstrumentationModule.java
@@ -22,7 +22,7 @@ public ElasticsearchRest7InstrumentationModule() {
 
   @Override
   public ElementMatcher.Junction<ClassLoader> classLoaderMatcher() {
-    // class introduced in 7.0.0
+    // Class `org.elasticsearch.client.RestClient$InternalRequest` introduced in 7.0.0.
     return hasClassesNamed("org.elasticsearch.client.RestClient$InternalRequest");
   }