diff --git a/instrumentation/netty/netty-4.1/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/netty/v4_1/client/HttpClientResponseTracingHandler.java b/instrumentation/netty/netty-4.1/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/netty/v4_1/client/HttpClientResponseTracingHandler.java
index 3087576aae50..29f06d4b0bd2 100644
--- a/instrumentation/netty/netty-4.1/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/netty/v4_1/client/HttpClientResponseTracingHandler.java
+++ b/instrumentation/netty/netty-4.1/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/netty/v4_1/client/HttpClientResponseTracingHandler.java
@@ -9,14 +9,20 @@
 
 import io.netty.channel.ChannelHandlerContext;
 import io.netty.channel.ChannelInboundHandlerAdapter;
+import io.netty.handler.codec.http.FullHttpResponse;
 import io.netty.handler.codec.http.HttpResponse;
+import io.netty.handler.codec.http.LastHttpContent;
 import io.netty.util.Attribute;
+import io.netty.util.AttributeKey;
 import io.opentelemetry.context.Context;
 import io.opentelemetry.context.Scope;
 import io.opentelemetry.instrumentation.netty.v4_1.AttributeKeys;
 
 public class HttpClientResponseTracingHandler extends ChannelInboundHandlerAdapter {
 
+  private static final AttributeKey<HttpResponse> HTTP_RESPONSE =
+      AttributeKey.valueOf(HttpClientResponseTracingHandler.class, "http-response");
+
   @Override
   public void channelRead(ChannelHandlerContext ctx, Object msg) {
     Context context = ctx.channel().attr(AttributeKeys.CLIENT_CONTEXT).get();
@@ -25,8 +31,15 @@ public void channelRead(ChannelHandlerContext ctx, Object msg) {
       return;
     }
 
-    if (msg instanceof HttpResponse) {
+    if (msg instanceof FullHttpResponse) {
       tracer().end(context, (HttpResponse) msg);
+    } else if (msg instanceof HttpResponse) {
+      // Headers before body have been received, store them to use when finishing the span.
+      ctx.channel().attr(HTTP_RESPONSE).set((HttpResponse) msg);
+    } else if (msg instanceof LastHttpContent) {
+      // Not a FullHttpResponse so this is content that has been received after headers. Finish the
+      // span using what we stored in attrs.
+      tracer().end(context, ctx.channel().attr(HTTP_RESPONSE).get());
     }
 
     // We want the callback in the scope of the parent, not the client span
diff --git a/instrumentation/netty/netty-4.1/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/netty/v4_1/server/HttpServerResponseTracingHandler.java b/instrumentation/netty/netty-4.1/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/netty/v4_1/server/HttpServerResponseTracingHandler.java
index 256d49e2b9af..adf6d7be4414 100644
--- a/instrumentation/netty/netty-4.1/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/netty/v4_1/server/HttpServerResponseTracingHandler.java
+++ b/instrumentation/netty/netty-4.1/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/netty/v4_1/server/HttpServerResponseTracingHandler.java
@@ -7,29 +7,73 @@
 
 import static io.opentelemetry.javaagent.instrumentation.netty.v4_1.server.NettyHttpServerTracer.tracer;
 
+import io.netty.channel.ChannelFuture;
 import io.netty.channel.ChannelHandlerContext;
 import io.netty.channel.ChannelOutboundHandlerAdapter;
 import io.netty.channel.ChannelPromise;
+import io.netty.handler.codec.http.FullHttpResponse;
 import io.netty.handler.codec.http.HttpResponse;
+import io.netty.handler.codec.http.LastHttpContent;
+import io.netty.util.AttributeKey;
 import io.opentelemetry.context.Context;
 import io.opentelemetry.context.Scope;
 
 public class HttpServerResponseTracingHandler extends ChannelOutboundHandlerAdapter {
 
+  private static final AttributeKey<HttpResponse> HTTP_RESPONSE =
+      AttributeKey.valueOf(HttpServerResponseTracingHandler.class, "http-response");
+
   @Override
   public void write(ChannelHandlerContext ctx, Object msg, ChannelPromise prm) {
     Context context = tracer().getServerContext(ctx.channel());
-    if (context == null || !(msg instanceof HttpResponse)) {
+    if (context == null) {
       ctx.write(msg, prm);
       return;
     }
 
+    final ChannelPromise writePromise;
+
+    if (msg instanceof LastHttpContent) {
+      if (prm.isVoid()) {
+        // Some frameworks don't actually listen for response completion and optimize for
+        // allocations by using a singleton, unnotifiable promise. Hopefully these frameworks don't
+        // have observability features or they'd be way off...
+        writePromise = ctx.newPromise();
+      } else {
+        writePromise = prm;
+      }
+      // Going to finish the span after the write of the last content finishes.
+      if (msg instanceof FullHttpResponse) {
+        // Headers and body all sent together, we have the response information in the msg.
+        writePromise.addListener(future -> finish(context, writePromise, (FullHttpResponse) msg));
+      } else {
+        // Body sent after headers. We stored the response information in the context when
+        // encountering HttpResponse (which was not FullHttpResponse since it's not
+        // LastHttpContent).
+        writePromise.addListener(
+            future -> finish(context, writePromise, ctx.channel().attr(HTTP_RESPONSE).get()));
+      }
+    } else {
+      writePromise = prm;
+      if (msg instanceof HttpResponse) {
+        // Headers before body has been sent, store them to use when finishing the span.
+        ctx.channel().attr(HTTP_RESPONSE).set((HttpResponse) msg);
+      }
+    }
+
     try (Scope ignored = context.makeCurrent()) {
-      ctx.write(msg, prm);
+      ctx.write(msg, writePromise);
     } catch (Throwable throwable) {
       tracer().endExceptionally(context, throwable);
       throw throwable;
     }
-    tracer().end(context, (HttpResponse) msg);
+  }
+
+  private static void finish(Context context, ChannelFuture future, HttpResponse response) {
+    if (future.isSuccess()) {
+      tracer().end(context, response);
+    } else {
+      tracer().endExceptionally(context, future.cause());
+    }
   }
 }